CARTI si PUBLICATII

TERAPII MIRACULOASE

„Daca doresti sa ai o viata lunga, trateaza-te corect si alimenteaza-te constient”
Dr. Mircea Ciuhrii

CUPRINS:

1.    Prefata
2.    Cum este conceput organismul uman
2.1.    Pielea – învelisul corpului uman
2.1.1.    Vascularizarea si inervatia pielii
2.2.    Scheletul corpului uman
2.3.    Aparatul digestiv
2.3.1.    Structura si functia ficatului
2.3.2.    Afectiunile cel mai des întâlnite ale ficatului
2.3.3.    Interpretarea rezultatelor de laborator privind situatii infectiilor hepatice
2.3.4.    Structura, functia si afectiunile pancreasului
2.4.    Aparatul urinar
2.5.    Aparatul respirator
2.6.    Aparatul cardio-vascular
2.7.    Structura sistemului nervos – Generalitati
2.8.    Notiuni de psihiatrie
2.8.1.    Tulburari de fond ale gândirii
2.8.2.    Tulburari toxice
2.9.    Fenomene nepercepute de ratiunea umana
2.9.1.    Fenomenul „India”
2.9.2.    Fenomenul „stigmatele”
2.9.3.    Autocontrolul functiilor fiziologice ale corpului uman
2.9.4.    Spatiul cosmic în viata fiintei umane
2.9.5.    Miracolul rugaciunii
3.    Faunoterapia – Utilizarea animalelor în tratarea si alimentatia omului
3.1.    Substante biologic active extrase din amfibieni
3.2.    Reptilele în farmacologie
3.3.    Toxinele paianjenilor si scorpionilor, utilizate în farmacie
3.4.    Utilizarea viermilor în farmacie
3.5.    Utilizarea feromonilor în reglarea comportamentului organismelor vii
3.6.    Obtinerea medicamentelor din keratine (coarne, copite, unghii)
3.7.    Utilizarea secretiei biliare în scop curativ
3.8.    Utilizarea organelor animale în reglarea proceselor vitale
4.    Entomoterapia
4.1.    Analize spectrale ale substantelor biologic active extrase din insecte
4.2.    Utilizarea insectelor în alimentatie
4.3.    Biologia moleculara a insectelor
5.    Actiuni specifice ale SBA din insecte
5.1.    Substante biologic active cu efect keratolitic
5.2.    Substante biologic active cu efect antiviral
5.3.    Substante biologic active cu efect antibacterian
5.4.    Substante biologic active cu efect antifungic
5.5.    Substante biologic active cu efect antitumoral
5.6.    Substante biologic active cu efect antiparadontoza
5.7.    Actiuni paradoxale ale organismelor vii
6.    Influenta SBA asupra functiilor hepatice
6.1.    Modele experimentale
6.2.    Influenta SBA asupra parametrilor biochimici în hepatita experimentata cu fenilefrina
7.    Eficacitatea produsului biologic activ în hiperplazia benigna a prostatei
8.    Determinarea toxicitatii SBA extrase din insecte
8.1.    Determinarea toxicitatii acute
8.2.    Determinarea toxicitatii cronice
8.3.    Determinarea influentei SBA asupra parametrilor biochimici
9.    Rezultatul studierii si evaluarii efectului antiviral al SBA
10.    Studiul actiunii cancerigene al SBA
11.    Studiul actiunii embriotoxice a SBA
11.1.    Determinarea dereglarilor dezvoltarii embrionilor în perioada Antenatala
11.2.    Determinarea dereglarilor dezvoltarii embrionilor în perioada Postnatala
12.    Activitatile antibacteriene si antifungice ale SBA
12.1.    Cercetarea activitatii antibacteriene
12.2.    Cercetarea activitatii antifungice
13.    Retete calitative ale preparatelor din gamele „Fly-Flz” si „Noblesse”
14.    Reguli generale despre regimul alimentar
14.1.    Echilibrul alimentar
14.2.    Hrana – medicament
14.3.    Terapie dietetica
14.4.    Regimul alimentar
14.5.    Dieta pentru ulcer gastric si duodenal
14.6.    Dieta pentru tratarea constipatiei
14.7.    Dieta pentru tratarea enterocolitelor
14.8.    Dieta pentru pacienti bolnavi de hepatita
14.9.    Dieta pentru pacienti bolnavi de colecist si pancreas
14.10.    Dieta pentru bolnavii de gonartroza
14.11.    Dieta pentru pacientii bolnavi de nefrite si nefroze
14.12.    Dieta pentru pacientii supraponderali
14.13.    Dieta pentru pacientii cu afectiuni cardiace sau circulatorii
14.14.    Dieta pentru pacientii bolnavi de tuberculoza sau alte afectiuni pulmonare
14.15.    Dieta pentru pacientii bolnavi de leucemie, anemie, distrofie
14.16.    Dieta pentru pacientii infectati cu agenti patogeni
14.17.    Dieta pentru pacientii bolnavi de hiperuricemie
14.18.    Dieta de dezintoxicare
14.19.    Recomandarile lui M. Garen
14.20.    Dieta dupa conceptia lui Eni Uigmor
14.21.    Dieta dupa G. Heia
15.    Comentariul autorului despre dietele alimentare
16.    Sapte conditii pentru evaluarea sanatatii fiintei umane
16.1.    Nutritia oamenilor vârstnici
16.2.    Regimul alimentar al gravidelor si al femeilor care alapteaza
16.3.    Influenta medicamentelor asupra mamei si copilului
16.4.    Alimentatia copiilor pâna la 1 an
16.5.    Alimentatia copiilor cu vârsta cuprinsa între 1 si 3 ani
16.6.    Alimentatia copiilor de vârsta scolara
16.7.    Meniu model pentru adolescenti
16.8.    Alimentatia oamenilor de vârsta a 3-a
16.9.    Comentariu la alimentatia batrânilor
16.10.    Despre consumul apei si vinului
16.11.    Dezintoxicarea organismului prin post
16.12.    Purificarea prin înfometarea de scurta durata
16.13.    Purificarea prin înfometarea de lunga durata (postul)
16.14.    Alimentatia cu carne
16.15.    Produsele alimentare obtinute din organele animalelor
17.    Experimentarea preparatelor obtinute din insecte pe corpul autorului

VIRUSUL, SPAIMA SI SPERANTA OMENIRII

De ce aceasta carte ?
Credem ca la ora actuala a sosit vremea sa fie scrisa o carte  planificata cu multi ani in urma, (aproximativ 30 de ani) si suntem convinsi ca aceasta carte este asteptata cu siguranta de catre societatea celor interesati atat de noutatile stiintifice cat si de bolnavi.  In ultimul timp virusologia ca obiect de cercetare a virusurilor este tot mai mult abordata de catre nespecialisti, de simplii cetatani care doresc sa stie si sa inteleaga tot mai mult din ceea ce se intampla in jurul lor. Oamenii nu pot intelege (fara explicatii ample aduse la zi, ca cele pe care le vor gasi in aceasta carte) ce se intampla cu infectiile virale. Multi dintre ei nu-si inchipuie ce sunt aceste structuri patogene, cum pot fi ele raspandite in mijlocul populatiei, care de multe ori provoaca infectii simple si pot duce rapid la decese.
In ultimul timp asistam la raspandirea virusului gripei aviare. Nimeni nu-si inchipuie cum acest virus al gripei aviare – care a creat deja panica- poate provoca o epidemie pe tot mapamondul, de aceea  toti sunt interesati de ce se poate intampla in cel mai apropiat timp. Din istorie toti isi amintesc o epidemie care a provocat aproape 50 de milioane de decese in anul 1919 sub denumirea de ,,pandemia spaniola ,,.
In acea vreme, virusologia era o directie absolut noua in stiinta. Ea a aparut in anul 1898. Acum, odata cu dezvoltarea progresului tehnico – stiintific apar alte probleme, apar probleme de constientizare a aparitiei infectiilor date de catre virusuri. Mai ales in toamna anului 2005 si iarna anului 2006, cand virusul gripei aviare a aparut pe teritoriul Romaniei, toti (administratia si populatia) au fost  speriati de aceste infectii, deoarece stirea a fost ca ele se pot transmite si la om, dar acest proces de trecere de la o specie la alta este un proces care se intampla in mod exceptional, lucru foarte greu de inteles. Insa spaima omului este extraordinar de mare. In fiecare zi, la fiecare ora erau difuzate informatii despre aparitia noilor focare provocate de virusul gripei aviare, care distruge o serie intreaga de specii de  pasari, dar care poate trece si la alte animale (in primul rand poate trece la porc si de la porc poate trece la om). Virusul gripei aviare, in primul rand poate infecta organismele umane cu un sistem imunitar scazut si principala teama este ca ele se pot adapta si trece de la pasari la fiinte mai bine dezvoltate, cum este fiinta umana.
Iata din ce cauza acest virus al gripei aviare este foarte periculos. Bineinteles ca vorbim astazi din ce in ce mai mult despre virusul gripei aviare, deoarece acest virus se raspandeste rapid mai ales in timpul toamnei si al primaverii cand sistemul imunitar este mai scazut la toate vietuitoarele.
Insa cum se intampla  aceasta transmitere a infectiilor virale in realitate ?
Vom vedea in cele ce urmeaza !
Acum spaima omenirii este de a nu apare o pandemie asemanatoare cu cea din secolul XX. Sunt foarte multe informatii despre aceasta pandemie care a sters de pe fata pamantului o buna parte a populatiei. Bineinteles ca la ora actuala cunoastem mult mai multe despre infectiile virale si mai ales despre infectiile cu virusul gripal care pot provoaca decese rapide, in timp de cateva zile, neexistand remedii specifice, de aceea spaima omului este si mai mare. Decesele apar in urma afectarii aparatului pulmonar in primul rand, si in mod secundar a inimii, ducand rapid la deces.
Alte virusuri, asa cum se va citi in cuprinsul acestui volum, pot provoca suferinte de lunga durata cu sfarsit tragic (SIDA, Hepatitele virale) sau cu sechele care vor marca intreaga viata (encefalitele, poliomielitele etc)
La inceputul anului  2006,  epidemiile gripei aviare au inceput in Thailanda, China, Vietnam si alte tari din Asia. Au fost incriminate drept sursa si vectori pasarile migratoare care se afla in timpul verii in zonele nordice ale planetei, unde se inmultesc asa cum se stie, apoi se retrag in timpul sezonului rece in zonele mai calde. In timpul zborului se presupune ca acest virus este eliminat prin  excrementele lor, si prin alte fractiuni ( cum este puful ori penele) care pot fi purtatoarele acestui virus si raspandite pe arii intinse intr-un timp relativ scurt. Au fost foarte multe variante, foarte multe propuneri de a stopa raspandirea virusului prin dirijarea cailor de migratie ale pasarilor migratoare.
Bineinteles, inca nu cunoastem multe din vietatile naturii care ar putea raspnadi infectiile virale. Pasarile migratoare au zburat, au calatorit de cand exista viata pe pamant si reglarea anumitor procese naturale in unele cazuri este imposibila. Este foarte greu de imaginat ca omul s-ar implica in dirijarea acestor fenomene fara a deranja echilibrul biologic a altor ecosisteme cu consecinte greu de imaginat.. Daca am face acest lucru, s-ar deregla ecosistemul natural si am ajunge la alte calamitati. Omul foarte repede se implica in dirijarea densitatii unor specii de animale sau a unor specii de plante si in aceste procese de schimbare a unor ecosisteme naturale, trebuie in primul rand foarte bine calculate situatiile care pot aparea in urma interventiei omului, dar au mai intervenit cum am spus si mai inainte in reglarea densitatii anumitor insecte prin utilizarea insecticidelor, dar cu consecinte nebanuite initial.  adica au lovit in sanatatea omului prin favorizarea aparitiei unui numar mai mare de tumori de diferite tipuri. In felul acesta s-a dirijat un proces si s-au dereglat alte procese care au intervenit ca un bumerang in sanatatea omului, in existenta lui. De aceea, omul ar trebuit sa ia aminte, ca atunci cand se implica in reglarea unui proces natural, trebuie sa stie dinainte ce se poate intampla dupa interventie (asa cum este exemplul clasic de utilizare a insecticidelor in reglarea densitatii de specii a anumitor insecte asa numite daunatoare. Acest proces de reglare a densitatii anumitor populatii de insecte nu a fost rezolvat, iar insectele au capatat  rezistenta, in fiecare an utilizandu-se concentratii mai mari de insecticide. Astfel insectele s-au adaptat la situatia data si si-au marit potentialul  de inmultire (depun o cantitate mai mare de oua) mult mai puternic decat pana la utilizarea insecticidelor. De exemplu omida paroasa a stejarului, Lymantria dispar, care inainte de aplicarea insecticidelor chimice, depunea 200 de oua in fiecare generatie, dupa interventia omului cu insecticide si-a marit potentialul de inmultire. Astazi o femela de Lymantria dispar depune pana la 2.000 – 3.000 de oua care provoaca un dezastru prin defolierea totala a padurilor foioase (si pierderea de masa lemnoasa). In natura, fara utilizarea anumitor preparate, de cele mai multe ori am avea adevarate calamitati (naturale) fiindca potentialul de inmultire a acestor insecte este extraordinar de mare si atunci vom avea defolieri totale si  paguba produsa de catre insecte este incalculabila. Trebuie de mentionat faptul ca orice fiinta are tendinta spre dominare, inmultindu-se mult si rapid si avand tendinta de a domina alte specii. Omul, care a devenit apogeul dezvoltarii fiintelor vii de pe Terra, trebuie sa regleze aceste procese de dezvoltare a anumitor specii de fiinte vii in asa fel incat sa stabileasca  un echilibru  ecologic, deoarece in natura exista un echilibru de dezvoltare a fiecarei specii, insa de multe ori aceste echilibru  este dereglat prin aparitia unui potential mult mai mare de inmultire a unor specii care le domina pe celelalte si in felul acesta produce acel dezechilibru  de care aminteam, punand in pericol existenta speciei dominate.
Aceeasi legitate este valabila si pentru colectivitatile umane, identificate pe criterii etnice, religioase, culturale etc
Acest dezechilibru poate fi reglat de catre alti factori naturali, insa interventia omului poate duce de multe ori  la complicatii atunci cand intervin cei neavizati, care ar trebui mai bine sa nu se implice si sa ceara interventia specialistilor competenti in  intretinerea biocenozei normale. In cazurile cand apare un dezechilibru virusurile pot provoca schimbari naturale infectand anumite specii de organisme dominante ,care pot duce la un dezechilibru natural .In acest proces omul nu poate interveni rational, atunci apare spaima  care este provocata de anumite informatii neclare (cum sunt infectiile virale si in primul rand daca vorbim de virusul gripei care poate provoca decese imediate).
Bineinteles ca sunt anumite actiuni  pentru a stopa infectiile acestea care pot duce la decesul celei mai dezvoltate fiinte, cum este fiinta umana.
Omul cunoaste diferitele evenimente care au existat pe Terra si  poate interveni cu anumite masuri sau cu anumite actiuni. Spaima infectiilor virale este mare si pana in prezent nu sunt elaborate unele metode de actiune impotriva infectiilor provocate de virusuri (de pilda virusul gripei aviare care a provocat spaima in specia umana). Mai sunt si alte virusuri si mai periculoase, dar credem ca este un exemplu de actiune a unui patogen impotriva caruia omul inca nu are metodele necesare stoparii, multiplicarii si transmiterii lui la om
Administrarea vaccinurilor sau a unor interferonuri inca nu poate rezolva stoparea infectiilor virale, deoarece aceste preparate sunt preventive si pot interveni numai in cazurile cand infectia virala nu s-a produs. Odata ce infectia s-a produs, pana in prezent nu exista metode de stopare a infectiilor.
Cele mai des intalnite virusuri sunt HIV/SIDA, infectiile virale hepatice care pot dezvolta o simptomatologie specifica  si provoca o serie intreaga de complicatii care duc la deces. Aceste virusuri au o particularitate :se dezvolta mult mai lent si provoaca decese  dupa o perioada variabila de timp  (cativa ani marcati de mare suferinta).
Virusul HIV, care ataca sistemul imunitar, poate produce decese dupa un  timp indelungat, cand boala atinge o forma  grava. Acest virus distruge celulele imunitare ale organismului uman, iar omul infestat moare prin infectii supraadaugate care nu mai sunt influientate de tratament.
Atunci cand raspandirea acestor infectii este mult mai rapida, ea este favorizata de anumiti factori ai mediului inconjurator ( frigul sau caldura in exces) ori factori generatori de stres social foamete, razboaie etc . Unele experiente personale care au fost implementate in anumite zone ale Terrei, unde avem o serie intreaga de preparate biologice care sunt utilizate constient pentru limitarea densitatii anumitor specii de insecte, au demonstrat ca, spre exemplu virusul poliedrozei nucleare a Lymatriei dispar, dintr-un singur punct provoca infectii artificiale care in timp de 5-6 zile se poate raspandi pe o raza de 40 de km. Ritmul transmiterii este foarte rapid si de multe ori pot aparea focare in alte zone, la sute de km departare de punctul de unde a pornit epidemia.
Asa s-a intamplat si cu virusul gripei aviare. Undeva, la inceputul toamnei, in septembrie, s-a difuzat informatia cum ca virusul gripei aviare a provocat moartea unor pasari migratoare din Thailanda, apoi din Vietnam, in zona asiatica. Intr-o luna de zile s-a determinat aparitia unor focare in zona Ucrainei, apoi in Romania si din Romania s-a raspandit in toata Europa (aproximativ in 15 tari).
Bineinteles ca toate masurile propuse de catre Uniunea Europeana sunt foarte drastice, deoarece a aparut spaima, frica fata de infectia gripei aviare, si anume  ca ea poate provoca decese si la om. De aceea in zonele unde apar cateva pasari moarte, unde s-a determinat virusul gripei aviare de mai multe tipuri H5N1 fiind cel mai periculos, s-a impus masacrarea tuturor pasarilor din zona data.
Este o situatie intr-adevar tragica, dar aceste masuri de masacrare a tuturor pasarilor din zona nu sunt suficiente pentru a putea stopa raspandirea infectiilor virale. Se produce totusi un fenomen interesant care ar trebui sa fie luat in considerare de catre specialistii chemati sa aplice aceste instructiuni si anume : de cele mai multe ori virusul se poate aflaa in organism in stare latenta, iar activarea lui se poate face in conditiile de stres citate mai sus. Masurile care sunt recomandate ca : spalarea rotilor la masini,  carantina umana in focarul aviar, nu au nici o ratiune, deoarece virusul se afla in celulele organismului dat.
In viata mea ( Prof Dr Doc M Ciuhrii) am creat arme biologice pentru reglarea densitatii organismelor nedorite ,in special al insectelor daunatoare. Eu am fost tot timpul implicat in domeniul utilizarii infectiilor virale.Cunosc foarte bine legitatile de dezvoltare a epizootiilor virale.Consider ca nu este cazul de masacrare a tuturor speciilor de animale ,deoarece virusurile sunt foarte bine specializate si nu pot trece de la o specie la alta .Mult mai rational ar fi fost izolarea stricta a speciilor infectate .In acest caz virusul nu provoaca moartea tuturor speciilor pana la 100% procente ,virusul nu isi taie craca pe care sta .El infecteaza de cele mai multe ori pana la 70-80 % procente .Fiintele neinfectate reprezinta un fond rezistent pentru dezvoltarea  generatiilor viitoare sanatoase. Acest fenomen, este bine cunoscut de populatia rurala, pe baza observatiilor empirice de sute de ani, timp in care strabunicii si parintii lor au asistat din timp in timp la aparitia ” molimelor ” in pasari, boli care niciodata nu au ucis toate pasarile. Acesta este numai un exemplu, dar aceasta legitate se regaseste la toate tipurile de infectii virale.
Noi credem ca daca s-ar fi luat un lot martor ca sa se determine legitatile de raspandire a infectiilor virale, am constata urmatoarele : daca nu ar fi fost aplicate instructiunile Organizatiei Mondiale a Sanatatii si nu am fi distrus toate pasarile din zona afectata  rezultatele ar fi fost identice cu cele unde au fost luate toate masurile.
In fiecare zi se anuntau descoperirea altor focare de infectie cu virusul gripei aviare. Este regretabil ca omul inconstient actioneaza in asemenea fel. De exemplu in judetele Constanta si Tulcea, Uniunea Europeana recomanda sa nu se mai creasca pasari timp de cativa ani de zile pana va trece acest val de epidemii. Bineinteles ca este o prostie. Speram ca in curand va aparea o directiva  care sa revina si sa anuleze acea hotarare.
Sunt niste masuri condamnabile si ar trebui ca acesti specialisti din Organizatia Mondiala a Sanatatii sa consulte nu numai specialisti in domeniul epidemiologiei omului, ar trebui sa ia informatii si de la specialistii care au creat arme biologice pe baza anumitor virusuri, sa vada care sunt legitatile acestea de dezvoltare sau de raspandire a virusurilor.
Eu, de exemplu, le-as fi dat multe informatii care ar reduce aceste masuri drastice. Sunt constient de faptul ca, atunci cand a aparut virusul gripei aviare in Geamurlia, trebuia in primul rand izolata aceasta zona, o parte din pasari  mureau si acestea trebuiau incinerate, iar cele care ramaneau in viata ar fi constituit un fond genetic pentru generatiile urmatoare de pasari care deveneau rezistente la infectiile cu virusul gripei aviare vreme de mai multi ani. Aceasta legitate este urmata de fiecare specie, care are particularitati specifice.
Legitatile epidemice nu sunt asa cum isi inchipuie unii ca ar merge distrugand tot. Nu ! Centrele de aparitie ale infectiilor pot fi la distante diferite. Se pot declansa cu viteze diferite sub influenta multor factori care inca nu sunt cunoscuti.
Mentionam ca virusurile sunt bine specializate pentru o singura specie, de pilda numai pentru gaini fara sa afecteze ratele sau gastele
Aceste masuri necugetate de masacrare a tuturor speciilor de pasari domestice ( gaini, rate, gaste, curcani etc) care au fost luate acum in diferite zone ale mapamondului s-a dovedit a fi fost zadarnice, au provocat pe langa pierderile economice, mai multe complicatii decat rezultate favorabile in dirijarea si controlul epidemiilor care s-au dezvoltat in ciuda masurilor luate, ca dovada ca ele nu  erau cele oportune.
Implicarea omului in dirijarea anumitor epidemii cu virusuri care pot infecta si omul trebuie foarte bine studiata.
Virusul este foarte bine specializat. El infecteaza anumite specii de organisme vii iar intr-un organism un anumit organ ( doar ficatul sau doar rinichii etc) si este foarte greu de imaginat cum s-ar putea transforma si deveni susceptibil un virus care astazi infecteaza pasarile sa infecteze si fiinta umana. Presupunem ca aceasta campanie de infricosare a populatiei a avut la baza un interes economic, ce se poate explica prin faptul ca in depozitele marilor companii farmaceutice producatoare de vaccinuri, s-au acumulat doze mari de vaccinuri ineficiente pantru v. Gripei care trebuiau vandute. S-au ales trei tari mai putin dezvoltate : Romania, Bulgaria si Turcia unde s-au aplicat fara rezultat clar vaccinurile respective amplificand starea de saracie. Densitatea populatiei umane este foarte greu de dirijat. Acum cand densitatea populatiei anumitor natiuni, in special in Asia este deosebit de mare, ( cum a fost si in vremea marilor migratii) bineinteles ca aparitia infectiilor virale este mult mai probabila si se poate declansa mult mai rapid decat in alte zone unde densitatea / km .p este mai mica.
In ultimul timp s-au facut progrese in combaterea multor infectii virale, insa aceste progrese nu sunt atat de semnificative.
Spre exemplu la virusul HIV, la virusurile hepatice au fost elaborate unele preparate de tip interferon. Substanta care este eliminata de catre celula la aparitia unor infectii, adica proteina care apare in celula – numita interferon- este ca un scut impotriva infectiilor virale. Dar  asa numitele interferonuri care se administreaza in patologia umana de cele mai multe ori sunt construite artificial prin metode biotehnologice.. Au o serie intreaga de efecte adverse. Spre exemplu, interferonul prescris pentru infectiile cu virusul hepatitei C, are niste reactii nedorite, foarte dure chiar, asupra organismului uman. De multe ori acest preparat nu poate fi aplicat la pacientii infectati datorita intolerantei, ori a faptului ca face mai mult rau decat bine.
In ultimul timp se mai gasesc si unele tipuri de proteine inhibitoare care pot inhiba intr-o anumita masura aparitia infectiilor. Vrem sa va aducem la cunostinta un lucru: noi  am fost primii in lume care am putut extrage enzime inhibitoare din organismul unor specii de insecte la o anumita faza de dezvoltare. Insectele se dezvolta in cateva etape. De cele mai multe ori, la Lepidoptere apare oul, dupa ou larva, apoi la sfarsitul dezvoltarii larvei, apare pupa. In pupa se formeaza adultul, fluturele. Uitati-va ca in aceasta directie se petrec niste fenomene foarte interesante. Proteina si lipidele predomina in tesuturile larvelor, la un moment dat sunt inhibate, se inhiba atat sinteza proteinelor cat si sinteza acizilor nucleici care transforma acest tesut intr-o chitina din care se formeaza adultul.
Din aceste faze de dezvoltare se pot extrage o serie intreaga de proteine inhibitoare. Aceasta cale de extragere a proteinelor inhibitoare, din anumite faze de dezvoltare, este mult mai adecvata pentru a construi preparate antivirale.
Atunci cand este inhibata sinteza proteinelor si acizilor nucleici de proteinele inhibitoare din tesuturile insectelor, proteine -pe care le administram omului infestat -in primul rand ele sunt absorbite de catre virusurile  care se afla in diferite tesuturi si atunci in primul rand este inhibata sinteza proteinelor si a acizilor nucleici virali ducand la stoparea multiplicarii virusurilor.
Aceasta metoda de extragere a enzimelor inhibitoare este pentru prima data utilizata in domeniul virusologiei in stoparea multiplicarii virusurilor.
Pentru prima data am reusit sa stopam multiplicarea virusurilor cu produse absolut naturale care sunt extrem de eficiente. In felul acesta putem include unele substante care sunt specializate pentru toate virusurile si evident pot influenta si asupra multiplicarii bacteriilor, altor microorganisme care pot sa se multiplice pe baza sintezei proteinelor si a acizilor nucleici.
Este o directie absolut noua, inca neexploatata de catre nimeni, decat de catre cercetatorii din consortiul INSECT FARM.
Pe baza acestor enzime s-au inregistrat doua preparate : Hepatito – Liz sau Imuheptin care stopeaza multiplicarea virusurilor hepatice (HCV si HBs). In cazul hepatitelor provocate de virusul hepatitei A lucrurile se intampla mult mai rapid. Asa ca in aceasta directie se fac cercetari aprofundate. A fost elaborata si tehnologia de stopare a infectiilor herpetice prin utilizarea unor unguente care includ SBA cu proprietati inhibitoare. In acelasi timp se utilizeaza si proteine inhibitoare incapsulate ,, per os ,,. Efectul este imediat si elimina infectiile pana la disparitia completa a virusului.
As dori sa vorbesc si sub alt aspect ,, Virusul, ca speranta a omenirii,, adica utilizarea virusurilor pentru a face servicii omului. De exemplu, in ultimul timp este o directie noua in a utiliza virusul impotriva tumorilor, tumori care formeaza un tesut specific si unele celule se multiplica gresit, in alta ordine decat tesutul afectat. In felul acesta formeaza o masa tumorala care de cele mai multe ori duce la absorbtia tuturor substantelor nutritive din organism pentru a forma masa tumorala care constituie o parte importanta din intregul  organism .
In ultimul timp s-au elaborat o serie intreaga de metode pentru a distruge aceste mase tumorale. Spre exemplu se iau celulele din masa tumorala, se multiplica in laborator in conditii speciale, se adapteaza un virus la aceste celule cancerigene, apoi se include virusul construit in masa tumorala. Virusul ataca tumora pana cand o distruge definitiv. In felul acesta unele virusuri pot fi utilizate in resorbtia formatiunilor tumorale produse de catre cancere.
Bineinteles ca este o metoda care va avea viitor. Virusurile pot fi utilizate si sub alt aspect, in reglarea densitatii diferitelor organisme nedorite de catre om, spre exemplu virusurile pot fi utilizate in dirijarea populatiilor de insecte de diferite tipuri care ataca produsele agricole si forestiere. Atunci cand apare o insecta daunatoare si distruge plantatiile agricole sau silvice.Pentru a dirija populatiile de organisme nedorite (in cazul dat insectele daunatoare )se utilizeaza un virus specific acestei insecte.Acest virus afecteaza tesuturile insectei pana cand le omoara , acesta provoaca o epizootie si in cateva zile distruge toate larvele insectelor si ataca plantatiile.
O alta directie de utilizare a virusurilor este reprezentata de bacteriofagi,(virusurile bacteriilor) care ataca bacteriile patogene.Aceste studii se efectueaza in anumite centre stiintifice si in viitorul apropiat vor aparea preparate noi care vor elimina din organism bacteriile patogene.Necesitatea acestor preparate este legata si de faptul ca in ultimul timp multe din bacterii au devenit rezistente la antibiotice de aceea se cer noi preparate efective in combaterea populatiilor de bacterii patogene .
Au fost descoperite virusuri si la diferite tipuri de micoze, care pot regla densitatea acestor organisme patogene. In acest caz aceste virusuri au o dezvoltare lenta si sunt necesare interventiile omului pentru a activa virusurile prin metodele ingineriei genetice.
S-au descoperit segmente ale genomului viral care pot ataca alte virusuri, adica sunt cunoscuti paraziti ai genomului viral care pot regla intensitatea infectiilor virale. Astfel, pana in prezent s-au descoperit virusuri la toate organismele vii, dar manipularea lor in diferite situatii raman inca nerezolvate.
O alta directie de utilizare a virusurilor este obtinerea unor substante organice de tipul vaccinurilor ,interferonurilor ,insulinei si altora prin metode de obtinere a recombinantilor baculovirusurilor si a altor virusuri care pot fi dirijate in obtinerea anumitor substante organice .Pentru aceasta in genomul unor virusuri se includ gene straine responsabile sintezei anumitor compusi organici .Asa spre exemplu in genomul baculovirusurilor se poate include o gena straina responsabila de sinteza unor vaccinuri.Astfel in procesul de sinteza a baculovirusurilor cu gena straina M10 responsabila de sinteza anvelopei virusului poliedrozei nucleare se sintetizeaza o alta proteina dorita de catre om .In cazul dat poate fi vorba de sinteza vaccinurilor .Astfel in tesuturile insectelor sau in culturile celulare de insecte care sunt infectate cu un virus recombinant se pot obtine proteine noi utilizate impotriva infectiilor virale cum sunt vaccinurile si interferonurile.Aceste noi tehnologii pot fi utilizate in farmacologia contemporana pentru obtinerea unor substante noi imposibil de sintetizat artificial,asa cum sunt interleucina si a unor tipuri de insulina si altele care pot servii in dirijarea unor procese vitale ale omului .
Noi propunem o noua directie de obtinere a acestor substante organice direct din organismele animalelor nevertebrate la anumite faze de dezvoltare.Aceste substante organice sunt sintetizate de organisme, numai trebuie sa stim unde sa le cautam.

DISCOVERY OF NATURAL CYTOSTATICS AND INTERFERONS’ (CAFEIC ACID)IN TISSUES OF SOME INSECT SPECIES

 

Habilitate Dr. Mircea CIUHRII, Monica Popescu, Alina Cochintu 

ABSTRACT. We found the presence of large amounts of protein in pupae, larvae and eggs of Lepidoptera. In the biologically active substances (BAS), proteins constitute up to 75%, more than any other organisms. The proteins are the main components of insect tissues at all stages of change development. The structure of protein modifies at every three hours. Such processes are specific only to insects that have four phases of development: egg, larvae, pupae and adults (imago). There are too little information on the molecular structure of insect tissues and in particular proteins. Unlike other living organisms, insects have a specific structure. For the first time I discovered the presents of the cofeic acids (polifenolics carboxid) in pupae component  of Limantria dispar, which are inhibitors of  tumor and viral formations. In the insects component this SBA exist in high concentrations in contrast with vegetables        .

INTRODUCTION

The insect component of the end phases of development form an enormous amount of keratin or chitin, which protects the insect body of adverse environmental actions. Thus, the ability to modify the protein structure and morphology of insects can be applied to humans, especially in cases of viral infection or the appearance of their tumor formation, which are subject to change and remove the body. It is an original idea, which was tested and confirmed by us.

Our proposal includes a description of the original ideas proposed during the research devoted to the influence of extracts from insect and virus on tumor formations. I found incredible cases to stop viral infections and tumor formations, but the mechanism of action remains unknown. At first, I did toxicity tests (Ciuhrii, 2005). When I was convinced that the order Lepidoptera insect tissues Dipterous and Colioptera are not toxic to human health and the environment, I had the courage to test the insect extracts on my own body, first at the surface of skin tissue (Fig. 1, 2, 3, 4, 6, 7), then in the interior in the form of supplements, and so I first registered at the Ministry of Health created the first dietary supplement based on insect tissue. As a result, we found that human tissue can be changed by action of extracts of insects at certain stages of development: egg, larva, pupae and imago (adult Lepidoptera). We created a number of biological preparations based on extracts of eggs, larvae, pupae and adults. In the early stages of development, when they contain substances activating and the late phases of development of insects occurring inhibitory substances, which stops both human life processes, as much as synthesis of virus and tumor formation. Thus, in the late phases of development life cycle of insects have found such inhibitors as cytostatics and interferon, which can stop the process of development of tumors and pathogens. So the inhibition of insect can be induced in human body, in some cases, when it comes to stopping the formation of tumors of viral replication process. An idea exposed and argued in premiere.  These events have enabled us to create a series of biological preparations after long testing we have registered and we have sold worldwide. We have created an online store that anyone can buy our preparations (www.insectfarm.com).

I want to mention some of the most popular prepared by us products are creams for skin care, care for feet, ankles, body massage, products used for removal of warts, moles undesirable to carcinomas and melanomas

We now have many cases to eliminate carcinomas, melanomas from skin. To remove hepatic viruses, herpes, skin and nose to remove warts, to eliminate respiratory infections. (See list of products prepared by us). This gives us hope to intensify the scientific research to understand more deeply the mechanism of action of preparations based on insect tissue.  At first I did toxicity tests for 14 years (Ciuhrii, 2002;2005;2008;2009;2010-a,b,c,d,e;2011) the removal of warts on fingers undersigned (Fig.1) Every night before sleep I applied the cream directly on the wart. Within one month wart gradually decreased in volume until it completely disappeared without leaving signs without causing unwanted and unpleasant pain. It is interesting that the lepidopteran SBA ointment was applied to a lipoma located in the neck undersigned. After 30 days of treatment the lipoma disappeared completely.  I got a great case, an example of an old woman, who addressed with a carcinoma giant head area. She said it was proposed to be operated, what was not real. Then we proposed treatment with an ointment made with an extract of Lepidoptera. After 30 days, the formation decreased obviously (Fig. 3), and then disappeared completely.

A man appeared behind a melanoma diagnosed by doctors at the hospital. I risked and I used cream of lepidopteran SBA. After 30 days the formation decreased obviously (Fig. 4).

A woman with a boil on the back located addressed to us with hope to help. She was allergic to the antibiotic, so the operation could not be done. We have given her our creams based on SBA extracted from beetles.(Marchiani, 1993) After 14 days formation withdrew completely (Fig.5). So I saved a woman from surgical intervention.

An extraordinary case was when a woman of 73 years with a lot of warts seboraece throughout the body addressed to us. I counted more than 300 groups. Many of them bleed and she could not sleep. I risked a lot and I started with it a specific contract for testing. I used the ointment on lepidopteran larvae for 30 days. Most of the warts disappeared (Fig. 5).  I got tremendous results for removal of prostate adenoma and uterine fibroids using rectal suppositories after defecation. We eliminate cases of prostate adenoma and uterine fibroid (Fig.8).

The cosmetic preparations based on action SBA in insects are formidable, eliminating layers of dead keratinized skin. Only after a single application, the face looks much better (Fig. 10). For the first time five years ago I tested creams to eliminate rosaceea, more specific for adolescents, which disappeared completely in two weeks. (Fig.9) we recorded a formidable action to eliminate keloids that occur after rosaceea (Fig.11).

Skin formation can be observed from different people that can not be liquidated without pain and without leaving undesirable traces. When a man about 35 years appears carcinoma forehead skin (Fig.13), which I removed with specific skin care cream in 14 days. The party has disappeared without trace and without pain. During our work we have eliminated many diseases caused by herpes viruses (Ciuhrii, 2005), including area-zoster. Images obtained encourage us to improve our preparations based on extracts from certain species of insects.

Thus at present we believe in the effect of tissue preparations from insects, but to find logical explanations are required complicated research at the molecular level. More sophisticated devices are needed for the study of insects SBA at different stages of development. Until now did anybody hasn’t imagine that some transformations of insects can be adopted for handling vital body processes.

The insect larvae include large amounts of lipoproteins, which are identical to the structure of the viral and tumor formations. Biologically active substances (BASs) of the insect are transformed into other components of lipoproteins pupae turns, forming adult (imago), namely, the phenomenon – the transformation of lipoproteins in other parts of the state based on the idea proposed: viral transformation and tumor formations other structures, which are eliminated from the body without causing adverse actions.

SBA of larvae turn into other structures at the same time of last phase of development of lepidopteran larvae. When the larvae, which includes large amounts of lipoprotein complete their cycle of development and form pupae in which adult form (imago) composition is changing radically. Instead lipoproteins appear polysaccharides (chitin) or keratin (specific proteins).

The mechanism of transformation of SBA in pupae, then imago is not yet known, but at this stage of development appear very complicated phenomena. Lipoprotein compositions are lyses to their disappearance. It would be very well if we could find the mechanism of changes at this time. We found the effect, but not yet the mechanism. Detecting the effect of certain compositions SBA insects at various stages of development now means a lot. In practice there are known preparations, which have some effect, but the mechanism of action remains an enigma.

These phenomena discovered by us is a world premiere. Now need to involve more profound research at the molecular level to highlight the compositions can destroy lipoprotein structures. Phenomenon discovered by us can be considered as a discovery of inhibitors (interferon or chemotherapy herbal) to stop viral infections and tumor diseases of man. Using a lyophilized powders of lepidopteran pupae reduced viral hepatitis viremia obvious (patent), used to stop HBs and HCV viral hepatitis. (See www.insectfarm.com). But how to explain this phenomenon remains an enigma to us.

The tumor diseases and viral infections lately cause most human deaths. There have been many tests to find biologically active substances in different species of plants and vertebrates, but in vain. So far the disease progresses rapidly, affecting serious human health.

Table 1. Action of BASs extracted from insects on cultures of glioblastoma tumor

Cells. PL: Lymantria dispar pupae (Lepidoptera); MM: Mellollonta mellollonta adults (Coleoptera); Dm: Musca domestica last instar larvae (Dipetra).

ACTION

RESULTS

•         Samples: PL, MM, Dm•         It was used a cell line of human tumor (human glioblastoma)•         Culture medium: DMEM+PSN+10%BFSDMEM = culture medium DULBECCOS MODIFIED EAGLES MEDIUMPSN = penicillin, streptomycin,neomycin

BFS = bovine fetal serum

It was used doses of PL, MM and Dm of 1-50μg/ml applied on the media with cell cultures.

After 24 hours from inoculation it were made the following observations at on optic microscopie.

For PL:•         the doses 1-12.5μg/ml were not cytotoxic.•         At 15μg/ml begun to appear morphological changes in tumor cells (the cells had a changed aspect, swollen, vacuolated)•         The doses over 20μg/ml are highly cytotoxic (all cells were affected, the majority died).For MM:•         the doses 1-15μg/ml had no cytotoxic effect;

•         at 20μg/ml it begun to appear morphological alterations in tumor cells;

•         at doses over 30μg/ml it appeared major alterations, many cells died.

For Dm:

•         the cells had a similar behavior to those treated with MM;

•         at 20μg/ml it appeared morphological alterations.

 Conclusion:•         All samples had an antiproliferation effect on tumor cells.•         The most efficient antiproliferation effect was shown by PL, which at doses of 15μg/ml inhibited the growing of tumor cells.•        The samples MM and Dm inhibited the growing at doses over 30μg/ml.

from last instars of Lepidoptera and Coleoptera are efficient in very small amounts (15μg/ml) and at 20-30μg/ml they kill all tumor cells in 24 hours.

The antimicrobial, antiviral and antimycotic substances which appear in larvae (Steiner et al., 1981; Marchini et al., 1993; Hetru et al., 1994; Chernysh et al., 1996; Holak et al., 1998; Sun et al., 1998) were named ,, defensis”.

The biochemical analyses of insects at various developmental stages have revealed that they contain various amounts of proteins, lipids and carbohydrates. The largest amounts

of proteins are in oven-dried Lymantria dispar eggs (71, 76%) and in Anoxia villosia adults (75,72%). The pupae contain 52, 78% proteins. The larvae contain 55, 34% proteins (l. dispar). Larger amounts of carbohydrates are in coleopteran adults (13, 71%). The eggs contain only 2% carbohydrates (Table 2.). The ashes content is 8-9%.

Table 2  Biochemical composition of the insect tissues (O-eggs; Li- larvae; P-pupae; CV – adults)

Nr.

crt.

Physico – chemical assays

U.M.

O atomized

Li

atomized

P  atomized

O

atomized

      A.v..

Oven dried

1

Dry matter

%

94,03

94,09

93,00

91,72

96,02

2

Protein

(nitrogen x 6,25) in g,

Of which:

•   total  nitrogen in g

•   aminoacids in g

•   nitrogen

non-precipitable

with T.C.A. in g

%

62,47

9,99

7,75

5,71

55,34

8,85

6,87

2,83

52,78

8,44

9,08

4,46

71,86

11,49

3,07

2,75

75,72

12,11

4,38

1,67

3

Total  lipids  in g

%

16,41

24,8

26,57

8,41

3,70

4

Total carbohydrates in g

%

2,82

4,92

8,44

2,44

13,71

5

Total ashes in g

%

9,85

8,93

4,37

8,69

1,53

For the first time (Ciuhrii, 2002;2005;2008;2009;2010;2011), we found extremely valuable phenomena. Some normal changes of insects can be adopted to guide human life processes. I’ll give an example:  larvae can transform the matrix of human tumor formations. Thus a carcinoma or sarcoma of the human body if it is attacked by the larvae Lepidoptera

SBA turns into another tumor matrix structure, which is eliminated from the body as a „foreign body” without causing pain and no scarring unwanted human body. We have a particular case, when a carcinoma attacked  hand of a patient, which caused the member to be amputated, but also affected the other hand, which had to be amputated (Fig. 14).  Was to be amputated and his other hand but I intervened with new preparations
insects and have saved the patient’s hand, which exists until now. This time I used the last age of lepidopteran pupae, which include large amounts of keratin to protect them from unfavorable environmental factors. We have confirmed this effect several times (Ciuhrii, 2005.2009), we have patented but the mechanism of action remains unknown. For this scientific research is needed deeper research with biochemical methods and by molecular biology, hoping to solve them in the frames of the project „ideas.”

Latest research of Lepidoptera larvae and pupae allowed us to detect the presence of polyphenolic acid carboxyl, which I think is to promote hatching larvae or adults from pupae.

The mechanism we suggested the idea of destruction of lipoprotein components similar to those present viral or tumor and humans. The mechanism of action is of great importance, because we could find an opportunity to destroy the skin lipoproteins of, especially in eliminating tumor formations. We have demonstrated this process of elimination of glioblastoma in cell culture (Ciuhrii, 2009), when tumor cells were destroyed with the SBA in lepidopteran pupae in 10 hours. The mechanism of action is unknown, but the effect is obvious SBA.

These mechanisms we can research on cell cultures that exist in other institutions before and we’ll create a specialized laboratory. But from the beginning is necessary to investigate insect morphogenesis at different stages of development (Fig. 1), where we discover new aspects of adult education. Some processes will suggest us new ideas for action of invertebrates, which will apply to vertebrates.

The beginning of 2000, for the first time we recorded a dietary supplement based on tissue obtained from lepidopteran larvae, which were lyophilized and then were encapsulated in gelatin capsules and administered in cases of dystrophy, especially children. The effect is immediately seen over 30 days.( Patent NA /00963) The patients (especially children) get an immediate immunity higher and is growing faster compared with individuals who do not take these supplements.

The insect’s composition occurs after large amounts of specific proteins, much higher than other organisms. Proteins constitute up to 75% by weight, fat is much less. Cholesterol does not form in the tissues of insects. Carbohydrates do not form in the tissues of insects. SBA type chitin and keratin influence human aging process. We are interested to produce large quantities of biologically active substances extracted from the insects because keratolytic effect, that these biological processes will develop technologies that will be great human longevity. We developed technology to eliminate the forming process of keratin, which are equivalent to the aging process. Until now we have developed about 50 parapharmaceutical products prepared, and cosmetics, all registered with the Ministry of Health (see list developed preparations.

It’s a fantastic idea that in the near future will revolutionize the pharmaceutical and food industry. If I will be understood, we will develop biological preparations and cosmetics, which will rejuvenate damaged tissues of the skin tissue, especially in the face. The insects, unlike other organisms are distinguished by the fact that they have a huge potential for propagation and transformation of tissue with a given composition in other forms.

We first have shown that the transformations of insects can be modeled on mammals, including humans. We found natural „chemotherapy” and „interferons” (Ciuhrii, 2009). So I came with the idea of transformation of unwanted formation of human, such as tumor matrix. So I prepared biological products from insect tissue to eliminate unwanted formations such as moles, seborrhoeic warts and others, which in contemporary medicine is only removed by knife and cattery. We have developed biological preparations for removal carcinomas, melanomas, and other tumor.

We developed antibacterial preparations, including for acne treatment considered incurable. We developed preparations to remove acne fast, without leaving undesirable traces on human skin, while you can remove and rosaceea and keloids (an area where more dilates blood vessels compared to the neighboring. the idea to use insect tissues is original. I found brand new directives in pharmacology, which in future will increase longevity of human being.

I am convinced that the structure of most insect species biochemical changes every 3-4 hours, which makes us to detect certain components at fixed intervals. For the first time, we found polyphenolic carboxylic acid (caffeic acids) present in pupae of the last age. I found the same acid content of eggs and larvae before hatching. Currently we are able to determine the role of this component in the development of Lepidoptera.

We hope in future to demonstrate the role of polyphenolic acid in insect development and possible involvement of this component in eliminating viral and tumor formations in the human body.

Fig.1. A wart located on left thumb. After applications for 24 days of the ointment “for skin care” before going to bed, the formation disappeared.

 

Fig.2. Treatment of a lipoma with keratolytic creams elaborated by the author. The lipoma was located on the neck of author. The operation would have been hazardous because of the risk to wound the nerves. The lipoma was removed without pain and undesired signs on skin.

Fig.3. Head cutaneous carcinoma during treatment with BASs extracted from insects.

Fig.4. Cutaneous melanoma on scalp, before and after treatment with the cream for “skin care” and “Imuno-max” capsules.

Fig.5. Furuncle treated with the preparation for “skin care” at an women, allergic to antibiotics.

Fig.6. Seborrhoeic keratoses on the skin of an 86 years old patient during the treatment with BASs extracted from insects.

Fig.7. Cutaneous carcinoma on the forehead of 35 years old man before and after the treatment

Fig.8. Ultra-sound investigation of a uterine fibroma, before and after administering of the preparation “Adenoprosin”.

Fig. 9. Face of an 18 years girl with acne rosea and keloids before and after treatment for three months with the preparation ,,for teen-agers”.

Fig.10. A 62 years old women with an aged look before and after 1 day treatment with the cream “eye contour”.

Fig.11. A 17 year’s old young boy treated with the “cream” and “lotion for teen-ager” for 21 days. The keloids disappeared completely.

Fig.12. Liposarcoma on the leg of a 67 years old patient, after 3 months of treatment.

Fig.13. Elimination of a cutaneous carcinoma from the forehead of a patient.

Fig.14. Cutaneous carcinoma on the hand of a 69 years old patient. The left hand was amputated from the same reason and it was proposed the amputation of the right hand also. But after 3 months of treatment with the entomological product “Cream for skin care” the carcinoma disappeared.

Acknowledgements                                

I wish to appreciate all my partners who participated and helped on this paper, first of all biochemists Monica Popescu and Alina Cochintu for the great contribution in obtaining the information’s in discovering the cafeic acid from the insects’ tissue. Also the technicians Viorica Degeratu and Valentina Luca for breading the insects and  Anca Nistor si Ionita Elena for preparing the creams and gels in the laboratory.

REFERENCES

1.Ciuhrii. M – “Entomotherapy – a new direction in contemporary medicine” ,2011
2. Ciuhrii. M – “Environmental Pollution and Public Health Impact of ITS”, Brasov, Ed,, Transylvania University, 2008.
3. Ciuhrii. M – The VII-th Symposium of Chemistry of colloids and surfaces, p.155, Bucharest 2002, Galati, 2011
Ciuhrii.M -, contemporary biotechnology and entomology, biotechnology development priorities in Romania. Possibilities and perspectives on the use of baculovirus in Romania in regulating insect pest density in forests”, Targoviste, 2002.
4 Ciuhrii.M – ,, Biological preparation for treatment for hemorrhoids, prostate adenoma and uterine fibroma, preparation procedure and utilization scheme of the active substances’’.
5. Ciuhrii. M – Biological preparation for treatment prostate adenoma and uterine

6. Ciuhrii. M –  ,, Biologically products from insects for the treatment of autoimmune affections, Tesla fest Invention festival of innovation and creations, Novi Sad 12-15 October, 2008.

7. Ciuhrii. M –  Sec of medicine science VIII Congress of national pharmaceuticals Therapy and Clinical Toxicology 6-8 June 2007, Targu Mures. 11. M. Ciuhrii cotemporary Entomotherapy in medicine, Biomed, Israel, 2010, The 9th National Science and Technology Week Live, Tel Aviv, Israel, June 14-16, 2010.

8. Ciuhrii M. Entomotherapy in contemporary medicine, Biomed, Israel, 2010, The 9th National Live Science and Technology Week, Tel Aviv, Israel, June 14-16, 2010

9. 12. Ciuhrii. M – “Entomotherapy in cosmetics”, 20.05.2009, Tashkent, Uzbekistan. Ciuhrii. M – Participation with four stands of four patents at the International Exhibition of Inventions Cluj Napoca, 2009. Winning four gold medals and trophy at the invention in 2010.

10. Ciuhrii. M – Invention Contest in Romania, the Romanian economy” Patent applied the Romanian economy”, Gold Trophy, Iasi 2010.

11. Ciuhrii M. – ,, Biologically Active Substances for human memory simulation, obtaining and utilization procedure’’, 37e Salon Inventions, p.114, Genève, 2009.

12. Steiner H., Hultmar kD., Engstrom Abennich H., Boman H.G.. Sequence and

specifity of two antibacterial proteins involved in insect immunity. Nature, 1981:292; 240-248.

13.Marchini D. GiorbanoPC., Amons R., BerniniLE., Dallai R. Purification and

primary structure of ceratotoxin A and B. Two antibacterial peptides from the female reproductive accessory glands of the medfla Cheratitis capitata- Diptera. Insect Biochem Mol. Biol, 1993; 23 591-618.

14.HetruC. Bulet.P Cociancich S. DimarcqJL HoffmanD.

15.Hoffman JA Antibacterial peptides/polypeptides in the insect host defenses a comparison with vertebrate antibacterial peptides/polypeptides In: Hoffman JA Janeway CA, Natori S eds Philogenetic Austin, TX: Landes Company, 1994; 43-66.

16.Hertu C., Hoffman D., Bulet P. Antimocrobial peptides from insects In: Brey PT, Hultmarc D., HoffmanJ.A., Antibacterial peptide? Polypeptides in the insect Host Defence Austin TX Landes Company 1994, p.43-66.

17.SunD., Ecleston ED., Fallon AM Peptide sequence of an antibiotic cecropin from the vector mosquito Aedes albopictus Biochem. Biopys Res. Comun 1998; 249 410-415.

18.Cherenysh S, Cociancich S, Briand J-P, Hetru C, Bulet P. The inducible antibacterial peptides of the hemipteran insect Palomena prasina: identification of a novel family of prolinerich peptides and a novel insect defensin. J. Insect Physiol.1996; 42:81-89.

ENTOMOTERAPIA  SI   PERSPECTIVELE   EI

CIUHRII MIRCEA
Dr.hab. in Biologie, specialitatea “virusologie“, Comandor si Mare ofiter in inventica, Membru AOS din Romania
INTRODUCERE

Inainte de a scrie aceasta carte sunt obligat sa-i multumesc “Creatorului lumii” – pentru harul si puterea de creatie cu care am fost incununat daruita unei directii noi in stiinta – ENTOMOTERAPIA – care in viitorul apropiat va produce o revolutie in Industria medicamentului pentru regenerarea indelungata a proceselor vitale ale fiimtei umane,a regenerarii anumitor tesuturi deteriorate, fara a efectua transplantul anumitor organe. Ea va produce o noua revolutie in medicina si in biotehnologia moderna. Astfel se va mari durata existentei omului – o nazuinta importanta a omenirii.
In prezent inca putini sunt cei care isi inchipuie importanta Entomoterapiei, care abia incepe. Eu sunt rescunoscator lui Dumnezeu pentru harul pe care mi l-a dat sa efectuez cercetari stiintifice cu rezultate ce sunt aplicate. In timpul cercetarilor efectuate de multe ori simteam o intuitie greu de inteles a mintii mele cand trebuia rezolvata o anumita problema. Nu voi uita niciodata faptul ca de la inceputul activitatii mele ca cercetator stiintific, conducatorul lucrarii mele de doctorat Acad. Matienco B. a fost uimit de potentialul meu creator, de cat de repede puteam rezolva problemele cele mai complicate puse in fata mea. Am facut primul doctorat in numai doi ani de zile si l-am sustinut la Consiliul Stiintific al Universitatii M. Lomonosov din Moscova – unul din cele mai prestigioase centre de cercetare  din lume. Atunci se punea problema ca lucrarea interpretata de mine, dupa parerea multor membri ai Consiliului stiintific corespundea gradului stiintific de Docent (doctorat si nu candidat in stiinte). Aveam numai 25 de ani .
Harul dat de Dumnezeu m-a ajutat sa ajung sa lucrez intr-un Institut prestigios al fostului “Imperiu sovietic”, care avea misiunea de a dirija procesele biologice in ecosistemele naturale cu scopul manipularii densitatii anumitor specii de insecte considerate daunatoare omului,cu toate ca tot ce este viu are dreptul la existenta. Nimeni nu are dreptul sa elimine unele dintre fiintele create pe Terra, dar Omul devenind “apogeul” dezvoltarii organismelor vii, se considera cea mai importanta fiinta, care in anumite momente isi asuma responsabilitatea de a se amesteca in treburile Creatorului si de multe ori provoaca multe procese dezastruoase, care actioneaza in primul rand tot impotriva lui. Asa s-a intamplat cu utilizarea chimiei in agricultura  S-au inventat pesticidele chimice pentru dirijarea unor procese naturale,in primul rand, pentru a starpi unele specii de insecte, care au devenit concurente omului pentru hrana si anumite materiale importante. Insectele  nedorite, desi au si ele dreptul la existenta, se doreste a fi starpite numai pentru faptul ca si ele doresc sa se hraneasca cu aceeasi hrana ca si omul. Pentru distrugerea lor omul a utilizat cele mai moderne arme fizice, chimice, biologice. In aceasta lupta apriga actiunile omului au esuat, deoarece insectele au rezistat, iar acesta a fost atacat de o serie de afectiuni provocate de scaderea imunitatii, de cancere, infectii virale, care au redus considerabil longevitatea. Ca urmare, s-au produs dezastre naturale determinate de schimbarea raportului de organisme in biocenozele naturale. Utilizarea pesticidelor chimice au dereglat multe procese naturale nevizibile pentru omul de rand. Astfel, s-a micsorat evident si longevitatea tuturor fiintelor vii. Se cereau urgent decizii ferme credibile pentru stoparea utilizarii intense a compusilor chimici si inlocuirea lor cu agenti biologici naturali, care sa actioneze conform unui program dirijat de catre Om. Este o problema, care parea o fantezie, deoarece Omul inca nu cunoaste multe legitati vitale si se implica in procesele naturale fara sa se stie ce poate urma dupa interventia lui, inca nu este constient ca in natura totul este calculat si programat de catre “o forta” inca neidentificata de catre fiinta umana. Pana in prezent avem multe exemple nereusite de implicare a omului in legile naturii si este de acum timpul sa constientizam, ca suntem neputinciosi in fata naturii. Exista inca multe fenomene neintelease de catre Om si poate ca nici nu trebuie sa stim aceste fenomene. Ele sunt prea complicate pentru fiinta umana. Este cazul sa asteptam momentul fericit de a interveni in legile naturii.
Am fost primul cercetator stiintific, care a studiat ultrastructura celulelor si a virusurilor la multe specii de insectele. Conform unei decizii a OMS (Geneva, 1973), am creat cateva arme biologice pe baza unor virusuri, care au fost inregistrate si implementate in practica. Aceste virusuri sunt specifice numai pentru anumite specii de insecte. Baculovirusurile sunt specifice si nu se intalnesc la alte organisme. Pentru om ele nu sunt periculoase deoarece au o structura specifica. Nucleocapsidele lor sunt incluse in supracapside de proteine foarte rezistente la conditiile mediului inconjurator si in mediul terestru pot rezista sute de ani de zile. Unul din aceste preparate virale  este utilizat si in Romania (sub denumirea “Inf-Ld), care este patentat si inregistrat la Ministerul sanatatii. In baza datelor obtinute am editat cartea (album) “Ultrastructura virusurilor insectelor”,carte a fost publicata la editura Stiinta din Chisinau in 1977) apoi tradusa in limba engleza si editata de catre editura Internationala “OXANIA PRESS”, Delhi – Calcutha in 1978. Mai tarziu dupa ce am avut ocazia sa fac cercetatari stiintifice la un centrul stiintific international din Franta, (Saint – Christol les-Ales), finantat de OMS am facut cercetari profunde atat in domeniul virusologiei generale, cat si in rezolvarea unor probleme concrete cum ar fi ultrastructura celulelor care formeaza tesuturile insectelor la diferite faze de dezvoltare si morfogeneza a Baculovirusurilor. Aceste cercetari au permis sa descopar multe fenomene biologice in relatiile organism – gazda. Astfel, aceste date mi-au permis sa determin ca la anumite faza de dezvoltare a insectelor, virusurile nu se mai pot replica. Atunci cand structurile lipoproteice din larve se lizeaza, incepe formarea structurii de chitina ce alcatuieste pupele si apoi adultii. Ea constitue mai mult de 90 % material inert. In acest moment apar peptide mici si enzime specifice, cum ar fi interferoni sau citostatice naturale. Aceste structuri pot stopa multiplicarea virusurilor si a celulelor tumorale. Conform unor date se interpreta gresit faptul ca aici se formeaza un tip de vaccinuri ( Cernysov,      )
Doresc sa fac un mic comentariu asupra cercetarilor din Franta. In primul rand m-am verificat pe mine insami daca pot face fata nivelului cercetatorilor Internationali. Numai in cateva saptamani am reusit sa-i uimesc pe colegii mei din Statiunea de Patologie Comparata prin faptul ca posedam la perfectie metodele  biologiei moleculare si microscopiei electronice, discipline care abia aparuse. Aceste activitati m-au incurajat foarte mult, deoarece eram verificat de catre specialisti din cei mai reputati in domeniu, cum ar fi academicianul francez C. Vago.
Potentialul meu de cercetare a fost mentionat de catre academicianul C. Vago care ma simpatiza. Aici am rezolvat cateva probleme importante pentru virusologie. In primul rand am reusit sa demonstrez prezenta ambilor acizi nucleici in virusurile poliedrozei nucleare. Pentru prima data am reusit sa demonstrez ca baculovirusurile include ambele virusuri nucleici (AND,ARN) localizarea acestor acizi in componenta unor virusuri: ADN in nucleocapside, iar ARN in matrixul suprapoliviriocapsidelor. Aceste rezultate au fost recunoscute pe plan International.
Alte descoperiri de importanta Internationala au rezultat din cercetarile infectiilor mixte. Pentru prima data am demonstrat ca in cazul infectiilor mixte cu virusuri care includ acizi nucleici diferiti apare interferenta – adica stoparea multiplicarii ambilor virusuri. Materialul a fost publicat in revista academiei franceze Compt Rendu (,Contr rendu N  ,Franta, Paris1982 ). Pentru prima data am demonstrat ca multiplicarea virusurilor poate fi oprita dupa infectia celulelor cu virusuri, care contin acizi nucleici diferiti – un fenomen extrem de important in virusologie si citologie, deoarece nimeni inca nu a putut opri procesul de multiplicare a virusurilor in celulele deja infectate. Pentru prima data am demonstrat ca o celula poate fi infectata cu doua virusuri, care include acizi nucleici diferiti , adica   unu include ADN localizat in nucleu si altul cu ARN ce se multiplica numai in citoplasma. In acest caz apare intrebarea, cum se poate intampla ca un virus specific numai pentru multiplicare in nucleu sa blocheze informatiile citoplasmei? Acest fenomen pune problema existentei unei autonomii a nucleului fata de citoplasma si apar alte probleme legate de sinteza proteinelor la nivel molecular.
Am cercetat si elaborat cateva tehnologii specifice de producere a preparatelor virale. Am demonstrat unele legitati ale raspandirii epizootiilor virali. Aceste legitati sunt valabile si in cazurile epidemiilor virale la Om si  animal.
Am elaborat standarde speciale de determinare a calitatii preparatelor virale, care sunt valabile pana astazi, deoarece parametrii biologici de calitate nu pot fi standardizati dupa criterii biologice, care sunt variabile si nu pot determina calitatea preparatelor biologice. Aceste criterii depind de foarte multi factori. Numai criteriile instrumentale sunt sigure si stabile.
In anul 1982 am am fost ales Presedintele Comisiei Internationale pentru determinarea calitatii preparatelor virale. Cunoscand Institutele Internationale care produceau preparate virale pentru provocarea infectiilor artificiale, am reusit sa creez preparate virale in colaborare cu cercetatori din Polonia, Canada, Franta. In aceasta ordine de idei, legitatile de raspandire a virusurilor sunt valabile si pentru infectiile virale la Om. Am participat impreuna cu alti specialisti – entomologi si virusologi la experimentarea preparatelor virale ca model de raspandire a infectiilor virale experimentale la animale, inclusiv a virusurilor specifice omului. Am participat la conferinte speciale pentru a demonstra ineficienta utilizarii armelor virale impotriva Omului, deoarece virusurile utilizate pentru a distruge populatii de oameni se pot imediat raspandi si impotriva acelora care au utilizat arma  biologica.
In Franta lucram intens, zi si noapte in laboratorul de ingenerie genetica a Baculovirusurilor. Asa s-a intamplat, ca intr-o dimineata dupa o noapte de cercetari intensa a unor recombinani de Baculovirusuri din padurile Canadiene,  In aceasta situatie am observat un fenomen neobisnuit, care a fost  important pentru Entomoterapia contemporana. Lucram cu unele tesuturi ale insectelor si am observat ca pielea de pe degetele mele s-a subtiat foarte mult. Cu ochiul liber vedeam cum pulseaza sangele prin vasele sanguine. Mi-am dat seama de existenta unor SBA (substante biologic active) cu efect cheratolitic. Am testat aceste substante pe diferite cheratoze la animale vertebrate si m-am convins ca actiunea cheratolitica exista. S-a produs un fenomen extraordinar,( asemanator cu acel a lui Zinger, care a inventat masina de cusut numai prin faptul ca a schimbat gaura acului de la coada la cap) In cazul dat s-a depistat o SBA in componenta tesuturilor insectelor cu efect cheratolitic. In mod normal cheratina este rezistenta la actiunele nefavorabile ale mediului inconjurator. Astfel parul, unghiile unui cadavru se pastreaza sute de ani. Firul viermelui de matase (Bombyx mori L) este excelent pentru imbracamintea omului si protejaza corpul uman de diferite actiuni nefavorabile ale mediului inconjurator. O insecta a imbracat “o lume intrega”, iar alta insecta – Apis melifera  hraneste o lume intreaga cu miere si propolis astfel incat a aparut o intreaga industrie de colectare si utilizare a produselor albinei melifere. Alte insecte au devenit celebre prin faptul ca au ajuns obiecte de studiu pentru Genetica generala ca de exemplu Drossofila melanogaster  care are o structura ce include numai doi cromozomi si permite studiul multor legi ale geneticii.
Biotehnologiile contemporane utilizeaza unele insecte din familia NOCTUIDAE pentru a obtine structuri organice fenomenale pe baza carora se produc medicamente noi, care inca nu pot fi sintetizate chimic (artificial). Pentru a obtine aceste produse (vaccinuri, interferonuri, leucine), care pot salva viata multor oameni se folosesc BACULOVIRUSURILE despre care am vorbit mai devreme si sunt specifice Artropodelor. Aceste virusuri poseda Suprapoliviriocapside  alcatuite din proteine. In genomul acestor virusuri se pot integra gene straine responsabile de sinteza specifica a unor componente proteice. Astfel, in locul unor gene specifice pentru sinteza unor proteine a supraviriocapsidelor, se pot include alte gene responsabile de sinteza altor proteine (spre exemplu a unui vaccin). Astfel in locul proteinei specifice baculovirusurilor se produce o alta proteina comandata de catre experimentator.
Dupa cercetari indelungate despre virusurile care pot distruge organisme nedorite, mi-a venit ideea ca si insectele pot fi utilizate impotriva infectiilor virale, bacteriene, micotice si a afectiunilor tumorale. Ideea a venit atunci cand am cunoscut mai bine morfogeneza virusurilor si a insectelor.
In timpul morfogenezei insectele isi schimba nu numai morfologia (ou, larva, pupa si adult) dar si compozitia chimica. Complexul lipoproteic din larvele insectelor este lizat de catre polipeptide, peptide cu greutati moleculare mici si enzime specifice si transformat in proteine insolubile in apa – cheratine, chitine si altele, care formeaza pupele si apoi adultii. Acest mecanism poate fi utilizat pentru stoparea multiplicarii virusurilor si pentru stoparea sintezei incetinirea afectiunilor tumorale. Am testat extractele mai intai pe culturi celulare cum ar fi  fibroblastoamele specifice craniului uman. Spre marea mea mirare una dintre SBA extrase din insecte a distrus toate celulele tumorale in timp de 12 ore, chiar daca a fost utilizata in concentratii extrem de mici. Conform acestor rezultate am testat SBA extrase din insecte la anumite faze de dezvoltare, cand apar unele polipeptide specifice si enzime cu proprietati de a transforma un complex lipoproteic intr-o substanta inerta. Aceste SBA pot elimina liposarcoamele, carcenoamele, melonoamele si alte formatiuni cutanate  (Tab.    ).
SBA din insecte influeteaza multiplicarea virusurilor din culturile celulare dar si a celor din intregul organism uman. Am constatat faptul ca unele SBA din insecte pot stopa multiplicarea virusurilor epatice,herhpetice, herpesvirusurilor , papilomovirusurilor. Noi credem ca mecanismul de actiune este blocarea sintezei proteinelor active si stoparea multiplicarii acizilor nucleici, deoarece SBA au fost extrase in timpul transformarilor complexului lipoproteic in alt complex de proteine insolubile in apa, care apartineau  unor specii de insecte din ordinul Lepidopterelor  si Coleopterelor. Probabil ca la aceasta faza exista unele  enzime, lipaze si peptide  specifice care pot liza lipoproteinele dintr-un complex.  Aceste SBA au fost experimentate pentru lizarea lipoamelor, carcinoamelor, verucilor seboreice la om si la animalele domestice (Fig.    ). Probabil ca SBA, care are proprietati de lizare a complexului lipoproteic nu numai la  la insecte,dar si la vertebrate.
In literatura (Chernisi et al    ) se explica acest fenomen prin faptul ca SBA din insecte ar fi aparut datorita unor infectii bacteriene ale insectelor, in urma carora au produs un tip de vaccin specific, care apoi poate fi utilizat pentru tratarea unor formatiuni tumorale sau infectii microbiene. Cred ca o asemenea gandire apartine unor specialisti care nu cunosc morfogeneza insectelor. In acest caz nu poate fi vorba de o actiune de tipul vaccinurilor induse special, ci de actiunea SBA din timpul transformarilor tesuturilor insectelor  la anumite faze de dezvoltare.
Aceasta interpretare este mai credibila decat cea a sintezei unor vaccinuri, care are un alt mecanism de actiune. In cazul dat, probabil ca este vorba despre actiunea substantelor inhibitoare de tipul interferonurilor sau aa citostaticelor biologice (naturiste) care apar in timpul stoparii multiplicarii celulare in ultima faza de dezvoltare a larvelor. Aici apare un alt mecanism inca nedescris de nimeni. Atunci cand dezvoltarea larvelor este la final, se produc transformari ale complexului lipoproteic si sintetizarea de substante inerte – chitina sau cheratina, din care apoi se formeaza adultii (imago). Aceste transformari biochimice sunt studiate inca prea putin. Credem ca exista enzime inhibitoare a sintezei proteinelor solubile in apa (Tab.   ) sub influenta unor peptide cu greutate moleculara mica, care transforma complexul lipoproteic intr-un tesut inert, din care se compun adultii la insecte.
Intuitiv, noi am testat actiunea SBA extrase din insecte apartinand unor ordine diferite, in ultima faza de dezvoltare a larvelor. Am testat insecte din ordinul Lepidoptere, Coleoptere si Diptere si  am constatat ca aceste SBA au o actiune de transformare a complexului lipoproteic in substante inerte. Ele au acelasi efect si in tesuturile vertebratelor inclusiv ale omului. Testarile au fost efectuate pe lipoame subcutanate. SBA extrase din larve in ultima faza de dezvoltare au fost testate pe lipoame subcutanate, care au o structura lipoproteica asemanatoare cu complexul lipoproteic al larvelor insectelor. Ca urmare am reusit sa transformam complexul lipoproteic al lipoamelor subcutanate, care se elimina din organism ca si “corpi straini”  ale omului. In acest fel am reusit sa efectuam o “operatie biologica” in premiera mondiala.
Am demonstrat ca un structura unui lipom subcutanat (Fig.  ) se transforma in alte substante,care se elimina prin porii pielii (Fig.    ) iar alta parte prin sange. Aceste SBA din insecte pot liza si alte formatiuni cutanate de tipul negilor, alunitelor, carcenoamelor, melanoamelor, bataturilor, astiofitelor etc (Fig.    ). Aceasta descoperire in cel mai  scurt timp va fi exploatat pentru a elabora preparate noi folosite in tratamentul multor afectiuni  ale omului. Dintre ele cele mai importante sunt tratarea infectiilor tumorale si a infectiilor virale.
Pana in prezent aceste SBA au fost patentate. Au fost elaborate tehnologii absolut noi pentru producerea de preparate farmaceutice, parafarmaceutice si cosmetice, care vor rezolva multe probleme grave a sanatatii omului.
Unele componente din insecte include cantitati mari de: Ca, P si Mg care se absorb rapid in organism si se fixeaza in os. Acest fenomen este necesar pentru om deoarece in ultimul timp organismul omului pierde mult Ca din cauza utilizarii intense a analgeticelor, iar acest element nu se asimileaza in cantitati suficiente pentru a echilibra necesarul de Ca din organism.
Un alt fenomen foarte des intalnit in populatie este pierderea memoriei la varste de 40-50 de ani, cand omul pleaca dintr-o camera in alta si uita pentru ce a venit.  Noi am elaborat o tehnologie specifica de extragere a hosphorului in cantitati semnificative din substante secretate de insecte pentru protectia oualor si pe care le putem folosi in prepararea de suplimente alimentare necesare omului (Ciuhrii M. Brevet N       ).

Entomoterapia este o directie absolut noua pentru medicina contemporana, care in viitorul apropiat va permite tratarea unor afectiuni considerate acum incurabile. Posibilitarea de a dirija procesele vitale ale organismelor vii va permite o crestere a calitatii si longevitatii..

INCURSIUNE IN MEDICINA COMPLEMENTARA

As dori in primul rand sa fac o comunicare pe intelesul tuturor privind ceea ce inseamna utilizarea preparatelor naturiste pentru imbunatatirea sanatatii omului. In acest sens este bine sa stim ca omul se gaseste intr-un ecositem alcatuit din organisme complexe si structure minerale care interfereaza permanent unele cu altele. In aceste biocenoze, in decursul a mii de ani, s-au realizat numeroase interactiuni intre toate componentele naturii. Omul a devenit dominant in aceasta lume si si-a luat angajamentul sa dirijeze multe dintre legile naturii in folosul lui. De multe ori, el, omul prin egoismul lui, nu s-a mai gandit la actiunile sale negative si si-a creat un confort excesiv de existenta. Progresul tehnico-stiintific rapid a dus la aparitia multor mecanisme de obtinere a energiei si la elaborarea unor serii de procese care au influentat negativ ecosistemul natural. In primul rand toata activitatea lui a dus la aparitia de deseuri nereciclabile, care polueaza biocenozele naturale. Cine oare astazi poate sa-si inchipuie viata fara curent electric, fara masini, fara prelucrarea produselor alimentare, fara o imbracaminte moderna? Cale de intoarcere nu mai exista. Constienti ne indreptam spre o poluare excesiva a mediului inconjurator si distrugerea biocenozelor naturale. Cine oare ne poate salva?

Unii cred ca exista o salvare, existenta unei forte supranaturale care ne supravegheaza continuu, dar ce se poate intampla nimeni nu stie. Nimeni nu crede ca el Omul, care este vinovat de cele intamplate, va supravietui. Acum suntem amenintati de aparitia unei catastrofe, care poate aparea si speram ca acest fenomen nu-l va atinge pe el – omul.

La ora actuala suntem constienti ca activitatea omului a dus la aparitia multor fenomene artificiale. Toata lumea doreste sa se fereasca de substante artificiale, mai ales de tratamentele de sinteza chimica.Acum putini sunt cei care pot suporta durerile, toti apeleaza la analgetice. Ei sunt constienti ca ele pot stopa durerea dar nu realizeaza ca aceste medicamente influenteaza alte procese vitale si mai ales ca duc la eliminarea Ca din sistemul osos, limiteaza longevitatea. Au aparut o serie de tipuri de cancere si infectii virale, care regleaza densitatea populatiilor organismelor vii. Se stie ca omul este interesat in primul rand de propria existenta si abia apoi se gandeste si la alte fiinte vii, cum ar fi animalele salbatice care multe ori dispar complet din biocenoze. In acest fel apar discrepante in lantul trofic care pot ameninta insasi existenta omului pe Terra. Avem multe exemple concrete de dezastre in ecosistemele naturale determinate de disparitia unor elemente importante pentru ecosistemele naturiste.

Omul inca nu este constient de complexitatea inter-relatiilor dintre ecosistemele naturale. Totul in aceasta lume este o creatie a unei supraputeri inimaginabile si daca omul inconstient influenteaza aceasta creatie, vom disparea cu totii, iar civilizatia va renaste de la inceput sub o alta forma. Intrebarea este ca cine va disparea si cine va supravetui? Exista probabil si aici o legitate neinchipuita inca de ratiunea umana.

La ora actuala omul are tendinta de a se intoarce la natura, este constient ca produsele de sinteza chimica, influenteaza negativ sanatatea omului. Se doreste ca afectiunele omului sa fie tratate numai cu substante naturale care sunt acceptate mai usor de catre organism. Aceste componente naturale sunt adaptate la reglarea proceselor vitale din organism, iar acesta le tolereaza mai usor in comparatie cu produsii de sinteza chimica la care omul nu este complet adaptat.

Nu toate resursele Terrei au fost epuizate. Mai exista inca multe resurse, care pot interveni in reglarea proceselor vitale ale fiintelor vii. Una din aceste surse sunt animalele nevertebrate existente pe Terra. Pana in prezent omul a recurs la resursele nutritive care sunt cel mai usor de obtinut. In primul rand plantele agricole si animalele vertebrate usor obtinute din biocenozele narurale, domesticindu-le pentru utilizare. Cresterea animalelor domestice a reusit sa creeze adevarate industrii de obtinere a produselor nutritive. Cine oare s-a gandit vreo data ca unele animale se pot transforma in adevarate surse de obtinere a produselor alimentare.Pentru obtinerea acestor produse alimentare producatorii utilizeaza diferiti activatori de crestere, care maresc productia intr-un timp mult mai scurt. Aceste substante activatoare au un effect negative asupra organismul consumatorilor, adica a oamenilor. Apar modificari metabolice sau chiar boli incurabile.

Sub notiunea de “medicina complementara” se subintelege utilizarea oricarei metode de tratament pentru corectarea functiilor vitale ale organismelor vii. Unele metode par stranii la prima vedere, deoarece la inceput par a fi necredibile. Trebuie sa recunoastem ca exista inca multe fenomene pe care omul inca nu le poate intelege, dar nici trebuie sa le ignoam. In timpul evolutiei toate fiintele vii s-au schimbat in directa dependenta de actiunea factorilor externi si interni. In urma participarilor la diferite intruniri, la conferinte si congrese de Medicina Complementara m-am convins ca exista multe actiuni fizice si psihologice care actioneaza asupra sistemului uman si care pot schimba unele stari fiziologice ale organismelor vii. Una din aceste actiuni am vazut-o la un asa- zis “vraci”, care trata orice afectiune cu o singura metoda: pacientul era pus pe o masa in mijlocul unei camere. Pe capul pacientului se punea o lumanare aprinsa, apoi se punea cate o lumanare pe degetele picioarelor si pe maini. “Vraciul” aprindea si el o lumanare si mergea in jurul pacientului culcat pe pat si soptea niste rugaciuni. Avea saculeti cu plante maruntite si o iconita pe care le punea pe ceafa pacientului. Procedura dura timp de o ora, dupa care pacientul se ridica si declara ca se simte mult mai bine. Oare ce s-a intamplat? Actiunea pare a fi o ”escrocherie”? Dar cred ca exista o explicatie si anume efectul psihologic asupra pacientului, care s-a simtit ca un om mort pe acel pat, avand parte de un ritual straniu. Oare asemenea procedee nu pot fi utilizate si de catre unii medici specialisti in medicina?

Un alt factor important care actioneaza asupra sanatatii omuluiestemediul inconjurator.In a doua jumatate a secolului XX au sporit considerabil ritmurile industrializarii si urbanizarii, fapt ce a dus la poluarea mediului ambiant. Concomitent a crescut nivelul radiatiei, vibratiei, influenta ultrasunetului si a undelor magnetice. Acesti factori fizici si chimici au influentat structurile biologice ale macro- si microorganismelor cu declansarea unor tulburari sistemice. Astfel, s-au creeat conditii pentru aparitia unor forme si variante noi ale proceselor patologice, cresterea frecventei bolilor incurabile: oncologice, autoimmune, metabolice (Tabel.1).

Tabel.1

Factori patogeni fizici

Influenta

1. Radiatia

a. cosmica

b. industriala (uzine, laboratoare)

c. televiziunea, undele radio, de telefon

SNC si sistemul nervos vegetativ, sistemul endocrine, vascular, hematopoeza

Stresul oxidativ

2. Ultrasunetul

a. industrie (uzine)

b. transport (aviatie)

c. televiziune, radio

SNC, sistemele: neuro-endocrin

3. Vibratia

a. uzine

b. transport

SNC, sistemul nervos vegetative, neuro-endocrin, endocrine, metabolic

Factori patogeni chimici

Influenta

1. Aerul

a. poluarea

b. uzinele

c. transportul

Sistemele: respirator, cardiovascular, neuro-endocrin, oxidativ

2. Agricultura

a. ingrasaminte

b. pesticide

Alergie, afectare hepatica, renala, tulburari neuropsihice

3.Industria alimentara

a. conservare

b. prelucrare la temperature inalte

c. prelucrare repetata

d. produse afumate

Alergie, afectare hepatica, tulburari ale sistemului digestive si de metabolism, oncopatologie

4. Detergenti

a. spalatorii

b. bucatarii

Alergie, sistem respirator, sistem digestiv

Studii contemporane biologice, imunologice, dezvoltarea tehnologiei nucleare, au dat posibilitatea de a elabora metode noi de diagnostic in cazul multor boli, chiar din stadiul initial (scintigrafia, tomografia computerizata, RMN, densitometria, s.a.). Paralel cu acestea s-a constatat cresterea nivelului factorilor nocivi de alt ordin – cresterea energiei cosmice, activitatii vulcanilor, alunecari de teren si multe altele care au influentat foarte mult sistemul de aparare si acomodare.

Astfel, dezvoltarea nivelului stiintific si tehnologic, a permis elucidarea mecanismelor etiopatogenice si a diagnosticului multor maladii, dar, au creeat conditii favorabile pentru cresterea frecventei bolilor incurabile: tumori, maladii autoimmune, diabet zaharat s.a.

Daca vom compara nivelul medicinii clinice a trecutului si prezentului, atunci nu vom observa mare diferenta (Tabel.2).

Tabel.2

In trecut

In prezent

Factori etiopatogenici

Infectii microbiene si virale

Infectii virale

Suprasolicitari fizice

Alimentatia incorecta

Supraracirea indelungata

Radiatia, vibratia, ultrasunetul

Modul sedentar de viata

Bolile

Ciuma

Cancerul

Holera

Bolile cardiovasculare

Poliomielita

Bolile autoimmune, vasculitele sistemice

Tuberculoza

Diabetul zaharat

Sifilisul

SIDA

Bruceloza

Artritele reactive-infectioase

Febra reumatismala

Tulburari neuro-psihice, narcomania

Infectii la copii

Osteoporoza sistemica

50% = 50%

Factorii ambientali contemporani au predispus catre aparitia tulburarilor immune specifice si nespecifice, catre cresterea frecventei mutatiilor ereditare si non-ereditare.

Evolutia acestor factori s-a manifestat prin aparitia si progresarea rapida a numeroaselor perturbari la nivel celular si molecular cu modificari clinice si evolutie nespecifica a bolilor interne in general si a celor reumatice in particular (reumatismul articular acut, TBC, pneumoniile infectioase etc.).

Vremuri noi, generatii noi, boli noi.

Deoarece acesti factori nocivi externi si interni au influentat continuu evolutia sistemelor de aparare si acomodare, va continua dezvoltarea unor mecanisme noi etiopatogenice.

Daca inceputul veacului trecut era marcat prin dominarea maladiilor contagioase, a TBC, la jumatate de secol, descoperirea antibioticelor a modificat spectrul bolilor. Reducerea considerabila a ponderii maladiilor infectioase a fost inlocuita, insa, de cresterea incidentei unor boli cu un nou aspect clinic, inclusiv a celor contagioase. Au aparut variante clinice discrete, cu activitate mai redusa, dar cu evolutii trenante, forme clinice infectioase reactive, cand procesul inflamator se afla la distanta de focarul infectios – artrite infectioase reactive cu focar primar respirator, intestinal, urogenital s.a.

Mai tarziu, in 1970-1980 s-a observat cresterea incidentei bolilor autoimmune (AR, LES, s.a), apoi a bolilor cerebro-vasculare, a diabetului zaharat, obezitatii, osteoporozei sistemice etc.

Industrializarea si automatizarea procesului de munca, viata sedentara favorizeaza fenomenul hipoxiei cronice urmata de intensificarea tulburarilor ischemice si, ca urmare, dezechilibrul proceselor de oxido-reducere. Cresterea nivelului radicalilor liberi este unul dintre factorii ce determina intoxicatia cronica si dezvoltarea multor patologii: cardiovasculare, cerebro-vasculare, cancerigene si metabolice.

Factorii patogenetici mentionati au influentat transformarea mecanismelor patogenice cu aparitia formelor maladive noi. Astfel reumatismul (febra reumatismala) treptat s-a modificat atat de mult, incat in anii 1970-1980 au fost lichidate multe centre si sectii specializate, insa, cu parere de rau, numarul de bolnavi reumatici ce prezinta valvulopatii si necesita interventii chirurgicale a crescut nu numai la noi in tara, dar si in tarile dezvoltate. S-a constatat ca la copii, febra reumatica, in prezent, frecvent evolueaza cu afectare solitara a miocardului, fara sa apara modificari fibroase, deseori in lipsa sindromului dureros. Afectarea valvulelor la acesti bolnavi este evidentiata in recidivele ulterioare la varsta de 20-30 de ani, iar insuficienta circulatiei este depistata si mai tardiv, la 40-50 de ani. Progresarea bolilor deseori nu este asociata cu modificarea evidenta a indicilorlor de laborator.

Deoarece sistemele de aparare si acomodare se afla sub un control strict al sistemului neuroendocrin, este evident ca, sub influenta factorilor nocivi, mai intai se va produce un raspuns neuroimun cu modificari la nivelul subpopulatiei T limfocitare, activarea killer-ilor naturali, limfocitelor B, interleukinelor, TNFa, IF.

Factorii nocivi fizici si chimici, stresul acut si cronic au influentat foarte mult starea functionala a sistemului nervos central si neurovegetativ si au determinat aparitia multor afectiuni neuropsihice ce impun necesitatea utilizarii multor medicamente psihotrope si, ca urmare, duc la farmacomanie, narcomanie si toxicomanie. Fiecare medicament influenteaza mai mult sau mai putin toxic. Medicamentul poseda actiune specifica indreptata contra unui anumit agent pathogenic sau a unui mecanism. Insa, frecvent procesul initiaza si se dezvolta sub influenta mai multor factori si la bolnavi pot aparea paralel si alte boli, mai ales la cei de varsta inaintata. In aceste cazuri tratamentul medicamentos va avea efect partial.

Actiunea factorilor nocivi patogenici conduce la aparitia tulburarilor continue in sistemele defensive, pierderea capacitatii de diferentiere a structurilor self si non-self. Cresterea excesiva a apoptozei agraveaza si mai mult aceste fenomene, deoarece, creste nivelul substantelor proteice similare celor straine. De aceea, este activat sistemul de autoagresiune cu dezvoltarea unor maladii autoimmune mai cu seama in prezenta unui teren genetic favorabil.

Stresul acut si cronic, care in ultimele decenii s-a accentuat din mai multe cause: probleme sociale, scadere brusca a nivelului socio-economic, pierderea locurilor de munca, conflicte armate, etc, a influentat negativ asupra sistemelor de adaptare a organismului, s-au modificat bioritmurile, ceea ce a predispus si mai mult la aparitia numerosilor patologii. In prezent, sedentarismul este apreciat ca stare de stress cronic, cand sistemele fiziologice ale organismului sunt supuse unui ritm lent de activitate.

Majoritatea lucrarilor consacrate studierii mecanismelor de dezvoltare a proceselor patologice sunt orientate spre evidentierea tulburarilor produse de un anumit agent patogen si foarte rar este luat in consideratie fenomenul comorbiditatii, fara manifestari clinice, cum ar fi prezenta infectiilor virale la personae de varsta inaintata, sau depistarea unor tulburari imunologice la pacientii cu osteoartroza. Administrarea unui tratament medicamentos, indeosebi in doze mari si timp indelungat, deseori poate complica procesul, facand sa apara si alte reactii aberante de aparare si acomodare a organismului. Pe acest fundal, poate avea loc activarea unor procese patologice, care pana la tratament erau inactive.

Evolutia bolilor cronice de origine inflamatorie sau degenerative-distrofica este frecvent asociata cu influenta unor noi factori patogeni, care raman neidentificati. Aceste cazuri frecvent sunt observate in perioada epidemiilor sporadice ale infectiilor virale.

Nu e cazul de a analiza in care situatii este mai binevenita administrarea medicamentelor si cand este necesar un tratament complementar. Vom accentua ca in terapia majoritatii bolilor trebuie de administrat un tratament complex.

Medicii astazi frecvent uita sa mentioneze in recomandari regimul alimentar necesar detaliat, sa sublinieze importanta regimului de activitate fizica si intelectuala, a starii psihice, emotionale a pacientului. Aceste recomandari in prezent au importanta deosebit de mare, deoarece ele sunt necesare pentru a neutraliza actiunea agentilor nocivi de care suntem inconjurati. Uneori, un examen minutios nu descopera tulburari organice si medical, in final recunoaste ca, pacientul are nevoie doar de repaus, alimentare corecta, liniste, odihna la aer curat si unele recomandari din cadrul medicinii alternative: extracte din ierburi, fructe, legume si miere de albine. Astfel, constient sau inconstient, recunoastem sau nu, bolnavul este tratat deseori prin metode complementare. Daca este asa, atunci apare necesitatea pentru medici de a studia mai profound mecanismul de actiune a multor metode de tratament complementar, de a evidential atat partile positive, cat si cele negative ale acestor metode (intoxicatia, alergia, infectii s.a.), pentru a nu ceda aceste modalitati de tratament diletantilor.

In cazul bolilor inflamatorii cronice si degenerative reumatice – eficacitatea tratamentului este asigurata la 70% de terapiile complementare si cca 30% de tratamentul medicamentos.

Cronicizarea frecventa a actiunilor reumatice inflamatorii si degenerative impune inevitabil asocierea terapiilor complementare.

Inofensivitatea metodelor complementare permite utilizarea lor pe larg si de durata.

Prioritatile acestor metode: 1) actiune mai fina; 2) sunt mai usor de selectat; 3) foarte rar exista contraindicatii; 4) pot fi usor individualizate; 5) nu duc la aparitia reactiilor adverse grave; 6) pot fi utilizate timp indelungat.

Majoritatea metodelor complementare de tratament au fost selectionate, analizate si perfectionate in cursul a sute si mii de ani si au ramas cele care trateaza si totodata mai putin dauneaza.

Asocierea mai multor boli, mai ales la aceleasi personae de varsta a treia, determina necesitatea unui tratament complex. In aceste cazuri exista riscul polipragmaziei. Astfel combinatiile preparatelor chimice pot duce la multiple reactii toxice cu evolutie imprevizibila, deseori fatala. In astfel de situatie, sunt binevenite metodele nemedicamentoase associate.

In acest mod, astazi exista suficiente argumente pentru oportunitatea aplicarii in complex a diferitelor metode de tratament asa-zise alternative. Nu poate fi acceptata atitudinea absolut negativa a unor medici fata de astfel de alternative terapeutice. Pe langa faptul ca nu le utilizeaza, ce nu este neaparat spre binele pacientului, neaga si necesitatea studierii acestor posibilitati. Astfel, neglijarea si chir negarea diferitelor medicatii traditionale, face ca acest domeniu sa scape din vizorul medicilor profesionisti, a savantilor si devine o sfera de exploatare de diversi diletanti, nu tocmai bine intentionati.

Terapiile complementare (TC) include un numar mare de metode de tratament, unele dintre care pana in prezent nu au fost appreciate si nu au fost cercetate in comunitatea stiintifica.

Actualmente, aceste metode ocupa un loc deosebit in tratamentul multor afectiuni reumatice, neurologice, dermatologice, in special cele cronice. Cheltuielile pentru aceste metode de tratament au constituit 10,3 mld dolari in SUA numai pentru un an (1990), din care 3 mld dolari au revenit tratamentului bolnavilor de artrite (Alan R. Erickson, MD, 1999).

Numarul de bolnavi care s-au tratat prin diferite metode complementare constituie cca 90%. Nu este pacient care sa nu fi folosit dietoterapia, psihoterapia sau hidroterapia. Atitudinea fata de medicina traditionala in diferite tari este diferita. Astfel, acupunctura – metoda practicata si studiata timp de mii de ani in China cu rezultate excelente la 90% din bolnavi, conform opiniei unor autori americani. Aproximativ aceleasi divergente au aparut in utilizarea diferitelor plante – in dependenta de zona geografica, compozitia solului, cantitatea energiei solare si multe altele. Astfel, terapiile complementare din Europa evident se deosebesc de cele chineze, japoneje, australiene.

Prin urmare, trebuie folosite acele metode de tratament complementar, autohtone care au fost studiate, analizate in zona de aplicare, cu experienta in aplicarea tratamentului pacientilor cu boli similane celor diagnosticate in prezent.

Vom accentua faptul ca pacientii, fiind informati superficial despre metode complementare, le folosesc pe larg, deseori incorrect, fara a se consulta cu medical care, de altfel nu le cunoaste nici el bine, din care cauza pot aparea unele reactii nedorite sau lipsa efectului.

Substantele utilizate extern sau intern au anumite indicatii sau contraindicatii. Prin urmare, medicii practicieni au datoria sa studieze mai profound diferite metode alternative de tratament pentru a realiza o supraveghere mai riguroasa a pacientilor.

Numai antrenarea medicilor practicienti in studierea terapiilor complementare, realizarea un control strict in ceea ce priveste utilizarea acestora, va permite indicarea lor corecta. Astfel, vor fi reduse cazurile de auto-tratament, cu rezultate cel putin nule (tabelul 3).

Adevarul este ca aceasta lista nu releva nivelul stiintific al multor metode complementare de tratament care deja s-au implementat cu success in practica medicala.

Legitimarea actiunii factorilor naturali ai mediului ambient reiese din insasi filo- si ontogeneza. Organismul in dezvoltarea sa istorica si in viata individuala este strans legat de mediul extern si formeaza un tot integru cu acestea. Etiopatogenia multor boli vechi (guta, febra reumatica) sub influenta factorilor agresivi nocivi contemporani s-a modificat – au aparut tulburari alergice, autoimmune, de aceea metodele vechi de tratament trebuie studiate din nou la un nivel stiintific mai inalt.

PRINCIPALELE TERAPII COMPLEMENTARE SI NIVELELE LOR DE ACTIUNE

TERAPIA

MIJLOACELE

NIVELUL DE ACTIUNE PREDOMINANTA

1. Psihoterapie

1. hipnoza

2. autosugestie

3. gandire pozitiva

1. SNC, sistem nervos vegetativ

2. sistem neuro-endocrin

3. imunitate

4. sistemele de oxidare si antioxidare

5. bioenergie

2. Dietoterapie

1. regim alimentar

2. compozitie

3. preparare

1. sistemul digestiv

2. sistemul cardiovascular

3. metabolism

4. imunitate

5. oxidare si antioxidare

6. sistemul urinar

3. Balneoterapie

1. ape minerale si termice, namol

1. sistemul neuro-vegetativ

2. sistemul neuro-endocrin

3. sistemul muscular, articular

4. sistemul cutanat

5. sistemul digestive

6. sistemul cardiovascular

7. metabolism

8. imunitate

4. Fizioterapie

1. electrostimulare

2. magnitoterapie

3. laser-terapie

4. ultrasunet

5. utilizarea luminii

6. electroforeza

7. raze ultraviolete

1. SNC, vegetativ, periferic

2. sistemul articular, musculo-axial

3. sistemul tegumentar

5. sistem cardiovascular

6. metabolism

7. oxidare si antioxidare

8. imunitate

5. Kinetoterapie

1. gimnastica

2. inot

3. activitate fizica

1. SNC, vegetativ, periferic

2. sistemul respirator

3. sistemul cardiovascular

4. sistemul digestiv

5. sistemul muscular, articular

6. metabolism

7. sistemele de oxidare si antioxidare

6. Acupunctura

Metoda se bazeaza pe teoria zonelor reflexogene ale nervilor; actionandu-se pe traiectul lor, se poate produce analgesia si chiar ameliorarea functiei unor organe.

1. SNC, vegetativ, periferic

2. sistemul cardiovascular

3.sistemul respirator

4. sistemul digestiv

5. sistemul urinar

6. sistemul muscular, articular

7. sistemul endocrin

8. imunitate

9. metabolism

10. sisteme de oxidare si antioxidare

7. Fitoterapie

1. medicamente din plante

2. utilizarea extractelor din plante

3. aromaterapie

1. SNC, vegetativ, periferic

2. sistemul cardiovascular

3.sistemul respirator

4. sistemul digestiv

5. sistemul urinar

6. sistemul muscular, articular

7. sistemul endocrin

8. imunitate

9. metabolism

10. sisteme de oxidare si antioxidare

8. Climatoterapie (Speleoterapie)

1. raze solare

2. aer de munte

3. clima maritima

1. sistemul respirator

2. sistemul cardiovascular

3. SNC, vegetative, periferic

4. sistemul muscular, articular

5. metabolism

6. oxidare si antioxidare

9. Faunoterapie

Extrase si remedii obtinute din diverse organe animaliere

1. SNC, sistem neuro-vegetativ

2. sistem cardiovascular

3. sistem digestive

4. sistem urinar

5. metabolism

6. imunitate

7. sistem de oxidare si antioxidare

10. Entomoterapie

Utilizarea extractelor din insecte

1. sistemul vascular

2. sistemul imun

3. sistemul digestive (hepar)

4. sistemul urinar (prostata)

5. sistemul cutanat

6. sistemul articular, axial

11. Ionoplasmoterapie

Aplicarea fluxului de ionoplasma pe suprafetele cutanate ale zonelor afectate si reflectorii

1. SNC, vegetativ, periferic

2. sistem endocrin

3. sistem vascular

4. sistem articular, axial

5. sistem muscular

6. sistem cutanat

7. metabolism

12. Homeopatie

Utilizarea substantelor in doze extrem de mici cu actiuni ce evoca simptome similare bolii

1. SNC, neuro-vegetativ

2. neuro-endocrin

3. vascular

4. respirator

5. imun

Factorii fizici si chimici naturali, care in perioada de evolutie au devenit iritanti reflexogeni pentru organism, actionand continuu in procesele filogenetice si ontogenetice devin iritanti reflector conditionati ce influenteaza factorii umorali, endocrine s.a. Unul din sistemele vechi este reprezentat de receptorii cutanati ce realizeaza perceptiile tactice, ale temperaturii, durerii. In procesele evolutive, in rezultatul dezvoltarii sistemului nervos central si periferic, s-a dezvoltat si diferentiat strict sistemul de receptori si, datorita acestora, reactiile biologice au raspuns la actiunea diferitor substante chimice, fizice decurg corespunzator perceptiei differentiate. Anume la acest nivel actioneaza direct factorii fizioterapeutici, balneologici, climaterici s.a.

Terapiile de alternativa include un numar mare de metode terapeutice (peste 20) cu diferite caracteristici. Oricare ar fi definitia terapiilor complementare, ea nu poate reflecta esenta acestor metode, diferite dupa origine si, produse din plante, animale si din insecte sau din substante analoge acestora.

Majoritatea metodelor complementare au fost studiate empiric. De-alungul mileniilor s-au perfectionat si au ramas doar cele cu eficienta mai inalta, fara efecte adverse. Interzicerea acestor metode de tratament, nerecunoscute oficial, va duce la cresterea rezultatelor nefavorabile, fiindca bolnavii vor continua sa foloseasca aceste metode nesupravegheati de profesionisti. OSTEOPOROZA

severitatea, cat si incidenta osteoporozei sunt mai crescute in tarile unde se consuma alimente bogate in proteine, mai ales produse lactate.

A fost relatat ca la eschimosi, care consuma cantitati mari de peste si oase, cantitatea de calciu consumata zilnic ajunge pana la 2500 mg, iar consumul de proteine la 200 – 400 gr. Consumul exagerat de proteina animala cauzeaza osteoporoza, datorita pierderii in cantitati mari a calciului. Astfel, alimentatia bogata in proteine de origine animala duce la diminuarea tesutului osos si dezvoltarea osteoporozei.

Nutritia bogata in proteine de origine animala, ce contin multi aminoacizi cu sulf, predispune la acidifierea sangelui. Deoarece sangele trebuie sa aiba un pH alcalin, aciditatea respectiva este neutralizata prin acumularea calciului in sistemul osos, eliminat ulterior prin urina. Astfel apare osteoporoza. In cazul surplusului de aminoacizi esentiali, enzimele ficatului descompun o parte substantele pana la uree, aceasta actionand ca diuretic, eliminand lichidul si mineralele. In producerea tesutului osos are importanta prezenta oxidului nitric, dar nivelul crescut de uree scade producerea oxidului.

Cele expuse pot fi confirmate prin urmatoarele exemple: s-a constatat ca in unele zone ale Africii, unde calciul consumat prin alimentatie ajunge la 200 mg/zi, fracturile de sold sunt cele mai rare in lume, pe cand la eschimosi, care folosesc zilnic 2000 mg de calciu, fracturile osteoporotice sunt cele mai frecvente in lume.

Factori de risc pentru osteoporoza

  1. Factori ereditari – transmiterea de la mama la fiica. La aceste femei riscul de fracturi este de 2 ori mai mare.

  2. Modul sedentar de viata

  3. Folosirea unor cantitati sporite de cafea pe zi ( mai mult de 1,5 ceasca de cafea)

  4. Utilizarea sporita de proteine de origine animala maresc riscul fracturilor de sold

  5. Consumul de alcool

  6. Expunerea insuficienta la soare

  7. Medicamente anticonvulsivante, antidepresante – dubleaza riscul fracturilor de sold.

Folosirea normala de calciu si utilizarea cantitatilor relativ mici de proteine pana la 30 ani, scade riscul osteoporozei.

Dupa datele unor autori (Jan Mayer, 1999) – ingestia sporita de potasiu si de magneziu ce se contin in alimente vegetariene, duc la marirea densitatii osoase la barbatii varstnici.

Absorbtia Ca++ din produsele vegetale este mult mai mare comparativ cu cea din lapte, din care 70-90% de Ca++ nu se absorb. S-a constatat ca dieta cu raportul fosfor/calciu mai mare de 2 duce la pierderea de calciu si deci la osteoporoza.

La persoanele care consuma proteine in cantitati mari riscul de aparitie a calculilor renali constituie 33% (Universitatea Harward). In SUA se inregistreaza cel mai mare consum de proteine de origine animala, dar si numarul de limfoame maligne este cel mai mare.

Cantitatea mare de proteine din alimentatie duce la scaderea numarului de celule asa numite “killer”, care distrug celulele straine in organism si cele canceroase. La 30% dintre pacientii diabetici care sunt tratati cu insulina apare insuficienta renala. Cantitatea recomandata de 40 g proteine/zi permite stoparea progresiei nefropatiei diabetice.

Multe surse, in special informatiile primite de la cercetatori germani, relateaza ca mezelurile si carnurile afumate ce contin multa sare (100g contine 5-6 g sare) favorizeaza aparitia hipertensiunii arteriale, cancerul gastric si osteoporoza. Pentru ca mezelurile si alte produse din carne sa aiba culoare frumoasa, apetisanta se adauga nitrati si nitriti. Insa reactiile intre nitriti si unele amine formeaza nitrosamine – despre care se presupune ca ar fi cancerigene. Temperaturile peste 1000C favorizeaza producerea nitrosaminelor. Mezelurile si carnea afumata contin hidrocarburi aromatice policiclice foarte cancerigene. Aceste hidrocarburi se formeaza in carnea prajita, la gratar, in fripturi. S-a dovedit ca in Islanda, unde se consuma multa carne si peste afumat, numarul de persoane cu cancer de tract digestiv este cu mult mai mare ca in Europa. Studiile din ultimele decenii au evidentiat ca temperaturile mai mari de 1000C in pregatirea alimentelor din carne dispun la formarea unor compusi cu capacitati mutagene pronuntate, comparabile cu cele ale benzipirenului. Carnurile bogate in acizi grasi polinesaturati omega-G favorizeaza procesul inflamator, tromboza si vasoconstrictia. Acidul arahidonic este furnizorul principal de acizi grasi, deoarece proteinele de origine animala (carne, oua, branzeturi), care contin acid arahidonic, sunt izvorul acizilor grasi polinesaturati omega-G. Ultimul are importanta in mecanismele antinflamatorii cronice si vasculare.

Sursele japoneze relateaza ca in urma unor studii epidemiologice au constatat actiunea puternica cancerigena a aminelor heterociclice ce apar in carnuri si peste pregatite la temperature ridicate. Au fost identificate peste 20 de amine mutagene sau cancerigene. Precursorii aminelor heterociclice sunt: creatina, peptidele, aminoacizii, proteinele si zaharurile.

In Uruguai cantitatea de carne consumata pe cap de locuitor este cea mai mare in lume, dar si neoplasmele sunt cele mai frecvente. Un interes deosebit il prezinta studiile efectuate de Institutul National al Cancerului (1998, SUA) unde au fost examinate 41836 femei. S-a constatat ca la femeile care utilizau carne pregatita prin actiunea temperaturilor ridicate si bine patrunsa, riscul de cancer era de 4-6 ori mai mare comparativ cu femeile ce consumau carnea mai putin expusa la temperaturi ridicate.

S-a confirmat ca uleiul de peste duce la cresterea diabetului, glicemiei, deoarece acidul eicosapentanoic scade secretia de insulina. De exemplu, la eschimosi, a caror alimentatie este bogata in peste, sunt mult mai frecvente hemoragiile cerebrale.

Cresterea continutului de ulei conduce la cresterea excesiva a vitaminei A si D – care devin toxice si scad nivelul vitaminei E. S-a constatat ca toxiinfectiile alimenare sunt cauzate de 15 ori mai frecvent de produsele din peste decat de cele din carne. Produsele din peste contin peste 200 substante chimice dintre care toxice: mercur, pesticide, dioxine.

In Japonia s-a observat ca la populatia care foloseste produse din peste, la copii nivelul de mercur este cu mult mai inalt in cordonul ombilical. Acesti copii au memoria si atentia redusa. Tumorile sunt frecvent depistate la populatia care foloseste produse din peste, deoarece pestele contine mai multe pesticide decat fructele, legumele, cerealele.

Datele studiilor efectuate in mai multe tari au constatat ca populatia care consuma predominant glucide (70-80%) nu sufera de boli degenerative: hipercolesterolemia, hipertensiune arteriala, diabetul zaharat, obezitatea.

Studiile de ultima ora au aratat ca utilizarea cantitatilor mari de glucide favorizeaza sinteza de proteine. Produsele de origine animala sunt lipsite de glucide, cu exceptia laptelui mamiferelor ce contine lactoza. Glucidele din plante sunt compuse monozaharide (glucoza, fructoza, galactoza, lactoza), dizaharide (zaharoza), polizaharide (amidonul). Pentru a asigura energia si functia normala a celulelor nervoase a celulelor nervoase este necesar un aport constant de glucoza.

Hiperglicemia duce la hiperproducerea insulinei, iar ultima favorizeaza arteroscleroza. Cafeaua, ceaiul contin cofeina; cacao si ciocolata – teobromina, care stimuleaza transformarea glicogenului in glucoza asociata cu eliberarea insulinei. Bauturile dulci acidulate contin pana la 150g de zahar la litru, ceea ce corespunde la 10 lingurite la un pahar de lichid.

Concomitent, legumele, zarzavaturile, cerealele nerafinate contin glucide complexe, cum ar fi amidonul, la care monozaharidele se elimina treptat, si nu duc la hiperglicemie si cresterea excesiva a nivelului de insulina.

Fructoza dispune la formarea grasimilor si poate produce rezistenta catre insulina, iar consumul de durata favorizeaza aparitia arterosclerozei. Bauturile dulci ce contin cantitati foarte mari de fructoza sunt periculoase, deoarece duc la tulburari metabolice (Institutul National Pentru Studierea imbatranirii, Baltimore, SUA).

Fibrele alimentare (substante de balast) de origine vegetala (polizaharide neamidonice) dispun de functia necesara pentru transportul si absorbtia substantelor in sistemul digestiv. Conform datelor unor autori necunoscuti, fibrele alimentare joaca un rol important in profilaxia cancerului intestinal. Stratul de aleuron exterior al fibrelor de cereale contine acizi grasi polinesaturati si vitaminele B si E cu actiune antioxidanta. Fructele dulci (ciresele) contin fibre de aceea au un indice glicemic mai redus, retin absorbtia zaharului rapid ce are importanta pentru diabetici.

Reiesind din cele expuse, este util de a aminti caracteristicile principale ale unor produse cerealiere care contin toate ingredientele necesare pentru a intretine starea optima fiziologica a organismului.

Astfel, produsele cerealiere care contin hidrati de carbon complecsi servesc ca sursa de energie principala a organismului. Toate cerealele contin proteine, acizi grasi nesaturati, fibre solubile si insolubile, vitamine B1, B2, acid folic si minerale: magneziu, fier, calciu.

Produsele cerealiere integrale (PCI) contin cantitati mari de lactina ce poseda actiune pozitiva asupra digestiei intestinale, sistemul imun, prin activarea fermentilor, hormonilor intestinali, previn aparitia cancerului intestinal. PCI actioneaza contra hemoragiilor cerebrale, bolilor cardiovasculare si diabetului.

Consumul excesiv de grasimi scade activitatea sistemului imun, favorizeaza dezvoltarea arterosclerozei, diabetului zaharat, obezitatii, cancerului, artrozelor, litiazei biliare. Dupa datele OMS (2001), obezitatea si sedentarismul contribuie la 33% din cauzele cancerului de intestin gros, rinichi, glanda mamara, esofag.

Spre deosebire de glucide si proteine, grasimile nu dau senzatia de satietate, din aceasta cauza ele au capacitatea de a se depune aproape nelimitat. Incalzirea grasimilor si uleiurilor usor supuse oxidarii cu formarea hidroperoxizilor, duce rapid la formarea produselor secundare de oxidare si aldehidelor, epoxizilor, compusilor ciclici hidrocarburati cu proprietati toxice si cancerigene.

Conform informatiilor Centrului Academic din Amsterdam – alimentarea timp de 3 saptamani a animalelor in experiment cu ulei de peste – tumorile de ficat au fost de 10 ori mai frecvente, iar metastazele de 1000 de ori mai frecvente comparativ cu lotul de control.

Margarina, care este mai putin daunatoare ca untul, este obtinuta prin solidificarea uleiurilor vegetale si de peste, iar solidificarea se realizeaza prin hidrogenare, unde are loc transformarea acizilor grasi nesaturati, adica asa cum sunt in grasimile de origine animaliera. Acizii grasi saturati obtinuti prin transformarea acizilor grasi nesaturati afecteaza celulele pancreatice secretoare de insulina si, totodata, inhiba biosinteza proteinelor tesutului osos. Din aceasta cauza apare osteoporoza.

S-a constatat ca 90% din acizii grasi, obtinuti prin transformarea acizilor grasi nesaturati provin din alimente pregatite industrial, prelucrate la temperaturi inalte – prajite. Dupa informatiile unor autori, alimentatia bogata in grasimi influenteaza negativ memoria.

Astfel, reprezinta un factor extrem de important atat in tratamentul, cat si profilaxia diferitelor afectiuni.

Fitoterapia. Fitoterapia exista de mii de ani. Prin experiente empirice s-au acumulat diferite metode de tratament ce au fost verificate de sute de ori si s-au pastrat. Au ajuns pana la noi numai cele confirmate atat de bolnavi, precum si de medici, care au dat rezultate favorabile fara a dauna sanatatii.

Este cunoscut ca pana in secolul trecut tratamentul cu diferite extrase din plante ocupa locul principal in tratamentul multor boli. Progresele in chimie, tehnologie permis obtinerea multor medicamente din plante, care ulterior au fost produse pe cale chimica.

Fitoterapia – utilizarea diferitelor extracte sau preparate obtinute din plante este una din cele mai vechi metode de tratament. Timp de milenii extractele din plante sau chiar plantele nemijlocit, au fost utilizate pretutindeni ca cele mai eficace metode de tratament pentru multe boli. Incepand cu prima jumatate a secolului trecut, treptat, preparatele chimice au predominat in practica medicala. Se stie ca circa 40% din medicamente sunt de origine vegetala, din ele cele cardiace constituie 70%. Fitoterapia este utilizata atat in tratamentul bolilor acute cu manifestari clinice evidente, cat si in cazurile cand are loc evolutie cu manifestari clinice cronice, dar mai ales cu scop de profilaxie. Vom accentua, ca in cazul multor boli cronice, mai ales reumatismale si neurologice, tratamentul este de durata si preparatele chimice deseori sunt asociate cu diferite reactii adverse.

Preparatele fitoterapice dispun de actiunea lor fiziologica naturala, deoarece organismul uman intotdeauna a fost alimentat vegetarian. Insuficienta enzimelor in diferite organe poate fi substituita cu enzimele obtinute din vegetatii. Fitoterapia poate fi recomandata timp indelungat (pana la 60 de zile), pe cand chimio-preparatele doar timp de 15-20 de zile. Semnificativ este faptul, ca fitoterapia nu este asociata cu aparitia dependentei si totodata foarte rar duce la dezvoltarea reactiilor alergice. Nu duce la disbacterioza, iar deseori, sub influenta acestui tratament, are loc normalizarea microflorei intestinale. Fitoterapia dispune de actiuni multilaterale: antiinflamatoare, analgetice, regleaza metabolismul s.a.

Tehnologia producerii preparatelor din plante a progresat evident odata cu aparitia fito-chimiei si fito-farmacologiei. Plantele contin multe glucide (70-80%), polizaharide care au actiune antiinflamatoare, gastro-protectoare, intensifica secretia glandelor digestive. Pentru dezvoltarea si intretinerea fiziologica normala a organismului este necesara prezenta mineralelor. Majoritatea lor se gasesc in plantele medicinale: potasiu, calciu, natriu, magneziu, fosfor, sulf, fier, cupru, arseniu, nichel, zinc, argint. In celulele plantelor au loc procesele de sinteza a unor substante biologice active cum ar fi: morfina, atropina, cofeina, chinina, efedrina, etc.

Plantele curative sunt organisme vii si sintetizeaza substante mai mult fiziologice pentru organismul uman comparativ cu preparatele sintetice, obtinute in laboratoare chimice si uzine. Plantele si preparatele din ele actioneaza asupra organismului afectat mai usor, nu evoca reactii negative, efectul apare lent, dar este durabil. Principalii compusi chimici sunt: alcaloizii, glicozidele, saponinele, flavonoizii, acizii organici, eterii, acizii grasi, vitaminele, cumarinele, tanantele, enzimele, sarurile, microelementele.

In medicina un loc deosebit ocupa alcaloizii – substante organice ce se contin in sucurile plantelor sub forma de acizi organici. Alcaloizii contin azot sunt foarte utilizate in multe preparate: morfina, codeina, platifilina, atropina, cofeina, s.a. Glicozidele se gasesc in multe plante: sfecla, fructele de diferite specii de plante, care au actiune stimulatoare selectiva asupra miocardului.

Saponinele – dispun de activitate biologica: actiune diuretica, actiune antisclerotica, anticanceroasa. Flavonoizii – substante biologic active regleaza permeabilitatea capilara, actioneaza antihipertensiv dar si in boli reumatice, pneumonii, in bolile inflamatorii cronice. Enzimele – substante proteice ce actioneaza in calitate de catalizatori atunci cand participa in reactiile complexe ale organismului. Acizii grasi duc la normalizarea proceselor digestive, stimuleaza activitatea intestinala.

Pentru dezvoltarea si intretinerea fiziologica a organismului este necesara prezenta multor minerale, majoritatea din ele se gasesc in plantele medicinale: potasiu, calciu, natriu, fosfor, magneziu, sulf; microelemente – fier, cupru, cobalt, arseniu, nichel, molibden, zinc si argint.

Astfel, colhicina se utilizeaza in multe boli reumatice: psoriazisul, sclerodermia, sarcoidoza, dermatomiozida ca si in ciroza hepatica, sindromul Behçet, boala periodica, amiliodoza.

Partea activa a acestei plante – alkaloid – a fost numita colchicina, in cinstea Colhidei, de unde planta a fost transportata. Formula empirica a fost descrisa de Demar (1995) – C22H25O6.

Acest preparat inhiba reactia celulara polinucleara participantii principali la procesul inflamator aseptic. Totodata preparatul scade permeabilitatea capilarelor, inhiba reactia endoteliala a capilarelor la mediatorii inflamatori. Astfel, colhicina blocheaza raspunsul vascular si leucocitar in inflamatia acuta, deprima secretia si agregarea trombocitelor, stimuleaza secretia steroizilor, influenteaza asupra celulelor imuno-reglatoare. In doze medii:colhicina scade producerea amiloidului si, ca urmare, duce la ameliorarea sindromului nefrotic.

Astfel, plantele au fost si au ramas una din sursele principale de alimentatie si medicamente, care pot fi utilizate timp indelungat fara a duce la reactii adverse grave.

Bolile cronice necesita un tratament indelungat, care poate fi realizat prin utilizarea fitoterapiei, deoarece remediile chimice mai frecvent duc la aparitia multiplelor reactii negative. Prioritatea remediilor fitoterapice consta in actiunea lor fiziologica, naturala, deoarece organismul uman intotdeauna s-a alimentat vegetal. In multe stari cronice are loc scaderea activitatii enzimatice. Insufucienta enzimatica din diferite organe poate fi limitata prin aport de enzime de provenienta vegetala.

Semnificativ este faptul ca fitoterapia nu este asociata cu aparitia dependentei si foarte rar duce la aparitia reactiilor alergice, nu favorizeaza aparitia disbacteriozei, chiar invers permite normalizarea florei intestinale. Preparatele fitoterapeutice dispun in acelasi timp de cateva actiuni: antiinflamatorie, analgetica, de stimulare a reactiilor immune, reglarea metabolismului etc. Plantele contin un procent mare de glucide, iar masa uscata a plantelor contine polizaharide ce actioneaza antiinflamator, gastroprotector, intensifica secretia glandelor endocrine.

Bolile cronice sunt asociate cu alte afectiuni ce duc la producerea reactiilor negative toxice. Iata de ce in aceste cazuri utilizarea unui complex de diferite plante nu se asociaza cu aceste reactii, dar da rezultat benefic.

Avantajele fitoterapiei: 1. dispune de actiune fiziologica; 2. posibilitatea utilizarii timp indelungat mai ales in tratamentul bolilor cronice; 3. foarte rar este asociata cu aparitia reactiilor negative, alergice; 4. lipsa dezvoltarii dependentei medicamentoase; 5. foarte rar sunt contraindicatii pentru acest tratament; 6. lipseste pericolul dezvoltarii disbacteriozei intestinale; 7. majoritatea plantelor medicinale cresc in toate zonele geografice; 8. posibilitatea selectarii plantelor necesare, deoarece se gasesc in cantitati mari.

Cu toate acestea mecanismele de actiune a substantelor din diferite plante nu sunt studiate suficient. Concomitent, plantele deseori contin diversi virusi, care nu rareori pot provoca procese patologice la om, ca sa nu mai mentionam reactiile alergice. De aceea este necesar ca in prezent, in noile conditii sa poata fi elaborate, verificate si evidentiate noi substante mai pure, care nu vor duce la reactii negative.

Deoarece bolile cronice sunt associate cu afectiuni de diferita natura, este necesar de administrat terapia combinata, iar administrarea in acelasi timp a catorva chimiopreparate deseori duce la producerea reactiilor negative, toxice. Iata de ce, in aceste cazuri, utilizarea unor combinatii din diferite plante permite evitarea reactiilor negative si realizarea efectului dorit curativ.

Extractele din diferite plante in infuzie, vapori, eter si lipide pot fi utilizate local si sistemic fara a evoca reactii adverse. Unele plante: gutuiul – contine vitaminele C, B, poseda actiune antiinflamatorie, diuretica, coleretica; pepenele verde – diuretic, coleretic, se recomanda pacientilor cu guta, nefrolitiaza, pielonefrita, anemie, diabet; vinetele se administreaza in anemie, diabet zaharat, boli cardiace, renale au actiune diuretica; strugurii (sucul) au actiune diuretica, sudoripara, hipotensiva, mucolitica si/sau expectoranta, antiinflamatorie, antinefrolitiazica; frunzele de vita-de-vie sut benefice in diabetul zaharat, extractele de frunze culese in luna mai sunt bune contra hipertensiunii arteriale; extractul de seminte de struguri – in diaree; vinul sec este detoxifiant si antisclerotic. Visinele influenteaza antipiretic, mucolitic/ expectorant, la pacientii cu anemie, tulburari de coagulare – efect antitrombotic, antibacterian, diuretic. Pepenele galben – contine fier util in prevenirea anemiei feriprive, in dischinezii intestinale. Are efect antisclerotic, diuretic, antigutos, nefrolitiazic, coleretic, sedativ. Coaja de zamos este recomandata in acnee, alunite. Capsunile regleaza metabolismul, indeosebi cel mineral, au efect antigutos, nefrolitiazic (se recomanda – 1 kg/zi timp de 10-15 zile pe an), regleaza metabolismul lipidic, tensiunea arteriala, se recomanda pacientilor cu hepatite, regleaza functia glandei tiroide. Pot fi folosite in tratarea helmintiazei: 3 kg capsuni la o masa in combinatie cu produse piperate au o actiune antihelmintica. Frunzele de capsuni regleaza metabolismul glucidic, au efect antialergic si antihemoragic. Varza este utila in caz de cefalee, insomnie. Aplicarea frunzelor local se recomanda in caz de edem, inflamatie articulara, furuncul, au efect analgezic si antimicotic. Varza se recomanda in bolile respiratorii, are continut sporit in vitamina C si poseda actiune antiulceroasa, favorizand regenerarea mucoasei intestinale.

Faunoterapia. Din antichitate, produsele din diferite organe ale animalelor au fost utilizate in tratamentul multor boli. Astfel, Aristotel descrie unele preparate obtinute din pestii exotici in tratamentul sistemului nervos. Avicenna in tratatul sau “Canoanele stiintei medicale” informeaza despre utilizarea carnii de rechin, balena si icre de peste marin pentru reglarea functiei sexuale.

Medical Pan-Sun, in publicatia sa “Izvorul sanatatii”, descrie proprietatile curative ale ficatului de Cambala (peste de mare) deoarece influenteaza sistemului de coagulare a sangelui. Multe substante extrase din organele animalelor nu au fost studiate suficient. In acest sens un interes deosebit prezinta buretele de mare, care contine substante bioactive: bactericide (inclusive cu actiune impotriva bacilului Koch), iar din arabinoza (care inlocuieste riboza in organismul lui) s-a elaborat preparatul anticancerigen citozin-arabinoza. Actiunea antiinflamatoare a SBA din buretele de mare se datoreaza prezentei hexalfluorului de sodium (Na2SiF6). Sunt prezentate date despre toxicitatea pestelui-balon din care au fost obtinute SBA – tetradoxinul cu actiune de 160.000 ori mai mare, comparativ cu cocaina si este folosit in anestezie in caz de operatii grave. Preparatele obtinute din ficatul unor rechini blocheaza dezvoltarea celulelor cancerigene fara a traumatiza alte tesuturi. Pe baza acestor extrase a fost elaborat preparatul pentoxil utilizat in tratamentul unor maladii hematologice si ca citostatic in tratamentul unor tumori maligne. Din nisetru este extras antibioticul ectolin, care dispune de capacitati pentru prelungirea actiunii altor antibiotice. Caracatita – elimina toxine din care s-a elaborat preparatul sepia utilizat in homeopatie si preparatul sepia utilizat in homeopatie si preparatul cefalotaxin utilizat in tratamentul bolilor nervoase, respiratorii. Extractele din unele midi sunt eficiente contra reumatismului. In bolile nervoase este folosita substanta de tip prostaglandina din corali. Alta substanta din corali (insule Hawaii) – politoxina – C1201H2231N3054 – are actiune anticancerigena. Din corpurile crevetilor, coralilor si racilor de mare a fost obtinuta SBA chitina, folosita contra formarii trombilor si pentru favorizarea vindecarii ranilor, pentru inlaturarea cheloizilor dupa arsuri, negilor, alunitelor carcinoamelor, melanoamelor.

Actualmente SBA obtinute din amfibii sunt putin studiate. A fost studiata eficacitatea SBA obtinute din broastele raioase, cu actiune asupra astmului bronsic. Toxinele obtinute din pielea broastelor testoase (America de Sud) se foloseau de catre indieni pentru pregatirea varfurilor sulitelor contra dusmanilor. Dupa cum a fost constatat toxinele broastei raioase in solutie 1:100 – provoaca moartea pasarilor si a soparlelor in timp de cateva minute. Toxinele broastei testoase au capacitatea de a ridica tensiunea arteriala si intensifica contractiile inimii – adica, poseda actiune asemenatoare actiunii preparatului strofantin.

Este cunoscut ca in unele tari (China), carnea de broasca testoasa este utilizata in tratamentul dizenteriei, are actiune antibacteriana, iar icrele de broasca testoasa au efect antireumatic. Totodata, ea este aplicata pe locurile de muscatura de sarpe. Din pielea de broaste au fost extrase SBA: serotonina, bradikinina, toxichinina si opioidele. Demorfina extrasa din pielea unor specii de broaste cu proprietati de anestezie de 11 ori mai mare decat SBA extrase din salamandra: samadarin, samadamaritin etc.

Tabelul 4. Organele unor animale folosite in tratamentul bolilor

Nr.

Organele interne ale animalelor

Indicatii in unele boli

1

Cheagul din stomacul de miel

Diareea

2

Vezica biliara de miel

Afectiunile microbiene ale ochilor, urechilor, cheratozelor

3

Vezica biliara de porc

Cresterea parului

4

Vezica biliara de cambala, stiuca

Contra infectiilor oculare

5

Vezica biliara de bovina si urs

Contra infectiilor organelor respiratorii superioare

6

Vezica biliara de la pasari (corb, prepelita, barza)

Pentru ameliorarea vederii

7

Oasele de bovine, maimute

Contra reumatismului

8

Oasele broastei testoase

Contra anemiei

9

Oasele de tigru, elefant

Cresterea potentei sexuale

10

Ficatul de bovine si gaini

Stimuleaza vederea

Ficatul mai multor animale este bogat in vitamina A. Astfel, ficatul de urs alb contine vitamina A in proportie de 10400 unitati, pe cand ficatul de rechin contine numai 400 unitati.

Savantul MacLeon (1916) a obtinut substante biologice active din ficatul de caine, ulterior numite heparina si apoi obtinute din alte organe interne (splina, plamani, muschi). Actualmente heparina este produsa din plamani de bovine. Ea dispune de actiune anticoagulanta si este utilizata in tratamentul tromboflebitelor, varicelor, pancreatitelor acute etc.

Tabelul 5. SBA obtinute din unele organe animale.

ORGANELE

SUBSTANTELE BIOLOGIC ACTIVE

Glandele salivare

Proteina – factor de crestere a nervilor (sporeste regenerarea epidermei)

Creierul, maduva spinarii

Peptid – factor de ameliorare functionala a nervilor periferici somnului, memoriei

Creierul

Factorul de alarma contine 105 de aminoacizi: endorfine si enkefaline

Creierul si maduva spinarii de bovine

Preparatul cerebrolectina si lipocerebrina ce stimuleaza functia SNC. Actiune antisclerozanta, normalizeaza metabolismul lipidic.

Creierul de bovine

Colesterolul si lecitina in stimularea cresterii

Mucoasele intestinului de porc

Pepsina

Cristalinul ocular de la bovine

Respiratia tesuturilor, contra reumatismului

Testiculele de bovine

Enzimele: lidaza, ronidaza – pentru regenerarea tesuturilor dupa arsuri, traume

Pancreasul bovin

Insulina, tripsina, chimotripsina, chimotripsinogenaza.

Ribonucleazele si dezoxiribonucleazele hidrolizeaza acizii nucleici. Aceste enzime sunt folosite pentru inhibarea microflorei straine si a virusilor. Colagenazele – pentru eliminarea necrozelor in urma arsurilor si degeraturilor.

Pancreasul porcinelor

Preparatele elastolitin, pantrepin contra pancreatitei acute. Preparatele: contrical, trasilol, tzalol, gordox in tratamentul artrozelor. Pancreatina, digestalul, mezimul, festalul, vegeratina – in patologiile gastro-intestinale. Calicreinele – andecalin, calicrein, dilminal cu actiune hipotensiva

Sangele bovinelor

Aminopeptid, fibrinosol – alimentatie in caz de tulburari digestive, de scadere ponderala. Preparatul polibiolin – antiinflamator si analgetic. Plasmolul – contra ridiculitei si ulcerului stomacal. Solcoseril – in tratamentul ulcerului peptidic, gangrenelor, arsurilor acute.

Sangele donatorilor

Fibrinogen contra tromboflebitei. Trombina in stoparea hemoragiilor. Varico-liz, Trombo-liz – in tromboflebitele varicoase. Hemor-liz – contra hemoroizilor.

Limfocite

Interferon – proteina contra infectiilor virale, tratament in hepatitele virale.

Din antichitate unele organe ale serpilor au fost folosite pentru pregatirea medicamentelor – in tratamentul reumatismului sau a ranilor. Carnea de arici se recomanda in cazurile intoxicatiilor acute si tuberculozei. Pielea de arici este folosita pentru stoparea hemoragiilor. Carnea de sarpe se recomanda in tratamentul sclerodermiei sistemice. Toxinele extrase din diferite specii de serpi au actiune: coagulanta si anticoagulanta cu impact asupra SNC si periferic, hemopoezei. Unicul tratament specific – in muscatura de sarpe este antiserul la toxina data (in acest caz este necesar de stiut specia sarpelui care a produs muscatura).

Neurotoxinele de sarpe au actiune: 1. Peptidica – blocheaza membranele sinaptice sensibile ale muschilor scheletici si a unor sectoare ale creierului; 2. Regleaza mediatorul de actiune al terminatiilor nervoase; 3. Polipeptidele – actiune de depolarizare a membranelor celulare. Din veninul de sarpe s-a obtinut substanta activa – tromboplastin cu actiune de coagulare, utilizata in tratamentul astmului bronsic, epilepsiei, tulburarilor nervoase, hemofiliei.

Medicamentele pe baza toxinelor extrase din serpi veninosi activeaza procesele de coagulare a sangelui, sunt folosite in anestezie, in tratamentul bolilor SNC (epilepsie).

Toxinele paianjenilor si ale scorpionilor sunt folosite in tratamentul multor boli. Sunt studiate aproximativ 30 000 de specii de paianjeni. La om, muscatura paianjenului de Curacuta este asemanatoare actiunii atropinei: spasm a sfincterelor, canalelor urinare, intestinului cu asocierea durerilor pronuntate, hipertensiune arteriala.

Veninul paianjenului de Curacuta provoaca eliminarea intensiva a acetilcolinei, dopaminei, noradrenalinei si acizilor gamma-amino-lipoici. Paianjenul Tarantula elimina toxine cu actiune hemolitica. Paianjeni ornitofagi (rapitori de pasari) secreta venin cu actiune directa asupra SNC: pot provoca somnolenta, moarte. Substanta accelereaza eliminarea acetilcolinei din sistemul nervos periferic. In Laos se prepara medicamentul din acest paianjen pentru calmare. Sunt cunoscute cca 500 de specii de paianjeni care pot supravietui pana la 1 an fara hrana. Toxinele de scorpioni actioneaza asupra ficatului, rinichilor si duce la aparitia vomei, frisoanelor, somnolentei. Veninul scorpionului este de natura hormonala, de aceea duce la cresterea glicemiei, provoaca intensiv eliminarea insulinei si tripsinei. Lipitorile – Hiruda medicinalis, viermi inelari – sunt larg folositi ca metoda de tratament. In momentul absorbtiei, lipitoarea elimina proteina – hirudina cu capacitatea de anticoagulare si inactivarea protrombinei. Hirudoterapia se foloseste in bolile cardiovasculare, tromboflebite. Substantele obtinute din viermi se recomanda contra bolilor reumatice, cheratitelor, frisoanelor, hemoragiilor, epilepsiei.

Produsele din coarne, copite, unghii, par si din crusta de rac au fost folosite cu 3700 ani in urma de faraonii egipteni. Aceste organe contin keratina – folosita in disfunctii sexuale si metabolism.

Preparatul pantocrin – suspensie de 10 % din coarne de ren, contine substante organice – grasimi; substante anorganice – Calciu, Magneziu, Fier, Siliciu, Fosfor, Sodiu, Natriu, Nichel, Cupru, Titan, Plumb, Bariu. Pantocrinul este utilizat in tratamentul multor patologii. El creste considerabil imunitatea si coagularea sangelui; normalizeaza somnul. De asemenea, are efect de calmare, antiulceros. Este folosit contra epilepsiei, psihozelor; amelioreaza functia musculara. Despre extrasul din coarne de ren se stie din sec. IV i.e.n. In China din tendoanele animalelor se prepara produse gelatinoase, folosite pentru ridicarea tonusului muscular si tratamentul tuberculozei.

Rumalon este un preparat produs din cartilagiu si maduva animalelor domestice. Chitozanul este folosit in dermatologie, cosmetologie ca un bun antiinflamator.

Acizii biliari influenteaza activitatea traiectului digestiv, sistemului endocrin, SNC, scade functia renala, reduce procesele de oxidare. Sucul biliar amelioreaza functia ficatului si a pancreasului. Cojile de ou de gaina se administreaza in diaree si nefrolitiaza.

Scorpionii sunt folositi in tratamentul limfaadenopatiei, in caz de tuberculoza, dermatite, ulceratii cutanate. Toxinele broastei sunt utilizate in tratamentul reumatismului, stoparea hemoragiilor interne.

Psihoterapia. Orice medic practician, constient sau inconstient foloseste aceasta metoda. Cunoscutul medic, academicianul B. Votcel, care a studiat zeci de ani multe medicamente, scrie ca eficacitatea oricarui medicament se datoreaza in 60% efectului psihoterapeutic. Razboaiele si conflictele armate, santajele cu arme nucleare, extremismul, terorismul, schimbarile oranduirilor sociale etc. continua sa influenteze sistemul nervos si duc la tulburari neuro-psihice si, prin urmare, favorizeaza dezvoltarea multor boli grave.

Stresul emotional, ca factor patogen psihotraumatic este neutralizat de fiecare om dupa posibilitati. Apararea psihologica este un mecanism normal perpetuu care asigura rezistenta organismului la boli si prevenirea dezorganizarii psihice.

Receptia, in aceste cazuri, se reorganizeaza in asa fel, incat rezultatul traumei psihologice treptat isi pierde importanta.

Autosugestia – factor foarte puternic, care influenteaza asupra gandirii, simtului, contra suferintei. Aceasta putere este cunoscuta de cca 2000 ani. Astfel, filozoful Seneca scria unui prieten: “Durerile pot fi usor suportate, daca nu le amplifici in gand, ci din contra, te incurajezi, spunand ca nu te afecteaza sau ca devin tot mai slabe”.

Psihoterapia (autosugestia) este mai frecvent aplicata de catre intelectuali, subiecti pregatiti si presupune auto-training-ul indelungat. La baza acestei metode stau mecanisme fiziologice complexe ce actioneaza asupra receptorilor neurali, in consecinta se elimina neuromediatorii cu efect de reducere a procesului patologic.

Stresul acut si cronic pot fi considerate afectiuni psihosenzoriale. Apararea psihologica este un mecanism firesc, continuu ce asigura rezistenta organismului in conditii nefavorabile sau nocive psihopatologice. In acest caz, mecanismul de aparare a organismului este indreptat spre neutralizarea actiunilor factorilor psihologici lezionali. Mecanismele de receptie se reformeaza in asa fel ca efectul factorului traumatic psihologic treptat pierde importanta sa si, prin urmare, nu duce la initierea unui process patologic. Un dialog eficient intre pacient si medic are actiune benefica din punct de vedere psihologic.

Psihoterapia generala printr-un complex de abordari psihologice cu actiune pozitiva asupra SNC, intensifica potentialul de rezistenta a organismului bolii.

Medical psihoterapeut este apreciat pentru urmatoarele calitati: rabdare, liniste, simt critic, corectitudine, pastrarea confidentialitatii, tact, abilitatea de comunicare deschisa, limbaj explicit, apreciere obiectiva, empatie, capacitatea de a conduce si dirija pacientul, diplomatia si multe altele.

Psihoterapeutul trebuie sa poata dialoga cu pacientul de la egal la egal.

Astfel, psihoterapia este un factor curativ foarte important si este necesar ca fiecare medic in activitate sa foloseasca aceasta metoda terapeutica.

Dietoterapia (DT). Dieta din limba latina “diaeta” – stilul de viata, presupune astfel, nu doar selectarea unor alimente.

Nu exista produs alimentar care sa nu posede calitati curative. In ratia alimentara a omului sunt incluse peste 600 de substante, fiecare din care are capacitati curative. Pentru a utiliza eficient majoritatea substantelor alimentare, mai intai este necesar de a le pregati calitativ. Alimentarea vicioasa constitue un pericol foarte mare pentru sanatatea omului. Hipocrate a definit medicina ca arta ce reflecta influenta naturii ca factor curativ si produsele alimentare au fost numite medicamentele noastre.

Tot complexul metabolismului in organism depinde de calitatea produselor ingerate. Noi putem modifica alimentatia, iar starea organismului se modifica in functie de compozitia alimentatiei.

Modificarile in calitatea alimentatiei duc la aparitia tulburarilor metabolismului Modificarile functionale ce apar in rezultatul alimentatiei necalitative duc la modificari morfologice care, fixate din generatie in generatie, se transforma in particularitati genetice.

Progresele inregistrate in domeniul biologiei moleculare, imunologiei, biofizicii au permis descifrarea unor mecanisme ale proceselor metabolice care, de regula, sunt strict legate de activitatea sistemelor neuro-endocrine, imun, de oxidare si antioxidare etc.

Numeroase studii effectuate in diverse centre stiintifice au stabilit importanta alimentatiei in dezvoltarea multor boli incurabile: cardiovasculare, metabolice, degenerative, procese tumorale.

Caracterul alimentatiei, se pare ca, este responsabil de dezvoltarea cancerului pana la 30-50% din numarul total de cazuri (Conferinta Europeana de Nutritie, Lyon, Franta, 2001).

S-a constatat ca in ultimii 20 de ani incidenta tumorilor cerebrale in Europa s-a dublat. Concomitent, frecventa osteoporozei sistemice a crescut foarte mult in tarile dezvoltate, unde se consuma cantitati foarte mari de produse bogate in grasimi: lapte, branzeturi, carne. Exista pareri eronate ca tehnologiile avansate sunt suficiente pentru a realiza prevenirea acestor stari grave si fara mari corectii ale modului de ciata; propagarea exagerata a unor medicamente sofisticate, diferite diete-minune nu respecta principiul “masurii” alimentare pentru asigurarea starii bune a sanatatii. Goana imbogatirii din contul sanatatii societatii umane va duce la distrugerea noilor generatii si va influenta negativ sanatatea urmasilor nostri.

De exemplu, alcoolul este una din principalele cauze ale tulburarilor mentale la generatiile noi. Embriopatia alcoolica este una din cele mai grave defecte de nastere; malformatiile organelor interne, faciale, afectari cerebrale. Chiar si cantitatile foarte mici de alcool sunt capabile sa dauneze embrionului, fatului, crescand frecventa copiilor cu sindromul alcoolic: hiperactivitate, afectari cerebrale, impulsivitate. Deseori, la acesti copii sunt evidentiate anomalii faciale deosebite: ochii mici cu riduri la coltul ochilor, deformari craniene si dimensiuni mici ale craniului, prezenta tulburarilor auditive, vizuale, de coordonare, scaderea barierei de aparare.

S-a constatat (Universitatea din Minnesota) ca riscul pentru dezvoltarea leucemiei acute mieloide la copii este de 3 ori mai mare, daca mamele in timpul sarcinii au consumat 20 de pahare de vin sau 20 de halbe de bere, iar in cazul mamelor care au consumat alcool in al 2-3 trimestru de graviditate, riscul pentru aparitia leucemiei mieloide acute a fost de 10 ori mai mare.

Numai intr-un singur an, in 1995, in Germania, s-au nascut 55000 de copii cu malformatii, ceea ce este echivalent cu 7% din numarul total de nasteri, din cauza utilizarii alcoolului si a prezentei obezitatii si a altor factori. In conditiile noi ce s-au creeat, a aparut rezistenta unor infectii catre antibiotice si chiar noi agenti patogeni. Progresele in medicina moderna nu au dus la scaderea incidentei bolilor incurabile, ba chiar invers incidenta cancerului, diabetului zaharat, arterosclerozei, bolilor autoimune s.a. a crescut.

Institutul National de Combatere a Cancerului din SUA informeaza ca 35 % din toate formele de cancer sunt cauzate de alimentatia incorecta, 30% – de fumat, 35% de alcool, virusi, insolatie, factori nocivi profesionali, factori genetici, poluarea mediului inconjurator.

Ca si intotdeauna, medicii sunt educati sa studieze bolile si cu parere de rau foarte putin sa-si modifice gandirea spre ameliorarea modului de viata, caracterului alimentatiei, a obiceiurilor.

Anual decedeaza aproximativ 400.000 de persoane din cauza bolilor legate de fumat; 500.000 – din motivul alimentatiei incorecte si modului sedentar de viata; 280.000 din cauza obezitatii; 100.000 din cauza consumului excesiv de alcool.

In Germania, unde se consuma cantitati mari de grasimi animale, fiecare al doilea deces este cauzat de infarct miocardic, pe cand in Japonia, unde se consuma multe alimente vegetale se imbolnavesc foarte rar de cancer al intestinului gros, comparativ cu tarile apusene.

Reducerea cantitatii de alimente consumate este una din masurile necesare pentru prelungirea vietii si prevenirea bolilor canceroase, deoarece celulele canceroase au necesitati energetice mai sporite decat cele sanatoase.

La varstnici scade activitatea sistemului imun si numarul de T-limfocite, ceea ce duce la cresterea predispozitiei catre infectii, boli immune, tumori. Totodata, la persoanele de varsta inaintata are loc cresterea nivelului radicalilor liberi (RL), iar folosirea unor antioxidante (medicamente) artificiale nu da rezultatele asteptate, deoarece ele nu pot inlocui antioxidantele vegetale. Plantele, in afara de vitamine, contin diverse substante bioactive, cu actiuni antitumorale. Este cunoscut faptul ca fitoestrogenele din salata, varza, conopida, cereale au actiune contra tumorilor de san, colon, prostata, uter. Leucopenul din rosii actioneaza contra cancerului de prostata, iar glucosinatele din varza, conopida, ridichi actioneaza contra infectiilor, prin activarea sistemului imun. Alte studii au constatat ca fitosterinele din seminte de floarea soarelui sau din nuci scad riscul cancerului de colon, iar flavonoidele continute in fructe (visine, cirese, capsuni, mere) si legume (cartofi, ceapa, ardei, sfecla rosie) sunt foarte active contra infectiilor si tumorilor. Fenolii din cereale si nucile au actiune antivirala, antimicotica, ntioxidanta. Sulfidele din usturoi, praz, ceapa au actiune antioxidanta si antitumorala. Saponinele continute in fasole, mazare, naut poseda actiune contra cancerului de intestin gros. Terpinele cu telina, menta retin dezvoltarea cancerului. Polifenolii din fructe, nuci participa la normalizarea activitatii sistemului vascular prin intensificarea producerii de oxid nitric ce duce la scaderea riscului pentru boli cardiovasculare.

Imunitatea este strans legata de caracterul alimentatiei. In asigurarea unui statut normal al imunitatii, de rand cu vitaminele, mineralele (zincul, fierul, cuprul, seleniul) o importanta mare apartine proteinelor si grasimilor vegetale.

Asupra sistemului imun actioneaza radicali liberi ai oxigenului. Pentru sustinerea unui echilibru normal intre sistemele oxidante si antioxidante este necesara utilizarea produselor cerealiere integrale, a fructelor si legumelor. Totodata utilizarea miltor suplimente alimentare ce contin antioxidanti si vitamine nu poate inlocui produsele naturale, legumele si fructele ce contin multe substante bioactive.

S-au inregistrat diferente foarte mari in ceea ce priveste incidenta tumorilor de prostata la populatia Angliei, Elvetiei, SUA in raport cu populatia din tarile asiatice. Ele se datoreaza utilizarii produselor vegetale de catre ultimii (in special soia care contine fitosteroizi, saponine, izoflavoine,cu actiune antitumorala.Produsele cereale contin hidrati de carbon complecsi care servesc ca sursa de energie principala a organismului. Totodata ele contin proteine, acizi grasi nesaturati, fibre solubile si insolubile, vitamina B1, B2, acid folic, minerale – magneziu, fier, calciu.

Painea din faina integrala nu ingrasa si, comparativ cu cea din faina alba, contine de 7 ori mai multe minerale si de 5-10 ori mai multe vitamine. Produsele cereale integrale (PCI) poseda actiuni contra bolilor cardiovasculare, diabetului, tumorilor. Astfel, folosirea PCI scade riscul de hemoragii cerebrale si infarct miocardic la 30%, iar riscul tumorilor maligne la 33%.

In tarile dezvoltate in alimentatie predomina proteinele de origine animala ce contin colesterol si grasimi saturate, care favorizeaza dezvoltarea arterosclerozei si imbatranirea.

Proteinele de origine animala duc la cresterea nivelului insulinei si accelereaza producerea colesterolului, care sunt principalii factori ce duc la cresterea riscului de afectiuni cardiovasculare, iar proteinele vegetale, din contra, scad sintetizarea insulinei si colesterolului. Frecventa infarctului miocardic este proportionala cu cresterea insulinei din cauza consumului de proteine animale.

In produsele vegetale continutul de aminoacizi arginina si glicina din proteine este mai mare comparativ cu proteinele de origine animala. Acesti aminoacizi duc la inhibarea sintezei colesterolului in organism.

In mentinerea unui echilibru normal metabolic are importanta raportul calciu/fosfor. Dupa cum se stie, cresterea concentratiei de fosfor este asociata cu micsorarea nivelului plasmatic de calciu. Atat micsorarea nivelului de calciu, cat si nivelul marit de fosfor duc la cresterea concentratiei hormonului paratiroidian, cu dezvoltarea ulterioara a osteoporozei. Concomitent, cresterea concentratiei de fosfor in sange duce la depozitarea de fosfor si calciu in organe interne: inima, rinichi si alte organe, favorizand dezvoltarea proceselor inflamatorii si degenerative.

S-a constatat ca proteinele modificate prin influenta caldurii actioneaza toxic, cancerigen, mutagen, mai ales cele prelucrate prin prajire, afumare si pregatire la gratar.

Organizatia Mondiala a Sanatatii a calculat ca normele necesare de aminoacizi din compozitia laptelui uman corespunde cel mai bine cu laptele de capra. Produsele vegetale contin toti aminoacizii esentiali in cantitati suficiente. Lactatele au un continut bogat in proteine. Atatseveritatea, cat si incidenta osteoporozei sunt mai crescute in tarile unde se consuma alimente bogate in proteine, mai ales produse lactate.

A fost relatat ca la eschimosi, care consuma cantitati mari de peste si oase, cantitatea de calciu consumata zilnic ajunge pana la 2500 mg, iar consumul de proteine la 200 – 400 gr. Consumul exagerat de proteina animala cauzeaza osteoporoza, datorita pierderii in cantitati mari a calciului. Astfel, alimentatia bogata in proteine de origine animala duce la diminuarea tesutului osos si dezvoltarea osteoporozei.

Nutritia bogata in proteine de origine animala, ce contin multi aminoacizi cu sulf, predispune la acidifierea sangelui. Deoarece sangele trebuie sa aiba un pH alcalin, aciditatea respectiva este neutralizata prin acumularea calciului in sistemul osos, eliminat ulterior prin urina. Astfel apare osteoporoza. In cazul surplusului de aminoacizi esentiali, enzimele ficatului descompun o parte substantele pana la uree, aceasta actionand ca diuretic, eliminand lichidul si mineralele. In producerea tesutului osos are importanta prezenta oxidului nitric, dar nivelul crescut de uree scade producerea oxidului.

Cele expuse pot fi confirmate prin urmatoarele exemple: s-a constatat ca in unele zone ale Africii, unde calciul consumat prin alimentatie ajunge la 200 mg/zi, fracturile de sold sunt cele mai rare in lume, pe cand la eschimosi, care folosesc zilnic 2000 mg de calciu, fracturile osteoporotice sunt cele mai frecvente in lume.

Factori de risc pentru osteoporoza

  1. Factori ereditari – transmiterea de la mama la fiica. La aceste femei riscul de fracturi este de 2 ori mai mare.

  2. Modul sedentar de viata

  3. Folosirea unor cantitati sporite de cafea pe zi (1,5 ceasca de cafea)

  4. Utilizarea sporita de proteine de origine animala maresc riscul fracturilor de sold

  5. Consumul de alcool

  6. Expunerea insuficienta la soare

  7. Medicamente anticonvulsivante, antidepresante – dubleaza riscul fracturilor de sold.

Folosirea normala de calciu si utilizarea cantitatilor relativ mici de proteine pana la 30 ani, scade riscul osteoporozei.

Dupa datele unor autori (Jan Mayer, 1999) – ingestia sporita de potasiu si de magneziu ce se contin in alimente vegetariene, duc la marirea densitatii osoase la barbatii varstnici.

Absorbtia Ca++ din produsele vegetale este mult mai mare comparativ cu cea din lapte, din care 70-90% de Ca++ nu se absorb. S-a constatat ca dieta cu raportul fosfor/calciu mai mare de 2 duce la pierderea de calciu si deci la osteoporoza.

La persoanele care consuma proteine in cantitati mari riscul de aparitie a calculilor renali constituie 33% (Universitatea Harward). In SUA se inregistreaza cel mai mare consum de proteine de origine animala, dar si numarul de limfoame maligne este cel mai mare.

Cantitatea mare de proteine din alimentatie duce la scaderea numarului de celule asa numite “killer”, care distrug celulele straine in organism si cele canceroase. La 30% dintre pacientii diabetici care sunt tratati cu insulina apare insuficienta renala. Cantitatea recomandata de 40 g proteine/zi permite stoparea progresiei nefropatiei diabetice.

Multe surse, in special informatiile primite de la cercetatori germani, relateaza ca mezelurile si carnurile afumate ce contin multa sare (100g contine 5-6 g sare) favorizeaza aparitia hipertensiunii arteriale, cancerul gastric si osteoporoza. Pentru ca mezelurile si alte produse din carne sa aiba culoare frumoasa, apetisanta se adauga nitrati si nitriti. Insa reactiile intre nitriti si unele amine formeaza nitrosamine – despre care se presupune ca ar fi cancerigene. Temperaturile peste 1000C favorizeaza producerea nitrosaminelor. Mezelurile si carnea afumata contin hidrocarburi aromatice policiclice foarte cancerigene. Aceste hidrocarburi se formeaza in carnea prajita, la gratar, in fripturi. S-a dovedit ca in Islanda, unde se consuma multa carne si peste afumat, numarul de persoane cu cancer de tract digestiv este cu mult mai mare ca in Europa. Studiile din ultimele decenii au evidentiat ca temperaturile mai mari de 1000C in pregatirea alimentelor din carne dispun la formarea unor compusi cu capacitati mutagene pronuntate, comparabile cu cele ale benzipirenului. Carnurile bogate in acizi grasi polinesaturati omega-G favorizeaza procesul inflamator, tromboza si vasoconstrictia. Acidul arahidonic este furnizorul principal de acizi grasi, deoarece proteinele de origine animala (carne, oua, branzeturi), care contin acid arahidonic, sunt izvorul acizilor grasi polinesaturati omega-G. Ultimul are importanta in mecanismele antinflamatorii cronice si vasculare.

Sursele japoneze relateaza ca in urma unor studii epidemiologice au constatat actiunea puternica cancerigena a aminelor heterociclice ce apar in carnuri si peste pregatite la temperature ridicate. Au fost identificate peste 20 de amine mutagene sau cancerigene. Precursorii aminelor heterociclice sunt: creatina, peptidele, aminoacizii, proteinele si zaharurile.

In Uruguai cantitatea de carne consumata pe cap de locuitor este cea mai mare in lume, dar si neoplasmele sunt cele mai frecvente. Un interes deosebit il prezinta studiile efectuate de Institutul National al Cancerului (1998, SUA) unde au fost examinate 41836 femei. S-a constatat ca la femeile care utilizau carne pregatita prin actiunea temperaturilor ridicate si bine patrunsa, riscul de cancer era de 4-6 ori mai mare comparativ cu femeile ce consumau carnea mai putin expusa la temperaturi ridicate.

S-a confirmat ca uleiul de peste duce la cresterea diabetului, glicemiei, deoarece acidul eicosapentanoic scade secretia de insulina. De exemplu, la eschimosi, a caror alimentatie este bogata in peste, sunt mult mai frecvente hemoragiile cerebrale.

Cresterea continutului de ulei conduce la cresterea excesiva a vitaminei A si D – care devin toxice si scad nivelul vitaminei E. S-a constatat ca toxiinfectiile alimenare sunt cauzate de 15 ori mai frecvent de produsele din peste decat de cele din carne. Produsele din peste contin peste 200 substante chimice dintre care toxice: mercur, pesticide, dioxine.

In Japonia s-a observat ca la populatia care foloseste produse din peste, la copii nivelul de mercur este cu mult mai inalt in cordonul ombilical. Acesti copii au memoria si atentia redusa. Tumorile sunt frecvent depistate la populatia care foloseste produse din peste, deoarece pestele contine mai multe pesticide decat fructele, legumele, cerealele.

Datele studiilor efectuate in mai multe tari au constatat ca populatia care consuma predominant glucide (70-80%) nu sufera de boli degenerative: hipercolesterolemia, hipertensiune arteriala, diabetul zaharat, obezitatea.

Studiile de ultima ora au aratat ca utilizarea cantitatilor mari de glucide favorizeaza sinteza de proteine. Produsele de origine animala sunt lipsite de glucide, cu exceptia laptelui mamiferelor ce contine lactoza. Glucidele din plante sunt compuse monozaharide (glucoza, fructoza, galactoza, lactoza), dizaharide (zaharoza), polizaharide (amidonul). Pentru a asigura energia si functia normala a celulelor nervoase a celulelor nervoase este necesar un aport constant de glucoza.

Hiperglicemia duce la hiperproducerea insulinei, iar ultima favorizeaza arteroscleroza. Cafeaua, ceaiul contin cofeina; cacao si ciocolata – teobromina, care stimuleaza transformarea glicogenului in glucoza asociata cu eliberarea insulinei. Bauturile dulci acidulate contin pana la 150g de zahar la litru, ceea ce corespunde la 10 lingurite la un pahar de lichid.

Concomitent, legumele, zarzavaturile, cerealele nerafinate contin glucide complexe, cum ar fi amidonul, la care monozaharidele se elimina treptat, si nu duc la hiperglicemie si cresterea excesiva a nivelului de insulina.

Fructoza dispune la formarea grasimilor si poate produce rezistenta catre insulina, iar consumul de durata favorizeaza aparitia arterosclerozei. Bauturile dulci ce contin cantitati foarte mari de fructoza sunt periculoase, deoarece duc la tulburari metabolice (Institutul National Pentru Studierea imbatranirii, Baltimore, SUA).

Fibrele alimentare (substante de balast) de origine vegetala (polizaharide neamidonice) dispun de functia necesara pentru transportul si absorbtia substantelor in sistemul digestiv. Conform datelor unor autori necunoscuti, fibrele alimentare joaca un rol important in profilaxia cancerului intestinal. Stratul de aleuron exterior al fibrelor de cereale contine acizi grasi polinesaturati si vitaminele B si E cu actiune antioxidanta. Fructele dulci (ciresele) contin fibre de aceea au un indice glicemic mai redus, retin absorbtia zaharului rapid ce are importanta pentru diabetici.

Reiesind din cele expuse, este util de a aminti caracteristicile principale ale unor produse cerealiere care contin toate ingredientele necesare pentru a intretine starea optima fiziologica a organismului.

Astfel, produsele cerealiere care contin hidrati de carbon complecsi servesc ca sursa de energie principala a organismului. Toate cerealele contin proteine, acizi grasi nesaturati, fibre solubile si insolubile, vitamine B1, B2, acid folic si minerale: magneziu, fier, calciu.

Produsele cerealiere integrale (PCI) contin cantitati mari de lactina ce poseda actiune pozitiva asupra digestiei intestinale, sistemul imun, prin activarea fermentilor, hormonilor intestinali, previn aparitia cancerului intestinal. PCI actioneaza contra hemoragiilor cerebrale, bolilor cardiovasculare si diabetului.

Consumul excesiv de grasimi scade activitatea sistemului imun, favorizeaza dezvoltarea arterosclerozei, diabetului zaharat, obezitatii, cancerului, artrozelor, litiazei biliare. Dupa datele OMS (2001), obezitatea si sedentarismul contribuie la 33% din cauzele cancerului de intestin gros, rinichi, glanda mamara, esofag.

Spre deosebire de glucide si proteine, grasimile nu dau senzatia de satutatie din aceasta cauza ele au capacitatea de a se depune aproape nelimitat. Incalzirea grasimilor si uleiurilor usor supuse oxidarii cu formarea hidroperoxizilor, duce, rapid la formarea produselor secundare de oxidare si aldehidelor, epoxizilor, compusilor ciclici hidrocarburati cu proprietati toxice si cancerigene.

Conform informatiilor Centrului Academic din Amsterdam – alimentarea timp de 3 saptamani a animalelor in experiment cu ulei de peste – tumorile de ficat au fost de 10 ori mai frecvente, iar metastazele de 1000 de ori mai frecvente comparativ cu lotul de control.

Margarina,, este obtinuta prin solidificarea uleiurilor vegetale si de peste, iar solidificarea se realizeaza prin hidrogenare, unde are loc transformarea acizilor grasi nesaturati, adica asa cum sunt in grasimile de origine animaliera. Acizii grasi saturati obtinuti prin transformarea acizilor grasi nesaturati afecteaza celulele pancreatice secretoare de insulina si, totodata, inhiba biosinteza proteinelor tesutului osos. Din aceasta cauza apare osteoporoza.

S-a constatat ca 90% din acizii grasi, obtinuti prin transformarea acizilor grasi nesaturati provin din alimente pregatite industrial, prelucrate la temperaturi inalte – prajite. Dupa informatiile unor autori, alimentatia bogata in grasimi influenteaza negativ memoria.

Astfel, reprezinta un factor extrem de important atat in tratamentul, cat si profilaxia diferitelor afectiuni.

Fitoterapia. Fitoterapia exista de mii de ani. Prin experiente empirice s-au acumulat diferite metode de tratament ce au fost verificate de sute de ori si s-au pastrat. Au ajuns pana la noi numai cele confirmate atat de bolnavi, precum si de medici, care au dat rezultate favorabile fara a dauna sanatatii.

Este cunoscut ca pana in secolul trecut tratamentul cu diferite extrase din plante ocupa locul principal in tratamentul multor boli. Progresele in chimie, au permis obtinerea multor medicamente din plante, care ulterior au fost produse pe cale de sinteza chimica. Este cazul de mentionat faptul, ca sinteza chimica nu intotdeauna a corespuns cu sinteza naturala a compusilor organici, deaceia de multe ori compusii sintetizati chimic dau multe reactii nedorite. Astfel interferonii de sinyeza chimica in cazul infectiilor viralehepatice provoaca si sineucidul, stari nervoase a pacientilor.

Fitoterapia – utilizarea diferitelor extracte sau preparate obtinute din plante este una din cele mai vechi metode de tratament. Timp de milenii extractele din plante sau chiar plantele nemijlocit, au fost utilizate pretutindeni ca cele mai eficace metode de tratament pentru multe boli. Incepand cu prima jumatate a secolului trecut, treptat, preparatele chimice au predominat in practica medicala. Se stie ca circa 40% din medicamente sunt de origine vegetala, din ele cele cardiace constituie 70%. Fitoterapia este utilizata atat in tratamentul bolilor acute cu manifestari clinice evidente, cat si in cazurile cand are loc evolutie cu manifestari clinice cronice, dar mai ales cu scop de profilaxie. Vom accentua, ca in cazul multor boli cronice, mai ales reumatismale si neurologice, tratamentul este de durata. Preparatele fitoterapice dispun de actiunea lor fiziologica naturala, deoarece organismul uman intotdeauna a fost alimentat vegetarian. Insuficienta enzimelor in diferite organe poate fi substituita cu enzimele obtinute din vegetatii. Fitoterapia poate fi recomandata timp indelungat (pana la 60 de zile), pe cand chimio-preparatele doar timp de 15-20 de zile. Semnificativ este faptul, ca fitoterapia nu este asociata cu aparitia dependentei si totodata foarte rar duce la dezvoltarea reactiilor alergice. Deseori, sub influenta acestui tratament, are loc normalizarea microflorei intestinale. Fitoterapia dispune de actiuni multilaterale: antiinflamatoare, analgetice, regleaza metabolismul s.a.

Tehnologia producerii preparatelor din plante a progresat evident odata cu aparitia fito-chimiei si fito-farmacologiei. Plantele contin multe glucide (70-80%), polizaharide care au actiune antiinflamatoare, gastro-protectoare, intensifica secretia glandelor digestive. Pentru dezvoltarea si intretinerea fiziologica normala a organismului este necesara prezenta mineralelor. Majoritatea lor se gasesc in plantele medicinale: potasiu, calciu, natriu, magneziu, fosfor, sulf, fier, cupru, arseniu, nichel, zinc, argint. In celulele plantelor au loc procesele de sinteza a unor substante biologice active cum ar fi: morfina, atropina, cofeina, chinina, efedrina, etc.

Plantele curative sunt organisme vii si sintetizeaza substante mai mult fiziologice pentru organismul uman comparativ cu preparatele sintetice, obtinute in laboratoare chimice si uzine. Plantele si preparatele din ele actioneaza asupra organismului afectat mai usor, nu evoca reactii negative, efectul apare lent, dar este durabil. Principalii compusi chimici sunt: alcaloizii, glicozidele, saponinele, flavonoizii, acizii organici, eterii, acizii grasi, vitaminele, cumarinele, tanantele, enzimele, sarurile, microelementele.

In medicina un loc deosebit ocupa alcaloizii – substante organice ce se contin in sucurile plantelor sub forma de acizi organici. Alcaloizii contin azot sunt foarte utilizate in multe preparate: morfina, codeina, platifilina, atropina, cofeina, s.a. Glicozidele se gasesc in multe plante: sfecla, fructele de diferite specii de plante, care au actiune stimulatoare selectiva asupra miocardului.

Saponinele – dispun de activitate biologica: actiune diuretica, actiune antisclerotica, anticanceroasa. Flavonoizii – substante biologic active regleaza permeabilitatea capilara, actioneaza antihipertensiv dar si in boli reumatice, pneumonii, in bolile inflamatorii cronice. Enzimele – substante proteice ce actioneaza in calitate de catalizatori atunci cand participa in reactiile complexe ale organismului. Acizii grasi duc la normalizarea proceselor digestive, stimuleaza activitatea intestinala.

Pentru dezvoltarea si intretinerea fiziologica a organismului este necesara prezenta multor minerale, majoritatea din ele se gasesc in plantele medicinale: potasiu, calciu, natriu, fosfor, magneziu, sulf; microelemente – fier, cupru, cobalt, arseniu, nichel, molibden, zinc si argint.

Astfel, colhicina se utilizeaza in multe boli reumatice: psoriazisul, sclerodermia, sarcoidoza, dermatomiozida ca si in ciroza hepatica, sindromul Behçet, boala periodica, amiliodoza.

Partea activa a acestei plante – alkaloid – a fost numita colchicina, in cinstea Colhidei, de unde planta a fost transportata. Formula empirica a fost descrisa de Demar (1995) – C22H25O6.

Acest preparat inhiba reactia celulara polinucleara participantii principali la procesul inflamator aseptic. Totodata preparatul scade permeabilitatea capilarelor, inhiba reactia endoteliala a capilarelor la mediatorii inflamatori. Astfel, colhicina blocheaza raspunsul vascular si leucocitar in inflamatia acuta, deprima secretia si agregarea trombocitelor, stimuleaza secretia steroizilor, influenteaza asupra celulelor imuno-reglatoare. In doze medii:colhicina scade producerea amiloidului si, ca urmare, duce la ameliorarea sindromului nefrotic.

Astfel, plantele au fost si au ramas una din sursele principale de medicamente, care pot fi utilizate timp indelungat fara a duce la reactii adverse grave.

Bolile cronice necesita un tratament indelungat, care poate fi realizat prin utilizarea fitoterapiei, deoarece remediile chimice mai frecvent duc la aparitia multiplelor reactii negative. Prioritatea remediilor fitoterapice consta in actiunea lor fiziologica, naturala, deoarece organismul uman intotdeauna s-a alimentat vegetal. In multe stari cronice are loc scaderea activitatii enzimatice. Insufucienta enzimatica din diferite organe poate fi limitata prin aport de enzime de provenienta vegetala.

Semnificativ este faptul ca fitoterapia nu este asociata cu aparitia dependentei si foarte rar duce la aparitia reactiilor alergice, nu favorizeaza aparitia bacteriozelor, permite normalizarea florei intestinale. Preparatele fitoterapeutice dispun in acelasi timp de cateva actiuni: antiinflamatorie, analgetica, de stimulare a reactiilor immune, reglarea metabolismului etc. Plantele contin un procent mare de glucide, iar masa uscata a plantelor contine polizaharide ce actioneaza antiinflamator, gastroprotector, intensifica secretia glandelor endocrine.

Bolile cronice sunt asociate cu alte afectiuni ce duc la producerea reactiilor negative toxice. Iata de ce in aceste cazuri utilizarea unui complex de diferite plante nu se asociaza cu aceste reactii, dar da rezultat benefice.

Avantajele fitoterapiei: 1. dispune de actiune fiziologica; 2. posibilitatea utilizarii timp indelungat mai ales in tratamentul bolilor cronice; 3. foarte rar este asociata cu aparitia reactiilor negative, alergice; 4. lipsa dezvoltarii dependentei medicamentoase; 5. foarte rar sunt contraindicatii pentru acest tratament; 6. lipseste pericolul dezvoltarii bacteriozelor intestinale; 7. majoritatea plantelor medicinale cresc in toate zonele geografice; 8. posibilitatea selectarii plantelor necesare, deoarece se gasesc in cantitati mari.

Cu toate acestea mecanismele de actiune a substantelor din diferite plante nu sunt studiate suficient. Concomitent, plantele deseori contin diverse virusuri, care in anumire cazurti pot produce recombinanti, periculosi pentru diferite organisme. Pot produce reactii alergice. De aceea este necesar ca in prezent, in noile conditii sa poata fi elaborate, verificari si evidentiate noi substante mai pure, care nu vor duce la reactii negative.

Deoarece bolile cronice sunt asociate cu afectiuni de diferita natura, este necesar de administrat terapia combinata, iar administrarea in acelasi timp a catorva chimiopreparate deseori duce la producerea reactiilor negative, toxice. Iata de ce, in aceste cazuri, utilizarea unor combinatii din diferite plante permite evitarea reactiilor negative si realizarea efectului dorit curativ.

Extractele din diferite plante in infuzie, vapori, eter si lipide pot fi utilizate local si sistemic fara a evoca reactii adverse. Unele plante: gutuiul – contine vitaminele C, B, poseda actiune antiinflamatorie, diuretica, coleretica; pepenele verde – diuretic, coleretic, se recomanda pacientilor cu guta, nefrolitiaza, pielonefrita, anemie, diabet; vinetele se administreaza in anemie, diabet zaharat, boli cardiace, renale au actiune diuretica; strugurii (sucul) au actiune diuretica, sudoripara, hipotensiva, mucolitica si/sau expectoranta, antiinflamatorie, antinefrolitiazica; frunzele de vita-de-vie sut benefice in diabetul zaharat, extractele de frunze culese in luna mai sunt bune contra hipertensiunii arteriale; extractul de seminte de struguri – in diaree; vinul sec este detoxifiant si antisclerotic. Visinele influenteaza antipiretic, mucolitic/ expectorant, la pacientii cu anemie, tulburari de coagulare – efect antitrombotic, antibacterian, diuretic. Pepenele galben – contine fier util in prevenirea anemiei feriprive, in dischinezii intestinale. Are efect antisclerotic, diuretic, antigutos, nefrolitiazic, coleretic, sedativ. Coaja de zamos (pepene galben) este recomandata in acnee, alunite. Capsunile regleaza metabolismul, indeosebi cel mineral, au efect antigutos, nefrolitiazic (se recomanda – 1 kg/zi timp de 10-15 zile pe an), regleaza metabolismul lipidic, tensiunea arteriala, se recomanda pacientilor cu hepatite, regleaza functia glandei tiroide. Pot fi folosite in tratarea helmintiazei: 3 kg capsuni la o masa in combinatie cu produse piperate au o actiune antihelmintica. Frunzele de capsuni regleaza metabolismul glucidic, au efect antialergic si antihemoragic. Varza este utila in caz de cefalee, insomnie. Aplicarea frunzelor local se recomanda in caz de edem, inflamatie articulara, furuncul, au efect analgezic si antimicotic. Varza se recomanda in bolile respiratorii, are continut sporit in vitamina C si poseda actiune antiulceroasa, favorizand regenerarea mucoasei intestinale.

Faunoterapia. Din antichitate, produsele din diferite organe ale animalelor au fost utilizate in tratamentul multor boli. Astfel, Aristotel descrie unele preparate obtinute din pestii exotici in tratamentul sistemului nervos. Avicenna in tratatul sau “Canoanele stiintei medicale” informeaza despre utilizarea carnii de rechin, balena si icre de peste marin pentru reglarea functiei sexuale.

Medical Pan-Sun, in publicatia sa “Izvorul sanatatii”, descrie proprietatile curative ale ficatului de Cambala (peste de mare) deoarece influenteaza sistemului de coagulare a sangelui. Multe substante extrase din organele animalelor nu au fost studiate suficient. In acest sens un interes deosebit prezinta buretele de mare, care contine substante bioactive: bactericide (inclusiv cu actiune impotriva bacilului Koch), iar din arabinoza (care inlocuieste riboza in organismul lui) s-a elaborat preparatul anticancerigen citozin-arabinoza. Actiunea antiinflamatoare a SBA din buretele de mare se datoreaza prezentei hexalfluorului de sodium (Na2SiF6). Sunt prezentate date despre toxicitatea pestelui-balon din care au fost obtinute SBA – tetradoxinul cu actiune de 160.000 ori mai mare, comparativ cu cocaina si este folosit in anestezie in caz de operatii grave. Preparatele obtinute din ficatul unor rechini blocheaza dezvoltarea celulelor cancerigene fara a traumatiza alte tesuturi. Pe baza acestor extrase a fost elaborat preparatul pentoxil utilizat in tratamentul unor maladii hematologice si ca citostatic in tratamentul unor tumori maligne. Din nisetru este extras antibioticul ectolin, care dispune de capacitati pentru prelungirea actiunii altor antibiotice. Caracatita – elimina toxine din care s-a elaborat preparatul sepia utilizat in homeopatie si preparatul sepia utilizat in homeopatie si preparatul cefalotaxin utilizat in tratamentul bolilor nervoase, respiratorii. Extractele din unele midii sunt eficiente contra reumatismului. In bolile nervoase este folosita substanta de tip prostaglandina din corali. Alta substanta din corali (insule Hawaii) – politoxina – C1201H2231N3054 – are actiune anticancerigena. Din corpurile crevetilor, coralilor si racilor de mare a fost obtinuta SBA chitina, folosita contra formarii trombilor si pentru favorizarea vindecarii ranilor, pentru inlaturarea cheloizilor dupa arsuri, negilor, alunitelor carcinoamelor, melanoamelor.

Actualmente SBA obtinute din amfibii sunt putin studiate. A fost studiata eficacitatea SBA obtinute din broastele raioase, cu actiune asupra astmului bronsic. Toxinele obtinute din pielea broastelor testoase (America de Sud) se foloseau de catre indieni pentru pregatirea varfurilor sulitelor contra dusmanilor. Dupa cum a fost constatat toxinele broastei raioase in solutie 1:100 – provoaca moartea pasarilor si a soparlelor in timp de cateva minute. Toxinele broastei testoase au capacitatea de a ridica tensiunea arteriala si intensifica contractiile inimii – adica, poseda actiune asemenatoare actiunii preparatului strofantin.

Este cunoscut ca in unele tari (China), carnea de broasca testoasa este utilizata in tratamentul dizenteriei, are actiune antibacteriana, iar icrele de broasca testoasa au efect antireumatic. Totodata, ea este aplicata pe locurile de muscatura de sarpe. Din pielea de broaste au fost extrase SBA: serotonina, bradikinina, toxichinina si opioidele. Demorfina extrasa din pielea unor specii de broaste cu proprietati de anestezie de 11 ori mai mare decat SBA extrase din salamandra: samadarin, samadamaritin etc.

Tabelul 4. Organele unor animale folosite in tratamentul bolilor

Nr.

Organele interne ale animalelor

Indicatii in unele boli

1

Cheagul din stomacul de miel

Diareea

2

Vezica biliara de miel

Afectiunile microbiene ale ochilor, urechilor, cheratozelor

3

Vezica biliara de porc

Cresterea parului

4

Vezica biliara de cambala, stiuca

Contra infectiilor oculare

5

Vezica biliara de bovina si urs

Contra infectiilor organelor respiratorii superioare

6

Vezica biliara de la pasari (corb, prepelita, barza)

Pentru ameliorarea vederii

7

Oasele de bovine, maimute

Contra reumatismului

8

Oasele broastei testoase

Contra anemiei

9

Oasele de tigru, elefant

Cresterea potentei sexuale

10

Ficatul de bovine si gaini

Stimuleaza vederea

Ficatul mai multor animale este bogat in vitamina A. Astfel, ficatul de urs alb contine vitamina A in proportie de 10400 unitati, pe cand ficatul de rechin contine numai 400 unitati.

Savantul MacLeon (1916) a obtinut substante biologice active din ficatul de caine, ulterior numite heparina si apoi obtinute din alte organe interne (splina, plamani, muschi). Actualmente heparina este produsa din plamani de bovine. Ea dispune de actiune anticoagulanta si este utilizata in tratamentul tromboflebitelor, varicelor, pancreatitelor acute etc.

Tabelul 5. SBA obtinute din unele organe animale.

ORGANELE

SUBSTANTELE BIOLOGIC ACTIVE

Glandele salivare

Proteina – factor de crestere a nervilor (sporeste regenerarea epidermei)

Creierul, maduva spinarii

Peptid – factor de ameliorare functionala a nervilor periferici somnului, memoriei

Creierul

Factorul de alarma contine 105 de aminoacizi: endorfine si enkefaline

Creierul si maduva spinarii de bovine

Preparatul cerebrolectina si lipocerebrina ce stimuleaza functia SNC. Actiune antisclerozanta, normalizeaza metabolismul lipidic.

Creierul de bovine

Colesterolul si lecitina in stimularea cresterii

Mucoasele intestinului de porc

Pepsina

Cristalinul ocular de la bovine

Respiratia tesuturilor, contra reumatismului

Testiculele de bovine

Enzimele: lidaza, ronidaza – pentru regenerarea tesuturilor dupa arsuri, traume

Pancreasul bovin

Insulina, tripsina, chimotripsina, chimotripsinogenaza.

Ribonucleazele si dezoxiribonucleazele hidrolizeaza acizii nucleici. Aceste enzime sunt folosite pentru inhibarea microflorei straine si a virusilor. Colagenazele – pentru eliminarea necrozelor in urma arsurilor si degeraturilor.

Pancreasul porcinelor

Preparatele elastolitin, pantrepin contra pancreatitei acute. Preparatele: contrical, trasilol, tzalol, gordox in tratamentul artrozelor. Pancreatina, digestalul, mezimul, festalul, vegeratina – in patologiile gastro-intestinale. Calicreinele – andecalin, calicrein, dilminal cu actiune hipotensiva

Sangele bovinelor

Aminopeptid, fibrinosol – alimentatie in caz de tulburari digestive, de scadere ponderala. Preparatul polibiolin – antiinflamator si analgetic. Plasmolul – contra ridiculitei si ulcerului stomacal. Solcoseril – in tratamentul ulcerului peptidic, gangrenelor, arsurilor acute.

Sangele donatorilor

Fibrinogen contra tromboflebitei. Trombina in stoparea hemoragiilor. Varico-liz, Trombo-liz – in tromboflebitele varicoase. Hemor-liz – contra hemoroizilor.

Limfocite

Interferon – proteina contra infectiilor virale, tratament in hepatitele virale.

Din antichitate unele organe ale serpilor au fost folosite pentru pregatirea medicamentelor – in tratamentul reumatismului sau a ranilor. Carnea de arici se recomanda in cazurile intoxicatiilor acute si tuberculozei. Pielea de arici este folosita pentru stoparea hemoragiilor. Carnea de sarpe se recomanda in tratamentul sclerodermiei sistemice. Toxinele extrase din diferite specii de serpi au actiune: coagulanta si anticoagulanta cu impact asupra SNC si periferic. Unicul tratament specific – in muscatura de sarpe este antiserul la toxina data (in acest caz este necesar de stiut specia sarpelui care a produs muscatura).

Neurotoxinele de sarpe au actiune: 1. Peptidica – blocheaza membranele sinaptice sensibile ale muschilor scheletici si a unor sectoare ale creierului; 2. Regleaza mediatorul de actiune al terminatiilor nervoase; 3. Polipeptidele – actiune de depolarizare a membranelor celulare. Din veninul de sarpe s-a obtinut substanta activa – tromboplastin cu actiune de coagulare, utilizata in tratamentul astmului bronsic, epilepsiei, tulburarilor nervoase, hemofiliei.

Medicamentele pe baza toxinelor extrase din serpi veninosi activeaza procesele de coagulare a sangelui, sunt folosite in anestezie, in tratamentul bolilor SNC (epilepsie).

Toxinele paianjenilor si ale scorpionilor sunt folosite in tratamentul multor boli. Sunt studiate aproximativ 30 000 de specii de paianjeni. La om, muscatura paianjenului de Curacuta este asemanatoare actiunii atropinei: spasm a sfincterelor, canalelor urinare, intestinului cu asocierea durerilor pronuntate, hipertensiune arteriala.

Veninul paianjenului de Curacuta provoaca eliminarea intensiva a acetilcolinei, dopaminei, noradrenalinei si acizilor gamma-amino-lipoici. Paianjenul Tarantula elimina toxine cu actiune hemolitica. Paianjeni ornitofagi (rapitori de pasari) secreta venin cu actiune directa asupra SNC: pot provoca somnolenta, moarte. Substanta accelereaza eliminarea acetilcolinei din sistemul nervos periferic. In Laos se prepara medicamentul din acest paianjen pentru calmare. Sunt cunoscute cca 500 de specii de paianjeni care pot supravietui pana la 1 an fara hrana. Toxinele de scorpioni actioneaza asupra ficatului, rinichilor si duce la aparitia vomei, frisoanelor, somnolentei. Veninul scorpionului este de natura hormonala, de aceea duce la cresterea glicemiei, provoaca intensiv eliminarea insulinei si tripsinei.

Lipitorile – Hiruda medicinalis, viermi inelari – sunt larg folositi ca metoda de tratament. In momentul absorbtiei, lipitoarea elimina proteina – hirudina cu capacitatea de anticoagulare si inactivarea protrombinei. Hirudoterapia se foloseste in bolile cardiovasculare, tromboflebite. Substantele obtinute din viermi se recomanda contra bolilor reumatice, cheratitelor, frisoanelor, hemoragiilor, epilepsiei.

Produsele din coarne, copite, unghii, par si din crusta de rac au fost folosite cu 3700 ani in urma de faraonii egipteni. Aceste organe contin keratina – folosita in disfunctii sexuale si metabolism.

Preparatul pantocrin – suspensie de 10 % din coarne de ren, contine substante organice – grasimi; substante anorganice – Calciu, Magneziu, Fier, Siliciu, Fosfor, Sodiu, Natriu, Nichel, Cupru, Titan, Plumb, Bariu. Pantocrinul este utilizat in tratamentul multor patologii. El creste considerabil imunitatea si coagularea sangelui; normalizeaza somnul. De asemenea, are efect de calmare, antiulceros. Este folosit contra epilepsiei, psihozelor; amelioreaza functiamusculara. Despre extrasul din coarne de ren se stie din sec. IV i.e.n. In China din tendoanele animalelor se prepara produse gelatinoase, folosite pentru ridicarea tonusului muscular si tratamentul tuberculozei.

Rumalon este un preparat produs din cartilagiu si maduva animalelor domestice.Chitozanul este folosit in dermatologie, cosmetologie ca un bun antiinflamator.

Acizii biliari influenteaza activitatea coledocului, sistemul endocrin, SNC, scade functia renala, reduce procesele de oxidare. Acizii biliari sunt folositi pe larg in tratamentul reumatismului. Amelioreaza functia ficatului si a pancreasului. Extractul sucului biliar intra in compozitia festalului, aloholului, indicate in colecistite si enterocolite. Este utilizat in tratarea hepatitelor si a obezitatii. Cojile de ou de gaina se administreaza in diaree si nefrolitiaza.

Scorpionii sunt folositi in tratamentul limfaadenopatiei, in caz de tuberculoza, dermatite, ulceratii cutanate. Toxinele broastei sunt utilizate in tratamentul reumatismului, stoparea hemoragiilor interne.

CLIMATOTERAPIA

“Cel mai bun doctor este natura – pentru ca vindeca 75% din bolnavi si niciodata nu se exprima urat despre colegii sai.”

Sanatatea omului este strans legata de variatiile climatului, care este influentat de mai multi factori: limitele temperaturii in timpul anului si a ondulatiei lor, numarul zilelor solare in timpul anului; frecventa cicloanelor cu furtuni si apoi torentiale, viscole, prezenta muntilor sau a campiilor, a zonelor cu depozite minerale subpamantene care intesifica magnetismul Terrei.

De aceste caracteristici ale climatului depinde sanatatea animalelor si a vegetatiei. Relatiile calitative si cantitative a factorilor sus numiti, determina particularitatile oricarei localitati, caracteristicile microclimatului.

Organismul uman in evolutie, s-a acomodat la diferite conditii climaterice, insa majoritatea populatiei s-a adaptat la o anumita regiune a Terrei, cu anumite caracteristici calendaristice. Au fost observate exemple cand pacienti cu boli grave si modificari radiologice, deplasandu-se in alta tara, peste un an s-au vindecat complet. De asemenea, pacientii cu cardiomiopatie dilatativa, carora li se administrau in doze mari preparate hormonale, aflandu-se in zone cu clima favorabila cel putin un an fara tratament, finisau cu vindecare completa. Deci, aceste fenomene sunt rezultatul influentei combinatiilor factorilor climaterici, cosmici etc. Climatoterapia include un sir de complexe naturale (munti, paduri, mari, ape curgatoare, lacuri) si are un rol decisiv in combaterea bolilor si prelungirea vietii. Muntii au fost adapostul omului din cele mai vechi timpuri; au evoluat impreuna, fiind amenintati de cataclisme, animale salbatice etc. Climatul muntos reduce tensiunea barometrica si presiunea partiala a oxigenului. In conditiile montane creste numarul eritrocitelor si a hemoglobinei. Aici sunt tratate multe patologii: pulmonare, anemie, tuberculoza, hipertensiunea arteriala, astenia musculara, obezitatea, nevrozele, rahitismul si multe tulburari endocrine (tiroidismul). De regula muntii sunt acoperiti cu paduri, dispun de multe mecanisme ce influenteaza organismul. Padurile au fost apreciate ca farmacii vii.

Silovoterapia – influenteaza toate sistemele organismului uman: neuro – endocrin, metabolic, cardio – vascular, respirator si altele. Padurea este un izvor de oxigen: un hectar de padure furnizeaza intr-o zi insorita circa 220 kg de oxigen, pe care il raspandeste in atmosfera si absoarbe 280 kg de dioxid de carbon. In padure se afla de 5 – 10 ori mai multi ioni negativi decat in atmosfera urbana. Un hectar de padure de pin sau de fag, retine aproximativ 56 – 63 tone de praf, iar un hectar de padure de stejar raspandeste in jur de 2 kg de ozon, ce are capacitatea de a elimina bacilul dizenteric si de a inhiba multe alte microorganisme. Intr-un m3 de aer de padure circula in jur de 500 de microorganisme, pe cand in aceeasi cantitate de aer dintr-un magazin urban exista 4 milioane de bacterii. Astfel se observa importanta padurilor ca filtru antibacterian.

Majoritatea populatiei inca nu a realizat ca factorul foarte daunator, zgomotul, se datoreaza nu numai strazilor si transportului, ci si aparatelor din incaperi: radio, televizor, telefon si altele. Zgomotul de durata, chiar daca este tolerabil este responsabil in 30 % din cazuri de nervozitate si in 80 % din cazuri de migrena. I. Thomson, care a efectuat investigatii speciale, a conchis, ca telefonul folosit intensiv si continuu, scurteaza viata cu 3 ani.

Oxigenul, azotul si dioxidul de carbon se afla in aer in proportii aproximativ fixe, pe cand ozonul, vaporii in proportii variate. In aer oxigenul exista in proportie de 20,95 %. Pentru om la efort fizic este necesara o concentratie de 15% oxigen in atmosfera. Azotul care exista la nivelul de 78,09% are actiune de stabilizare a oxigenului. Bioxidul de carbon in aer exista in concentratie 0,03%. Concentratia de CO2 mai mare de 3% in atmosfera este toxica, iar peste 5% duce la asfixie.

Aerul mai contine ozonul 1 – 2 g la 100 m3, vapori de apa, gaze: argon, heliu, neon, xenon, cripton, ammoniac, oxid de carbon, clorura de sodium, fum si praf. Oxigenul este principalul component ce determina procesele de obtinere a energiei din organism; intretine nervii, metabolismul in procesele de oxidare.

Dupa unele calcule ale specialistilor, un om adult necesita 1 kg de alimente pe zi, 1,5 l de lichide si 12 m3 de aer. Concentratia maximala a ozonului este la distanta de 18 – 35 km de pamant, formand un strat protector de ozon, care are functia de aparare a vietii pe pamant, filtrand razele cosmice din numai 20 % ajung pe pamant. Pe Terra, ozonul apare in urma descarcarilor electrice cu descompunere de oxigen. In zonele muntoase creste concentratia ozonului. El are actiune antibacteriana, prin care se explica aerul curativ montan. S-a constatat ca aerul ce contine concentratie buna de ozon, actioneaza pozitiv asupra organismului: devine mai rezistent la frig, toxicitati, amelioreaza hemocirculatia. In natura aerul ionizeaza sub actiunea radioactivitatii unele elemente din aer si sol. Totodata, ionii care au capacitati nocive pentru organism, sunt neutralizati de cei cu actiune pozitiva.

Prin influenta radiatiilor cosmice si de pamant are loc dezlipirea unui electron de pe suprafata atomului si ulterioara alipire de alt atom, astfel primul devenind negativ, iar al doilea pozitiv. Ionizarea negativa a aerului influenteaza pozitiv asupra organismului uman.

Aerul uscat de munte contine intre 800 si 1500 de ioni negativi in 1 cm3, de campie numai 400, iar cel din oras doar 150 ioni negativi. Incalzirea aerului si conditionarea lui duce la reducerea cantitatii de ioni negativi din aerul rece. Ionii negativi influenteaza favorabil procesele metabolice, respiratorii, cardiace, endocrine, SNC, normalizand somnul, realizand scaderea bolilor cancerigene. Concomitent inhiba actiunea microbilor si a virusilor. Aerul rece stimuleaza functia sistemului neuro – vascular, crescand rezistenta contra bolilor.

Razele ultraviolete reprezinta numai 1 % din ceea ce este inregistrata la limita normala a atmosferei. Razele ultraviolete sunt absorbite de tesutul cutanat si ulterior transformate in vitamina D, participa activ in metabolismul calciului si fosorului, activeaza functia glandei tiroide, influenteaza procesele respiratorii, digestive, hemocirculatia, sistemul endocrin. Femeile sunt cu 20% mai sensibile la influenta aerului decat barbatii, in special in perioada primaverii. Copii si batranii sunt mai putin sensibili la razele ultraviolete, comparativ cu adultii. In timpul verii sensibilitatea organismului este mai redusa decat primavara si iarna. Razele infrarosii influenteaza metabolismul, activitatea celulara, hemocirculatia.

Hidroterapia. Pentru sanatatea omului nimic nu este mai de pret decat apa. Apei i-a fost data puterea magica de a deveni seva vietii pe pamant (Leonardo da Vinci). Toate vietuitoarele Terrei au aparut datorita soarelui si datorita apei. Apa este cea mai scumpa si mai perfecta substanta a naturii.

Principalele surse de lichid in organism sunt: apa potabila, apa din alimente (legume, fructe care contin pana la 90 % apa). Concomitent, in anumite limite organismul poate sa produca singur apa necesara asa – numita apa endogena, care este rezultatul reactiilor de metabolizare prin polimerizare. Astfel, prin polimerizarea a 100 kg de produs se obtin 107,1 ml de apa. Cu timpul, cantitatea apei in organism scade. Daca la varsta de 30 de ani lichidul constituie 60 % din masa corporala, atunci la varsta de 70 de ani – numai 46%. De obicei omul bea apa cand ii este sete, insa exista in comert o diversitate de lichide ce contin diferite ingrediente dulci. Copiii beau acest lichid nu din cauza setei, ci din placerea de a consuma aceste sucuri care deseori contin substante toxice, ce duc la aparitia unor tulburari in organism. Apa este apreciata ca fiind cel mai principal medicament. Apa trebuie bauta nu doar cand iti este sete, ci repetat la 1-2 ore pentru a exercita actiunea fiziologica necesara.

Socrate umbla descult, spunand ca aceasta favorizeaza ,,ascutirea mintii’’, iar Horatiu a fost fortat de medic sa umble descult pe pietre ascutite si, ca urmare, s-a vindecat de o boala grava. Se recomanda la inceput cate 5 minute de mers fara incaltaminte, apoi durata acestor plimbari sa fie marita pana la o ora pe zi.

Hidroterapia exista de mii de ani si are importanta in intretinerea sanatatii. Mecanismele de actiune imputate sunt exercitarea receptorilor termici, mecanici si absorbirea unor substante minerale prin tegument.

Apele sunt folosite sub forma hidroterapiei cand temperatura apei este cuprinsa intre 0 si 42º C, sub forma termoterapiei daca temperatura este de 42 – 80º C, sub forma de vapori prin supraincalzirea aerului si sub forma de crioterapie folosind gheata. Baile au actiune vasodilatatoare si duc la scaderea tensiunii arteriale prin influenta asupra vasoconstrictiei. Concomitent, influenteaza si circulatia venoasa. Baile termice cu vapori si sauna activeaza functia glandelor sudoripare si ca rezultat are loc eliminarea la nivelul capilarelor a mai multor metaboliti si totodata faciliteaza activitatea excretoare a rinichilor eliminandu-se surplusul de lichid din organism.

In timpurile noastre cand conditiile artificiale si epuizante ale vietii cotidiene apasa asupra omului, balneologia reprezinta o reintoarcere la natura si aceasta nu este doar o simpla reintoarcere, ci o revenire la starea de sanatate, efect determinat in multe studii experimentale.

Fiecare izvor are propriile particularitati. In afara de compozitia fizica si chimica a apei, in apa diferitor izvoare exista substante in cantitati foarte mici dar cu efecte importante asupra organismului. Cu toate acestea nu este exclus ca tocmai aceste componente suplimentare sa dispuna de capacitati curative. In ultimii 20 – 30 de ani s-a acordat o atentie mica tratamentului balneologic, considerandu-se ca toate izvoarele sunt deja de mult timp cunoscute. Credem ca, totusi, in natura nu sunt stabilite reactiile ce se produc sub influenta energiei cosmice si a Terrei. Tulburarile ce au loc in diverse zone ale Terrei influenteaza asupra compozitiei fizico – chimice a apei.

Totul in natura se petrece nu rectiliniu, ci sub forma unor multiple ondulatii de frecvente mari si mici. Unele izvoare au avut capacitati curative in trecut, insa treptat aceste actiuni s-au diminuat. La Institutul Central de Terapie si Fizioterapie al fostei URSS un grup de medici in frunte cu prof. Z. E. Bahovschi au tratat un lot mare de pacienti cu ape sulfuroase cu concentratie de la 44 mg/l pana la 400 mg/l. Rezultatele au fost identice, iar la unii pacienti mult mai slabe, comparativ cu rezultatele obtinute la baile din Piatigorsk, unde concentratia era in jur de 24 – 40 mg/l. Aceleasi rezultate au fost constatate si in studiile comparative ale bailor cu radon de compozitie artificiala si a celor de provenienta naturala. In final studiile s-au oprit.

Datele prezentate ne conving ca actualmente este necesar sa fie prelungite studiile multor izvoare curative, la nivel stiintific contemporan.

Studiile din anii 1944 – 1960 sunt majoritatea consacrate efectelor apelor minerale datorita actiunii acestora asupra receptorilor periferici. Apele minerale au actiune complexa, deoarece actioneaza la diferite nivele, mai intai asupra receptorilor cutanati cu efect la nivelul sistemului neurovegetativ, asupra centrelor subcorticale si SNC, cu raspuns reflexogen si stimularea sistemului endocrin (glandei suprarenale) deoarece normalizeaza secretia unor hormoni si ca urmare au efecte antiinflamatorii, antialergice, angioprotectoare. Concomitent, apele de anumite temperaturi duc la dilatarea patului vascular, a sistemului capilar cu cresterea permeabilitatii si dispune patrunderea percutana in organism a unor microelemente. Ultimele se gasesc, de regula, in cantitati foarte mici, dar efectele lor sunt favorabile, actionand asupra mecanismelor metabolice ale organsimului. Introducerea artificiala a acestor elemente in cantitati mari deseori poate avea efecte nefaste. Prezenta unui surplus de microelemente poate da nastere unei reactii in lant de producere a radicalilor liberi cu actiune toxica a caror actiune nociva este bine cunoscuta.

Eu amdescoperit 8un izvpr de apa minrrala in zona Cheia, unde din varful muntelui Zaganu curgeun izvor, care nu era utilizat de nimeni. In anul 2007 intamplator am ajuns in aceasta zona si am poposit la statiunea “NICOLTANA” unde am servit apa din robinet. Am simtit un aspect deosebit a apei minerale. Cand am luat probe si le-am analizat in laborator, am constatat, ca apa nu contine clor – 0,001 ml, ceia ce m-a fascinate, Acum toate apele minerale include cantitati mari de Cl, deoarece toate rezervele de ape sunt clorurizate, deacea in organismul uman s-a acumulat cantitati maxime de clor. Acum s-a creat o uzina de acumulare de apa deminerala cu denumirea de “KEIA”, care absoarbe cantitatile mari de Cl din organism, influentind benefic starea sanatatii omului.

Cateva din efectele pozitive particulare ale diferitelor bai: baile sulfuroase influenteaza metabolismul la nivelul ficatului, rinichilor; baile cu radon, ce contin gaze radioactive si produse elementare, actioneaza asupra receptorilor cutanati; apele io-brom-natriu-chloride contin microelemente: fier, brom, cupru, magneziu, cobalt, arsenic, silicat de potasiu, mangan, fluor s.a. Apele din zonele unde se extrage petrolul si gazul contin iod in cantitati mai mari. Aceste ape influenteaza pozitiv in hemopatii (creste numarul eritrocitelor si a leucocitelor, cantitatea hemoglobinei in sange), amelioreaza circulatia in capilare, normalizeaza tensiunea arteriala. Concomitent, aceste bai regleaza functionarea glandei tiroide si a glandei suprarenale.

Majoritatea apelor termominerale timp de milenii au fost in primul rand folosite in tratamentul bolilor articulare, musculare, vasculare, ale coloanei vertebrale.

Influenta apelor de mare asupra mecanismelor fiziologice ale organismului se manifesta prin actiunea de reglare functionala, deci poate fi apreciata ca un medicament. Filozoful Platon spunea ca ,,marea spala toate rautatile omului’’, iar Hipocrate recomanda bolnavilor bai cu apa de mare.

Astfel, din antichitate, talasoterapia a fost apreciata drept una din cele mai eficiente metode de tratament.

Cu toate acestea, multe componente ce se gasesc in apele marine inca nu au fost studiate pentru a determina efectul lor asupra organismului, de aceea tratamentul la mare include mai multi factori: aerul purificat deosebit, razele de soare, nisipul cald, peisajul marin, aroma si multe altele.

La congresul de talasoterapie (Saint Malo, Franta) s-a declarat ca in apele calde de mare se potenteaza actiunea ionilor de calciu, magneziu, potasiu, iod etc. cu posibilitatea de a patrunde in interiorul organismului. Totodata, se acorda atentie si influentei algelor la nivelul tegumentelor. Substantele bioactive si ionizate, minerale, vitamine, proteine influenteaza pozitiv mecanismele de aparare a organismului.

Talasoterapia trateaza bolile cronice respiratorii; stimuleaza cresterea in inaltime la copii; actioneaza impotriva bolilor alergice, hematologice, cardiovasculare, contra bolilor articulare si axiale, miofasciale, ginecologice si dermatologice.

Fizioterapia. Metodele fizioterapeutice ocupa un loc deosebit de important in tratamentul majoritatii bolilor in asociere cu tratamentul medicamentos sau in monoterapie.

Cresterea influentei diferitelor energii (cosmica, electrica, celei din laboratoare, a undelor radio, telefonizarea si multe altele) fac susceptibil sistemul bioenergetic al organismului uman, predispunand spre cresterea incidentei si prevalentei multor patologii ale SNC si SNP, sistemului imun, endocrin, metabolismului si oxidarii si antioxidarii.

Din cele expuse reiese ca metodele fizioterapeutice trebuie sa fie folosite nu numai pentru stimularea unor procese fiziologice, dar mai mult in reglarea lor functionala prin actiunea selectiva asupra sistemelor de adaptare, cu utilizarea micro-dozelor de energie de frecventa foarte joasa. Aceste metode au actiune nu numai la nivel celular si molecular, ele influentand metabolismul membranar si al altor organe celulare, dar au si capacitatea de a modifica structura genei.

Utilizarea unor metode contemporane fizioterapeutice da posibilitatea de a determina pronosticul eficacitatii tratamentului fizioterapeutic al multor boli cardiace si reumatologice. Metodele fizioterapeutice au actiune heterogena cu trecerea de la actiunea specifica la actiunea sindrom – patogenica.

Studiile fundamentale efectuate in fizioterapia contemporana au evidentiat fenomene determinismului genetic al mecanismelor de actiune a metodelor in cauza (fizio – genetica si modularea capacitatilor functionale celulelor mezenchimale trunchiale (CMT) ce au stat la baza terapiei fiziomodulatorii celulare.

A fost evidentiata dependenta functionala intre nivelul eficacitatii curative a factorului fizioterapeutic si caracteristicile genetice ale bolnavului, ce ne ofera posibilitatea de a aprecia ca metoda de diagnostic polimorfismului genelor in pronosticul eficacitatii tratamentului fizioterapeutic.

Astfel, fiziogenetica studiaza bazele genetice senzoriale individuale ale organismului pacientului fata de factorul fizioterapeutic si influenta capacitatii functionale a genei: expresia, nestabilitatea, reactiile reciproce intre gene s.a.

In prezent, sunt utilizate cu succes iradierea laser de intensitate joasa, lumina, campul magnetic, iradierea electro-magnetica de diapazonul de frecventa a undelor scurte (FUS). Iradierea cu lumina laser influenteaza multe procese biologice in organism: stimuleaza sistemul imun, normalizeaza procesele metabolice, actioneaza antiinflamator, analgezic s.a. Iradierea laser de intensitate joasa (ILIJ), in asociatie cu iradierea luminoasa (diapazonul spectrului 630-850-890-1300 nm) activeaza metabolismul, reactiile imune, contribuie la restabilirea membranei celulare, activeaza reactiile enzimatice, normalizeaza circulatia sangvina si limfatica.

Campul magnetic continuu (CMC), mecanismele caruia influenteaza normalizarea potentialelor membranare si a proceselor oxidative determina o actiune sedativa, antiiflamatoarie si stimuleaza activitatea sistemului endocrin. CMC actioneaza asupra sistemului celular cu efect de orientare a cromozomului in campul magnetic – factor ce intensifica susceptibilitatea genetica fata de campul de iradiere a rezonantelor.

Iradierea electromagnetica din diapazonul de frecventa joasa stimuleaza procesele adaptive ale organismului, normalizarea functiilor neuroumorale, duce la modificarea compozitiei fizico-chimice a sangelui si lipidelor in membranele celulare. Asocierea CMC cu actiunea undelor de intensitate joasa sporeste eficacitatea de 1,5 – 2 ori si durata efectului terapeutic.

Metodele terapiei prin biorezonanta pot fi explicate prin fenomenul ce are loc in modificarile functionale membranare si ale organelor intracelulare care sunt tinta campului electromagnetic, cu actiune asupra proceselor de oxidare si antioxidare legate de mecanismele de fosforilare. Aceste doua metode au actiune sinergetica determinata de lungimea undelor, actiune energetica, componentul sunetului, functiei laserului si sursei de lumina diodica cu efect biologic.

Tulburarile frecventei de generare a campurilor electromagnetice celulare proprii, ce apar in urma diferitelor procese patologice cu anumiti parametri se normalizeaza spre intensitate normala datorita reformarii generatorilor celulari. Reactiile reciproce ale campurilor interne si externe constituie esenta mecanismelor de actiune a acestor metode. Factorul fizioterapeutic ulterior este asociat cu manifestari biofizice intercelulare.

ILIJ se bazeaza pe un camp de unde milimetrice, iar CMC pe un camp de unde micrometrice. Daca in primul caz actiunea de rezonanta are loc la nivelul celular si organic, in al doilea caz are loc la nivel molecular. Profunzimea patrunderii campurilor bioenergetice si gradul de absorbtie a acestor radiatii diferite (2-6 cm pentru campul magnetic continuu, 300-500 mkm pentru FUS), iradierea CMC+FUS asigura omogenizarii proceselor celulare si subcelulare in volum mare de tesuturi. Deoarece exista un sinergism dintre aceste 2 metode – efectul comun produs este mult mai mare. Razele de frecventa joasa sunt absorbite de catre stratul superior al pielii (epiderma si stratul superior al dermei) adica acele regiuni unde se gasesc majoritatea receptorilor senzoriali, care interactioneaza cu SNC.

Absorbtia intensiva a concentratiei ionilor liberi de Ca++ in citoplasma. CMC se poate aplica pe deasupra hainelor, pansamentelor umede cu medicamente, cremelor. Undele de frecventa joasa sunt destinate aplicarii pe materiale textile uscate, masa plastica, lemn, ghips, 2 straturi de tifon umed.

Undele de intensitate joasa sunt mai eficiente, fiind aplicate deasupra organelor, vaselor, ganglionilor limfatici, gladelor endocrine, punctelor specifice pentru acupunctura.

Parametrii efectelor globale (hipotensive, dilatare coronariana, hipolipidemie s.a) au fost evidentiate independent atat de factorii de ,, baza ‘’, cum ar fi polimorfismul genetic ce determina dezvoltarea bolii respective cat si de influenta mediului, in calitatea carora apare instabilitatea si expresia genei.

A fost evidentiata dependenta functionala intre nivelul efectului curativ al factorului fizioterapeutic si caracteristicile genetice ale bolnavilor ce permite a aprecia importanta diagnosticala a polimorfismului genetic pentru eficacitatea tratamentului.

Fiziogenetica reprezinta domeniul de studiu fizioterapeutic ce investigheaza bazele genetice senzoriale individuale ale pacientului catre factorul fizioterapeutic si influenta legitima a capacitatii functionale a genei: expresia, instabilitatea, reactiile reciproce intre gene s.a.

Studiile de ultima ora (G.N. Ponomarecno, 2006) stau la baza posibilitatii de a dovedi ca metodele fizioterapeutice (iradiere laser, unde de frecventa extrem de inalta) au capacitatea de a stimula migrarea celulelor mezenchimale trunchiale (CMT) ale maduvei osoase la pacientii cu unele afectiuni cardiace grave (cardiomiopatia dilatativa).

Lumina polarizata este utilizata in tratamentul multor boli, ducand la ameliorarea microcirculatiei, exercitand actiune antiinflamatorie si imunomodulatoare. In tratamentul multor boli este folosita lumina policromatica polarizata produsa de aparatul fototerapeutic ,,Bioptron-2’’ (Elvetia: 480-3400nm, 12J/cm 2 , 95% polarizare, D=15 cm). La utilizarea acestei metode dupa 24 de ore s-a constatat: ameliorarea hemocirculatiei si a capacitatii reologice si de transport a eritrocitelor, scaderea agregarii trombocitelor, intesificarea activitatii leucocitare, scaderea in plasma a concentratiei citokinelor proinflamatorii (IL6, IL12, TNF-alfa, IFN-1) la indivizii cu acesti indici crescuti si cresterea nivelului citokinelor antiinflamatorii (IL-10, TGF-beta, IFN-gamma), precum si stimularea proliferarii celulare, activarea capacitatii plasmatice de reparatie a AND in celulele afectate.

Organismul uman utilizeaza energie solara, eritrocitele sunt apreciate ca sursa luminii solare. Polarizarea luminii creste activitatea optica si eficacitatea actiunii. Actiunea iradierii policromatice polarizate cu ajutorul aparatului Bioptron contribuie la activarea mecanismelor de adaptare si aparare imuna. S-a constatat ca lumina activeaza enzimele antioxidante, iar iradierea indelungata duce la activarea antioxidanta a membranelor eritrocitare.

Efectul modulatiei mezodiencefalice (MMD) asupra activitatii SNC este exprimat prin compensarea proceselor de hiperexcitare si are efect in normalizarea puterii excitatiei si stabilizarea proceselor de inhibitie, ce a fost dovedit prin analiza datelor testarii psihologice. MMD actioneaza pozitiv asupra homeostazei, are efect detoxifiant, amelioreaza procesele adaptive si statutul neuro – psihologic.

Electrostimularea transcraniana (EST) este orientata spre actiunea selectiva asupra sistemului de aparare (antinociceptie), a mecanismelor formatiunilor nervoase aflate in structurile subcorticale trunchiale a caror functie este realizata prin participarea endorfinelor si serotoninei ca neurotransmitatori si neuromodulatori. Experimantal s-au stabilit efecte ca: analgezia intensivasi scaderea pronuntata a reactiilor vasomotorii, stimularea proceselor de regenerare a tesuturilor afectate, activarea reactiilor imune, indeosebi ale celulelor NK (natural killer) ce a dus la activarea fagocitozei, inhibarea cresterii tumorale.

S-a stabilit ca metodele fizioterapeutice influenteaza pozitiv asupra activitatii proceselor imune celulare si umorale prin activarea organelor imunocompetente: glandele endocrine, care regleaza imunogeneza si organele sistemului limfoid.

Metodele actioneaza asupra sistemului limfoid periferic alcatuit din: splina, ganglionii limfatici periferici, ficatul; intensifica imunitatea prin locul de proiectie a glandelor endocrine: hipofiza, tiroida, suprarenalele.

Reabilitarea include un complex de procese: mecanismele bioritmice, mecanismele si fenomenele de acomodare, sincronizarea activitatii diferitelor organe si sisteme.

Sincronizarea adaptiva este modificatain procesele acute si cronice si este asociata cu incetinirea hemocirculatiei. S-a stabilit ca inainte si dupa operatie la pacienti are loc incetinirea hemocirculatiei, iar, ulterior, are loc normalizarea postoperationala.

Reabilitarea este un complex de activitati cu multe metode de actiune ce duc la normalizarea mecanismelor bioritmice de acomodare (adaptive) si sincronitatea activitatii diferitelor organe si sisteme. Activitatea integrala a SNC este determinata de acceleratia hemocirculatiei cerebrale, ce dispune la reabilitarea mai rapida a bolnavilor.

Fizioterapia criogena este o metoda de tratament bazata pe actiunea stimulatoare a gazului rece (de la 150-130 º C) pe suprafata corpului uman. Regimul de temperatura si durata procedurii sunt selectate in comformitate cu inertia calorica a corpului uman. Actiunii unor temperaturi semnificativ scazute sunt supuse acele sectoare ale pielii care dispun de mai multi receptori pentru temperaturi reci. Modificarea campului de temperatura a invelisului cutanat se constata la cel mult 14 mm in profunzime. Crioterapia – stimuleaza hemocirculatia periferica, poseda efect analgezic si stimuleaza sistemul imun.Reactia la actiunea criogena este bazata pe aferentele informationale de la receptorii stratului cutanat. Legatura cantitativa dintre intensitatea excitatiei si intensitatea semnalelor parvenite de la receptori este determinata de legea psiho-fiziologica a lui Stevenson, care descrie legatura de cauzalitate si dependenta proportionala. S-a constatat ca crioterapia asigura scaderea temperaturii suprafetelor cutanate pana la – 2ºC, degeraturile superficiale sunt posibile la scaderea temperaturii pielii pana la -2,5º C, prin urmare, crioterapia asigura supraracirea subtermala a pielii.Receptorii sistemului sensorial lemniscal asigura controlul racirii suprafetei cutanate. Astfel, in ultimul deceniu, au fost obtinute rezultate experimentale si clinice noi, ce au permis folosirea factorilor fizici curativi de intensitate joasa extrema la nivel celular si molecular. Factorii fizici influenteaza eterogen asupra organismului, evocand actiune diferentiata patogenica. Studiile fundamentale in domeniul fizioterapiei au evidentiat fenomenele determinismului genetic in mecanismele actiunii curative a metodelor fizioterapeutice. Apar posibilitati de a utiliza metode fizioterapeutice eficiente pentru realizarea tratamentului imunomodulator prin folosirea dozelor extrem de mici ai factorilor fizici, care nu vor fi asociate cu reactii negative. Cele expuse permit concluzia ca, in prezent, metodele fizioterapeutice pot fi aplicate mult mai larg, atat in procese cronice, cat si in cele acute, atat in boli degenerative, cat si inflamatorii si autoimmune si sunt foarte eficiente pentru profilaxia multor boli.

Aceasta stare duce la excitarea receptorilor prag ai sistemului sensorial extralemniscal (SSEL). Receptorii SSEL se activeaza numai la actiuni fizice, intensitatea carora prezinta pericol de alterari ireversibile tisulare. SSEL apreciaza cu dificultate localizarea factorului iritant, iata de ce crioterapia induce analgezia in organe care nu au fost supuse efectului hipotermic. Semnalele parvenite de la acesti receptori se repartizeaza prin toata regiunea responsabila de termoreglare a encefalului. Un semnal puternic, dar nerepartizat prin toata aria, nu evoca o reactie intensa de raspuns si vice-versa. Numai crioterapia generalizata permite stimularea intregii arii de termoreglare. Pentru activarea acestui sistem sunt necesari stimuli brutali, la limita distrugerii suprafetelor cutanate. Stimularea este eficienta daca temperatura inregistrata de receptorii de temperaturi reci se apropie de pragul terminal.

Mecanismele de influenta a metodelor fizioterapeutice sunt foarte complexe si multe fenomene putin cunoscute, progresele in domeniul tehnologiei nucleare au dat posibilitatea de a evidentia unele fenomene electrofiziologice care evidentiaza micro-modificari la nivel molecular.

Deoarece procesul patologic initiaza mai intai prin aparitia tulburarilor la nivelul sistemului bioenergetic este evident ca pentru a elabora metode pentru diagnosticul precoce si de a efectua un tratament eficace este necesar de efectuat studii profunde la nivelul sistemului bioenergetic.

In prezent, metodele fizioterapeutice mai putin indreptate spre stimulare electromagnetica si rolul principal, folosind microdoze de energie in reglarea tulburarilor campurilor bioenergetice ce sunt in organism. Circuitul ce apare mai ales in procese patologice acute: spasm-durere-spasm, apare mai intai datorita tulburarilor campului bioenergetic din cauza insuficientei sau spasmului microvascular. In acest caz, doze mici ale factorului fizioterapeutic vor duce la reglarea migrarii campului bioenergetic, raspandirea lui pe anumite conducte neuro-hemostatice. Aceste tulburari bioenergetice apar nu numai la subiectii ce au contact cu anumite masini, instrumente, laboratoare, uzine, dar si in urma influentei televizoarelor, undelor radio, telefoanelor celulare s.a. Un factor foarte important in declansarea procesului patologic este frecventa ritmurilor exterioare asupra organismului.

Electroimpulsatia reprezinta repetarea impulsurilor de durata scurta de intensitate mica si frecventa cu pauza intre ele. Impulsurile pot fi unice sau in serii.

Impulsurile sunt diferentiate dupa forma, durata si frecventa. In dependenta de aceste caracteristici, impulsurile pot irita (electrostimularea muschilor) sau inhiba (efect pe care se bazeaza electroanalgezia). Combinarea dintre stimulare si inhibare a electroimpulsurilor se realizeaza prin diadinamoterapie (amplipulsterapia). Amplipulsterapia este realizata prin utilizarea modulatorului de frecventa joasa (10-150 Hz), care formeaza serii de impulsuri cu frecventa de 10 – 150 Hz.

Magnetoterapia actioneaza prin unde de frecventa joasa ce formeaza campul magnetic. Actiunea campului magnetic consta in faptul ca au efect asupra particulelor incarcate, prin urmare, asupra proceselor fizice, chimice si biochimice ce au loc in organism. Dupa legea inductiei magnetice, in sange si limfa apare o electricitate redusa, ce modifica decurgerea proceselor metabolice, actioneaza asupra componentelor solutiilor cristaline, asupra apei, proteinelor, polipeptidelor etc. Sub actiunea campului magnetic actioneaza legaturile reciproce electrice si magnetice ale structurilor celulare si extracelulare, modificandu-se procesele metabolice si permeabilitatea membranelor celulare.

Ionoplasmoterapia. In prezent, ca urmare a unor tulburari ce au loc in mediul inconjurator s-a constatat cresterea excesiva a campurilor energetice externe, care influenteaza sistemul bioenergetic al organismului uman. Acestea au favorizat aparitia multor tulburari functionale si morfologice, mai intai la nivelul SNC si a sistemului neuro-vegetativ, care sunt principalii producatori si realizatori de bioenergie. Deoarece in orice molecula, celula dispune de o anumita incarcatura electromagnetica, surplusul de energie din exterior a influentat foarte mult asupra organismului ducand la initierea multor patologii sistemice, dar mai ales afectari ale SNC (nervozitate, depresii, agresivitate si, ca urmare, alcoolism, narcomanie, toxicomanie, suicid, omoruri ale rudelor, colegilor (SUA). Actiunea continua a acestor factori energetici duce treptat la dezvoltarea afectarilor morfologice, care ulterior se transforma in procese genetice. Radiatia cosmica crescuta, razele gamma, razele X, fasciculele de electroni si neutroni au influentat foarte puternic asupra organismului. Mecanismele de dezvoltare a procesului patologic depind foarte mult de lungimea de unda a razelor. Astfel, radiatia cu lungimea de unda 240-300 nm evoca modificari grave la nivelul proteinelor. Tulburarile electromagnetice influenteaza intens asupra sistemelor de oxidare si antioxidare cu cresterea excesiva acontinutului RL. Acestia joaca un rol important in structurile celulare de tipul proteine, acizi nucleici, s.a. Bolile evocate de radiatie sunt cauzate mai intai de acumularea unor cantitati mari de radicali liberi ai oxigenului. In

mecanismele patologiei cardiovasculare participa radicali liberi ai oxigenului, cum ar fi oxidul nitric.

Cu scopul de a influenta reglarea sistemului bioenergetic, am studiat metoda ionoplasmica in tratamentul multor boli: reumatice, neurologice, metabolice s.a, cu ajutorul aparatului ,, Rotor’’, constructor d.s.t. Valeriu Rudenko.

Fluxul de plasma ionica este obtinut prin expuneri la fluxuri de ioni bipolari cu densitati reglate independent a fluxurilor de ioni pozitivi si negativi la puterea eficienta a curentului de 20 – 300 mcA si durata expunerii 1-10 s.

Esenta metodei propusa consta in urmatoarele. De pacient este atasat electrodul pasiv, ulterior, asupra zonelor afectate sau reflexogene se actioneaza cu flux de ioni cu ajutorul electrozilor activi, care nu au contact direct cu corpul. Electrozilor activi li se transmite tensiune de la generatorul bipolar de voltaj inalt. Cu ajutorul comutatorului sursa transmite electrozilor alternativi tensiuni inalte pozitive si negative. In spatiul dintre electrod si suprafata tegumentelor apare ionizarea si tegumentelor pacientului li se transmit alternativ aeroioni pozitivi si negativi. Densitatea fluxului de ioni, determinata de frecventa impulsurilor de voltaj inalt, poate fi stabilita in mod egal pentru ambele polaritati, dar poate fi si diferita. Aceasta se obtine prin reglarea valorilor tensiunii. Frecventa factorului electric bipolar este determinata de frecventa schimbarii contactului comutatorului. Durata expunerii pentru fiecare polaritate poate fi stabilita egala sau diferita. Durata procedurii in functie de densitatea stabilita a ionilor este de 5-20 minute. Numarul total de proceduri este determinat de dinamica procesului de insanatosire. Nu au fost observate cazuri de agravare a starii pacientilor, complicatii sau alte efecte adverse in timpul tratamentului prin aceasta metoda si in perioada ulterioara acestuia.

Metoda de actiune asupra organismului pacientului cu flux de ioni bipolari, cu parametri reglati independent, permite actiunea diferentiata si focusata asupra regiunilor afectate ale pacientului, zonelor reflectorii ale tegumentului sau, evocand selectiv inhibitia sau excitarea. Pot avea ca efect reducerea termenelor de vindecare a pacientului.

Experienta cercetarilor efectuate permite recomandarea metodei propuse pentru tratamentul neinvaziv al afectiunilor reumatice, neurologice, cat si pentru reabilitarea bolnavilor posttraumatici si postoperatori.

Activitatea fizica. Industrializarea, automatizarea, predominanta muncii intelectuale au dus la viata sedentara si ca urmare la dezvoltarea multor boli cronice incurabile: obezitatea, osteoporoza, ateroscleroza s.a.

Hipokinezia este asociata cu hipotrofia musculara, scaderea functiei miocardului, scaderea functiei glandelor secretorii, se micsoreaza capacitatea vitala a plamanilor. In acest context obezitatea a devenit o problema de importanta deosebita medico-sociala, care serveste ca substrat pentru initierea multor boli cardiovasculare: infarct miocardic, hipertensiune arteriala precum si pentru osteoporoza, cancer.

Organismul uman reprezinta un complex ce include multiple sisteme cu diferite functii si toate actioneaza ritmic , fiecare avand un ritm deosebit, menit sa asigure functionarea optimala fiziologica si specifica. Miscarea este generatorul activitatii bioelectrice ce asigura functiile organismului; regleaza hemocirculatia, digestia, respiratia, eliminarea metabolitilor toxici din organism, normalizeaza si intensifica procesele intelectuale. Unul din principalii factori de intretinere a normelor fiziologice ale organismului, ce favorizeaza perfectionarea organismului si adaptarea la conditiile noi ale naturii este mersul pe jos, cu alte cuvinte exercitiul fundamental cel mai vechi al omului. In organismul uman in mers pe teren verde, vis-à-vis de gradina, padure, rau, mare, munte se intesifica procesele de absorbtie si utilizare, in afara de oxigen, a multor altor substante din mediul inconjurator.

Munca fizica, miscarile sunt privite ca necesitate pentru existenta si asigurarea sanatatii omului. Modificarile ce apar in sistemul digestiv la pacientul imobilizat indelungat la pat este apreciat ca sindrom special, ce duce la tulburari concomitente de activitate a pancreasului, scaderea activitatii motrice a intestinului, aparitiei disbacteriozei.

Hipokinezia este asociata cu scaderea functiei musculare, activitatii bioelectrice, scaderea metabolismului si a concentratiei de calciu in sitemul osos, scaderea proceselor de gluconeogeneza in ficat. Hipokinezia influenteaza sinteza lipidelor, procesele de hidroliza, transport, absorbtie a lipidelor in sistemul digestive, sustinerea hipercolesterolemiei si constituie un teren avantajos pentru producerea calculilor.

Homeopatia. Homeopatia reprezeinta metoda de tratament la baza careia sta tratamentul cu asemanatori (similia similibus curantur), adica toate medicamentele care au capacitatea sa provoace starea de imbolnavire la omul sanatos si, cu toate acestea, sa inlature aceasta stare la bolnavi.

Exemplu – opium in doze mari, la omul sanatos, evoca somnolenta, iar in doze mici vindeca un bolnav de aceasta stare. Alt exemplu – pe zonele degerate se aplica zapada.

Dupa Hanemann (1790) – La oricare boala o substanta poate fi considerata tratamentul corect daca acea substanta influenteaza asemanator la omul sanatos. Hanemann a numit aceasta metoda ,, homeopatie’’ de la cuvantul grecesc homios – asemanator si pathos – suferinta, iar tratamentele clasice au fost numite ,, alopatie’’ (alos – alta).

Aceasta conceptie a influentat asupra scolii vechi prin faptul ca s-a revazut principiul conform caruia dozele mai mari exercita actiune terapeutica mai intensa si s-a stabilit principiul: simplex veri sigilum (simplu este stampila adevarului).

Medicamentele sunt recomandate in cele mai mici doze, fiindca natura si asa actioneaza pentru anihilarea tulburarilor ce au aparut in organism. Efectul in tratamentul homeopatic de obicei apare tardiv de aceea trebuie asteptat mai mult timp.

In cazul maladiilor acute este necesar ca remediile sa fie recomandate mai frecvent sau in combinatie cu mai multe medicamente.

Experimentele lui von Reichenbach au determinat prezenta puterii, care circula prin nervi – numita forta odica (energia bioelectrica), care cum el se exprima ocupa locul intre magnetism, electricitate, lumina si caldura, care se aseamana cu toate aceste puteri si, totodata, se deosebeste de ele.

Datorita descoperirii puterii bioelectrice, s-a schimbat parerea despre mecanismele de dezvoltare a bolilor. Dupa parerea acestui curent, cauza oricarei boli este bazata pe tulburarile ce apar in activitatea sistemului bioenergetic, care, de regula, apare mai inainte de semnele clinice ale bolii. Sanatatea este apreciata ca relatie dintre organism si bioenergie pozitiva si cea negativa. In organismul sanatos predomina activitatea negativa a fluxului bioenergetic, care, in organismul animalelor joaca un rol mai important, comparativ cu cel al plantelor. Cu cat e mai sanatos organismul, cu atat mai mult se dezvolta energia negativa (Karl Ludwig von Reichenbach).

Hanemann scrie ca medicamentul homeopat are actiune sufleteasca, cum are loc manipulatia cu hipnoza. Hipnotizorul concentreaza puterea curativa, lasand-o singura sa gaseasca drumul, iar homeopatul da directia necesara si domina boala prin impartasirea homeopatica a proprietatilor medicamentului transmise apei sau spirtului, a particularitatilor bioenergetice ale medicamentului homeopatic.

Cu cat mai mica este cantitatea substantei, cu atat mai bine patrunde ea in organism, cu cat este mai mica particula cu atat este mai mare puterea ei de difuzie.Particularitatile calitative ale substantei nu se modifica la micsorarea cantitativa.Organismul este reprezentat de partea dreapta – cu forta Odica negativa si stanga – cu forta Odica pozitiva. Diferite medicamente inafara de actiunea lor specifica, in anumita masura influenteaza forta odica pozitiva sau negativa.In momentul tratamentului este interzis consumul de alcool, cafea, condimente, ape minerale. Se permite alimentatia simpla, de obicei, cu predominarea alimentelor vegetale.

Daca la doza primita de medicament, nu au aparut schimbari in starea bolnavului, trebuie sa se astepte un anumit timp, apoi se recomanda alt medicament. Numai acel preparat va inlatura boala care este selectat corect. Atunci cand un astfel de medicament este identificat, cu cat mai putin sau cu cat mai rar va fi administrat acesta, cu atat mai bun va fi efectul.

In bolile acute medicamentele trebuie administrate mai frecvent sau este indicat sa se foloseasca 2-3 medicamente.Astfel autorul descrie un nou principiu al tratamentului. In prezent s-a constatat ca papilele gustative pot aprecia stricnina intr-o dilutie de 1:1000000. Eficacitatea metodei homeopatice consta in faptul ca pacientul primeste doze extrem de mici, deci este exclusa actiunea lui toxica, ce se observa la toate remediile. Administrarea tratamentului timp indelungat influenteaza asupra celulelor nervoase.

E necesar de amintit ca la majoritatea cazurilor, mai ales cand este un proces cronic, apar tulburari in mai multe sisteme. In toate cazurile medicamentul ajuta organismul, dar nu inlocuieste functia lui. Deci, posibil ca in mai multe boli este necesar un impuls orientativ, foarte mic, ca urmare, sa aiba loc o reactie in lant, presupunem prin mecanismele radicalilor liberi. Ca sa apara reactia alergica, de hipersensibilizare este suficienta o adiere de aroma de planta la care organismul este sensibilizat. Pentru a include in acest ansamblu al sistemelor immune, producerea neuromediatorilor, interleukinelor nu e necesar de introdus cantitati mari de substanta, ci doar repetat, ele vor duce la aparitia efectelor de hipersensibilizare

Ce este ENTOMOTERAPIA?

Administrarea preparatelor obtinute din tesuturile diferitor specii de insecte a demonstrat efecte pozitive in tratarea multelor boli ale omului ( Ciuhrii, 2005). Insectele sunt unele dintre cele mai vechi vietati eucariote de pe Terra. Albina este cea mai bine cunoscuta insect, produsele careia se utilizaza pentru tratarea unor afectiuni ale omului Produsele obtinute de insecte sunt utilizate in tratamentul multor afectiuni. Inca din vremurile antice, veninul albinelor se recomanda in tratamentul multor boli: pentru anestezie, normalizari digestive, tratamentul ranilor (Egipt, India, China, Grecia), in hipotensiune, normalizarea proceselor metabolice si a functiei proceselor virale si reglarii proceselor vitale si a eliminarii unor procese vitale.. Dar trebuie sa fim constienti ca in cazurile unor infectii virale stimularea proceselor vitale ale organismului vital, pot grabi mulutiplicarea virusurilor sau altor patogeni si formatiunelor tumorale si atunci procesele patologice se intensifica ducand organismul la complicatii si mai mari. Un exemplu classic este comportarea cainilor, care in timpul infectiunelor grave inceteaza sa manance pana cand afectiunele nu se amelioreaza.

Actualmente nu sunt studiate suficient modificarile ce au loc la nivelul molecular al insectelor in dependenta de faza dezvoltarii lor, care se deosebeste considerabil comparativ cu acestea de alte vietati. Ingineria genetica a dat posibilitatea de a modifica structura genetica a baculovirusilor, prin inserarea genelor straine. De aceea genomul bacilovirusilor, dispune de un donator puternic ce creeaza conditii necesare pentru fixarea genelor straine in structura genomului viral. Acest genom recombinat da posibilitatea de a obtine substante active dorite. SBA ca interferonii, vaccinele, interleukinele si altele au fost obtinute prin aceste metode.

Metoda de inlocuire a genei proprii cu gena straina, asigura conditii ca producerea proteinei proprii (de exemplu A10) sa fie substituita cu cea a proteinei dorite (M. Ciuhrii, 2003). Este constatat ca, insectele artropode dispun de compozitie specifice, ce se deosebesc foarte mult in diferite faze de dezvoltare.

Astfel, larvele care se hranesc foarte intens acumuleaza o cantitate mare de proteine si lipide, iar transformarea larvelor in pupe, cand o parte din componentele lipoproteice a larvelor se transforma in alte compozitii (chitine sau cheratine inerte) inerte, care ocupa o mare parte din pupe. Proteinele din pup dispar si apare keratina, ce constituie 80-90% din corpul fluturilor (imago). Ulterior timp de 4-5 zile se fecundeaza adultii (imaga) si depun ouale, ce dispun de o structura biochimica specifica. In organismele insectelor se contin proteine, care uneori depasesc 70% din materialul uscat ( Tab. ), totodata la fiecare cateva ore compozitia aminoacizilor din proteine, se modifica (Tab. ).

Substantele biologic active extrase din larvele insectelor poseda actiune keratolitica, bactericida, antivirala, antifungica, antireumatica, antitrombotica, anticancerigena ( Fig. ). Proteinele ce au efect keratolitic, in continutul lor predomina fenilalanina, acidul glutamic, asparagina si lizina. Experimentele pe animale (iepuri, caini, cai) au demonstrat, ca folosirea substantelor biologic active duce la disparitia formatiunilor keratinice (veruci seboreice)

fara a lasa urme. Medicamentele keratolitice au efect puternic de resorbtie a keloizilor dupa arsuri, rani, sau a bataturilor ( Ciuhr5ii, 2005).

Proteinele obtinute din hemolimfa unor insecte au efect pozitiv contra infectiilor stafilococice si streptococice si pentru reglarea densitatii populatiei de E. Coli. In prezent sunt cunoscute 5000 de specii ce contin substante biologic active (SBA) cu diferite actiuni si 6000 de SBA studiate. Numarul mare al speciilor de insecte determina diversitatea SBA, cu structura morfologica si biochimica diferita.

Din vremurile antice (China, India, Egipt, Grecia) au fost folosite produse de albine: veninul, propolisul, polenul, laptisorul de matca in tratamentul multor boli (rani, boli digestive, anestezie). Veninul de albina purificat a fost obtinut pentru prima data de catre N. Pollak (1928). Veninul de albine contine: peptide toxice, amine vasoactive si enzime. Componentul principal al veninului este peptidul de melitina, care contine 26 de aminoacizi cu greutatea moleculara de 284 Da. Alt peptid de baza al veninului de albine este MCD ce include 22 de aminoacizi si dispune de actiune analgetica mai puternica comparativ cu metilina cu efect antiinflamator si de 100 de ori mai activ ca hidrocortizonul. Polipeptidul apomina ce determina efectul neurotoxic al veninului influenteaza asupra sistemului nervos al maduvei spinarii, ficatului si muschilor. In cantitati mici au fost obtinute alte peptide: tertiapina cu actiune presinaptica, cardiopenul influenteaza activitatea cordului, secapina – cu efect sedativ si antipiretic, procamina – efect anestezic. In cantitati foarte mici au fost obtinute amine vasoactive de tipul histaminei, dopaminei si noradrenalinei. Fosfolipaza proceselor hidrolizei fosfolipidelor formeaza lizolicitina, ultima cu efect de distrugere a membranei celulare si blocarea eliberarii mediatorilor din terminatiile celulelor nervoase. Din veninul de albine au fost obtinute enzimele: hialuronidaza, fosfataza acida, fosfomonoesteraza.

Propolisul – “pro” – pentru si “polis” – oras – substanta care este utilizata pentru lipirea orificiilor stupilor, are actiune antibacteriana. Propolisul actioneaza efectiv asupra a 100 de specii de bacterii si are un effect analgezic contra ranilor, exemelor, ulcerelor varicoase, furunculozei, arsurilor, ulcerului gastric si duodenal.

Larva de matca se hraneste cu laptisor si in 6 zile se mareste de 2700 de ori si depune 1500 de oua intr-o zi. Longevitatea ei este de 3-5 ani, pe cand a albinelor lucratoare este de numai 1-8 luni. Laptisorul de matca contine 45,15% proteine, 13,55% lipide, 20,39% glucide (glucoza si fructoza), vitamine, aminoacizi, microelemente, hormoni si alte substante biologic active. Savantul francez Caylas I. (1953) scria “Albinele sunt izvorul tineretii si alvietii”, pentru ca substantele produse de ele au efect tonifiant, stimuleaza procesele metabolice, normalizeaza activitatea sistemelor cardio-vascular si digestive. Mierea de albine este recomandata in bolile ficatului, rinichilor, stomacului, intestinelor si cailor respiratorii.

Mai putin cunoscute sunt efectele produselor din gandaci, care contin substante biologic active cu efect curativ contra ranilor cutanate, stimularea potentei sexuale si actiune antitumorala.

Extractele din furnici sunt utilizate din antichitate pentru tratarea unor boli articulare sau ale sistemului nervos. Toxinele extrase din furnicile rosii contin acid formic (CH2O2), care este substanta activa, iar componentii citronealului si citralul (9:1), cu structura asemenatoare vitaminei A, au actiune analgezica, antiinflamatoare, vasodilatatoare, antikeratozica, anticonjunctivitica. Iridomicina obtinuta din furnici dispune de actiune bactericida. Toxinele extrase din furnici au fost recomandate pentru cremele contra proceselor reumatice (Seren Samonic sec. II). In present, sunt recomandate preparate ce contin acidul formic in alcool etilic (14g+100ml alcool etilic 70º) contra sindromului dureros reumatic.

Medicamentele produse din gandacii de bucatarie (Blata orientalis si Blata germanica) sunt utilizate pentru stimularea activitatii glandelor sexuale si diurezei, consolidarea fracturilor osoase, pentru eliminarea lichidului la pacienti cu ciroza hepatica (S.R. Botchin, 1876).

Extractele din larvele de muste sunt folosite contra multor afectiuni: infectii acute, plagi purulente, osteomielita, TBC, infectii streptococice. Mecanismele de actiune a larvelor de muste sunt exprimate prin actiunea enzimelor proteolitice, care inhiba dezvoltarea bacteriilor. Ureaza, ce se gaseste in extracte, prin interactiunea cu urea, formeaza amoniacul. Extractele din larvele de musca au fost utilizate in tratamentul multor boli: a osteomielitei, keloizilor dupa arsuri, gangrenelor. In antichitate se foloseau extracte din larvele unor specii de muste in tratamentul multor afectiuni purulente (stafilococice, streptococice): rani, infectii acute, osteomielita. Avicenna si Diascorid foloseau plosnitele si puricii ca mobile in tratamentul malariei. Dupa unele informatii ale arabilor – pupele insectelor Mantis religiosa, au capacitatea de stimulare a activitatii sexuale la barbati si femei; regleaza functia rinichilor. Substantele extrase din greieri, sunt administrate in tratamentul colitelor si hepatitelor, iar extrasele din lacuste (China, Japonia) sunt administrate cu scopul inlaturarii alunitelor si hemoroizilor. In multe tari se recomandau paduchii contra malariei, cirozei hepatice. Extractele din greieri sunt utile in tratamentul scabiei si urticariei. Studiile biochimice au evidentiat unele deosebiri in compozitia lipidelor obtinute din extrasele Lepidopterelor, Coleopterelor, Dipterelor si Aphidiilor. Ele se deosebesc de cele extrase din alte vietati, deoarece lipidele extrase din insecte contin acizi grasi nesaturati deosebiti de cei evidentiati la animale si, totodata, cu portiuni commune cu cele extarse din plante. Un interes deosebit reprezinta artropodele, care in procesul dezvolarii se hransec foarte intens, acumuland o cantitate mare de lipide, iar la transformarea larvelor in pupe se acumuleaza unele cantitati mari de proteine, ultimele se transforma in keratina ce constituie 80 – 90% din corpul fluturelui (imago).

Deoarece compozitia aminoacizilor din proteinele de insecte se modifica la fiecare cateva ore, acestea dau posibilitatea de a obtine proteine cu proprietati diferite. Astfel, Lepidopterele contin acidul glutamic, acidul aspartic, prolina, alanina si glicocoluluil in proteinele fazei de ou; proteina din larvacontine alanina, acidul glutamic, glicocolul, acid aspartic, leucina; in proteina din pupa predomina acidul glutamic si acidul aspartic, alanina, glicocolului si serina.

Mecanismul de actiune a preparatelor antivirale din SBA obtinute din insecte este exprimat prin capacitatea lor de a transforma unele compozitii in altele, de aceea ele au capacitatea de a stopa multiplicarea virusurilor in organism. La anumite faze de dezvoltare a insectelor apar unii inhibitori ai sintezei proteinelor si acizilor nucleici. Acesti inhibitori patrund in celula hepatica infectata cu virus si stopeaza sinteza proteinelor si acizilor nucleici.

SBA extrase din hemolimfa unor insecte dispun de capacitati antibacteriene (contra Staph. Spp., Strep. E. colli) cu succes folosite in tratamentul bolilor, mai ales in cazurile cand lipseste raspunsul la actiunea antibioticelor.

Tratamentul candidozelor bucale, vaginale si cutanate este bazat pe SBA care are particularitati de stopare a multiplicarii virusurilor si a micozelor. Este necesar de a obtine din insecte SBA cu efecte antitumorale, antibacteriene, antimicotice care in viitor vor putea stopa multe din infectii.Rezultate positive au fost obtinute in tratamentul adenomului de prostata si fribomului uterin.

ENTOMOLOGIA este o stiinta, care studiaza insectele ca atare – mormologia, raspandirea lor, iar terapia este parte a medicinei, care se ocupa cu mijloacele medicamentoase destinate vindecarii sau ameliorarii bolilor – TRATAMENT. In cazul dat tesuturile insectelor se utilizeaza pentru producerea medicamentelor, deoarece acum ne dam seama ca in organismul insectelor, in timpul morfogenezei, se petrec multe schimbari sub influenta diferitor enzime si defensine ce pot regla anumite procese vitale ale organismului uman. Apare o industrie noua a medicamentelor in baza Substantelor Biologic Active (SBA) din diferite specii de insecte. In viitorul apropiat se vor produce suplimente alimentare, care se vor utiliza pentru reglarea functiei normale a organismului in anumite situatii. Astfel se va mari si longevitatea omului si a altor animale dorite de catre om.

Insectele au corpul segmentat, au cate sase picioare. Multi cred ca sitintarii, lacustele, libelulele, paianjenii apartin clasei insectelor. Aceasta a afirmatie nu este adevarata, deoarece insectele sunt numai acelea, care au corpul segmentat.

Prima data cand multi dintre oameni aud ca exista medicamente naturale obtinute din insecte, au o repulsie, o frica si imediat isi inchipue cele mai des intalnite insecte, care apar in viata omului, cum ar fi gandacul de bucatarie (Blata orientalis sau Blata germanica), mustele (Diptera), gandacul de Colorado (Colioptera) si altele. Mai putin repelente sunt fluturii frumos colorati, gandacii de padure. Unora mai greu le vine sa inteleaga cum aceste fiinte pot fi de folos omului? Intre insectele folositoare sunt albinele, care hranesc o lume intreaga cu mierea cea gustoasa sau viermele de matase, care imbraca o lume intreaga cu matasea, care pana acum este considerata de cea mai buna calitate. Se pune intrebarea oare nu mai exista si alte specii de insecte atat de folositoare omului? Autorul acestei lucrari crede ca exista inca multe specii de insecte, care pot juca un rol important in viata omului. In ultimul timp Drossofila melanogaster a devenit un obiect clasic de studii pentru Genetica contemporana. Aceasta insecta are numai doi cromozomi si este un obiect de studiu pentru a obtine informatii genetice si informatii despre legitatile de transmitere a informatiilor de la o generatie la alta. Toate aceste transformari se efectueaza numai prin cei doi cromozomi, fapt care permite sa se determine functiile genomului celular. Aceasta insecta a permis sa se determine multe legitati genetice.

Si mai nou sunt insectele din familia NOCTUIDAE, in special Autographa californica, Trihoplusia ni, Mamestra brrassicae care se pot infesta cu recombinanti ai baculovirusurilor pentru a produce proteine noi cu anumite proprietati. Astfel, se pot produce interferonuri, vaccinuri absolute noi.

Pana in prezent in medicina complementara exista notiuni de “apiterapia”, care cerceteaza produse obtinute de la albine (Apis melifera), mai ales mierea de albine, propolisul, veninul de albine.

“Fitoterapia” – studiaza plantele utilizate in medicina

“Animalo-terapia” – o directie, care studiaza produsele de origine animala utilizate pentru reglarea proceselor vitale ale Omului.

In aceasta ordine de idei si termenul ENTOMOTERAPIA – este o directie noua in stiinta, care studiaza utilizarea Substantelor Biologic Active (SBA) in reglarea diferitor procese vitale ale organismului uman si a animalelor domestice . Nimeni inca nu s-a gandit ca in tesuturile anumitor specii de insecte exista SBA, care pot servi pentru reglarea anumitor procese vitale ale fiintei umane in reglarea anumitor compozitii, a aminoazizilor din proteine. Astfel, daca in componentele proteinelor umane lipsesc sau nu sunt suficienti anumiti aminoacizi ei se pot completa din alte resurse, mai ales din tesuturile anumitor specii de insecte la anumite faze de dezvoltare.

SBA din insecte pot fi utilizate si in cazurile aparitiei infectiilor provocate de virusuri, bacterii sau fungi, deoarece unele SBA din insecte pot stopa multiplicarea anumitor patogeni sau exista compozitii de tipul “citostaticelor” sau “interferonilor”

Insectele, care exista pe Terra de mai mult de 3 miliarde de ani pana aparitia omului au un alt sistem de aparare fata de infectiile bacteriene si virale . Insectele, spre deosebire de vertebrate, nu formeaza anticorpi, ele formeaza oligopeptide, care regleaza activitatea imunitara a organismelor. Acest sistem este eficient si pentru ridicarea imunitatii organismelor umane in diferite cazuri. Daca am putea adapta sistemul imunitar de la unele organisme a nevertebratelor atunci s-ar mari si longevitatea omului cu mai multi ani de zile – nazuinta tuturor oamenilor.

Utilizarea insectelor in medicina este o directie absolut noua care in viitorul apropiat va revolutiona producerea medicamentelor. Putini sunt cei care cunosc ca insectele sunt fiinte stravechi pe Terra. Diversitatea acestor organisme este extrem de mare si include mai mult de 61 % din toate organismele de pe Terra (Dimarcq 2003). De-a lungul timpului insectele la randul lor au fost atacate de diferiti patogeni, inclusiv virusuri (Ciuhrii, 1972 – 2007), care au raspuns diferit la patogeni. In primul rand organismul insectelor nu formeaza anticorpi, asa cum reactioneaza vertebratele. Insectele au obtinut un sistem imunitar deosebit fata de alte organizme. Compozitia chimica a tesuturilor insectelor (Hetru, Hoffmann, Hancock 2002, Knoppe, Mizina 2003) difera complet de alte organisme. Spre deosebire de alte animale, insectele parcurg mai multe faze de dezvoltare (fig. ): ou, larva, pupa si adult (imago)

Fig. Morfogeneza Lepidopterelor: mai intai se formeaza oul, apoi larva, pupa si imago (adultul)

La fiecare etapa insectele isi schimba nu numai morfologia, ci si compozitia chimica. Conform unor date (Ciuhrii 1977, 1982, 1988, 1995, 2005, Jean-Luc Dimarcq 2003) tesuturile insectelor includ substante biologic active (SBA) cu diferite proprietati. Pana in omul prezent a cercetat insectele mai mult pentru a gasi metode de combaterea lor. Astfel s-au elaborat cele mai performante arme chimice, fizice si biologice pentru a le distruge. Aceste arme au provocat aparitia noilor posibilitati de rezistenta ale insectelor prin marirea potentialului de inmultire si schimbarea compozitiei chimice a tesuturilor pentru a rezista la aceste atacuri. De mentionat faptul ca noi am elaborat preparate virale creend noi posibilitati de reglare a densitatii populatiilor de insecte nedorite. La infectiile virale, insectele nu formeaza anticorpi (imunitate) ca si organismele vertebrate. Rezistenta la diferitele tipuri de infectii la insecte inca este foarte putin studiata.

Fig. Proprietatile Substantelor biologic Active a insectelor

Utilizarea intensa a insecticidelor a dus la dezastre naturale, provocand dezechilibru in ecosistemul natural, care a dus la aparitia unui numar mare de afectiuni ale oamenilor si animalelor.

A aparut o disciplina noua Patologia insectelor unde Weiser (1972) a constatat, ca si insectele sunt atacate de patogeni, printre care cele mai eficiente sunt Baculovirusurile (Ciuhrii 1977, 1982, 1988). Cercetarile efectuate in ultimul timp (Ciuhrii 2000) au demonstrat ca insectele, spre deosebire de alte organisme au alt tip de aparare decat celelalte fiinte. In compozitia tesuturilor sunt incluse o cantitate mai mare de micromolecule (peptide) care joaca rolul de aparare (Cecropine, Drosomycine, Attacine, Defensine, Diptericine). De la insecte pot fi extrase peptide si polipeptide (alloferon 1 si alloferon 2), care ridica imunitatea omului fata de diferite infectii.

2 Directiile principale ale medicinei complementare:

Homeopatia;

Acupunctura

Fitoterapia;

Entomoterapia;

Apiterapia;

Presopunctura;

Reflexoterapia

Masajul terapeutic;

Meloterapia;

Cromoterapia;

Cristaloterapia

Kineziterapia;

Bioenergoterapia;

Sacroterapia

Aero-, helio- si talazoterapia;

Sacroterapia.

Ultima directie este cea mai veche si cea mai eficienta, daca se face cu credinta adevarata. Este o forta inca neinchipuita de ratiunea umana

Toate fenomenele naturii sunt indreptate spre corectarea proceselor vitale ale fiintei umane, a carei structura si functii inca nu sunt pe deplin cunoscute, cu toate ca exista

Institute specializate in diferite domenii: cardiologie, pneumologie, oftalmologie, ORL, Institute de cercetare specializate pentru tratarea anumitor afectiuni, Institute de oncologie, psihiatrie, neurologie, pftiziologie, reumatologie, cardiologie si multe altele, au o intensa activitate de cercetare pentru a identifica noi metode si a ameliora disfunctiile anumitor sisteme vitale ale omului. Sunt inregistrate o multime de inventii ale dirijarii proceselor vitale ale omului si cu toate acestea longevitatea omului este inca mica fata de cea dorita. Toata lumea asteapta noi descoperiri in domeniul sanatatii omului, in primul rand pentru a gasi noi posibilitati de hrana si medicamente adecvate, care ar mari longevitatea.

Trebuie sa recunoastem ca in multe cazuri medicii privesc disperati la decesele semenilor lor, cand nu mai pot interveni cu metode adecvate pentru salvarea bolnavilor. In multe cazuri bolnavii apeleaza la alte metode, care in anumite cazuri pot salva vieti.

ENTOMOTHERAPY

ENTOMOTERAPIA AND ITS FUTURE PERSPECTIVE Vol1


INTRODUCTION
Before writing this book I’m  bound to thanks to „the Creator of the world” – for the grace and creative power that I was crowned given to a new direction in science – The ENTOMOTERAPY – that in the near future will produce a revolution in the drug industry to prolong regeneration of the life processes of human beings, the regeneration of some damaged tissue, without performing transplantation of certain organs. It will produce a new revolution in modern medicine and biotechnology. This will increase the duration of human existence – an important aspiration of humanity.
In the present theere are  few of those who can imagine the importance of Entomoterapy, which is just at the beginning. I am grateful to God for the grace given to me to perform scientific research with results that can be applied. In the studies  I performed often it makes it hard to understand the insight to my mind when I had solved a particular problem. I will never forget that the beginning of my work as a researcher, the head of my PhD work, Academician. B. Matienco was amazed by my creative potential, as I could solve the fastest the most complicated problems put in front of me.
I made the first doctorate in just two years and I sustained the Scientific Council of Moscow M. Lomonosov University – one of the most prestigious research centers in the world. When it was a question about the work performed by me, in the opinion of many members of the Scientific Council, my work corresponded of Docent Scientific degree (doctorate-Ph D, not candidate of sciences). I was only 25 years old.
The grace given by God helped me work in a prestigious institute of the ex „Soviet Empire”, which had the mission to conduct biological processes in natural ecosystems for the purpose to manipulate the density of certain species of insects considered harmful to human, although all living creatures have the right to exist. Nobody has the right to eliminate some of the creatures on Earth, but man became „peak” development of living organisms; it is considered the most important being that in certain moments take responsibility to interfere in the affairs of the Creator and often causes many disastrous processes, primarily acting against him.It was  the same with using chemistry in agriculture. Chemical pesticides were invented to control natural processes, first, to kill some insect species that have become man competitors for food and some important material. Unwanted insects, although they also have the right to existence, are cut off just because they want to feed with the same food as humans.
For their destruction human being has used the most modern weapons: physical weapons, chemical weapons, biological weapons. In this fierce fight human actions have failed, because the insects have survived, and this has was attacked by a series of diseases caused by weakening of the immune, cancers, viral infections, which have significantly reduced the longevity.
Natural disasters occurred as a result and were caused by changing the balance of organisms in natural biocenoses. The use of chemical pesticides have disturbed many natural processes invisible to ordinary people. So obviously decreased longevity for the living beings.
Is urgently required firm credible decisions to stop the intense use of chemical compounds and their replacement with natural biological agents. This problem  seemed fantasy, because man does not know many details yet essential for vital processes and is involved in natural processes without knows what may follow after his intervention, still not conscious that in nature everything is calculated and programmed by „one force” being still unidentified by the human beings.
Until now we have many unsuccessful examples of human involving in the laws of nature and it is time to realize that we are powerless in the face of nature.
There are still many need to know/want to know phenomena by humans proving  are too complicated for human beings. Should we wait patincetly  when to intervene in the laws of nature?
I was the first researcher who studied the ultrastructure of cells and viruses in many species of insects. According to a decision by the WHO (Geneva, 1973), I created some biological weapons based on viruses that have been recorded and implemented in practice. These viruses are specific only to certain species of insects. The baculovirus is specific and not found in other organisms. They are not dangerous to humans because they have a specific structure.
Their nucleocapsids are included in supracapsides protein very resistant to the environment and in terrestrial environment can survive hundreds of years.One of these viral preparations are used in Romania (known as „Inf-Ld), which is patented and registered at the Ministry of Health. Based on data obtained I edited the book (album) “The ultrastructure of insect viruses”, the book was published by Publisher of Science in Chisinau in 1977) and then translated into English and published by International Publishers’ OXANA N PRESS „Delhi – Calcutha in 1978.
Later after I had the opportunity to do scientific research at an international scientific center in France (Saint – CHRISTOL les-Ales), financed by the WHO I did extensive research in the field of general virology both and specific as to solve concrete problems such us the ultrastructure of cells forming as insect tissues at different stages of development and morphogenesis of baculovirus.

This research has permitted to discover many biological phenomena in relations body – host. Thus, these data allowed me to determine that at some stage of development of insect, the viruses can not already replicate.
When lipoprotein structures from the larvae it lysesdevelop into structures with chitin or keratin, which later formed pupae, where there are not really living cells. The kiss is made massive changes, which form the „imago” Here begins the formation of chitin structures that comprise almost 90% adult’s inert material. At this time appear small peptides and enzymes, such as interferons or natural cytotoxic (Ciuhrii, 2010). These structures can block the multiplication of viruses and tumor cells. Becouse to some data misinterpret that there is formed a type of vaccine (Cernysov,).

I want to do a little comment regarding research effectuate on Comparative Pathology Center of Saint Cristol les Ales in France.  First I checked myself if I could cope with the International researchers. Only in a few weeks I managed to amaze my colleagues in Comparative Pathology Station in that have a perfect molecular biology and electron microscopy methods, disciplines that just appeared. These activities have encouraged me very much because I was checked by specialists of the most famous in the field, such as French academician C. Vago.
My research potential was noted by Academician C. Vago which sympathize me. Here we solve some important problems for virology.  First, we were able to demonstrate the presence of both nucleic acids in nuclear polyhedrosis viruses. For the first time I was able to prove that baculovirus include both nucleic viruses (DNA, RNA) location of these acids in the composition of viruses: DNA nucleocapsid and matrix RNA in suprapoliviriocapsids. These results have been recognized internationally.
Other discoveries of an international importance resulted from the research of mixed infections. For the first time I demonstrated that when mixed infections with different viruses that include nucleic acid interference occurs – meaning stopping the multiplication of both viruses. Material has been published in the French Academy Compte Rendu (, N Compte Rendu, France, and Paris1982).
For the first time I demonstrated that virus replication can be stopped after cell infection with viruses containing different nucleic acids – an extremely important phenomenon in virology and cytology, because no one yet was unable to stop the multiplication of viruses in infected cells.

For the first time I demonstrated that a cell can be infected with two viruses, which include different nucleic acids, which means one include DNA located in the nucleus and another with RNA that multiplies only in the cytoplasm. In this case the question arises, how it can happen that a specific virus multiplication only in the nucleus can block information of cytoplasm? This phenomenon raises the issue of the existence of nucleus autonomy to the cytoplasm and other issues appear regarding the protein synthesis at molecular level.
I have researched and elaborated a few technologies to produce specific viral preparations. We have demonstrated some regularity of epizootic viral spread. This regularity applies in cases in humans and animal viral epidemics.

I have elaborated specific standards for determining the quality of virus preparations, which is valid until today, because the biological quality can not be standardized by biological criteria, which are variable and can not determine the quality of the biological preparations. These criteria depend on many factors. Only the instrumental criteria are safe and stable.
In 1982 I was elected President of the International Commission I for determining the quality of virus preparations. Knowing the International Institute for Viral preparations wich produces artificial infection challenge, I managed to create viral preparations in collaboration with researchers from Poland, Canada and France. Regarding this aspect, the regularities of propagation of viruses and viral infections are also valid in humans. Meeting together with other specialists – entomologists and virologists to experience viral preparations as a model of experimental viral infections spread from animals, including human-specific viruses.
I have participated in a special conference to demonstrate ineffective use of viral weapons against human, because viruses used to destroy populations of people can immediately spread and against those who used biological weapons.
In France I work hard, day and night in the laboratory of genetic engineering with the baculovirus and one morning after a night of intense research I found that the  baculovirus recombination is in the  Canadian forests. In this case I observed an unusual phenomenon, which was important for contemporary Entomoterapia.
I work with some insect tissues and noticed that the skin on my fingers has thinned a lot. With the naked eye I could see the blood pulsating through the blood vessels. I realized the existence of SBA (biologically active substances) with cheratolitic effect.
We tested these substances in different vertebrates and keratoses and I was convinced by their cheratolitical action. There was an extraordinary phenomenon (similar to that of  Zinger, who invented the sewing machine, which changed only in that the needle hole at the bottom of the head) invented the sewing machine.

In this case the existence of SBA was found in the insect tissues with cheratolitic efect. Normally, keratin is resistant to unfavorable environmental actions. Therefore hair, nails of a cadaver is kept hundreds of years. The lead of of silk worm (Bombyx die L) is excellent for human clothing and protects the body from various unfavorable environmental actions. An insect wearing the “whole world” with and other insect – Apis mellifera feeding the whole world with honey and propolis. Other insects have become famous in that it have reaced subjects reached research items for General Genetics like Drossofila melanogaster which has a structure including only two chromosomes and allows study of many laws.
The modern biotechnology use some insects of the NOCTUIDAE family to achieve phenomenal organic structures based on which to produce new drugs that may not yet be chemically synthesized (artificially).Obtaining  these products (vaccines, interferons), which can save the lives of many people by using baculovirus that we talked about earlier are specific to arthropods. These viruses have Suprapoliviriocapsids composed of proteins. In the genome of these viruses can be integrated foreign genes responsible for specific synthesis of some protein components. Thus, instead of specific genes for the synthesis of some proteins of supraviriocapsids, can include other genes responsible for synthesis of other proteins (eg a vaccine). So instead of specific protein of   baculovirus to produce another protein ordered by the experimenter.
After long research regarding the viruses that can destroy unwanted organisms, I got the idea that insects can be used against viral, bacterial, fungal and tumor diseases. The idea came when I have known better morphogenesis of viruses and insects.
During morphogenesis insects not only change their morphology (egg, larva, pupae and adult) as well as chemical composition. Lipoprotein complex from insect larvae is lysed by polypeptides, peptides with low molecular weight and specific enzymes and transformed into a protein water insoluble – keratin, chitin and others, wich form pupae and then adults.
This mechanism can be used to stop the multiplication of viruses and to stop the synthesis of tumor diseases. Firstly I tested the extracts on cell culture such as the fibroblastoams specific of human cranium. To my great surprise one of the SBA extracted from insects destroy all tumor cells during 12 hours, even if it was used in extremely small concentrations.
According to these results we tested SBA extracted from insects to certain phases of development, when there are some specific polypeptides and enzymes with ability to transform a lipoprotein complex in an inert substance. These SBA can eliminate carcinomas, melanomas, lipomas and other skin formations. The SBA fom insects influences the multiplication of viruses from cell cultures influences as well as those of the entire human body. We found that some SBA from insects can stop multiplying hepatic viruses, herpes, herpesviruses, papilomoviruses. We believe that the mechanism of action is blocking the active protein synthesis and stop duplicating nucleic acids because SBA was extracted during lipoprotein complex transformations in another protein complex insoluble in water, belonging to species of lepidopteran and coleopterans. Perhaps at this stage there are some enzymes, lipase and specific peptides wich can lysis of a complex lipoproteins. These SBA have been experienced for lipomas, carcinomas, seborrheic warts lisys in humans and animals. Perhaps the SBA, which has properties to lysis lipoprotein complex not only in the insect, but also in vertebrates.
In literature (Chernisi et al) explains this phenomenon by the fact that the SBA from insects would be appeared due to some bacterial infection of the insects, after which produced a specific type of vaccine, which can then be used to treat a tumor or microbial infections.
I think such thinking belongs to specialists who are not familiar with the insect morphogenesis. In this case can not be an action such as special vaccine-induced, but the SBA action from the time of tissue transformation of insects to certain stages of development.
This interpretation is more credible than the synthesis of vaccines, which has a different mechanism of action. In this case, it is likely that the action of inhibitory substances of the type interferon or biological cytostatic (natural) that occur during stopping of cell multiplication in the last stage of larval development. Here is still another mechanism indescribable to anyone. When larval development is finised  it  produces  transformations of lipoproteic complex and synthesis of inert substance – chitin or keratin, which then forms the adult (imago). These biochemical transformations are still too little studied. We believe that there are inhibitors enzymes of protein synthesis soluble in water (Tab.) under the influence of some peptides with low molecular weight, which turns the lipoprotein complex in an inert tissue, from which is, composed adults on insects.
Intuitively, we tested the SBA action extracted from insects belonging to different orders in the last stage of larval development. We tested the insect from order of Lepidopteras, Coleopteras si Dipteras and we found that the SBA has a transforming action of lipoprotein complex in inert substances. These have the same effect in vertebrate’s tissues including human. The tests were performed on subcutaneous lipomas. The SBA extracted from larvae in the last phase of development was tested on subcutaneous lipomas, which have a similar lipoprotein structure with lipoprotein complex of insects larvae.
As a result we managed to turn lipoprotein complex of subcutaneous lipomas, which are eliminated from the body as „foreign bodies” of human being. In this way we managed to perform a „biological surgery” in the world premiere.

We demonstrated that the structure of a subcutaneous lipoma (Fig.) is transformed into other substances that are eliminated by pores (Fig.) and the other by blood. These SBA from insects can lysis other skin formations of the type as skin warts, moles, carcenoamelor, melanomas, corns, etc. astiofits (Fig.). This discovery in the shortest time will be used to produce new preparations to use in the treatment of many diseases of human. Among them most important are treating viral infections and cancer.
Until now these SBA have been patented.  Absolutely new technologies have been elaborated to produce pharmaceutical, parapharmaceutical productsand cosmetics, which will solve many serious problems of the human health.
Some components from insects include large quantities of: Ca, P and Mg which are rapidly absorbed into the body and is fixed in bone. The phenomenon is necessary for humans because the human body loses lately a lot of Ca that because of the intensive use of the analgesics, and this element is not enough to assimilate the necessary balance of calcium in the body.
We have developed a specific technology to extract significant quantities of phosphor from substances secreted by insects to protect eggs wich we can use in preparation of food supplements human required. (M. Ciuhrii Patent N).
The Entomoterapyis an entirely new one for the contemporary medicine, which in the near future would allow the treatment of diseases now considered incurable. Ability to manage vital processes of living organisms would allow an increase in quality and longevity.

INSIGHTS INTO COMPLEMENTARY MEDICINE

First of all I would like to make an understandable communication of what are natural preparations for improving human health. In this sense it is good to know that the man is found in an ecositem structure composed of complex organisms and minerals that permanently interfere with each other. In this biocoenosis, during thousands of  years have been made numerous interactions between all components of nature. Man has become dominant in the world and has made a commitment to conduct many of the laws of nature in his favor. Often, he, the selfishness of the man, never thought about his actions and created negative and excessive comfort living. Rapid scientific and technical progress has led to several mechanisms to obtain energy and to develop a series of processes that have negatively influenced the natural ecosystem. First of all his work led to non-recyclable waste that pollutes natural biocenoses. Who today can really imagine life without electricity, without cars, without food, without modern clothing? There was no turning back. Conscious we are going to excessive environmental pollution and destruction of natural biocenoses. Who really can save us?
Some people believe that there is a rescue, the existence of supernatural forces that continuously monitors us, but what can happen nobody knows. Nobody believed him, the man, who is responsible for what happened, will survive. Now we are threatened by the emergence of a disaster that may occur and we hope that this phenomenon will not touch him – the man.
Currently we are aware that human activity has caused the emergence of many artificial phenomena. Everyone wants to avoid the artificial substances, especially synthetic chemical treatments. Now few are those who can bear the pain, all turning to analgesics. They are aware that they can stop the pain but do not realize that these drugs affect other vital processes and especially that lead to the Elimination of bones, limited longevity. Appeared a number of cancers and viral infections, which regulates the population density of living organisms. We know that man is primarily interested in its existence and then thinks to other living beings like wild animals often disappear completely in the biocoenosis. In this way, discrepancies occur in the food chain that can threaten the very existence of man on Earth. We have many examples of disasters in natural ecosystems caused by the disappearance of natural ecosystems important elements.
Man is not yet aware of the complexity of the interrelationship between natural ecosystems. Everything in this world is a creation of a super man, unconscious influence, unimaginable and we will all disappear, and civilization will be reborn from the beginning in a different form. The question is who will disappear and who will survive? There is probably no law that can imagine the human resoning.
Today man has a tendency to return to nature, is aware that the products of chemical synthesis, adversely affect human health. People want to be treated only with natural substances that are more easily accepted by the body. These natural ingredients are adjusted to regulate vital processes in the body, and they tolerate it more easily in comparison with products of chemical synthesis that man is not fully adapted.
Not all of Earth’s resources have been exhausted. There are still many resources that can intervene in regulating life processes of living beings. One of these sources are invertebrate animals existing on Earth. Until now man has used the resources of nutrients that are most easily obtained. First agricultural plants and vertebrate animals easily obtained from biocoenoses narurale, tamed them for use. Domestic livestock industry has succeeded in creating real products for obtaining nutrients. Who thought is time that some animals become real sources of obtaining food product.Getting these manufacturers  to use various activities to increase production in a much shorter time was a challange. These substances have an effect activating negative consumer body, that of men. Metabolic changes occur or incurable diseases.
The notion of „complementary medicine” can be inferred using other methods of treatment to correct the vital functions of living organisms. Some methods seem strange at first, because at first seem to be uncredited. We must recognize that there are still many phenomena that man still can not understand, nor should they  be ignored. During the evolution of all living things we have changed indirect dependence on external factors and internal action. Following participation in various meetings, conferences and congresses of Complementary Medicine, I believe that there are many physical and psychological actions acting on the human system and can change some physiological states of living organisms. One of these actions I saw it a so-called „witch doctors” who treat any disease with a single method: the patient was placed on a table in the middle of a room. The patient’s head was placed a lighted candle, then place a candle on many toes and hands. „Spook” and he lit a candle and walked around the patient lying on the bed and whispered like prayers. He had bags with chopped herbs and an icon that was placed on the patient’s neck. The procedure takes an hour, after which the patient up and says he feels much better. What happened? The action appears to be a „scam”? But I think there is an explanation, namely the psychological effect on the patient, who felt like a dead man on that bed, with part of a strange ritual. Do such methods can not be used by some medical specialists in medicine?
Another important factor that acts on human health is the environment. In the second half of the twentieth century has increased the pace of industrialization and urbanization, which has led to environmental pollution. Simultaneously increased the radiation, vibration, ultrasound and magnetic waves influence. These factors influenced the physical and chemical structures of biological macro-and micro-organisms with the onset of systemic disorders. Thus, they created conditions for the emergence of new variants of shapes and pathological processes, increased incurable diseases: cancer, autoimmune, metabolic (Tabel.1).

Tabel.1

The influence of physical pathogens
1. A. Cosmic radiation
b. industrial (factories, laboratories)
c. television, radio waves, telephone CNS and autonomic nervous system, endocrine system, vascular, hematopoeza
Oxidative stress
2. A. ultrasound industry (factories)
b. transport (aviation)
c. television, radio CNS systems: neuro-endocrine
3. A. plant vibration
b. CNS transport, autonomic nervous system, neuro-endocrine, endocrine, metabolic
Influence chemical pathogens
1. A. Air pollution
b. plants
c. transport systems: respiratory, cardiovascular, neuro-endocrine, oxidative
2. A. Agricultural fertilizers
b. Allergy pesticides, liver, kidney, impaired neuropsychological
A. food preservation 3.Industria
b. processing at high temperatures
c. repeated processing
d. Allergy smoked products, liver, digestive system disorders and metabolic oncopatologie
4. A. laundry detergents
b. kitchens Allergy, respiratory system, digestive system
Studies of contemporary biological, immunological, developing nuclear technology, have enabled to develop new methods of diagnosis for many diseases, even in the initial stage (scintigraphy, CT scan, MRI, densitometry, etc.). Parallel to these harmful factors found to increase the level of another order – increasing energy cosmic, volcanic activity, landslides and many others that have greatly influenced the defense system and accommodation.
Thus, the S & T development has allowed the elucidation of mechanisms of disease-modifying and diagnosis of many, but have created favorable conditions for increasing the frequency of incurable diseases: tumors, autoimmune diseases, diabetes was
If we compare the clinical medicine from the past and present, then we will not notice much difference (Tabel.2).

Tabel.2

In the past Today
Factors aetiopathogenetic
Microbial and viral infections viral infections
Improper diet physical strain
Extensive supercooling radiation, vibration, ultrasound
Sedentary way of life
Diseases
Plague Cancer
Cardiovascular disease cholera
Polio autoimmune diseases, systemic vasculitis
Diabetes Tuberculosis
AIDS Syphilis
Brucellosis-infectious reactive arthritis
Rheumatic fever neuro-psychic disorders, drug abuse
Osteoporosis systemic infections in children
50% = 50%
Contemporary environmental factors prone to immune disorders specific and nonspecific appearance, are increasing the frequency of mutations hereditary and non-hereditary.
The evolution of these factors manifested by the appearance and rapid progression of many disturbances in cellular and molecular evolution of clinical and nonspecific changes of internal diseases in general and in particular rheumatic (rheumatic fever, tuberculosis, infectious pneumonia, etc..).
New times, new generation, new diseases.
Because these internal and external harmful factors influenced the ongoing evolution of defense systems and accommodation, will continue to develop new modifed  mechanisms.
If the beginning of last century was marked by domination of infectious diseases, TB, half a century, the discovery of antibiotics alter disease spectrum. Considerable reduction in the share of infectious diseases has been replaced, but the increased incidence of diseases with a new clinical aspects, including contagious. Discrete clinical variants have emerged, with lower activity, but with developments train, infectious clinical forms reactive, when the inflammatory process are the focus away from infectious – infectious arthritis reactive with primary outbreak respiratory, gastrointestinal, urogenital to
Later, in 1970-1980 there was an increased incidence of autoimmune diseases (RA, SLE, etc.), cerebrovascular disease, diabetes mellitus, obesity, osteoporosis, etc. systemic.
Industrialization and automation of work, sedentary lifestyle promotes chronic hypoxia followed by increasing phenomenon of ischemic disorders and, therefore, unbalanced oxidation-reduction processes. Increased levels of free radicals is one of the factors that cause chronic poisoning and development of many diseases: cardiovascular, cerebrovascular, cancer and metabolic disorders.
Mentioned pathogenetic factors influenced the emergence of pathogenic mechanisms transforming us unhealthy. Thus rheumatism (rheumatic fever) gradually changed so much that in 1970-1980 we were eliminating many specialized centers and departments, even though the number of patients presenting rheumatic valvular surgery  not only increased in our country but also in developed countries. It was found that in children, rheumatic fever, now, often solitary evolving myocardial damage without fibrous changes occur often in the absence of pain syndrome. Valve damage in these patients is highlighted in subsequent recurrences 20-30 years old and insufficient flow is detected and the later at 40-50 years. Disease progression is often associated with a distinct change indicilorlor laboratory.
Because defense systems and accommodation are under strict control of neuroendocrine system, it is obvious that, under the influence of harmful factors, first there will be a response to changes in the neuroimun T lymphocyte subpopulations, activation of natural killers, B lymphocytes, interleukins, TNFa, IF.
Harmful physical and chemical factors, acute and chronic stress have greatly influenced the functional status of central nervous system and neurovegetative and have led many neuropsychiatric disorders that call for more use of psychotropic drugs and, therefore, lead to farmacomanie, drug abuse and addiction. Each drug affects more or less toxic. Possess drug action directed against a specific pathogenic agent or mechanism. But the process often initiates and develops under the influence of several factors and can occur while patients and other diseases, especially those of advanced age. In these cases, drug therapy will have partial effect.
Pathogenic action of harmful factors leads to further disorder in defensive systems, loss of differentiation capacity of self and non-self structures. Excessive increase of apoptosis further aggravate this phenomenon, because similar protein increases foreign substances. Therefore, self harm system is activated with the development of autoimmune diseases especially in the presence of a favorable genetic field.
Acute and chronic stress, which in recent decades has increased from several causes: social problems, sudden drop in socio-economic levels, job losses, armed conflicts, etc., a negative influence on the body’s adaptive systems were altered biorhythms, which likely further to the development of numerous pathologies. Currently, physical inactivity is explained thru the  condition of chronic stress when the body’s physiological systems are subject to a slow activity.
Most works devoted studying the mechanisms of development of pathological processes are aimed at highlighting the disorders caused by a pathogen and is rarely taken into account comorbidities phenomenon without clinical manifestations, such as the presence of viral infections in persons of advanced age, or the detection of immunological disorders in patients with osteoarthritis. Administration of medication, especially at high doses for a long time, can often complicate the process, causing different reactions and the body defenses and accommodation imposible. Against this background, can take place activation of pathological processes, which were inactive up to treatment.
Evolution of chronic inflammatory diseases or degenerative-dystrophy is frequently associated with the influence of new pathogens that remain unidentified. These cases are frequently observed in sporadic outbreaks of viral infections.
Not applicable to analyze the situation and drug administration is more appropriate when additional treatment is required. We emphasize that most disease therapy should be given comprehensive treatment.
Doctors today often forget to mention diet recommendations that are a necessary detail to emphasize the importance of physical activity regime and intellectual, mental status, emotional patient. These recommendations have now very great importance, because they are necessary to neutralize the action of harmful agents that we are surrounded. Sometimes a thorough examination reveals no organic medical disorders, finally admits that the patient only needs rest, proper food, quiet, resting in fresh air and some recommendations from the alternative medicine: herbal extracts, fruits, vegetables and honey bee. Thus, consciously or unconsciously, recognize or not the patient is often treated by complementary methods. If so, then the need for physicians to study more deeply the mechanism of action of many complementary methods of treatment, both sides emphasized the positive, and the negative of these methods (poisoning, allergy, infection, etc.), not  begginer who  give these treatment modalities.
In chronic inflammatory diseases and degenerative rheumatic – efficacy is provided to 70% of complementary therapies and about 30% of drug therapy.
Common chronic inflammatory and degenerative rheumatic actions inevitably require pairing complementary therapies.
Safety of complementary methods allows their use on large and long lasting.
The priorities of these methods: 1) smoother action, 2) are easier to select, 3) there are rarely contraindications, 4) can be easily customized, 5) lead to serious side effects, 6) can be used for a long time.
Most complementary methods of treatment were selected, analyzed and perfected during hundreds and thousands of years and remained the treating and also less harmful.
Association of several diseases, especially in the elderly the same persons, determine the need for complex treatment. In these cases polipragmaziei risk. Such combinations may result in multiple chemical reactions to evolution unpredictable toxic, often fatal. In such a situation, non-drug methods associated welcomed.
In this way, today there are sufficient arguments for the opportunity of applying the different methods in complex so-called alternative treatment. It can not be accepted absolutely negative attitude of doctors towards such alternatives. Besides not using them, not necessarily for the good of the patient, and denies the need to study these possibilities. Thus, neglect and denial of various medications traditional Kir, makes the field to escape the sight medical professionals, scientists and becomes a sphere of operation of various amateur, not just well intentioned.
Complementary therapies (CT) includes a number of methods of treatment, some of which until now were not appreciated and were not investigated in the scientific community.
Currently, these methods occupy a special place in the treatment of various rheumatic, neurological, dermatological, particularly chronic. Expenses for these methods of treatment were 10.3 billion U.S. dollars for one year only (1990), of which 3 billion dollars back treatment of arthritis patients (Alan R. Erickson, MD, 1999).
Number of patients who were treated with various complementary methods is about 90%. It is not patient who has not used diet therapy, psychotherapy or hydrotherapy. Attitude towards traditional medicine in different countries is different. Thus, acupuncture – the method practiced and studied for thousands of years in China with excellent results in 90% of patients, in the opinion of American authors. Approximately the same divergence occurred in the use of different plants – depending on geographical area, soil composition, amount of solar energy and more. Thus, complementary therapies in Europe clearly differ from the Chinese japoneje, Australia.
Therefore, those methods should be used complementary therapy, native who studied, analyzed in the application area, experienced in the treatment of patients with disease diagnosed similane.
We emphasize that the patients are informed about ways complementary surface, use them extensively, often incorrectly, without consulting with doctors who, in fact he did not know any better, the cause may be some side effect of unwanted or missing.
External or internal substances used have certain indications or contraindications. Therefore, practitioners have a duty to study more profoundly different treatment alternatives to achieve a more rigorous monitoring of patients.
Only training doctors in the study of complementary therapies practicienti, achieving tight control in terms of their use will allow their correct indication. There will be reduced when self-treatment, with results at least zero (Table 3).
The truth is that this list does not reveal the science of many complementary methods of treatment that have already successfully implemented in medical practice.
Legitimizing the action of ambient natural factors is clear from the very pro-and ontogenesis. Body in its historical development and individual life is closely linked to the external environment and form an integral whole with them. Old etiopathogenesis of many diseases (gout, rheumatic fever) under the influence of harmful aggressive contemporary change – appeared allergic disorders, autoimmune, so older methods of treatment should be studied again at a higher scientific level.

Complementary therapies and their levels MAIN ACTION

Acts primarily THERAPY LEVEL MEANS
1. Psychotherapy  1. Hypnosis
2. Autosuggestion
3. a positive thinking. CNS, autonomic nervous system
2. neuroendocrine system 3. immunity
4. oxidation and antioxidant systems
5. bioenergy
2. A diet therapy. diet
2. composition
3. Preparation 1. digestive system
2. cardiovascular system
3. metabolism 4. immunity
5. oxidation and antioxidant
6. urinary system
3. Balneotherapy 1. mineral waters and thermal mud 1. neuro-vegetative system
2. neuro-endocrine system
3. muscle system, joint
4. skin system 5. digestive system
6. cardiovascular system
7. metabolism
8. immunity
4. Physiotherapy 1. electrostimulation
2. magnitoterapie
3. laser therapy
4. ultrasound
5. using light
6. Electrophoresis
7. UV 1. CNS vegetative peripheral
2. joint system, musculo-axial
3. skin system 5. cardiovascular system
6. metabolism
7. oxidation and antioxidant
8. immunity
5. Physical Therapy 1. gymnastics
2. swimming
3. a physical activity. CNS vegetative peripheral
2. respiratory system
3. cardiovascular system
4. digestive system 5. muscle system, joint
6. metabolism
7. oxidation and antioxidant systems
6. The method is based on acupuncture theory nerve reflex areas; actionandu on their track, it can produce analgesia and even improve the function of organs. 1. CNS vegetative peripheral
2. cardiovascular system
Respiratory 3.sistemul
4. digestive system
5. Urinary system 6. muscle system, joint
7. endocrine system
8. immunity
9. metabolism
10. oxidation and antioxidant systems
7. Phytotherapy 1. herbal medicines
2. use of plant extracts
3. Aromatherapy 1. CNS vegetative peripheral
2. cardiovascular system
Respiratory 3.sistemul
4. Digestive system
5. Urinary system 6. muscle system, joint
7. Endocrine system
8. Immunity
9. Metabolism
10. Oxidation and antioxidant systems
8. Climatic (speleotherapy) 1. sunlight
2. Mountain air

3. A maritime climate. respiratory system
2. Cardiovascular system
3. CNS, autonomic, peripheral 4. muscle system, joint
5. Metabolism
6. Oxidation  and antioxidant
9. Faunoterapie extracts obtained from various organs and animal remedies
10. CNS neuro-vegetative system
2. Cardiovascular system
3. Digestive system
4. Urinary system 5. metabolism
6. Immunity
7. Oxidation and antioxidant system
10. Entomoterapie use an insect extracts. vascular system
2. Immune system
3. Digestive system (hepar)
4. Urinary system (prostate)
5. Skin system
6.  Joint system, axial
11.  Application flow ionoplasma Ionoplasmoterapie skin surfaces of affected areas and a reflector. CNS vegetative peripheral
2. Endocrine system
3. Vascular system
4. Joint system, axial 5. Muscular system
6. Skin system
7. Metabolism

12. Homeopathy use extremely small doses of substances with actions that evoke similar symptoms a disease. CNS neuro-vegetative
2. Neuro-endocrine 3. Vascular
4. Respiratory
5. immune
Natural physical and chemical factors, which in evolutionary reflex became irritating to the body, acting phylogenetic and ontogenetic processes continuously become irritable reflector humoral factors influencing conditioned, to endocrine One of the older systems is the cutaneous receptors which makes tactical perceptions, temperature, pain. In evolutionary processes, as a result of central and peripheral nervous system development, developed and strictly differentiated receptor system and due to their biological reactions responded to the action of various chemicals, under appropriate physical differential perception. Specific factors acting directly at this level physiotherapy, balneology, climatic to
Alternative therapies include a large number of therapeutic methods (over 20) with different characteristics. Whatever the definition of complementary therapies, it can not reflect the essence of these methods, different by origin and plant products, animals and the insects or their analogues.
Most of complementary methods have been studied empirically. Throughout the millennia has been improved and remained only those with higher efficiency without adverse effects. Banning these methods of treatment, unrecognized, will increase the adverse results, because patients will continue to use these methods unsupervised professionals. Osteoporosis

-Some parts of large quantities of insects include: Ca, P and Mg which are rapidly absorbed into the body and is fixed in bone. This is necessary for humans because the human body loses lately than that due to intensive use analgeticelor, and this element is not enough to assimilate the necessary balance of Ca in the body.
Another phenomenon is very common in the population memory loss at age 40-50 years, when the man goes from one room to another and look what came. We have developed a specific technology to extract significant amounts fosphorului substances secreted by insects to protect eggs and we can use in preparing the necessary supplements human (M. Ciuhrii Patent N).
Entomoterapia is an entirely new one for contemporary medicine, which will allow future treatment of diseases now considered incurable. Posibilitarea leading the life processes of living organisms will allow an increase in quality and longevity ..

Insights into Complementary Medicine

I would like first to make an understandable communication of what is natural preparations for improving human health. In this sense it is good to know that the man is found in a ecositem structure consists of complex organisms and minerals that permanently interfere with each other. In these biocoenosis, during thousands of years, have made numerous interactions between all parts of nature. Man has become dominant in the world and has committed to conduct many of the laws of nature in his favor. Often, he, the selfishness of man, never thought about his actions and has created negative and excessive comfort of living. Rapid scientific and technical progress led to several mechanisms to obtain energy and to develop a series of processes that have influenced negatively the natural ecosystem. First of all his work led to the non-recyclable waste, which pollutes the natural biocoenoses. Who today can really imagine life without electricity, without cars, without food, without clothes modern? There was no turning back. Aware we head towards excessive environmental pollution and destruction of natural biocenoses. Who did we save?
Some believe there is a rescue, the existence of supernatural forces that continuously monitors us, but what can happen nobody knows. Nobody thinks he man who is guilty of what happened, will survive. Now we are threatened by the emergence of a disaster that may occur and we hope that this phenomenon will not touch it – man.
Currently we are aware that human activity has led to many artificial phenomena. Everyone wants to avoid the artificial substances, especially synthetic treatments chimica.Acum few are those who can bear the pain, all resort to analgesics. They are aware that they can stop the pain but do not realize that these drugs affect other vital processes and especially that lead to the Elimination of bones, limited longevity. Appeared a number of cancers and viral infections, which regulates the population density of living organisms. It is known that man is primarily interested in its existence and then thinks to other living beings such as wild animals often disappear completely from biocoenosis. In this way, discrepancies occur in the food chain that can threaten the very existence of man on Earth. We have many examples of disasters on natural ecosystems caused by the disappearance of natural ecosystems important elements.
Man is not yet aware of the complexity of the interrelationship between natural ecosystems. Everything in this world is a creation of a super man unconscious influences unimaginable and if this creation, we will all disappear, and civilization will be reborn from the beginning in a different form. The question is who will disappear and who will survive? There are probably still unimaginable here a law of human reason.
Today man has a tendency to return to nature, is aware that the products of chemical synthesis, adversely affect human health. The human afectiunele wants to be treated only with natural substances that are more easily accepted by the body. These natural ingredients are adjusted to regulate vital processes in the body, and they tolerate it more easily in comparison with products of chemical synthesis that man is not fully adapted.
Not all of Earth’s resources have been exhausted. There are still many resources that can intervene in regulating life processes of living beings. One of these sources are invertebrate animals existing on Earth. Until now man has used the resources of nutrients that are most easily obtained. First agricultural plants and vertebrate animals easily obtained from biocoenoses narurale, tamed them for use. Domestic livestock industry has succeeded in creating real products for obtaining nutrients. Who thought it about time that some animals can become real sources of obtaining food products alimentare.Pentru getting these manufacturers use various activities to increase, that increase production in a much shorter time. These substances have an effect activating negative consumer body, that of men. Metabolic changes occur or incurable diseases.
The notion of „complementary medicine” can be inferred using other methods of treatment to correct the vital functions of living organisms. Some methods seem strange at first, because at first seem to be uncredited. We must recognize that there are still many phenomena that man still can not understand, nor should they ignored by fel. During the evolution of all living things have changed in direct dependence on external factors and internal action. Following participation in various meetings, conferences and congresses of Complementary Medicine, I believe that there are many physical and psychological actions acting on the human system and can change some physiological states of living organisms. One of these actions I saw in a so-called „witch doctors” who treat any disease with a single method: the patient was placed on a table in the middle of a room. The patient’s head was placed a lighted candle, then place a candle on many toes and hands. „Spook” and he lit a candle and walked around the patient lying on the bed and whispered like prayers. He had bags with chopped herbs and an icon that was placed on the patient’s neck. The procedure takes an hour, after which the patient up and says he feels much better. What happened? The action appears to be a „scam”? But I think there is an explanation, namely the psychological effect on the patient, who felt like a dead man on that bed, with part of a strange ritual. Do such methods can not be used by some medical specialists in medicine?
Another important factor that acts on human health is the environment. In the second half of the twentieth century have increased the pace of industrialization and urbanization, which has led to environmental pollution. Simultaneously increased the radiation, vibration, ultrasound and magnetic waves influence. These factors influenced the physical and chemical structures of biological macro-and micro-organisms with the onset of systemic disorders. Thus, they created conditions for the emergence of new variants of shapes and pathological processes, increased incurable diseases: cancer, autoimmune, metabolic (Tabel.1).

Tabel.1

The influence of physical pathogens
1. A. Cosmic radiation
b. industrial (factories, laboratories)
c. television, radio waves, telephone CNS and autonomic nervous system, endocrine system, vascular, hematopoeza
Oxidative stress
2. A. ultrasound industry (factories)
b. transport (aviation)
c. television, radio CNS systems: neuro-endocrine
3. A. plant vibration
b. CNS transport, autonomic nervous system, neuro-endocrine, endocrine, metabolic
Influence chemical pathogens
1. A. Air pollution
b. plants
c. transport systems: respiratory, cardiovascular, neuro-endocrine, oxidative
2. A. Agricultural fertilizers
b. Allergy pesticides, liver, kidney, impaired neuropsychological
A. food preservation 3.Industria
b. processing at high temperatures
c. repeated processing
d. Allergy smoked products, liver, digestive system disorders and metabolic oncopatologie
4. A. laundry detergents
b. kitchens Allergy, respiratory system, digestive system
Studies of contemporary biological, immunological, developing nuclear technology, have enabled to develop new methods of diagnosis for many diseases, even in the initial stage (scintigraphy, CT scan, MRI, densitometry, etc.). Parallel to these harmful factors found to increase the level of another order – increasing energy cosmic, volcanic activity, landslides and many others that have greatly influenced the defense system and accommodation.
Thus, the S & T development has allowed the elucidation of mechanisms of disease-modifying and diagnosis of many, but have created favorable conditions for increasing the frequency of incurable diseases: tumors, autoimmune diseases, diabetes was
If we compare the clinical medicine of the past and present, then we will not notice much difference (Tabel.2).

Tabel.2

In the past Today
Factors aetiopathogenetic
Microbial and viral infections viral infections
Improper diet physical strain
Extensive supercooling radiation, vibration, ultrasound
Sedentary way of life
Diseases
Plague Cancer
Cardiovascular disease cholera
Polio autoimmune diseases, systemic vasculitis
Diabetes Tuberculosis
AIDS Syphilis
Brucellosis-infectious reactive arthritis
Rheumatic fever neuro-psychic disorders, drug abuse
Osteoporosis systemic infections in children
50% = 50%
Contemporary environmental factors prone to immune disorders specific and nonspecific appearance, to increase the frequency of mutations in hereditary and non-hereditary.
The evolution of these factors manifested by the appearance and rapid progression of many disturbances in cellular and molecular evolution of clinical and nonspecific changes of internal diseases in general and in particular rheumatic (rheumatic fever, tuberculosis, infectious pneumonia, etc..).
New times, new generation, new diseases.
Because these internal and external harmful factors influenced the ongoing evolution of defense systems and accommodation, will continue to develop new mechanisms-modifying.
If the beginning of last century was marked by domination of infectious diseases, TB, half a century, the discovery of antibiotics alter disease spectrum. Considerable reduction in the share of infectious diseases has been replaced, but the increased incidence of diseases with a new clinical aspects, including contagious. Discrete clinical variants have emerged, with lower activity, but with developments train, infectious clinical forms reactive, when the inflammatory process are the focus away from infectious – infectious arthritis reactive with primary outbreak respiratory, gastrointestinal, urogenital to
Later, in 1970-1980 there was an increased incidence of autoimmune diseases (RA, SLE, etc.), cerebrovascular disease then, diabetes mellitus, obesity, osteoporosis, etc. systemic.
Industrialization and automation of work, sedentary lifestyle promotes chronic hypoxia followed by increasing phenomenon of ischemic disorders and, therefore, unbalanced oxidation-reduction processes. Increased levels of free radicals is one of the factors that cause chronic poisoning and development of many diseases: cardiovascular, cerebrovascular, cancer and metabolic disorders.
Mentioned pathogenetic factors influenced the emergence of pathogenic mechanisms transforming unhealthy us. Thus rheumatism (rheumatic fever) gradually changed so much that in 1970-1980 were liquidated many specialized centers and departments, however, grudgingly, the number of patients presenting rheumatic valvular surgery and require not only increased in our country but also in developed countries. It was found that in children, rheumatic fever, now, often solitary evolving myocardial damage without fibrous changes occur often in the absence of pain syndrome. Valve damage in these patients is highlighted in subsequent recurrences 20-30 years old and insufficient flow is detected and the later at 40-50 years. Disease progression is often associated with a distinct change indicilorlor laboratory.
Because defense systems and accommodation are under strict control of neuroendocrine system, it is obvious that, under the influence of harmful factors, first there will be a response to changes in the neuroimun T lymphocyte subpopulations, activation of natural killers, B lymphocytes, interleukins, TNFa, IF.
Harmful physical and chemical factors, acute and chronic stress have greatly influenced the functional status of central nervous system and neurovegetative and have led many neuropsychiatric disorders that call for more use of psychotropic drugs and, therefore, lead to farmacomanie, drug abuse and addiction. Each drug affects more or less toxic. Possess drug action directed against a specific pathogenic agent or mechanism. But the process often initiates and develops under the influence of several factors and can occur while patients and other diseases, especially those of advanced age. In these cases, drug therapy will have partial effect.
Pathogenic action of harmful factors leads to further disorder in defensive systems, loss of differentiation capacity of self and non-self structures. Excessive increase of apoptosis further aggravate this phenomenon, because similar protein increases foreign substances. Therefore, self harm system is activated with the development of autoimmune diseases especially in the presence of a favorable genetic field.
Acute and chronic stress, which in recent decades has increased from several causes: social problems, sudden drop in socio-economic levels, job losses, armed conflicts, etc., a negative influence on the body’s adaptive systems were altered biorhythms, which likely further to the development of numerous pathologies. Currently, physical inactivity is estimated that chronic stress condition when the body’s physiological systems are subject to a slow activity.
Most works devoted to studying the mechanisms of development of pathological processes are aimed at highlighting the disorders caused by a pathogen and is rarely taken into account comorbidities phenomenon without clinical manifestations, such as the presence of viral infections in persons of advanced age, or the detection of immunological disorders in patients with osteoarthritis. Administration of medication, especially at high doses for a long time, can often complicate the process, causing aberrant reactions occur and other body defenses and accommodation. Against this background, can take place activation of pathological processes, which were inactive up to treatment.
Evolution of chronic inflammatory diseases or degenerative-dystrophy is frequently associated with the influence of new pathogens that remain unidentified. These cases are frequently observed in sporadic outbreaks of viral infections.
Not applicable to analyze the situation and Drug Administration is more appropriate when additional treatment is required. We emphasize that most disease therapy should be given comprehensive treatment.
Doctors today often forget to mention diet recommendations necessary detail to emphasize the importance of physical activity regime and intellectual, mental status, emotional patient. These recommendations have now very great importance, because they are necessary to neutralize the action of harmful agents that we are surrounded. Sometimes a thorough examination reveals no organic medical disorders, finally admits that the patient only needs rest, proper food, quiet, resting in fresh air and some recommendations from the alternative medicine: herbal extracts, fruits, vegetables and honey bee. Thus, consciously or unconsciously, recognize or not the patient is often treated by complementary methods. If so, then the need for physicians to study more deeply the mechanism of action of many complementary methods of treatment, both sides emphasized the positive, and the negative of these methods (poisoning, allergy, infection, etc.), not diletantilor give these treatment modalities.
In chronic inflammatory diseases and degenerative rheumatic – efficacy is provided to 70% of complementary therapies and about 30% of drug therapy.
Common chronic inflammatory and degenerative rheumatic actions inevitably require pairing complementary therapies.
Safety of complementary methods allows their use on large and long lasting.
The priorities of these methods: 1) smoother action, 2) are easier to select, 3) there are rarely contraindications, 4) can be easily customized, 5) lead to serious side effects, 6) can be used for a long time.
Most complementary methods of treatment were selected, analyzed and perfected during hundreds and thousands of years and remained the treating and also less harmful.
Association of several diseases, especially in the elderly the same persons, determine the need for complex treatment. In these cases polipragmaziei risk. Such combinations may result in multiple chemical reactions to evolution unpredictable toxic, often fatal. In such a situation, non-drug methods associated welcomed.
In this way, today there are sufficient arguments for the opportunity of applying the different methods in complex so-called alternative treatment. It can not be accepted absolutely negative attitude of doctors towards such alternatives. Besides not using them, not necessarily for the good of the patient, and denies the need to study these possibilities. Thus, neglect and denial of various medications traditional Kir, makes the field to escape the sight medical professionals, scientists and becomes a sphere of operation of various amateur, not just well intentioned.
Complementary therapies (CT) includes a number of methods of treatment, some of which until now were not appreciated and were not investigated in the scientific community.
Currently, these methods occupy a special place in the treatment of various rheumatic, neurological, dermatological, particularly chronic. Expenses for these methods of treatment were 10.3 billion U.S. dollars for one year only (1990), of which 3 billion dollars back treatment of arthritis patients (Alan R. Erickson, MD, 1999).
Number of patients who were treated with various complementary methods is about 90%. It is not patient who has not used diet therapy, psychotherapy or hydrotherapy. Attitude towards traditional medicine in different countries is different. Thus, acupuncture – the method practiced and studied for thousands of years in China with excellent results in 90% of patients, in the opinion of American authors. Approximately the same divergence occurred in the use of different plants – depending on geographical area, soil composition, amount of solar energy and more. Thus, complementary therapies in Europe clearly differ from the Chinese japoneje, Australia.
Therefore, those methods should be used complementary therapy, native who studied, analyzed in the application area, experienced in the treatment of patients with disease diagnosed similane.
We emphasize that the patients are informed about ways complementary surface, use them extensively, often incorrectly, without consulting with doctors who, in fact he did not know any better, the cause may be some side effect of unwanted or missing.
External or internal substances used have certain indications or contraindications. Therefore, practitioners have a duty to study more profoundly different treatment alternatives to achieve a more rigorous monitoring of patients.
Only training doctors in the study of complementary therapies practicienti, achieving tight control in terms of their use will allow their correct indication. There will be reduced when self-treatment, with results at least zero (Table 3).
The truth is that this list does not reveal the science of many complementary methods of treatment that have already successfully implemented in medical practice.
Legitimizing the action of ambient natural factors is clear from the very pro-and ontogenesis. Body in its historical development and individual life is closely linked to the external environment and form an integral whole with them. Old etiopathogenesis of many diseases (gout, rheumatic fever) under the influence of harmful aggressive contemporary change – appeared allergic disorders, autoimmune, so older methods of treatment should be studied again at a higher scientific level.

Complementary therapies and their levels MAIN ACTION

Acts primarily THERAPY LEVEL MEANS
1. Psychotherapy 1. hypnosis
2. autosuggestion
3. a positive thinking. CNS, autonomic nervous system
2. neuroendocrine system 3. immunity
4. oxidation and antioxidant systems
5. bioenergy
2. A diet therapy. diet
2. composition
3. Preparation 1. digestive system
2. cardiovascular system
3. metabolism 4. immunity
5. oxidation and antioxidant
6. urinary system
3. Balneotherapy 1. mineral waters and thermal mud 1. neuro-vegetative system
2. neuro-endocrine system
3. muscle system, joint
4. skin system 5. digestive system
6. cardiovascular system
7. metabolism
8. immunity
4. Physiotherapy 1. electrostimulation
2. magnitoterapie
3. laser therapy
4. ultrasound
5. using light
6. Electrophoresis
7. UV 1. CNS vegetative peripheral
2. joint system, musculo-axial
3. skin system 5. cardiovascular system
6. metabolism
7. oxidation and antioxidant
8. immunity
5. Physical Therapy 1. gymnastics
2. swimming
3. a physical activity. CNS vegetative peripheral
2. respiratory system
3. cardiovascular system
4. digestive system 5. muscle system, joint
6. metabolism
7. oxidation and antioxidant systems
6. The method is based on acupuncture theory nerve reflex areas; actionandu on their track, it can produce analgesia and even improve the function of organs. 1. CNS vegetative peripheral
2. cardiovascular system
Respiratory 3.sistemul
4. digestive system
5. Urinary system 6. muscle system, joint
7. endocrine system
8. immunity
9. metabolism
10. oxidation and antioxidant systems
7. Phytotherapy 1. herbal medicines
2. use of plant extracts
3. Aromatherapy 1. CNS vegetative peripheral
2. cardiovascular system
Respiratory 3.sistemul
4. digestive system
5. Urinary system 6. muscle system, joint
7. endocrine system
8. immunity
9. metabolism
10. oxidation and antioxidant systems
8. Climatic (speleotherapy) 1. sunlight
2. mountain air
3. a maritime climate. respiratory system
2. cardiovascular system
3. CNS, autonomic, peripheral 4. muscle system, joint
5. metabolism
6. oxidation and antioxidant
9. Faunoterapie extracts obtained from various organs and animal remedies 1. CNS neuro-vegetative system
2. cardiovascular system
3. digestive system
4. Urinary system 5. metabolism
6. immunity
7. oxidation and antioxidant system
10. Entomoterapie use an insect extracts. vascular system
2. immune system
3. digestive system (hepar) 4. urinary system (prostate)
5. skin system
6. joint system, axial
11. Application flow ionoplasma Ionoplasmoterapie skin surfaces of affected areas and a reflector. CNS vegetative peripheral
2. endocrine system
3. vascular system
4. joint system, axial 5. muscular system
6. skin system
7. metabolism

12. Homeopathy use extremely small doses of substances with actions that evoke similar symptoms a disease. CNS neuro-vegetative
2. neuro-endocrine 3. vascular
4. respiratory
5. immune
Natural physical and chemical factors, which in evolutionary reflex became irritating to the body, acting phylogenetic and ontogenetic processes continuously become irritable reflector humoral factors influencing conditioned, to endocrine One of the older systems is the cutaneous receptors which makes tactical perceptions, temperature, pain. In evolutionary processes, as a result of central and peripheral nervous system development, developed and strictly differentiated receptor system and due to their biological reactions responded to the action of various chemicals, under appropriate physical differential perception. Specific factors acting directly at this level physiotherapy, balneology, climatic to
Alternative therapies include a large number of therapeutic methods (over 20) with different characteristics. Whatever the definition of complementary therapies, it can not reflect the essence of these methods, different by origin and plant products, animals and the insects or their analogues.
Most of complementary methods have been studied empirically. Throughout the millennia has been improved and remained only those with higher efficiency without adverse effects. Banning these methods of treatment, unrecognized, will increase the adverse results, because patients will continue to use these methods unsupervised professionals. Osteoporosis
severity, and incidence of osteoporosis are higher in countries where they eat foods high in protein, especially dairy products.
It was reported that the Eskimos, who consume large amounts of fish and bones, the amount of calcium consumed daily reach up to 2500 mg, and protein intake to 200-400 grams. Excessive consumption of animal protein causes osteoporosis, because calcium loss in large quantities. Thus, diets rich in animal protein lowers bone tissue and develop osteoporosis.
Nutrition rich in animal protein, sulfur-containing amino acids, prone to blood acidification. Because blood must have an alkaline pH, the acidity that is neutralized by the accumulation of calcium in the bones, then eliminated through urine. Such is osteoporosis. In case of excess amino acids, liver enzymes break down some substances to urea, which acts as a diuretic, eliminating liquid and minerals. In bone tissue production of nitric oxide in this matter, but decreases production of urea increased the oxide.
The display can be confirmed by the following examples: it was found that in some areas of Africa where the dietary calcium consumed reaches 200 mg / day, hip fractures are the rarest in the world, while the Eskimos, using 2000 mg daily calcium, osteoporotic fractures are most common in the world.
Risk factors for osteoporosis
1. Hereditary factors – transmission from mother to daughter. In these women the risk of fracture is two times higher.
2. Sedentary way of life
3. The use of increased amounts of coffee per day (1.5 cup of coffee)
4. Increased use of animal protein increases the risk of hip fractures
5. Alcohol
6. Insufficient exposure to sunlight
7. Anticonvulsant drugs, antidepressants – doubles the risk of hip fractures.

Normal use of calcium and protein using relatively small amounts up to 30 years decreases the risk of osteoporosis.
After the data authors (Jan Mayer, 1999) – Increased intake of potassium and magnesium in foods that contain vegetarian, lead to increased bone density in elderly men.
Absorption of Ca + + from plant products is much higher than that of milk, of which 70-90% of Ca + + does not absorb. His report found that dietary phosphorus / calcium more than 2 leads to loss of calcium and so on osteoporosis.
In people who consume large amounts of protein risk of kidney stones is 33% (Harvard University). The U.S. recorded the highest consumption of animal protein, and the number of malignant lymphomas is highest.
Large amount of protein in the diet lowers the number of cells so-called „killer” cells that destroy foreign body and the cancer. 30% of diabetic patients who are treated with insulin is kidney failure. Recommended amount of 40 g protein / day allows progression of diabetic nephropathy.
Many sources, including information received from German researchers, reported that sausages and smoked meats containing high salt (100g contains 5-6 g of salt) favors the appearance of hypertension, gastric cancer and osteoporosis. For sausages and other meat products have beautiful color, appetizing add nitrates and nitrites. But the reaction between nitrites and amines form nitrosamines, some – which is supposed to be carcinogenic. Favors production of nitrosamines above 1000C. Sausages and smoked meats contain highly carcinogenic polycyclic aromatic hydrocarbons. These hydrocarbons are formed in meat roasted, grilled, in stews. It turned out that in Iceland, where they eat much meat and smoked fish, the number of people with digestive tract cancer is much higher than in Europe. Studies have shown for decades that temperatures above 1000C in food preparation have meat to the formation of mutagenic compounds pronounced capabilities comparable to those of benzipirenului. Meats rich in polyunsaturated fatty acids omega-G promotes inflammation, thrombosis and vasoconstriction. Arachidonic acid is the main provider of fatty acids as animal proteins (meat, eggs, cheese), which contain arachidonic acid, are the source of polyunsaturated fatty acids omega-G. Last antinflamatorii matter in chronic vascular mechanisms.
Japanese sources reported that after some epidemiological studies have found a potent carcinogenic heterocyclic amines in meats and fish that appear prepared at high temperatures. Were identified over 20 mutagenic or carcinogenic amines. Heterocyclic amines are precursors: Creatine, peptides, amino acids, proteins and sugars.
In Uruguay the amount of per capita meat consumption is highest in the world, but are the most common malignancies. A special interest presents studies by the National Cancer Institute (1998, USA) where 41 836 women were examined. It was found that the women who used the meat prepared by the action of high temperatures and well done, the risk of cancer was 4-6 times higher than women who ate meat less exposed to high temperatures.
It was confirmed that fish oil increases diabetes, blood glucose, as eicosapentaenoic acid reduces the secretion of insulin. For example, the Eskimos, whose diet is rich in fish, are more cerebral bleeding.
Increasing oil content leads to excessive growth of vitamin A and D – which are toxic and lower levels of vitamin E. It was found that foodstuff poisoning caused 15 times more frequently than the products over meat. Over 200 products containing toxic chemicals including: mercury, pesticides and dioxins.
In Japan it was observed that the population that uses products from fish, mercury levels in children is much higher in the umbilical cord. These children have reduced memory and attention. Tumors are frequently found in the population that uses fish products because fish contain more pesticides than fruits, vegetables, cereals.
Data studies in several countries have found that populations who consume mostly carbohydrates (70-80%) do not suffer from degenerative disease: high cholesterol, hypertension, diabetes, obesity.
Studies have shown that the use of latest high amounts of carbohydrates promotes protein synthesis. Animal products are free of carbohydrates, except for milk which contains lactose mammals. Carbohydrates are composed of plant monosaccharides (glucose, fructose, galactose, lactose), disaccharides (sucrose), polysaccharides (starch). To power the normal function of nerve cells and nerve cells need a constant intake of glucose.
Hyperglycemia leads to insulin hiperproducerea and last favors atherosclerosis. Coffee, caffeinated tea, cocoa and chocolate – theobromine, which stimulates the conversion of glycogen to glucose associated with insulin release. Sweet fizzy drinks contain up to 150g of sugar per liter, which corresponds to 10 teaspoons in a glass of liquid.
Simultaneously, legumes, vegetables, unrefined grains contain complex carbohydrates such as starch, which monosaccharides are phased out, and do not lead to excessive growth of hyperglycemia and insulin levels.
Fructose has the formation of fat and can cause resistance to insulin and consumption of time favors the appearance of arteriosclerosis. Sweet drinks containing large amounts of fructose are dangerous, since lead to metabolic disorders (National Institute for the Study of Aging, Baltimore, USA).
Dietary fiber (ballast substances) of vegetable origin (neamidonice polysaccharides) have the necessary function for transport and absorption of chemicals in the digestive system. According to some authors unknown, dietary fiber plays an important role in prevention of intestinal cancer. Aleuron outer layer of cereal fiber and polyunsaturated fatty acids vitamins B and E with antioxidant. Sweet fruits (cherries) contain fibers that have a lower glycemic index, retain the rapid absorption of sugar is important for diabetics.
Based on the above mentioned, it is useful to recall the main features of grain products that contain all the ingredients necessary to maintain optimal physiological condition of the body.
Thus, grain products that contain complex carbohydrates serve as the main energy source of the organism. All grains contain protein, unsaturated fatty acids, soluble and insoluble fiber, vitamins B1, B2, folic acid and minerals: magnesium, iron, calcium.
Whole grain products (PCI) contain large amounts of positive action lactina possessing the intestinal digestion, the immune system by activating ferments, hormones intestinal prevent intestinal cancer. PCI acts against cerebral hemorrhages, cardiovascular disease and diabetes.
Excessive consumption of fat lowers the immune system, favors the development of atherosclerosis, diabetes, obesity, cancer, arthrosis, gallstones. According to WHO (2001), obesity and sedentary lifestyle contribute to cancer causes 33% of the large intestine, kidney, mammary gland, esophagus.
Unlike carbohydrates and proteins, fats do not give the feeling of satiety, that is why they have the ability to make almost unlimited. Heating fats and oils undergo oxidation to form hydroperoxides easily, quickly lead to the formation of oxidation products and aldehydes, epoxides, cyclic hydrocarbon compounds toxic and carcinogenic properties.
According to information Academic Centre in Amsterdam – for 3 weeks feeding of animals in experiments with fish oil – liver tumors were 10 times more frequent, and metastasis of 1000 times more frequent compared with the control group.
Margarine, which is less harmful as butter, vegetable oil is obtained by solidification and over, and solidification is achieved by hydrogenation, where the change occurs unsaturated fatty acids, ie, as is the animal fat. Saturated fatty acids unsaturated fatty acids obtained by transforming pancreatic cells affect insulin secretion and also inhibits bone protein biosynthesis. That’s why osteoporosis occurs.
It was found that 90% of fatty acids, unsaturated fatty acids obtained by transformation from industrial prepared food, processed at high temperatures – fried. After information of authors, high-fat diets negatively affect memory.
Thus, it is an extremely important factor in both the treatment and prophylaxis of various diseases.
Phytotherapy. Phytotherapy there for thousands of years. The accumulated empirical experience different treatment methods have been checked hundreds of times and have been preserved. They come down to us only those confirmed so sick and the doctors who gave favorable results without harming your health.
It is known that by taking the last century various ranks mainly extracted from plants to treat many diseases. Advances in chemistry, technology allowed to obtain many herbal medicines, which have been chemically produced.
Phytotherapy – the use of various herbal extracts or preparations obtained is one of the oldest methods of treatment. For millennia herbal extracts directly or plants were used everywhere as the most effective methods of treatment for many diseases. Starting with the first half of last century, gradually prevailed preparations in clinical practice. It is known that about 40% of drugs are of plant origin, of which the heart is 70%. Phytotherapy is used both to treat acute diseases obvious clinical manifestations, and in cases where development occurs with chronic clinical manifestations, especially with the goal of prevention. We emphasize, as with many chronic diseases, particularly rheumatic and neurological treatment duration and preparations is often associated with different side effects.
Naturals preparations have their natural physiological action because the body was always vegetarian fed. Renal enzymes in various organs may be substituted with enzymes derived from vegetation. Phytotherapy can be recommended for a long time (up to 60 days), while chemo-only preparations for 15-20 days. Significantly, the phytotherapy is not associated with dependence and also very rare occurrence leads to the development of allergic reactions. Not lead to dysbacteriosis, and often under the influence of this treatment, there is normalization of intestinal microflora. Phytotherapy has multilateral action: anti-inflammatory, analgesic, its metabolism
Herbal preparations production technology progressed with the advent obvious chemistry and phyto-phyto-pharmacology. Plants contain many carbohydrates (70-80%), polysaccharides which have anti-inflammatory, gastro-protective, increase secretion of digestive glands. To develop and maintain the body’s normal physiological require the presence of minerals. Most of them are found in medicinal plants: potassium, calcium, sodium, magnesium, phosphorus, sulfur, iron, copper, arsenic, nickel, zinc, silver. In plant cells occurring processes of synthesis of biologically active substances such as morphine, atropine, caffeine, quinine, ephedrine, etc..
Plants are living organisms and synthesize curative substances more physiological for the human body than synthetic preparations obtained in laboratories and chemical plants. Plants and preparations they act on the body more easily affected, not evoke negative reactions, the effect is slow, but sustainable. The main chemical compounds are alkaloids, glycosides, saponins, flavonoids, organic acids, ethers, fatty acids, vitamins, cumarinele, tanantele, enzymes, salts, trace elements.
In medicine occupies a special place alkaloids – substances that contain organic plant juices form of organic acids. Nitrogen-containing alkaloids are used in many dishes: morphine, codeine, platifilina, atropine, caffeine, to Glycosides found in many plants: beet, fruits of different plant species that have selective action on cardiac pacemakers.
Saponins – have biological activity: diuretic action, action antisclerotica, anticancer. Flavonoids – biologically active substances regulate capillary permeability, acting antihypertensive but also in rheumatic diseases, pneumonia, chronic inflammatory diseases. Enzymes – protein substances that act as catalysts when the body part in complex reactions. Fatty acids lead to normalize digestive process, stimulates bowel activity.
To develop and maintain the body’s physiological require the presence of several minerals, most of them are found in medicinal plants: potassium, calcium, sodium, phosphorus, magnesium, sulfur, micronutrients – iron, copper, cobalt, arsenic, nickel, molybdenum, zinc and silver.
Thus, colhicina is used in many rheumatic diseases: psoriasis, scleroderma, sarcoidosis, dermatomiozida as in cirrhosis, Behcet’s syndrome, the disease Periodicals amiliodoza.
The activity of this plant – Alkaloida – was called colchicine, in honor Colhidei, where the plant was transported. Empirical formula was described by Embark (1995) – C22H25O6.
This preparation inhibits cellular reaction mainly polynuclear participants aseptic inflammatory process. Preparation also decreases the permeability of capillaries, inhibit capillary endothelial response to inflammatory mediators. Thus, vascular responses and leukocyte colhicina block in acute inflammation, suppress the secretion and platelet aggregation, stimulates the secretion of steroids, immuno-regulatory influences on cells. In medium doses: decreased production of amyloid colhicina and, therefore, lead to improvement of nephrotic syndrome.
Thus, plants have been and remained one of the main sources of food and medicines, which can be used for long periods without leading to serious side effects.
Chronic diseases require long treatment, which can be achieved by using phytotherapy as chemical remedies most frequently lead to the appearance of many negative reactions. Priority action remedies lies in their physiological naturals, natural, because the body always plant foods. In many states there is chronic lower enzyme activity. Insufucienta enzyme in different organs can be limited by the contribution of enzymes of plant origin.
It is significant that phytotherapy is not associated with occurrence of addiction and rarely cause allergic reactions, does not favor the appearance dysbacteriosis even reverse allows normalization of intestinal flora. Herbal preparations have several actions simultaneously: anti-inflammatory, analgesic, stimulating immune reactions, metabolic, etc.. Plants contain a high percentage of carbohydrates and plant dry weight polysaccharides that act contains anti-inflammatory, gastroprotective, enhance the secretion of endocrine glands.
Chronic diseases are associated with other conditions that lead to production of toxic adverse reactions. That is why in these cases using a different set of plants not associated with these reactions, but give good results.

Advantages of phytotherapy: 1. physiological features, 2. Long-term possibility especially in treatment of chronic diseases, 3. very rarely is associated with adverse reactions, allergic, 4. lack of development Drug addiction, 5. very rarely are contraindications for this treatment, 6. risk of developing intestinal dysbacteriosis missing 7. most herbs grow in all geographical areas 8. possibility of selecting plants necessary because there are large quantities.
However the mechanisms of action of substances in different plants are not studied enough. Simultaneously, the plants often contain various viruses, which rarely can cause pathological processes in humans, not to mention allergic reactions. Therefore it is necessary now, in new conditions can be developed, reviewed and highlighted new substances cleaner that will not lead to negative reactions.
Because chronic diseases are associated with problems of different nature, it is necessary to administer combination therapy, and administration while a few chimiopreparate often give rise to negative reactions, toxic. That’s why, in these cases, using different combinations of plants and avoiding negative reactions achieve the desired effect healing.
Extracts from various plants in infusion, steam, air and fat can be used to evoke local and systemic side effects without. Some plants: gutuiul – contains vitamins C, B, possess anti-inflammatory, diuretic, choleretic, watermelon – diuretic, choleretic, is recommended in patients with gout, nephrolithiasis, pyelonephritis, anemia, diabetes, eggplant is administered in anemia, diabetes, diseases heart, kidney have diuretic action, grapes (juice) have diuretic action, sweat, hypotension, mucolytics and / or expectorant, anti-inflammatory, antinefrolitiazica; leaves of grape-vine percent beneficial in diabetes, extracts of leaves collected in May are Good against high blood pressure, grape seed extract – the diarrhea, the wine is detoxifying and antisclerotic sec. Sour cherries influence antipyretic, mucolytic / expectorant in patients with anemia, bleeding disorders – antithrombotic effect, antibacterial, diuretic. Melon – contains useful in preventing iron deficiency anemia in intestinal dyskinesia. Antisclerotic effect, diuretic, antigout nephrolithiasis, choleretic, sedative. Zamos peel is recommended for acne, moles. Strawberries metabolism, especially the mineral effect antigout nephrolithiasis (recommended – 1 kg / day for 10-15 days per year), lipid metabolism, blood pressure is recommended in patients with hepatitis, regulates thyroid function. Can be used in treating helmintiazei: 3 kg strawberries at a table in combination with steep products have anthelmintic action. Strawberry leaves carbohydrate metabolism, and antihemoragic antiallergic effect. Cabbage is useful in case of headache, insomnia. Application of local leaves is recommended in case of edema, joint swelling, boil, analgesic and antifungal effect. Cabbage is recommended in respiratory diseases has increased in vitamin C content and possesses antiulcer action, favoring the regeneration of intestinal mucosa.

Faunoterapia. From ancient times, in different organs of the animal products were used in the treatment of many diseases. Thus, Aristotle describes some preparations obtained from exotic fish in the treatment of nervous system. Avicenna in his treatise „Canons of medical science” tells about the use of shark meat, whale and marine fish eggs to regulate sexual function.
Medical Pan-Sun, in its publication „Health Source” describes the healing of the liver of bill of exchange (over sea) because it influences blood clotting system. Many substances extracted from animal organs have not been studied enough. In this respect a special interest presents large sponge that contains bioactive substances: antibacterial (including action against Koch bacillus) and of arabinose (which replaces the body’s ribose) develop anticancer preparation cytosine-arabinose. SBA has anti-inflammatory action of sea sponge due to the presence of sodium hexalfluorului (Na2SiF6). Are presented data on the toxicity of fish-ball of which were obtained SBA – acting tetradoxinul 160,000 times, compared with cocaine and anesthesia is used in case of serious operations. Preparations obtained from liver of sharks block cancer cell growth without traumatize other tissues. Based on these statements was developed preparation used in the treatment of diseases pentoxil Blood and that chemotherapy in the treatment of malignant tumors. Ectolin antibiotic is extracted from sturgeon, which has the capacity to prolong the action of other antibiotics. Octopus – remove toxins from that used in homeopathy sepia preparation developed and used in homeopathy sepia preparation and preparation used to treat diseases cefalotaxin nerve, respiratory. Some extracts are effective against rheumatism midi. In nerve disease type prostaglandin substance is used in coral. Another substance in corals (island Hawaii) – politoxina – C1201H2231N3054 – has anticancer action. Bodies of shrimp, coral and sea crayfish chitin was obtained SBA, used against thrombus formation and promote wound healing, to remove cheloizilor burns, warts, moles carcinomas, melanomas.
SBA currently obtained in amphibians are poorly studied. Studied the effectiveness of SBA was obtained from toads, with action on asthma. Toxins derived from skin turtles (South America) were used by Indians for training tips spears against enemies. As was found in solution toxins Toads 1:100 – kills birds and lizards in a few minutes. Turtle toxins have the ability to raise blood pressure and strengthens your heart – that is, possessing drug action strofantin asemenatoare action.

It is known that in some countries (China), turtle meat is used to treat dysentery, has antibacterial and turtle eggs for antirheumatic effect. Also, it is applied to places of snake bite. From frog skin was extracted SBA: serotonin, bradykinin, and opioids toxichinina. Demorfina extracted from the skin of some species of frogs with anesthetic properties 11 times removed of salamander SBA: samadarin, etc. samadamaritin.

Table 4. The bodies of animals used in the treatment of diseases

No. Internal organs of animals in some disease indications
A lamb rennet from the stomach Diarrhea

2 lamb gallbladder disorders microbial eyes, ears, keratoses
3 Hair Growth pig gallbladder

4 The bill gallbladder, eye infections pike Counter

5 of bovine gallbladder and upper respiratory infections Contra Bear
6 gallbladder from birds (crow, quail, stork) To improve vision
7 The bones of cattle, monkeys Against rheumatism

8 turtle bones for anemia

9 bones of tiger, elephant increase sexual potency

10 cattle and chicken liver stimulates the

The liver of many animals is rich in vitamin A. The white bear liver contains vitamin A at a rate of 10,400 units, while shark liver contains only 400 units.
MacLeon Scientist (1916) biologically active substances obtained from the livers of dog, called heparin and then subsequently obtained from other internal organs (spleen, lungs, muscles). Currently, heparin is produced in the lungs of cattle. It has anticoagulant action and is used in the treatment of thrombophlebitis, varicose veins, acute pancreatitis, etc..
Table 5. SBA obtained from animal organs.

BIOLOGICAL ACTIVE BODIES
Salivary gland protein – nerve growth factor (increases skin regeneration)
Brain, spinal cord peptide – functional improvement factor of peripheral nerves sleep, memory
Factor brain contains 105 amino acids alarm: endorphins and enkefaline
Bovine brain and spinal cord preparation that stimulates lipocerebrina cerebrolectina and CNS function. Action antisclerozanta, normalize lipid metabolism.
Bovine brain cholesterol and lecithin in stimulating
Pepsin pig intestinal mucosa
Ocular lens tissue from cattle breath against rheumatism
Bovine testes enzymes: lidaza, ronidaza – to regenerate tissue after burns, trauma
Bovine pancreas insulin, trypsin, chymotrypsin, chimotripsinogenaza.
Ribonucleazele and dezoxiribonucleazele hydrolyze nucleic acids. These enzymes are used to inhibit foreign microflora and viruses. Colagenazele – to eliminate from burns and frostbite necrosis.
Pig pancreas preparations elastolitin, pantrepin against acute pancreatitis. Preparations: contrical, trasilol, tzalol, gordox in the treatment of arthrosis. Pancreatina, digestalul, mezimul, festalul, vegeratina – in gastrointestinal pathology. Calicreinele – andecalin, calicrein, acting hypotensive dilminal
Aminopeptid cattle blood, fibrinosol – food in case of digestive disorders, weight loss. Polibiolin drug – anti-inflammatory and analgesic. Plasmolul – against ridiculitei and stomach ulcers. Solcoseril – to treat ulcers peptide, gangrene, acute burns.
Fibrinogen Blood donors against thrombophlebitis. Thrombin in stopping bleeding. Varicose-liz, thrombo-liz – in varicose thrombophlebitis. Hamor, Liz – against hemorrhoids.
Lymphocyte interferon – proteins against viral infections, viral hepatitis treatment.

Ancient organs of snakes were used to prepare drugs – to treat rheumatism or injury. Meat of hedgehog is recommended in cases of acute poisoning and tuberculosis. The skin is used to stop bleeding hedgehog. Snake meat is recommended in the treatment of systemic scleroderma. Toxins extracted from various species of snakes have action: coagulant and anticoagulant affecting the CNS and peripheral hemopoezei. The only specific treatment – in snake bite antiserum to toxin is the date (in this case it is necessary to know the species that produced snake bite).
Neurotoxinele snake through skin: 1. Peptide – blocks the synaptic membranes of skeletal muscle and sensitive sectors of the brain, 2. Mediator regulates the action of nerve endings, 3. Polypeptides – action of cell membrane depolarization. Was obtained from snake venom active ingredient – acting thromboplastin clotting, used to treat asthma, epilepsy, nerve disorders, haemophilia.
Drugs based on extracts from poisonous snakes toxins activate the blood clotting process, are used in anesthesia, the treatment of CNS diseases (epilepsy).
Spiders and scorpions toxins are used in the treatment of many diseases. I studied about 30 000 species of spiders. In humans, the spider bite is similar Curacuta atropine action: spasm of the sphincters, urinary ducts, intestinal pain association pronounced hypertension.
Spider venom causes the intensive Curacuta acetylcholine, dopamine, norepinephrine and gamma-amino-lipoic acid. Tarantula spider eliminate toxins with hemolytic action. Ornitofagi spiders (predators of birds) secrete venom acting directly on the CNS can cause drowsiness and death. Substance accelerates elimination of acetylcholine in the peripheral nervous system. In Laos the drugs for relief of this spider. There are about 500 known species of spiders that can survive up to 1 year without food. Scorpion toxins acting on the liver, kidneys and cause vomiting, chills, sleepiness. Scorpion venom is hormonal, that increases the glucose, insulin and trypsin causes intensive removal. Leeches – Hiruda medicinalis, ring worms – are widely used as a method of treatment.

. Any medical practitioner, consciously or unconsciously using this method. The famous physician, academician B. Votcel, who studied decades many drugs, write the efficacy of any drug is 60% due to psychotherapeutic effect. Wars and armed conflicts, santajele nuclear weapons, extremism, terrorism, changes in social order, etc.. continue to influence the nervous system and lead to neuro-psychic disorders and, therefore, favors the development of many serious diseases.
Emotional stress as a pathogenic factor psihotraumatic is neutralized by everyone if possible. Is a psychological defense mechanism that ensures perpetual normal resistance to disease and prevention of mental disorganization.
Reception, in these cases is reorganized in such a way that the result of psychological trauma gradually loses its importance.
Autosuggestion – very strong factor that influences the thinking, feeling, against suffering. This power is known about 2000 years. Thus, the philosopher Seneca wrote a friend: „Pain can be easily supported, if not increase their in thought, but on the contrary, I encourage you, saying do not affect or become weaker.”
Psychotherapy (autosuggestion) is most frequently applied by intellectuals, subjects self-trained and the training involves long. The basis of this method are complex physiological mechanisms that act on neural receptors, thereby eliminate the effect of reducing neuromediatorii disease process.
Acute stress and chronic diseases can be considered psychotherapy. Is a natural psychological defense mechanism, continuously providing the body’s resistance to adverse conditions or psychopathological harm. In this case, the body’s defense mechanism is directed toward neutralizing the actions lesional psychological factors. Reforming mechanisms reception is so traumatic psychological effect factor gradually lost its importance and therefore does not lead to the initiation of a pathologic process. An effective dialogue between patient and physician has sedative action.
General Psychotherapy through a complex psychological approaches with positive action on the CNS, increase the body’s disease resistance potential.
Medical psychotherapist is appreciated for these qualities: patience, quiet, critical sense, fairness, confidentiality, tact, ability to open communication, explicit language, objective assessment, empathy, ability to lead and manage the patient, diplomacy and more.
Therapist must be able to discuss with the patient peer.
Thus, psychotherapy is a very important curative factor is necessary for every doctor to use this method of therapeutic activity.

Diet therapy (DT). Latin Diet „diaeta” – lifestyle, thus requires not only the selection of food.
There is food that does not possess curative qualities. The man’s rations included over 600 substances, each of which has curative abilities. To use the most efficient supply substances, first it is necessary to prepare quality. Vicious power constitutes a danger to human health very high. Hippocratic medicine has defined as art that reflects the influence of nature as a healing factor and food were called our medicines.
All complex metabolism in the body depends on the quality of the products ingested. We can modify diet and body condition changes depending on diet composition.
Changes in food quality resulting in the appearance of metabolic disorders that occur as a result of functional changes lead to poor quality food that morphological changes, fixed from generation to generation, in particular genetic turn.
Progress in molecular biology, immunology, biophysics allowed deciphering mechanisms of metabolic processes which usually are strictly related to neuro-endocrine system activity, immune, etc. Oxidation and antioxidant.
Numerous studies in various scientific centers effectuate importance of nutrition in development have established many incurable diseases: cardiovascular, metabolic, degenerative, tumoral processes.
Character of food, it seems, is responsible for the development of cancer to 30-50% of total cases (European Nutrition Conference, Lyon, France, 2001).
It was found that in the past 20 years the incidence of brain tumors in Europe has doubled. Simultaneously, the frequency of systemic osteoporosis has increased dramatically in developed countries, where they consume large amounts of high-fat products: milk, cheese, meat. There erroneous opinions that advanced technologies are sufficient to achieve prevention of these serious conditions without large corrections ciated how to propagate exaggerated sophisticated medication, different diets, miracle follows the „measure” to ensure food good health condition. Chase health enrichment at the expense of human society will destroy the new generation and our descendants will negatively influence health.
For example, alcohol is one of the main causes of mental disorders to new generations. Alcoholic embryology is one of the most serious birth defects, malformations of internal organs, face, brain damage. Even very small amounts of alcohol are able to damage the embryo, fetus. Increase the frequency of alcohol syndrome children: hyperactivity, brain damage, impulsive. Often these children are highlighted in special facial abnormalities: small eye wrinkles at the corner of eye, brain and small deformations of the skull, this hearing disorders, visual coordination, loss of barrier protection.
It was found (University of Minnesota) that the risk for acute myeloid leukemia in children is 3 times higher if the mothers during pregnancy consumed 20 glasses of wine or 20 pints of beer, and if mothers who consumed alcohol in the 2-3 trimester, the risk for the occurrence of acute myeloid leukemia was 10 times higher.
Only in a single year, 1995, in Germany, 55,000 were born with birth children, which is equivalent to 7% of total births, due to alcohol use and the presence of obesity and other factors. The new conditions that were created, appeared resistant to infection by antibiotics and even new pathogens. Advances in modern medicine have resulted in decreased incidence of incurable diseases and even reverse the incidence of cancer, diabetes, atherosclerosis, autoimmune diseases to increased.
National Institute for Combating Cancer in the U.S. reports that 35% of all cancers are caused by improper diet, 30% – smoking, 35% alcohol, viruses, heatstroke, harmful occupational factors, genetic factors, environmental pollution.
As always, physicians are educated to study diseases and regret very little to change thinking to improve lifestyle, food character, habits.
Approximately 400,000 people die annually from diseases related to smoking; 500,000 – due to incorrect diet and sedentary way of life, because obesity 280.000, 100.000 due to excessive alcohol consumption.
In Germany, where they consume large amounts of animal fat, every second death is caused by myocardial infarction, while in Japan, where many plant foods are consumed rarely get sick of colon cancer compared with Western countries.
Reducing the amount of food eaten is one of the necessary measures to extend life and prevent cancer, because cancer cells have higher energy needs more than healthy.
The elderly and immune system decreases the number of T-lymphocytes, leading to increased susceptibility to infections, immune diseases, tumors. Also, your old age there is increasing levels of free radicals (RL) and the use of antioxidant (drugs) man does not give the expected results because they can not replace antioxidantele plant. Plants, other than vitamins, contain various bioactive substances with anti-tumor actions. It is known that fitoestrogenele of lettuce, cabbage, cauliflower, cereals have action against tumors of the breast, colon, prostate, uterus. Leukopenia of red works against prostate cancer and glucosinatele of cabbage, cauliflower, radishes act against infections by activating the immune system. Other studies have found that fitosterinele of sunflower seeds or nuts decrease risk of colon cancer, and flavonoids contained in fruits (cherry, cherries, strawberries, apples) and vegetables (potatoes, onions, peppers, beets) are very active against infections and tumors. Phenols in cereal and nuts are acting antiviral, antifungal, ntioxidanta. Sulfids garlic, leeks, onions have antioxidant and antitumor.  Saponins contained in beans, peas, chickpeas have action against bowel cancer. Terpinele with celery, mint retain cancer development. Polyphenols in fruits, nuts participate in normalizing the vascular system by increasing the activity of nitric oxide production leads to lower risk for cardiovascular disease.
Immunity is closely related to food character. In ensuring a normal immune status, along with vitamins, minerals (zinc, iron, copper, selenium) belongs to an important high protein and vegetable fat.
Acts on the immune system of oxygen free radicals. To support the normal balance between oxidant and antioxidant systems is necessary to use whole grain products, fruits and vegetables. Milt also use dietary supplements that contain antioxidants and vitamins can not replace natural products, vegetables and fruits that contain many bioactive substances.
There were large differences in the incidence of prostate tumors in the population of England, Switzerland, the United States in proportion to the population of Asian countries. They are caused by past use of plant products (especially soybeans containing fitosteroizi, saponins, izoflavoine, acting antitumorala.Produsele grains contain complex carbohydrates that serve as the body’s main energy source. Also they contain protein, unsaturated fatty acids , soluble and insoluble fiber, vitamin B1, B2, folic acid, minerals – magnesium, iron, calcium.
Whole wheat bread and not gain weight, compared with white flour, contains seven times more minerals and 5-10 times more vitamins. Whole grain products (PCI) have actions against cardiovascular disease, diabetes, tumors. Thus, the use of PCI reduces the risk of cerebral hemorrhage and myocardial infarction in 30% and 33% risk of malignant tumors.
In developed countries predominate in animal protein diet containing cholesterol and saturated fat, which promotes development of atherosclerosis and aging.
Animal proteins lead to increased insulin levels and accelerate production of cholesterol, which are the main factors leading to increased risk of cardiovascular disease and plant proteins, on the contrary, lower insulin and cholesterol synthesis. Frequency is proportional to the increase in myocardial insulin because of the consumption of animal protein.
Amino acid content in plant products of protein arginine and glycine is higher than animal proteins. These amino acids lead to inhibition of cholesterol in the body.
In maintaining a normal metabolic balance is important ratio calcium / phosphorus. As is known, increasing the concentration of phosphorus is associated with decreasing serum calcium levels. As calcium levels decrease, and increased levels of phosphorus lead to increased parathyroid hormone, with subsequent development of osteoporosis. Simultaneously, increasing the concentration of phosphorus in the blood leads to storage of phosphorus and calcium in the internal organs: heart, kidneys and other organs, favoring the development of inflammatory and degenerative processes.
It was found that proteins modified by the influence of heat acting toxic, carcinogenic, mutagenic, especially those processed by roasting, smoking and grilled.
World Health Organization calculated that the necessary rules of amino acids in human milk composition corresponds best with goat’s milk. Vegetable products contain all essential amino acids in sufficient quantities. Dairy products are rich in protein. Both severity, and incidence of osteoporosis are higher in countries where they eat foods high in protein, especially dairy products.
It was reported that the Eskimos, who consume large amounts of fish and bones, the amount of calcium consumed daily reach up to 2500 mg, and protein intake to 200-400 grams. Excessive consumption of animal protein causes osteoporosis, because calcium loss in large quantities. Thus, diets rich in animal protein lowers bone tissue and develop osteoporosis.
Nutrition rich in animal protein, sulfur-containing amino acids, prone to blood acidification. Because blood must have an alkaline pH, the acidity that is neutralized by the accumulation of calcium in the bones, then is eliminated through urine. Such is osteoporosis. In case of excess amino acids, liver enzymes break down some substances to urea, which acts as a diuretic, eliminating liquid and minerals. In bone tissue production of nitric oxide in this matter, but decreases production of urea increased the oxide.
The display can be confirmed by the following examples: it was found that in some areas of Africa where the dietary calcium consumed reaches 200 mg / day, hip fractures are the rarest in the world, while the Eskimos, using 2000 mg daily calcium, osteoporotic fractures are most common in the world.
Risk factors for osteoporosis
8. Hereditary factors – transmission from mother to daughter. In these women the risk of fracture is two times higher.
9. Sedentary way of life
10. The use of increased amounts of coffee per day (1.5 cup of coffee)
11. Increased use of animal protein increases the risk of hip fractures
12. Alcohol
13. Insufficient exposure to sunlight
14. Anticonvulsant drugs, antidepressants – doubles the risk of hip fractures.

Normal use of calcium and protein using relatively small amounts up to 30 years decreases the risk of osteoporosis.
After the data authors (Jan Mayer, 1999) – Increased intake of potassium and magnesium in foods that contain vegetarian, lead to increased bone density in elderly men.
Absorption of Ca + + from plant products is much higher than that of milk, of which 70-90% of Ca + + does not absorb. His report found that dietary phosphorus / calcium more than 2 leads to loss of calcium and so on osteoporosis.
In people who consume large amounts of protein risk of kidney stones is 33% (Harvard University). The U.S. recorded the highest consumption of animal protein, and the number of malignant lymphomas is highest.
Large amount of protein in the diet lowers the number of cells so-called „killer” cells that destroy foreign bodies and the cancer. 30% of diabetic patients who are treated with insulin develop later on kidney failure. Recommended amount of 40 g protein / day allows progression of diabetic nephropathy.
Many sources, including information received from German researchers, reported that sausages and smoked meats containing high salt (100g contains 5-6 g of salt) favors the appearance of hypertension, gastric cancer and osteoporosis. For sausages and other meat products have beautiful color, appetizing add nitrates and nitrites. But the reaction between nitrites and amines form nitrosamines, some – which is supposed to be carcinogenic. Favors production of nitrosamines above 1000C. Sausages and smoked meats contain highly carcinogenic polycyclic aromatic hydrocarbons. These hydrocarbons are formed in meat roasted, grilled, in stews. It turned out that in Iceland, where they eat much meat and smoked fish, the number of people with digestive tract cancer is much higher than in Europe. Studies have shown for decades that temperatures above 1000C in food preparation have meat to the formation of mutagenic compounds pronounced capabilities comparable to those of benzipirenului. Meats rich in polyunsaturated fatty acids omega-G promotes inflammation, thrombosis and vasoconstriction. Arachidonic acid is the main provider of fatty acids as animal proteins (meat, eggs, cheese), which contain arachidonic acid, are the source of polyunsaturated fatty acids omega-G. Last antinflamatorii matter in chronic vascular mechanisms.
Japanese sources reported that after some epidemiological studies have found a potent carcinogenic heterocyclic amines in meats and fish that appear prepared at high temperatures. Were identified over 20 mutagenic or carcinogenic amines. Heterocyclic amines are precursors: Creatine, peptides, amino acids, proteins and sugars.
In Uruguay the amount of per capita meat consumption is highest in the world, but are the most common malignancies. A special interest presents studies by the National Cancer Institute (1998, USA) where 41 836 women were examined. It was found that the women who used the meat prepared by the action of high temperatures and well done, the risk of cancer was 4-6 times higher than women who ate meat less exposed to high temperatures.
It was confirmed that fish oil increases diabetes, blood glucose, as eicosapentaenoic acid reduces the secretion of insulin. For example, the Eskimos, whose diet is rich in fish, are more cerebral bleeding.
Increasing oil content leads to excessive growth of vitamin A and D – which are toxic and lower levels of vitamin E. It was found that foodstuff poisoning caused 15 times more frequently than the products over meat. Over 200 products containing toxic chemicals including: mercury, pesticides and dioxins.
In Japan it was observed that the population that uses products from fish, mercury levels in children is much higher in the umbilical cord. These children have reduced memory and attention. Tumors are frequently found in the population that uses fish products because fish contain more pesticides than fruits, vegetables, cereals.
Data studies in several countries have found that populations who consume mostly carbohydrates (70-80%) do not suffer from degenerative disease: high cholesterol, hypertension, diabetes, obesity.
Studies have shown that the use of latest high amounts of carbohydrates promotes protein synthesis. Animal products are free of carbohydrates, except for milk which contains lactose mammals. Carbohydrates are composed of plant monosaccharides (glucose, fructose, galactose, lactose), disaccharides (sucrose), polysaccharides (starch). To power the normal function of nerve cells and nerve cells need a constant intake of glucose.
Hyperglycemia leads to insulin hiperproducerea and last favors atherosclerosis. Coffee, caffeinated tea, cocoa and chocolate – theobromine, which stimulates the conversion of glycogen to glucose associated with insulin release. Sweet fizzy drinks contain up to 150g of sugar per liter, which corresponds to 10 teaspoons in a glass of liquid.
Simultaneously, legumes, vegetables, unrefined grains contain complex carbohydrates such as starch, which monosaccharides are phased out, and do not lead to excessive growth of hyperglycemia and insulin levels.
Fructose has the formation of fat and can cause resistance to insulin and consumption of time favors the appearance of arteriosclerosis. Sweet drinks containing large amounts of fructose are dangerous, since lead to metabolic disorders (National Institute for the Study of Aging, Baltimore, USA).
Dietary fiber (ballast substances) of vegetable origin (neamidonice polysaccharides) have the necessary function for transport and absorption of chemicals in the digestive system. According to some authors unknown, dietary fiber plays an important role in prevention of intestinal cancer. Aleuron outer layer of cereal fiber and polyunsaturated fatty acids vitamins B and E with antioxidant. Sweet fruits (cherries) contain fibers that have a lower glycemic index, retain the rapid absorption of sugar is important for diabetics.
Based on the above mentioned, it is useful to recall the main features of grain products that contain all the ingredients necessary to maintain optimal physiological condition of the body.
Thus, grain products that contain complex carbohydrates serve as the main energy source of the organism. All grains contain protein, unsaturated fatty acids, soluble and insoluble fiber, vitamins B1, B2, folic acid and minerals: magnesium, iron, calcium.
Whole grain products (PCI) contain large amounts of positive action lactina possessing the intestinal digestion, the immune system by activating ferments, hormones intestinal prevent intestinal cancer. PCI acts against cerebral hemorrhages, cardiovascular disease and diabetes.
Excessive consumption of fat lowers the immune system, favors the development of atherosclerosis, diabetes, obesity, cancer, arthrosis, gallstones. According to WHO (2001), obesity and sedentary lifestyle contribute to cancer causes 33% of the large intestine, kidney, mammary gland, esophagus.
Unlike carbohydrates and proteins, fats satutatie fail because of this feeling they have the ability to make almost unlimited. Heating fats and oils easily undergo oxidation to form hydroperoxides, leading quickly to the formation of oxidation products and aldehydes, epoxides, cyclic hydrocarbon compounds toxic and carcinogenic properties.
According to information Academic Centre in Amsterdam – for 3 weeks feeding of animals in experiments with fish oil – liver tumors were 10 times more frequent, and metastasis of 1000 times more frequent compared with the control group.
Margarine, vegetable oil is obtained by solidification and over, and solidification is achieved by hydrogenation, where the change occurs unsaturated fatty acids, ie, as is the animal fat. Saturated fatty acids unsaturated fatty acids obtained by transforming pancreatic cells affect insulin secretion and also inhibits bone protein biosynthesis. That’s why osteoporosis occurs.
It was found that 90% of fatty acids, unsaturated fatty acids obtained by transformation from industrial prepared food, processed at high temperatures – fried. After information of authors, high-fat diets negatively affect memory.
Thus, it is an extremely important factor in both the treatment and prophylaxis of various diseases.
Phytotherapy. Phytotherapy there for thousands of years. The accumulated empirical experience different treatment methods have been checked hundreds of times and have been preserved. They come down to us only those confirmed so sick and the doctors who gave favorable results without harming your health.
It is known that by taking the last century various ranks mainly extracted from plants to treat many diseases. Advances in chemistry have allowed obtaining several herbal medicines, which have been produced by chemical synthesis. Appropriate to mention that, as chemical synthesis does not always correspond to the natural synthesis of organic compounds, therefore synthesized chemical compounds often give many unwanted reactions. Thus interferons by chemical sinyeza for infections and sineucidul viralehepatice causes, states of nervous patients.
Phytotherapy – the use of various herbal extracts or preparations obtained is one of the oldest methods of treatment. For millennia herbal extracts directly or plants were used everywhere as the most effective methods of treatment for many diseases. Starting with the first half of last century, gradually prevailed preparations in clinical practice. It is known that about 40% of drugs are of plant origin, of which the heart is 70%. Phytotherapy is used both to treat acute diseases obvious clinical manifestations, and in cases where development occurs with chronic clinical manifestations, especially with the goal of prevention. We emphasize, as with many chronic diseases, particularly rheumatic and neurological treatment is long lasting. Naturals preparations have their natural physiological action because the body was always vegetarian fed. Renal enzymes in various organs may be substituted with enzymes derived from vegetation. Phytotherapy can be recommended for a long time (up to 60 days), while chemo-only preparations for 15-20 days. Significantly, the phytotherapy is not associated with dependence and also very rare occurrence leads to the development of allergic reactions. Often under the influence of this treatment, there is normalization of intestinal microflora. Phytotherapy has multilateral action: anti-inflammatory, analgesic, its metabolism
Herbal preparations production technology progressed with the advent obvious chemistry and phyto-phyto-pharmacology. Plants contain many carbohydrates (70-80%), polysaccharides which have anti-inflammatory, gastro-protective, increase secretion of digestive glands. To develop and maintain the body’s normal physiological require the presence of minerals. Most of them are found in medicinal plants: potassium, calcium, sodium, magnesium, phosphorus, sulfur, iron, copper, arsenic, nickel, zinc, silver. In plant cells occurring processes of synthesis of biologically active substances such as morphine, atropine, caffeine, quinine, ephedrine, etc..
Plants are living organisms and synthesize curative substances more physiological for the human body than synthetic preparations obtained in laboratories and chemical plants. Plants and preparations they act on the body more easily affected, not evoke negative reactions, the effect is slow, but sustainable. The main chemical compounds are alkaloids, glycosides, saponins, flavonoids, organic acids, ethers, fatty acids, vitamins, cumarinele, tanantele, enzymes, salts, trace elements.
In medicine occupies a special place alkaloids – substances that contain organic plant juices form of organic acids. Nitrogen-containing alkaloids are used in many dishes: morphine, codeine, platifilina, atropine, caffeine, to Glycosides found in many plants: beet, fruits of different plant species that have selective action on cardiac pacemakers.
Saponins – have biological activity: diuretic action, action antisclerotica, anticancer. Flavonoids – biologically active substances regulate capillary permeability, acting antihypertensive but also in rheumatic diseases, pneumonia, chronic inflammatory diseases. Enzymes – protein substances that act as catalysts when the body part in complex reactions. Fatty acids lead to normalize digestive process, stimulates bowel activity.
To develop and maintain the body’s physiological require the presence of several minerals, most of them are found in medicinal plants: potassium, calcium, sodium, phosphorus, magnesium, sulfur, micronutrients – iron, copper, cobalt, arsenic, nickel, molybdenum, zinc and silver.
Thus, colhicina is used in many rheumatic diseases: psoriasis, scleroderma, sarcoidosis, dermatomiozida as in cirrhosis, Behcet’s syndrome, the disease Periodicals amiliodoza.
The activity of this plant – Alkaloida – was called colchicine, in honor Colhidei, where the plant was transported. Empirical formula was described by Embark (1995) – C22H25O6.
This preparation inhibits cellular reaction mainly polynuclear participants aseptic inflammatory process. Preparation also decreases the permeability of capillaries, inhibit capillary endothelial response to inflammatory mediators. Thus, vascular responses and leukocyte colhicina block in acute inflammation, suppress the secretion and platelet aggregation, stimulates the secretion of steroids, immuno-regulatory influences on cells. In medium doses: decreased production of amyloid colhicina and, therefore, lead to improvement of nephrotic syndrome.
Thus, plants have been and remained one of the main sources of drugs, which can be used for long periods without leading to serious side effects.
Chronic diseases require long treatment, which can be achieved by using phytotherapy as chemical remedies most frequently lead to the appearance of many negative reactions. Priority action remedies lies in their physiological naturals, natural, because the body always plant foods. In many states there is chronic lower enzyme activity. Insufucienta enzyme in different organs can be limited by the contribution of enzymes of plant origin.
It is significant that phytotherapy is not associated with occurrence of addiction and rarely cause allergic reactions, does not favor the appearance bacterioses allows normalization of intestinal flora. Herbal preparations have several actions simultaneously: anti-inflammatory, analgesic, stimulating immune reactions, metabolic, etc.. Plants contain a high percentage of carbohydrates and plant dry weight polysaccharides that act contains anti-inflammatory, gastroprotective, enhance the secretion of endocrine glands.
Chronic diseases are associated with other conditions that lead to production of toxic adverse reactions. That is why in these cases using a different set of plants not associated with these reactions, but give beneficial results.
Advantages of phytotherapy: 1. physiological features, 2. Long-term possibility especially in treatment of chronic diseases, 3. very rarely is associated with adverse reactions, allergic, 4. lack of development Drug addiction, 5. very rarely are contraindications for this treatment, 6. risk of developing intestinal missing bacterioses 7. most herbs grow in all geographical areas 8. possibility of selecting plants necessary because there are large quantities.
However the mechanisms of action of substances in different plants are not studied enough. Simultaneously, the plants often contain various viruses, which can produce some cazurti recombinant dangerous for different organisms. Can cause allergic reactions. Therefore it is necessary now, in new conditions can be developed, tests, highlighted new substances cleaner that will not lead to negative reactions.
Because chronic diseases are associated with problems of different nature, it is necessary to administer combination therapy, and administration while a few chimiopreparate often give rise to negative reactions, toxic. That’s why, in these cases, using different combinations of plants and avoiding negative reactions achieve the desired effect healing.
Extracts from various plants in infusion, steam, air and fat can be used to evoke local and systemic side effects without. Some plants: gutuiul – contains vitamins C, B, possess anti-inflammatory, diuretic, choleretic, watermelon – diuretic, choleretic, is recommended in patients with gout, nephrolithiasis, pyelonephritis, anemia, diabetes, eggplant is administered in anemia, diabetes, diseases heart, kidney have diuretic action, grapes (juice) have diuretic action, sweat, hypotension, mucolytics and / or expectorant, anti-inflammatory, antinefrolitiazica; leaves of grape-vine percent beneficial in diabetes, extracts of leaves collected in May are Good against high blood pressure, grape seed extract – the diarrhea, the wine is detoxifying and antisclerotic sec. Sour cherries influence antipyretic, mucolytic / expectorant in patients with anemia, bleeding disorders – antithrombotic effect, antibacterial, diuretic. Melon – contains useful in preventing iron deficiency anemia in intestinal dyskinesia. Antisclerotic effect, diuretic, antigout nephrolithiasis, choleretic, sedative. Zamos peel (melon) is recommended for acne, moles. Strawberries metabolism, especially the mineral effect antigout nephrolithiasis (recommended – 1 kg / day for 10-15 days per year), lipid metabolism, blood pressure is recommended in patients with hepatitis, regulates thyroid function. Can be used in treating helmintiazei: 3 kg strawberries at a table in combination with steep products have anthelmintic action. Strawberry leaves carbohydrate metabolism, and antihemoragic antiallergic effect. Cabbage is useful in case of headache, insomnia. Application of local leaves is recommended in case of edema, joint swelling, boil, analgesic and antifungal effect. Cabbage is recommended in respiratory diseases has increased in vitamin C content and possesses antiulcer action, favoring the regeneration of intestinal mucosa.
Faunoterapia. From ancient times, in different organs of the animal products were used in the treatment of many diseases. Thus, Aristotle describes some preparations obtained from exotic fish in the treatment of nervous system. Avicenna in his treatise „Canons of medical science” tells about the use of shark meat, whale and marine fish eggs to regulate sexual function.
Medical Pan-Sun, in its publication „Health Source” describes the healing of the liver of bill of exchange (over sea) because it influences blood clotting system. Many substances extracted from animal organs have not been studied enough. In this respect a special interest presents large sponge that contains bioactive substances: antibacterial (including action against Koch bacillus) and of arabinose (which replaces the body’s ribose) develop anticancer preparation cytosine-arabinose. SBA has anti-inflammatory action of sea sponge due to the presence of sodium hexalfluorului (Na2SiF6). Are presented data on the toxicity of fish-ball of which were obtained SBA – acting tetradoxinul 160,000 times, compared with cocaine and anesthesia is used in case of serious operations. Preparations obtained from liver of sharks block cancer cell growth without traumatize other tissues. Based on these statements was developed preparation used in the treatment of diseases pentoxil Blood and that chemotherapy in the treatment of malignant tumors. Ectolin antibiotic is extracted from sturgeon, which has the capacity to prolong the action of other antibiotics. Octopus – remove toxins from that used in homeopathy sepia preparation developed and used in homeopathy sepia preparation and preparation used to treat diseases cefalotaxin nerve, respiratory. Some mussel extracts are effective against rheumatism. In nerve disease type prostaglandin substance is used in coral. Another substance in corals (island Hawaii) – politoxina – C1201H2231N3054 – has anticancer action. Bodies of shrimp, coral and sea crayfish chitin was obtained SBA, used against thrombus formation and promote wound healing, to remove cheloizilor burns, warts, moles carcinomas, melanomas.
SBA currently obtained in amphibians are poorly studied. Studied the effectiveness of SBA was obtained from toads, with action on asthma. Toxins derived from skin turtles (South America) were used by Indians for training tips spears against enemies. As was found in solution toxins Toads 1:100 – kills birds and lizards in a few minutes. Turtle toxins have the ability to raise blood pressure and strengthens your heart – that is, possessing drug action strofantin asemenatoare action.

It is known that in some countries (China), turtle meat is used to treat dysentery, has antibacterial and turtle eggs for antirheumatic effect. Also, it is applied to places of snake bite. From frog skin was extracted SBA: serotonin, bradykinin, and opioids toxichinina. Demorfina extracted from the skin of some species of frogs with anesthetic properties 11 times removed of salamander SBA: samadarin, etc. samadamaritin.

Table 4. The bodies of animals used in the treatment of diseases

No. Internal organs of animals in some disease indications
A lamb rennet from the stomach Diarrhea

2 lamb gallbladder disorders microbial eyes, ears, keratoses
3 Hair Growth pig gallbladder

4 The bill gallbladder, eye infections pike Counter

5 of bovine gallbladder and upper respiratory infections Contra Bear
6 gallbladder from birds (crow, quail, stork) To improve vision
7 The bones of cattle, monkeys Against rheumatism

8 turtle bones for anemia

9 bones of tiger, elephant increase sexual potency

10 cattle and chicken liver stimulates the

The liver of many animals is rich in vitamin A. The white bear liver contains vitamin A at a rate of 10,400 units, while shark liver contains only 400 units.
MacLeon Scientist (1916) biologically active substances obtained from the livers of dog, called heparin and then subsequently obtained from other internal organs (spleen, lungs, muscles). Currently, heparin is produced in the lungs of cattle. It has anticoagulant action and is used in the treatment of thrombophlebitis, varicose veins, acute pancreatitis, etc..

Table 5. SBA obtained from animal organs.

BIOLOGICAL ACTIVE BODIES
Salivary gland protein – nerve growth factor (increases skin regeneration)
Brain, spinal cord peptide – functional improvement factor of peripheral nerves sleep, memory
Factor brain contains 105 amino acids alarm: endorphins and enkefaline
Bovine brain and spinal cord preparation that stimulates lipocerebrina cerebrolectina and CNS function. Action antisclerozanta, normalize lipid metabolism.
Bovine brain cholesterol and lecithin in stimulating
Pepsin pig intestinal mucosa
Ocular lens tissue from cattle breath against rheumatism
Bovine testes enzymes: lidaza, ronidaza – to regenerate tissue after burns, trauma
Bovine pancreas insulin, trypsin, chymotrypsin, chimotripsinogenaza.
Ribonucleazele and dezoxiribonucleazele hydrolyze nucleic acids. These enzymes are used to inhibit foreign microflora and viruses. Colagenazele – to eliminate from burns and frostbite necrosis.
Pig pancreas preparations elastolitin, pantrepin against acute pancreatitis. Preparations: contrical, trasilol, tzalol, gordox in the treatment of arthrosis. Pancreatina, digestalul, mezimul, festalul, vegeratina – in gastrointestinal pathology. Calicreinele – andecalin, calicrein, acting hypotensive dilminal
Aminopeptid cattle blood, fibrinosol – food in case of digestive disorders, weight loss. Polibiolin drug – anti-inflammatory and analgesic. Plasmolul – against ridiculitei and stomach ulcers. Solcoseril – to treat ulcers peptide, gangrene, acute burns.
Fibrinogen Blood donors against thrombophlebitis. Thrombin in stopping bleeding. Varicose-liz, thrombo-liz – in varicose thrombophlebitis. Hamor, Liz – against hemorrhoids.
Lymphocyte interferon – proteins against viral infections, viral hepatitis treatment.

Ancient organs of snakes were used to prepare drugs – to treat rheumatism or injury. Meat of hedgehog is recommended in cases of acute poisoning and tuberculosis. The skin is used to stop bleeding hedgehog. Snake meat is recommended in the treatment of systemic scleroderma. Toxins extracted from various species of snakes have action: coagulant and anticoagulant CNS and peripheral impact. The only specific treatment – in snake bite antiserum to toxin is the date (in this case it is necessary to know the species that produced snake bite).
Neurotoxinele snake through skin: 1. Peptide – blocks the synaptic membranes of skeletal muscle and sensitive sectors of the brain, 2. Mediator regulates the action of nerve endings, 3. Polypeptides – action of cell membrane depolarization. Was obtained from snake venom active ingredient – acting thromboplastin clotting, used to treat asthma, epilepsy, nerve disorders, haemophilia.
Drugs based on extracts from poisonous snakes toxins activate the blood clotting process, are used in anesthesia, the treatment of CNS diseases (epilepsy).
Spiders and scorpions toxins are used in the treatment of many diseases. I studied about 30 000 species of spiders. In humans, the spider bite is similar Curacuta atropine action: spasm of the sphincters, urinary ducts, intestinal pain association pronounced hypertension.
Spider venom causes the intensive Curacuta acetylcholine, dopamine, norepinephrine and gamma-amino-lipoic acid. Tarantula spider eliminate toxins with hemolytic action. Ornitofagi spiders (predators of birds) secrete venom acting directly on the CNS can cause drowsiness and death. Substance accelerates elimination of acetylcholine in the peripheral nervous system. In Laos the drugs for relief of this spider. There are about 500 known species of spiders that can survive up to 1 year without food. Scorpion toxins acting on the liver, kidneys and cause vomiting, chills, sleepiness. Scorpion venom is hormonal, that increases the glucose, insulin and trypsin causes intensive removal.
Leeches – Hiruda medicinalis, ring worms – are widely used as a method of treatment. When absorption, remove leech protein – hirudin anticoagulation and inactivation capacity of prothrombin. Hirudotherapy use in cardiovascular disease, thrombophlebitis. Substances obtained from worms is recommended for rheumatic diseases, keratitis, chills, bleeding, epilepsy.
Horn products, hooves, nails, hair and the crust of crayfish have been used 3700 years ago Egyptian pharaohs. These organs contain keratin – used in sexual dysfunction and metabolism.
Pantocrin preparation – 10% suspension of reindeer horn, containing organic substances – fat, inorganic substances – calcium, magnesium, iron, silicon, phosphorus, sodium, Sodium, Nickel, Copper, Titanium, Lead, Barium. Pantocrinul is used to treat many diseases. It increases the immunity and blood clotting, normalizes sleep. It also has a calming effect, ulcer. It is used against epilepsy, psychosis, improves muscle function. About the statement of reindeer horns are known in sec. IV i.e.n. Animal tendons in China to prepare gelatin products used to increase muscle tone and treatment of tuberculosis.
Rumalon product is a preparation of cartilage and bone of domestic animals. Chitozanul used in dermatology, cosmetology as a good anti-inflammatory.
Bile acids influence coledocului activity, endocrine system, central nervous system, reduces kidney function, reduce oxidation processes. Bile acids are widely used to treat rheumatism. Improves liver and pancreas function. Extract bile juice in the composition festalului, aloholului indicated in cholecystitis and enterocolitis. It is used to treat hepatitis and obesity. Chicken egg shells is given in diarrhea and nephrolithiasis.
Scorpions are used to treat limfaadenopatiei in case of tuberculosis, dermatitis, skin ulcers. Frog toxins are used to treat rheumatism, stopping internal bleeding.

Climatic

„The best doctor is the nature – because 75% of patients heal and never wished to express about his colleagues.”

Human health is closely related to climate variations, which is influenced by several factors: temperature limits during the year and their undulations, the number of sunny days during the year, frequency of storms and cyclones and then rain, blizzards, this mountain or plains, areas with underground mineral deposits that intensify Earth magnetism.
For these characteristics of climate and vegetation depend on animal health. Qualitative and quantitative relationships of the above-mentioned factors, determine the specifics of any localities, microclimate characteristics.
The human body in evolution, to accommodate different weather conditions, but most people have adapted to a certain region of Earth, with some calendar features. Examples were seen when patients with serious diseases and radiological changes, moving to another country, in a year were completely healed. Also, patients with dilated cardiomyopathy, which receive large doses of hormone preparations, being in areas with favorable climate at least one year without treatment, finished with complete cure. So, these phenomena are the result of climatic factors influence combinations, etc. cosmic. Climatic complex includes a number of natural (mountains, forests, big rivers, lakes) and has a decisive role in combating disease and prolong life. Mountains have been housed in ancient times human, have evolved together, being threatened by disasters, wild animals etc.. Mountain climate, and barometric pressure reduces the partial pressure of oxygen. In mountain conditions increase the number of erythrocytes and hemoglobin. There are many diseases treated: lung, anemia, tuberculosis, hypertension, muscle fatigue, obesity, neuroses, rickets and multiple endocrine disorders (tiroidismul). Usually the mountains are covered with forests, have several mechanisms that influence the body. Forests were found living pharmacies.
Silovoterapia – affects all body systems: neuro – endocrine, metabolic, cardio – vascular, respiratory and others. Forest is a source of oxygen: a hectare of forest in a sunny day provides about 220 kg of oxygen, which he spread in the atmosphere and absorbs 280 kg of carbon dioxide. The forest is of 5 to 10 times more negative ions than in the urban atmosphere. A hectare of forest of pine or beech, holds about 56-63 tons of dust and a hectare of oak forest spreads around 2 kg of ozone, which has the ability to remove bacillus dysentery and many other microorganisms to inhibit . In a forest m3 air circulates around 500 organisms, while the same amount of air in urban store there are 4 million bacteria. So you can see the importance of forests as antibacterial filter.
Most people have not yet realized that very detrimental factor, noise, is due not only roads and transport, but the rooms equipment: radio, television, telephone and others. Noise term, even if tolerance is responsible in 30% of cases of anxiety and in 80% of cases of migraine. I. Thomson, who performed special investigations, concluded, the phone used intensively and continuously shortens life by 3 years.
Oxygen, nitrogen and carbon dioxide in the air in some fixed proportions, while ozone, vapor in varying proportions. There oxygen in the air at a rate of 20.95%. For man to exercise requires a concentration of 15% oxygen atmosphere. Nitrogen level of 78.09% There is action to stabilize the oxygen. Carbon dioxide concentration in the air there in 0.03%. The concentration of CO2 in the atmosphere than 3% is toxic, and more than 5% lead to asphyxia.
Ozone air also contains 1-2 g per 100 m3, water vapor, gas: argon, helium, neon, xenon, krypton, ammonia, carbon oxide, sodium chloride, smoke and dust. Oxygen is the main component that determines the process of obtaining energy from the body maintain nerves in the processes of oxidative metabolism.
After some calculations of experts, a human adult requires 1 kg of food per day, 1.5 liters of liquid and 12 m3 of air. The maximum concentration of ozone is at a distance of 18-35 km from the earth, forming a protective layer of ozone, which has the function of protecting life on earth, cosmic rays filtering in only 20% reach the ground. On Earth, ozone occurs after electric discharge decomposition of oxygen. In mountainous areas increases the concentration of ozone. It has antibacterial action, which explains mountain fresh air. It was found that air containing high concentrations of ozone, acts positively on the body: it becomes more resistant to cold, toxicity, improve hemocirculatia. In nature ionizes air under the action of radioactivity in the air and ground elements. Also, the ions that are harmful to the body capabilities are neutralized by those with positive action.
The influence of cosmic radiation and the earth there is detachment of an electron from the surface atom and subsequent annexation by another atom, thus becoming the first negative and the second positive. Negative air ionization positive influence on the human body.
Mountain Dry air contains between 800 and 1,500 negative ions in 1 cm3, only 400 plain and the city at only 150 negative ions. Heating and air conditioning reduces the amount of negative ions in cold air. Negative ions favorably affect metabolic processes, respiratory, cardiac, endocrine, CNS, normalizing sleep, making cancers decreased. Simultaneously inhibit the action of microbes and viruses. Cold air stimulates the neuromuscular system function – vascular, increasing resistance against diseases.

UV light is only 1% of what is recorded to normal levels of the atmosphere. UV rays are absorbed by the skin tissue and then converted into vitamin D, calcium metabolism and actively participate in fosorului, activates the thyroid gland function, influencing processes respiratory, digestive, hemocirculatia, the endocrine system. Women are 20% more sensitive than men to influence air, especially during spring. Children and the elderly are less sensitive to UV rays, compared with adults. During the summer body sensitivity is lower than spring and winter. Infrared metabolism, cell activity, hemocirculatia.

Hydrotherapy. Human health is nothing more precious than water. Water was given magic power to become the sap of life on earth (Leonardo da Vinci). All living things have occurred due to the sun and Earth because of water. Water is the most expensive and most perfect substance of nature.
The main sources of fluid in the body are: water, water from food (vegetables, fruits that contain up to 90% water). Simultaneously, within certain limits the body can produce only water needed so – called endogenous water, which is the result of the polymerization reactions of metabolism. Thus, by polymerization of 100 kg of product is obtained 107.1 ml of water. They explain the rise in obesity by using water. Over time, the amount of water in the body decreases. If the age of 30 years constitute 60% of the fluid body, then at the age of 70 years – only 46%. Usually when I drink man is thirsty, but there are a variety of commercially different liquids containing sweet ingredients. Children not drink this liquid because of thirst, but the pleasure of consuming these beverages often contain toxic substances that lead to the occurrence of disturbances in the body. Water is considered as the main drug. Water should not only drink when you are thirsty, but repeated every 1-2 hours to perform necessary physiological actions.

Socrates walked barefoot, saying it favors, sharpening the mind”and Horace was forced to walk barefoot on physician sharp stones and, therefore, was cured of a serious illness. It is recommended to start every 5 minutes walking without shoes, and during these walks to be increased to one hour per day.

Hydrotherapy there for thousands of years and is important in maintaining health. The mechanisms of action are charged to exercise receptors thermal, mechanical and absorption of minerals through the skin.

Waters are used as hydrotherapy when water temperature is between 0 and 42 ° C, as termoterapiei if the temperature is 42-80 º C, in the form of vapor and air overheating in the form of cryotherapy using ice. The bathrooms have vasodilatory action and lead to lower blood pressure to influence vasoconstriction. Simultaneously, the influence and circulation. Thermal baths and steam sauna sweat gland function activates and results in elimination occurs in the capillaries of several metabolites and excretory activity of the kidneys also facilitates eliminating excess fluid from the body.
In our time when artificial and debilitating conditions of daily life of man hit, balneology is a return to nature and it is not simply a return but a return to health, many experimental studies determined effect.
Each source has its own particularities. Besides physical and chemical composition of water in different water fountains there are substances in small quantities but significant effects on the body. However it is possible that additional components to order just the curative capabilities. In the last 20-30 years has been given little attention Balneological treatment, considering that all springs are known for a long time. We think, however, in nature not established reactions that occur under the influence of cosmic energy and the Earth. Disorders that occur in different parts of the Earth affects the composition and physical – chemical water.

Everything in nature is not going straight, but in the form of multiple large and small frequency undulations. Some springs have healing capabilities in the past, but these actions were gradually diminished. Central Institute of Physiotherapy of the former USSR Curortologie and a group of physicians led by Prof. ZE Bahovschi treated a group of patients with sulfur water with concentration of 44 mg / l to 400 mg / l. The results were identical and much weaker in some patients compared with the results of Piatigorsk baths, where the concentration was about 24-40 mg / l. The same results were observed in comparative studies with radon baths and the artificial composition of natural origin. Finally studies have been stopped.
Data presented convince us that actually need to extend studies of many fountains clean, contemporary scientific level.
Studies in the years 1944 – 1960 are mostly devoted to the effects of mineral water due to their action on peripheral receptors. The mineral waters have complex action, because it acts at different levels, first the effect of cutaneous receptors in the neurovegetative system, the subcortical centers and CNS with reflex response and stimulating the endocrine system (adrenal gland) because it normalizes the secretion of hormones and therefore have inflammatory, allergic, angioprotectoare. Simultaneously, water temperatures lead to some vascular bed dilation, increased permeability of the capillary system and has percutaneous penetration of trace elements in the body. Last found, usually in very small quantities, but their effects are favorable, acting on metabolic mechanisms organsimului. Artificial introduction of these elements in large quantities often can have adverse effects. The presence of an excess of trace elements can give rise to a chain reaction producing toxic radicals whose acting is well known injurious.
I amdescoperit 8un minrrala water izvpr key area where the summit Zaganu curgeun spring, which was not used by anyone. In 2007 I got this chance and I arrived at the resort area „NICOLTANA” where I served tap water. I felt a particular aspect of mineral water. When we took evidence and we analyzed in the laboratory, we found that the water contains no chlorine – 0,001 ml, which also fascinated me, now all mineral waters include large amounts of Cl, because all water reserves are clorurizate, DEAC in body Human accumulated maximum amounts of chlorine. Now create a demineralized water storage plant under the name „KEIA” which absorbs large amounts of Cl in the body, beneficial influence human health status.
Some of the positive effects of various private bathrooms: bath sulfur metabolism in the liver, kidney radon baths, containing radioactive gas and basic products, acts on receptors in cutaneous, water and a sodium-chloride-bromine-containing trace elements: iron, bromine , copper, manganese, cobalt, arsenic, potassium silicate, manganese, fluorine was Waters in areas where iodine-containing extract oil and gas in large quantities. These positive influences hemopatii water (increase the number of erythrocytes and leukocytes, the amount of hemoglobin in the blood), improves capillary circulation, normalize blood pressure. Simultaneously, these bathrooms regulate thyroid function and adrenal gland.
Most thermo water for millennia have been primarily used in treatment of joint, muscle, vascular, spinal cord.
Sea water influence on physiological mechanisms of the body occurs through the action of functional control, so it can be appreciated as a medicine. The philosopher Plato said that the great wash all the wickedness of man”and Hippocrates recommended patients seawater baths.
Thus, in antiquity, thalassotherapy was acclaimed as one of the most effective treatment methods.
However, many components found in marine waters have not yet been studied to determine their effect on the body, so treatment of the sea includes several factors: highly purified air, sunshine, hot sand, seascape, aroma and more.
At the congress of thalassotherapy (Saint Malo, France) to said warm sea waters enhances the action of calcium ions, magnesium, potassium, iodine, etc.. with the ability to penetrate inside the body. Also, attention and influence of algae on the skin. Bioactive substances and ionized, minerals, vitamins, proteins positively influence the body’s defense mechanisms.
Seawater therapy treats chronic respiratory stimulates the growth in height in children, acts against allergic diseases, hematological, cardiovascular and joint diseases against axial miofasciale, gynecological and dermatological.
Physiotherapy. Physiotherapeutic methods occupy a special place in the treatment of most diseases important in combination with drug therapy or alone.
Increasing influence of different energies (cosmic power, those in laboratories, radio waves, telephone lines and more) are likely bioenergetic system of human body, predisposing to increased incidence and prevalence of many diseases of CNS and PNS, immune, endocrine, metabolic and oxidation and antioxidarii.
From the above results that physiotherapeutic methods must be used not only to stimulate physiological processes, but more in their functional regulation by selective action on adaptive systems, using micro-doses of very low frequency energy. These methods have not only action at the cellular and molecular level, they influence the metabolism of membrane and other cellular bodies, but also have the ability to alter gene structure.
The use of modern physiotherapeutic methods enable to determine the effectiveness of physiotherapy treatment prognosis of many diseases and rheumatic heart. Physiotherapeutic methods are heterogeneous action with the transition from action to action specific syndrome – pathogenic.
Fundamental studies performed in contemporary physiotherapy phenomena reveal the mechanisms of action of genetic determinism in question methods (physio – genetic and functional capacity of mesenchymal cells modulate the truncated (CMT) which formed the basis of cell therapy fiziomodulatorii.
Functional dependence was evident between the curative effectiveness of physiotherapy factor and genetic characteristics of the patient, which allows us to assess the diagnostic method of gene polymorphism on treatment efficacy of physiotherapy prognosis.
Thus, individual sensory fiziogenetica studying the genetic basis of the patient’s body from physiotherapy and influence functional capacity factor gene: expression, nestabilitatea, mutual reactions between genes to
Now, are successfully used low-intensity laser irradiation, light, magnetic field, electro-magnetic radiation of short wave frequency tuning fork (FSU). Irradiation with laser light influences many biological processes in the body: stimulating the immune system, normalizes metabolic processes, acts anti-inflammatory, analgesic to Low intensity laser irradiation (Ilija), in association with light irradiation (spectrum a range 630-850-890-1300 nm) activates metabolism, immune reactions, contributes to the restoration of cell membrane, activating enzymatic reactions, normalizes blood circulation and lymphatic.
Continuous magnetic field (CMC), the mechanisms which influence the normalization of membrane potential and oxidative processes cause a sedative action, and stimulates the endocrine system antiiflamatoarie. CMC acting on the cellular effect of chromosome orientation in the magnetic field – genetic susceptibility factor to enhance the resonance radiation field.
Electromagnetic radiation in low frequency tuning fork stimulates the body’s adaptive processes, normalization neuroumorale functions, lead to changes in physico-chemical composition of blood and lipids in cell membranes. CMC association with low intensity wave action increases the effectiveness of 1.5 – 2 times and duration of therapeutic effect.
Bioresonance therapy methods can be explained by the phenomenon that occurs in functional changes membrane and intracellular organs that are targeted electromagnetic field acting on the processes of oxidation and antioxidant mechanisms related to phosphorylation. These two methods have synergistic action determined by the length of wave action energy, audio component, function and laser diode light source biological effect.
Disorders frequency electromagnetic fields to generate their own cell, which arose from the different pathological processes with several parameters are normalized to the intensity due to reform normal cell generators. Mutual reactions of internal and external fields are essentially mechanisms of action of these methods. Factor is associated with physiotherapy after intercellular biophysical events.
Ilija is based on a field of millimeter wave, and CMC in a field where the micrometer. If the first case the action of resonance occurs at the cellular level and organic, in the second case occurs at the molecular level. Bioenergy field penetration depth and the absorption of these different radiation (2-6 cm for the magnetic field continuously for FSU 300-500 mkm), CMC + irradiation FSU ensure homogenization and subcellular processes in large cellular tissue. Because there is a synergism between these two methods – common effect produced is much higher. Low frequency rays are absorbed by the top layer of skin (epidermis and upper layer of the dermis) that is those regions where the majority are sensory receptors that interact with the CNS.
Intensive absorption of free ion concentration of Ca + + in the cytoplasm. CMC can be applied over clothing, wet dressings with drugs, creams. Low frequency waves are suitable for application on dry fabric, plastic, wood, gypsum, 2 layers of wet gauze.
Low-intensity waves are more efficient, being applied over the organs, vessels, lymph nodes, gladelor endocrine specific acupuncture points.
The parameters of the overall effects (hypotension, coronary dilation, hipolipidemie etc.) were highlighted as factors independent of, the basis”, such as genetic polymorphisms that determine disease development and environmental influence in the quality of which is instability and gene expression .
Functional dependence was evident between the curative effect of physiotherapy and genetic characteristics of factor allowing patients to appreciate the importance of genetic polymorphism diagnosis for effective treatment.
Fiziogenetica physiotherapy field of study is investigating the genetic basis of individual sensory and physiotherapy patient factors influence the functional capacity of legitimate gene: expression, instability, mutual reactions between genes to
Art studies (GN Ponomarecno, 2006) underlying the possibility to prove that physiotherapy methods (laser irradiation, where extremely high frequency) have the ability to stimulate mesenchymal cell migration truncated (CMT) of bone marrow in patients with some serious heart disease (dilated cardiomyopathy).
Polarized light is used to treat many diseases, leading to improvement of microcirculation, exerting anti-inflammatory and immunomodulatory. Is used to treat many diseases polarized polychromatic light produced by the device fototerapeutic,, Bioptron-2”(Switzerland: 480-3400nm, 12J/cm 2, 95% polarization, D = 15 cm). When using this method after 24 hours was found: improving hemocirculatiei and rheological and transport capacity of erythrocytes, decreased platelet aggregation, leukocyte intesificarea activity, decreased plasma concentrations of proinflammatory cytokines (IL6, IL12, TNF-alpha, IFN-1 ) in individuals with the indices raised and increased inflammatory cytokines (IL-10, TGF-beta, IFN-gamma) and stimulate cell proliferation, activation of DNA repair capacity in plasma of affected cells.
The human body uses solar energy, erythrocytes are valued as a source of sunlight. Polarization optical light increases the activity and effectiveness of action. Action polarized polychromatic irradiation device using Bioptron contribute to activation of immune defense and adaptation. It was found that light activates antioxidant enzymes and antioxidant activation leads to prolonged irradiation of erythrocyte membranes.
Mezodiencefalice modulation effect (MMD) on CNS activity is expressed by compensating process and is effective in normalizing hiperexcitare power excitation and inhibition processes to stabilize, which was proven by analysis of psychological testing. MMD will positively affect homeostasis, detoxifying effect, improve processes and adaptive neuro status – psychologically.
Transcranial electric stimulation (EST) is selective action oriented defense system (antinociceptie), mechanisms of nerve formations found in subcortical structures whose function is truncated by the participation of endorphins and serotonin performed as neurotransmitter and neuromodulator. Have established experimental effects such as analgesia and decreased intensive pronounced vasomotor reactions, stimulate tissue repair processes affected, the activation of immune reactions, especially of NK cells (natural killer) led to activation of phagocytosis, inhibition of tumor growth.
Physiotherapeutic methods has been established that positive influence on immune cell activity and humoral processes by activating immunocompetent organ: endocrine glands that regulate lymphoid system imunogeneza and organs.
Acting on the peripheral lymphoid methods consisting of: spleen, peripheral lymph nodes, liver, enhance immunity by place of projection of the endocrine glands: pituitary, thyroid, adrenals.
Rehabilitation includes a complex of processes: mechanisms of biorhythm, mechanisms and phenomena of conditioning, synchronization activity of various organs and systems.
Adaptive synchronization process is altered in acute and chronic and is associated with slowing hemocirculatiei. It was agreed that before and after surgery in patients hemocirculatiei slowdown occurs and then there is normalization of post-operation.
Rehabilitation is a complex activity with many methods of action that lead to normalization of adjustment mechanisms biorhythm (adaptive) and different organs and systems sincronitatea activity. Full activity of the CNS is determined by the acceleration hemocirculatiei brain, which have faster rehabilitation of patients.
Cryogenic physiotherapy is a treatment based on stimulating the action of cold gas (at 150-130 ° C) on the human body. Temperature regime and duration of the procedure are selected by inertia caloric According to our body. Action to significantly lower temperatures are subject to those sections of skin have more receptors for cold temperatures. Change shell skin temperature field is found to no more than 14 mm in depth. Cryotherapy – hemocirculatia stimulates peripheral possesses analgesic effect and stimulates the immune system
Cryogenic Reaction to action is based on information from receptor afferents skin layer. Quantitative link between excitation intensity and the intensity of signals received from the receptors is determined by the law of psycho-physiological Stevenson, describing causation and dependence proportional. It was found that skin surface temperature drops cryotherapy provides up to – 2 ° C, superficial frostbite is possible to decrease skin temperature to -2.5 ° C, therefore, ensure supercooling subtermala cryotherapy skin.

Lemniscal sensory receptor system provides control skin surface cooling. Thus, in the last decade, experimental and clinical results were obtained in November, which allowed the use of low-intensity physical factors extreme healing cellular and molecular level. Physical factors influencing the heterogeneous body, evoking the differentiated pathogenic action. Physiotherapy core studies reveal genetic determinism phenomena curative action mechanisms physiotherapeutic methods. Appear possible to use methods for achieving effective physiotherapy treatment using immunomodulators extremely low doses of physical factors, which are not associated with adverse reactions. The display allows the conclusion that currently, physiotherapeutic methods can be applied more widely, both in chronic processes, and in the acute, both in degenerative diseases, inflammatory and autoimmune as well and are very effective for preventing many diseases.
This condition leads to receptor excitation threshold of the sensory system extralemniscal (SSEL). SSEL receptors are activated only physical actions, the intensity of which presents a danger of irreversible tissue alterations. SSEL appreciate the difficulty locating irritating factor, is why cryotherapy induces analgesia in organs that have not undergone hypothermic effect. Signals received from these receptors are distributed around the brain region responsible for thermoregulatory. A strong signal, but not distributed all over the area, does not evoke an intense reaction response and vice versa. Cryotherapy only stimulate the entire generalized thermoregulatory areas. To activate this system are brutal stimuli required to limit skin damage surfaces. Stimulation is effective if the temperature recorded by cold temperatures receptors terminal is approaching the threshold.
Mechanisms of influence of physiotherapeutic methods are very complex and many lesser-known phenomena, progress in nuclear technology have made it possible to highlight some events that highlight the micro-electrophysiological changes at the molecular level.
Because the disease process initiated by the appearance first bioenergetic system disorders is obviously to develop methods for early diagnosis and effective treatment to make the necessary depth studies in the bioenergetic system.
Currently, methods aimed at physiotherapy less electromagnetic stimulation lead role in regulating energy use disorders microdoze bioenergy fields that are in the body. Circuit which is especially acute pathological processes: spasm-pain-spasm occurs first bioenergetic field disturbances due to their insufficient or microvascular spasm. In this case, low doses of physiotherapeutic factor regulating migration will lead to bioenergetic field, spread it on some neuro-hemostatic pipes. These disorders appear not only in subjects bioenergy that have contact with certain machines, tools, laboratories, factories, and from the influence of television, radio, cellular phones to A very important factor in triggering the disease process is common outside the body rhythms.
Electroimpulsatia is repeated short pulses of low intensity and frequency of pauses. Impulses can be single or in series.
Pulses are differentiated by the shape, duration and frequency. Depending on these characteristics, impulses can irritate (electro muscle) or inhibit (an effect which is based electroanalgezia). The combination of stimulation and inhibition is achieved by diadinamoterapie electroimpulsurilor (amplipulsterapia). Amplipulsterapia modulator is achieved by using low frequency (10-150 Hz), forming a series of pulses with frequency of 10-150 Hz.
Magnetic low-frequency waves work by forming the magnetic field. Action is that the magnetic field effect on charged particles, hence the physical, chemical and biochemical taking place in the body. After magnetic induction law, in blood and lymph is a low power, the change decurgerea metabolic processes, acting on components of crystalline solutions on water, proteins, polypeptides etc.. Under the action of the magnetic field acting electric and magnetic mutual ties of cellular and extracellular structures by editing the permeability of cell membranes and metabolic processes.

Ionoplasmoterapia. Currently, due to disturbances occurring in the environment was found excessive growth of external energy fields that affect the human body’s bio-energy. They have helped many functional disorders and morphological appearance, first in the CNS and neuro-vegetative system, which are major producers and filmmakers of bioenergy. As in any molecule, the cell has a specific electromagnetic charge, the excess energy outside the body greatly influenced the initiation of many pathologies leading to systemic, especially damage to the CNS (nervousness, depression, aggression and, therefore, alcoholism, drug abuse, addiction, suicide, murder of relatives, colleagues (USA). The action of these factors continue to gradually lead to the development of impaired energy morphology, which then turns into genetic processes. increased cosmic radiation, gamma rays, X rays, electron beams and neutrons have very strong influence on the body. pathologic process of developing mechanisms depend very much on the wavelength of radiation. The radiation wavelength 240-300 nm evoke serious changes in the protein. disorders intense electromagnetic influence on oxidation systems and antioxidant content with excessive growth of RL. They play an important role in cellular structures such as proteins, nucleic acids, was evoked by radiation diseases are caused first by the accumulation of large amounts of oxygen free radicals. radicals participate in the mechanisms of cardiovascular pathology free of oxygen, such as nitric oxide.

In order to influence the regulation of bio-energy system, we studied the method in treating many diseases ionoplasmica: rheumatic, neurological, metabolic to, using the device, Rotor”, dst builder Valeriu Rudenko.

Ionic plasma flow is produced by exposure to bipolar ion flow density independent set of positive and negative ions flow to the power efficiency of current 20-300 MCA and exposure time 1-10 s.

The proposed method essentially consists of the following. The passive electrode is attached to the patient, then the affected areas or reflex to act ion flow through the active electrodes, which have direct contact with the body. Active electrodes are bipolar transmit voltage from high voltage generator. The electrodes transmit alternative source switch high voltage positive and negative. In the space between the electrode and skin surface ionization occurs and the patient’s skin are transmitted alternately positive and negative aeroioni. Ion flux density, determined by high-voltage pulse frequency can be set equally for both polarities, but can be different. This is achieved by adjusting the voltage values. Frequency factor is determined by the frequency electric pole change switch contact. Exposure duration for each polarity can be set equal or different. During the procedure depending on the density of ions is determined 5-20 minutes. The total number of procedures is determined by the dynamic recovery process. There were no observed cases of patient deterioration, complications or other adverse effects during treatment with this method and beyond it.
Method of action on the patient’s body with bipolar ion flow, with parameters adjusted independently, allowing differential action and focused on the patient’s affected regions, areas of skin or reflectors, evoking selective inhibition or excitation. May result in the reduction of healing the patient.
Research experience made the recommendation allows noninvasive method for treatment of rheumatic diseases, neurological rehabilitation and post-traumatic and postoperative patients.
Physical activity. Industrialization, automation, work predominantly intellectual and sedentary lifestyle led to the development because many incurable chronic diseases: obesity, osteoporosis, atherosclerosis was
Hypokinesia is associated with muscle hypotrophy, decreased myocardial function, decreased gland secretory function, vital lung capacity shrinks. In this context, obesity has become a matter of medical and social importance, which serves as substrate for the initiation of several cardiovascular disease: myocardial infarction, hypertension as well as osteoporosis, cancer.
The human body is a complex that includes multiple systems with different functions and all works rhythmically, each with a special rate designed to provide optimal physiological functioning and specific. Movement is bioelectrical activity generator that provides the functions of the body, regulates hemocirculatia, digestion, respiration, elimination of toxic metabolites in the body, normalize and enhance the intellectual processes. One of the main physiological factors of maintenance of the body of rules that favor the improvement of body and adapt to new conditions of nature is walking, in other words, the exercise of fundamental human oldest. In the human body in the field went green, vis-à-vis the garden, forest, river, sea, mountain intensify the processes of absorption and utilization, in addition to oxygen, many other substances in the environment.
Physical work, movements are seen as necessary for ensuring health and human existence. Changes that occur in the digestive system to the patient immobilized in bed is a long held that special syndrome that lead to disorders of the pancreas concomitant activity, decreased activity of intestinal motor, dysbacteriosis appearance.
Hypokinesia is associated with decreased muscle function, bioelectrical activity, decreased metabolism and calcium concentration in the system is now bone decreasing gluconeogenesis in the liver processes. Hypokinesia influence lipid synthesis, hydrolysis processes, transport, lipid absorption in the digestive system, supporting hypercholesterolemia and is advantageous for producing a field computer.
Homeopathy. Homeopathy treatment method it represents the standing-like treatment (Similia similibus curantur), that all medicines have the ability to cause disease state in healthy men, however, to remove this condition in patients.
Example – opium in large doses in healthy man, evoke sleepiness, and in small doses cure a patient of this state. Another example – the areas of applied snow frozen.
Following Hanemann (1790) – On any disease can be considered a substance if that substance affects the fair treatment similar in healthy man. Hanemann called this method,”the Greek word homeopathy Homie – similar and pathos – suffering and traditional treatments have been called,”allopathy (Alosa – Alta).
This concept has influenced the old school that was reviewed by the principle that higher doses more intense exercise therapeutic action and established the principle: sigilum summers simplex (simple truth is stamped).
Medications are recommended in the smallest doses, because it acts to annihilate nature and disorders that occurred in the body. Effect of homeopathic treatment usually occurs in late so you have to wait longer.
In case of acute diseases is necessary remedies to be recommended more frequently or in combination with several drugs.
Von Reichenbach’s experiments led to the present power that flows through the nerves – called Fort odica (bioelectric energy), which expresses how he ranks between magnetism, electricity, light and heat, which is like all these powers and also to different from them.
Due to the discovery of bioelectric power, it changed her mind about the mechanisms of disease development. In the opinion of this trend, because any disease is based on the disorders that occur in bioenergetic system activity, which usually occurs before clinical signs of disease. Health is appreciated that the relationship between body and positive and negative bioenergy. In healthy people prevail bioenergetic flow negative activity, which, in animals play an important role compared to that of plants. The more healthy body, the more negative energy grow (Karl Ludwig von Reichenbach).
Hanemann says that homeopathic medicine is spiritual action, as occurs with hypnosis manipulative. Hipnotizorul focuses its healing power, leaving it only to find their way and give directions required homeopath and homeopathic dominate the disease by sharing drug properties sent water or drinks, the bioenergetic peculiarities of homeopathic medicine.

The lower is the amount of the substance, the better it gets into the body, the smaller the particle the greater the qualitative difuzie.Particularitatile her power does not change the reducing substance is the right cantitativa.Organismul – and left with negative Odica force – by force Odica positive. Different drugs outside of their specific action, in some degree or negativa.In positive influence odica force when treatment is prohibited alcohol, coffee, spices, mineral water. It allows simple food, usually with predominance of plant food.
If the dose of drug received, no changes have occurred in the patient’s condition, have to wait a while, then recommend another medication. Only those preparations will remove the disease is selected correctly. When such a drug is identified, with as little or as it is rarely used, the better will be the effect.
In acute diseases or drugs should be administered more frequently is advisable to use 2-3 medicamente.Astfel author describes a new principle of treatment. Now it was found that taste buds can appreciate the strychnine in a dilution of 1:1000000. Effectiveness of homeopathic method is that extremely low doses the patient receives, so it is excluded by toxic action that is seen in all remedies. Receiving treatment for a long time influence on nerve cells.
It is necessary to remember that in most cases, especially when a chronic process, occurring disorders in multiple systems. In all cases the drug helps the body, but does not replace its function. So in many diseases may need a boost guidance, very small due to take place a chain reaction, we assume the mechanisms of free radicals. To protect the allergic reaction, hypersensitivity is sufficient breeze aroma of plant body is sensitized. To include in the overall immune systems, producing neuromediators, interleukins is not necessary to insert large amounts of substance, but again, they cause hypersensitivity effects

What is ENTOMOTERAPIA?

Administration preparations obtained dintesuturile insect species showed different positive effects in treating many human diseases (Ciuhrii, 2005). Insects are among the oldest living things on Earth eukaryotes. Albina is the best known insect to treat human diseases einsecte products obtained are used to treat many diseases. Since ancient times, bee venom to treat many diseases are recommended: for anesthesia, normalize digestion, wound treatment (Egypt, India, China, Greece), in blood pressure, normalize metabolic processes and function processes and regulation of viral life processes and eliminating vital processes against infection. But be aware that tewbuie in cases of viral infections to stimulate the body’s vital life processes, can speed up viruses or other pathogens and mulutiplicarea formatiunelor tumor and then intensify the pathological processes leading to complicatiisi larger body. A classic example is the behavior of dogs, that during severe sfectiunelor stop eating until afectiunele not improve.
Currently not sufficiently studied changes occurring at the molecular level of insects depending on their development phase, which differs considerably compared with those of other creatures. Genetic engineering has made it possible to modify the genetic structure of baculovirus by inserting foreign genes. Therefore bacilovirusilor genome, has a powerful donor creates conditions necessary to secure foreign genes in viral genome structure. This recombinant genome enables to obtain the desired active substance. SBA as interferons, vaccines, interleukins and others were obtained by these methods.
Own gene replacement method of gene foreign Ensure that their protein production (eg A10) to be substituted with the desired protein (M. Ciuhrii, 2003). It is found that arthropod insects have specific composition, which differ greatly in different phases of development of other species.
Thus, larvae that feed very intensively accumulate large amounts of proteins and lipids, and transform into pupae larvae, when part of the lipoprotein components of the larvae turn into polisaharide or protein (chitin or keratin inert) inert, which occupies a large part from pupae. Turns stern protein keratin, which constitutes 80-90% of body butterfly (imago). Subsequently for 4-5 days and lay eggs are fertilized, which have a biochemical structure. In the insect bodies contain proteins that exceed 70% of the dry, every few hours also amino acid composition of proteins changes.
Biologically active substances extracted from insect larvae possess keratolytic action, bactericidal, antiviral, antifungal, antirheumatic, anti-thrombotic, anti-cancer (Fig.). Proteins having keratolytic effect in their content dominated phenylalanine, glutamic acid, asparagine and lysine. Experiments on animals (rabbits, dogs, horses) have shown that using biologically active substances leads to the disappearance of keratin formations (seborrheic warts)
without leaving traces. Keratolytic drugs have a strong effect of resorption keloizilor burns, wounds, or corns (Ciuhr5ii, 2005).
Proteins obtained from haemolymph of insects have a positive effect against staphylococcal and streptococcal infections and population density regulation of E. coli. Currently 5,000 species are known to contain biologically active substances (BAS) with different actions and studied SBA 6000. The large number of insect species diversity SBA determines, with different morphological and biochemical structure.
From ancient times (China, India, Egypt, Greece) were used bee products: venom, propolis, pollen, royal jelly to treat many diseases (injuries, digestive disorders, anesthesia). Purified bee venom was obtained for the first time by N. Pollak (1928). Bee venom contains: toxic peptide, vasoactive amines and enzymes. Is the main component of the venom peptides melittine, which contains 26 amino acids with a molecular weight of 284 Da. Another basic peptide of bee venom is MCD, which includes 22 amino acids and analgesic action has stronger anti-inflammatory effect compared with metilina and 100 times more active as hydrocortisone. Apomina polypeptide that causes neurotoxic venom affects the nervous system of the spinal cord, liver and muscles. Small amounts of other peptides were obtained: tertiapine with presynaptic action, cardiopenul affect heart activity, secapine – sedative and antipyretic, procamina – anesthetic effect. In very small quantities were obtained vasoactive amines such as histamine, dopamine and norepinephrine. Phospholipase hydrolysis processes lizolicitina phospholipids form, the latter effect the destruction of the cell membrane and blocking the release of mediators from nerve cell endings. Of bee venom were obtained enzymes: hyaluronidase, acid phosphatase, fosfomonoesteraza.
Propolis – „pro” – for the „polis” – city – the substance that is used for bonding holes hives, has antibacterial action. Propolis acts effectively on the 100 species of bacteria and has an analgesic effect against wounds, exemelor, varicose ulcers, furunculosis, burns, gastric and duodenal ulcers.
Larva feeds on royal jelly and increases in 6 days or 2700 and make 1500 eggs a day. Her longevity is 3-5 years, while the worker bees is only 1-8 months. Royal jelly contains protein 45.15%, 13.55% fat, 20.39% carbohydrates (glucose and fructose), vitamins, amino acids, trace elements, hormones and other biologically active substances. French scientist Caylas I. (1953) wrote „Bees are the source of youth and life,” that substances produced by them have tonic effect, stimulate metabolic processes, normalize cardiovascular activity and digestive systems. Honey is recommended for diseases of the liver, kidney, stomach, intestine and airways.
Less known are the effects of cockroaches products that contain biologically active substances with curative effect for skin wounds, boost sexual potency and antitumor action.
Extracts of the ants are used in antiquity to treat joint disease or nervous system. Toxins extracted from red ants contain formic acid (CH2O2), which is the active ingredient and excipients and citralul citronealului (9:1), the structure asemenatoare vitamin A, have analgesic action, anti-inflammatory, vasodilator, antikeratozica, anticonjunctivitica. Iridomicina obtained from ants have bactericidal activity. Toxins were extracted from ants creams recommended for rheumatic processes (Serena Samonic sec. II). Currently, preparations are recommended as formic acid in ethyl alcohol (100 ml 14g alcohol 70 °) against rheumatic pain syndrome.
Medicinal products cockroaches (orientalis leaf and leaf Germany) are used to stimulate the activity of sex glands and diuresis, strengthen bone fractures, to remove fluid from patients with liver cirrhosis (SR Botchin, 1876).

Extracts of the larvae of flies are used against many diseases: acute infection, purulent wounds, osteomyelitis, tuberculosis, strep throat. Mechanisms of action of the larvae of flies are expressed through the action of proteolytic enzymes, which inhibit bacterial growth. Urease, found in extracts, the interaction with urea, forming ammonia. Fly larvae extracts were used in the treatment of many diseases: a osteomyelitis, keloizilor burns, gangrene. In ancient times they used extracts from larvae of several species of flies in the treatment of purulent diseases (staphylococcal, streptococcal): wounds, infections, acute osteomyelitis. Avicenna and bugs and fleas Diascorid used as mobile in the treatment of malaria. After some information of the Arabs – Mantis religiosa insect pupae have the ability to stimulate sexual activity in men and women regulate kidney function. Substances extracted from crickets, are administered to treat colitis and hepatitis, and extracts from locusts (China, Japan) are taken with a view to removing moles and hemorrhoids. In many countries malaria is recommended lice, liver cirrhosis. Extracts are useful in treating scabies crickets and urticaria. Biochemical studies have revealed some differences in the composition of lipid extracts obtained from Lepidopterelor, beetles, and Aphidiilor Dipterelor. They are different from those extracted from other creatures, because lipids extracted from insects contain unsaturated fatty acids of the outstanding highlight animal and also the common parts of the plant extarse. Of particular interest are arthropods, which is dezvolarii hransec intense process, accumulating a large amount of fat, and the larvae transform into pupae accumulate some large amounts of protein, keratin last turns constituting 80-90% of body butterfly (imago).
Because amino acid composition of proteins from insects change every few hours, they make it possible to obtain proteins with different properties. Thus, Lepidopterele contain glutamic acid, aspartic acid, proline, alanine and glicocoluluil in phase protein egg protein larva contains alanine, glutamic acid, glicocolul, aspartic acid, leucine, in stern predominant protein glutamic acid and aspartic acid, alanine, glicocolului and serine.
The mechanism of action of antiviral preparations obtained from insect SBA is expressed by their ability to transform some compositions in others. type keratin. In some phase of development of insects appear some inhibitors of protein synthesis and nucleic acids. These inhibitors penetrate the liver cells infected with virus and inhibits protein synthesis and nucleic acids.
they extracted from the haemolymph of insects have antibacterial capabilities (against Staph. Spp., Strep. Spp., E. Colli) successfully used to treat diseases, especially in cases when the missing response to antibiotics.
treatment of oral candidiasis, vaginal and skin were developed antifungal protein that stops multiplication of yeast.
It is necessary to obtain antitumor effects of insect SBA already has found the effectiveness of these substances in the treatment of cutaneous melanomas and carcinomas. Positive results were obtained in the treatment of prostate adenoma and cancer fribomului.

Entomology is a science that studies the insects as such – mormologia, their spread, and therapy is part of medicine, which deals with healing or improving the means for medical diseases – Treatment. In this case the insect tissues are used to produce drugs, because now we realize that in the insect body during morphogenesis, the many changes under the influence of various enzymes and defensin which can adjust certain vital processes of the body. There is a new drug industry based biologically active substances (BAS) from different species of insects. In the near future will produce dietary supplements that will be used to regulate the body’s normal function in certain situations. This will increase the longevity and human and other animals desired by man.
Insects have segmented bodies, each have six legs. Many believe that mosquitoes, locusts, dragonflies, spiders belong to the insect class. This statement is not true, because insects are only those that have segmented bodies.
The first time many people hear that there are natural medicines derived from insects, have a revulsion, a fear and immediately imagines the most common insects that occur in human life, such as cockroach (leaf or leaf orientalis Germany) , flies (dipterous), the Colorado beetle (Colioptera) and others. Repellents are less colorful butterflies, beetles forest. Some find it difficult to understand how these can help human beings? Among insects are bees, which feed the whole world with tasty honey or silk worm, the silk dress with the whole world, which until now is considered the best quality. The question does not exist and other insect species so useful to man? The author of this paper believe that there are still many species of insects, which can play an important role in human life. Lately melanogaster became an object Drossofila classic contemporary genetics studies. This insect has only two chromosomes and is an object of study to obtain genetic information and information about the regularities of transmitting information from one generation to another. All these changes are made only by the two chromosomes, which allows to determine the cellular genome functions. This bug allowed to determine many genetic regularity.
And insects of the family are NOCTUIDAE new, especially Autograph californica, Trihoplusia us, Mamestra brrassicae that can infest the recombinant baculovirus of new proteins to produce certain properties. Thus, it can produce interferonuri, vaccines brand new.
So far in complementary medicine no notion of „Apitherapy” which explores the products obtained from bees (Apis mellifera), especially honey, propolis, bee venom.
„Herbal” – studying the plants used in medicine
„Animal-therapy” – a direction that studying animal products used to regulate life processes of man.
In this context the term ENTOMOTERAPIA – is a new direction in science which studies the use of biologically active substances (BAS) important biologically active substances (BAV) in the regulation of various vital processes of the human body and domestic animals. Nobody has yet thought that tissues of certain species of insects exist SBA, which may serve to regulate certain vital processes of human beings in the regulation of certain compositions, the protein aminoazizilor. Thus, if the human protein components are missing or are not sufficiently certain amino acids it can complement other sources, especially certain species of insect tissues at certain stages of development.
SBA of insects can be used in cases of infection caused by viruses, bacteria or fungi, because some insects may stop replication of SBA certain pathogens or there compositions such as „cytostatic” or „interferons”
Insects that exist on Earth for more than 3 billion years before humans have been another system of defense against bacterial and viral infections. Insects, unlike vertebrates, does not form antibodies, they form the oligopeptides, which regulate the activity of immune bodies. This system is effective and to lift the immunity of human bodies in different cases. If we could adapt some of the bodies immune system of invertebrates were higher then and human longevity with several years – the aspiration of all people.
Insects use in medicine is an entirely new one which will revolutionize the future production of medicines. Few people know that insects are ancient beings on Earth. The diversity of these organisms is extremely high and includes more than 61% of all organisms on Earth (Dimarcq 2003). Over time the insects in turn were attacked by different pathogens, including viruses (Ciuhrii, 1972 – 2007), which responded differently to pathogens. First, insect body does not form antibodies react as vertebrates. Insects have achieved a great immune system from other organisms. Chemical composition of insect tissues (Hetru, Hoffmann, Hancock 2002, Knopp, Mizina 2003) differs completely from other organisms. Unlike other animals, insects go through several stages of development (Fig.): egg, larva, pupa and adult (imago).
Fig. Lepidopterelor morphogenesis: first form the egg, then larva, pupa and imago (adult)

At each stage the insects not only change their morphology but also chemical composition. According to data (Ciuhrii 1977, 1982, 1988, 1995, 2005, Jean-Luc Dimarcq 2003) insect tissue include biologically active substances (BAS) with different properties. Until now man looked more insects to find ways to combat it. Thus was developed the most advanced chemical weapons, biological physical and destroy them. These weapons have caused the emergence of new possibilities of insect resistance by increasing the potential for breeding and changing the chemical composition of tissues to resist these attacks. It is curious that insects have developed new ways of resistance to attacks of various kinds of infections and toxins. Viral infections, insects do not form antibodies (immunity) as vertebrate organisms. Different types of infections resistant to insects is still very little studied.
Fig. Properties of biologically active substances of insects

Intense use of insecticides has led to natural disasters, causing imbalance in natural ecosystem, leading to a large number of diseases of humans and animals.
There was a new discipline where Weiser Insect Pathology (1972) found that insects are attacked by pathogens, among which are the most effective baculovirus (Ciuhrii 1977, 1982, 1988). Research conducted recently (Ciuhrii 2000) have shown that insects, unlike other bodies have other defense than other beings. The tissue composition includes a greater amount of micromolecule (peptides) that plays defense (Cecropine, Drosomycine, Attacine, defensin, Diptericine). The insect can be extracted peptides and polypeptides (1 and alloferon alloferon 2), which raises human immunity against various infections.

Two main directions of complementary medicine:

Homeopathy;
Acupuncture
Phytotherapy;
Entomoterapia;
Apitherapy;
Acupressure;
Reflexology
Therapeutic massage;
Music therapy;
Chromotherapy;
Crystal
Kineto;
Bioenergoterapia;
Sacroterapia
Aero-, helio-and talazoterapia;
Sacroterapia.

Last direction is the oldest and most effective if done with true faith. It is an unimaginable force of human reason yet
All phenomena of nature are directed toward correcting the life processes of human beings, whose structure and functions are not yet fully known, although there
Institute specialized in different areas: cardiology, pulmonology, ophthalmology, ENT, specialist research institutes for the treatment of certain diseases, Institute of oncology, psychiatry, neurology, pftiziologie, Rheumatology, Cardiology and more, have an intense research to identify new methods and systems to improve certain vital human dysfunction. I recorded a lot of inventions of directing human life processes and human longevity however is still lower than that desired. Everyone expects new discoveries in the field of human health, primarily to find new possibilities for food and medicines proper, which would increase longevity.
We must recognize that in many cases desperate private doctors in the deaths of their peers, they can not interfere with the proper methods for saving patients. In many cases, patients resort to other methods, which in some cases can save lives. Cases cured us to examine other methods that are not supported by the Ministries of Health. There are many contradictions between patients and administration that put the deficultate authorities. In many cases occur when situations are desperate cases to recover without medical explanation logical. Exactly this situation makes us to discuss further directions of complementary medicine, which is not yet supported by official medicine. We are also convinced that the meetings have to gain. Maybe some information can come from outside the medical system. Besides allopathic medicine has benefited from many directions of development in different fields: chemistry, physics, mathematics was
The diversity of living organisms
1.5 million species of insects
300 000 plant species
90 000 species of mollusks
70 000 species of vertebrates
35 000 species of arachnids

As far there Phytopathology studying the use of plants in medicine, so the insects used in pharmacy may be called,, entomoterapie ”

The main directions of complementary medicine:

Homeopathy;
Acupuncture
Phytotherapy;
Entomoterapia;
Apitherapy;
Acupressure;
Reflexology
Therapeutic massage;
Music therapy;
Chromotherapy;
Crystal
Kineto;
Bioenergoterapia;
Sacroterapia
Aero-, helio-and talazoterapia;
Sacroterapia.
Last direction is the oldest and most effective if done with true faith. It is still a force of unimaginable human reason. All phenomena of nature are directed toward correcting the life processes of human beings, whose structure and functions are not yet fully known, although there are specialized institutes in various areas: cardiology, pulmonology, ophthalmology, ENT, specialist research institutes for the treatment of certain diseases, Institute of oncology, psychiatry, neurology, pftiziologie, rheumatology, cardiology and many others who have an intense research to identify new methods and systems to improve certain vital human dysfunction. I recorded a lot of inventions of directing human life processes and human longevity however is still lower than that desired. Everyone expects new discoveries in human health, primarily to find new possibilities for food and medicines proper, which would increase longevity.
We must recognize that in many cases desperate private doctors in the deaths of their peers, they can not interfere with the proper methods for saving patients. In many cases, patients resort to other methods, which in some cases can save lives. Cases cured us to examine other methods that are not supported by the Ministries of Health. There are many contradictions between patients and administration that put the deficultate authorities. In many cases occur when situations are desperate cases to recover without medical explanation logical. This situation makes us to discuss further directions of complementary medicine, which is not yet supported by official medicine. We are also convinced that the meetings have to gain. Maybe some information can come from outside the medical system.
Besides allopathic medicine has benefited from many directions of development in different fields: chemistry, physics, mathematics was
As far there Phytopathology, who studies the use of plants in medicine, so the use of insects in pharmacy may be called,, entomoterapie „, which is a new direction more. When we speak of entomoterapie not talking about using insect products (honey, wax, propolis, royal jelly), but extracts from insect tissues at different stages of development. Insects, unlike other bodies, in their cycle of morphogenesis, not only morphology but also changes its chemical structure (chemical composition see inesctelor). These biologically active substances extracted from insects at certain stages of development have certain properties (Fig. 2).
We have focused on the study of lepidopteran insects, Caliopterelor, Dipterelor, Aphidiilor and others who are able to multiply rapidly and in significant amounts. In this way we obtain SBA of insects in significant amounts. So far SC INSECT FARM SA and SC,, TO SHOWCASE MAGIQUE „Ltd. have extracted SBA quantities of more than 40 species of insects, which are used efficiently to produce para preparations, food supplements and cosmetics (see list prepared belonging to the ranges,, FLY – FLY ‘and NOBLESSE „dietary supplements, HEPATITO-LIZ 1 and 2”, „immuno-MAX 1 and 2”), prepared registered at fine health Miniterul Moldova.
Based on SBA were prepared several patented (Patent List), which obtained so far a number of medals and diplomas at international exhibitions and competitions (the list of diplomas and medals).
It appeared the idea of using keratolytic enzymes performing biological operations replace surgical scalpel and scalpel. Biological operations can eliminate unwanted formations on human skin without pain and without leaving traces unpleasant because tissue has the ability to repair genetic exactly as built.
These operations represent a biological world premiere and were distinguished by more than 50 gold medals at International Exhibitions of Inventions and cosmetics.
Such preparations have created large biological perspective for contemporary medicine. It made one of the great aspirations of mankind – biological operations that obtained using SBA of insects can become sick in a healthy tissue.
Was recently recorded a very important biological preparation of prevention of blood vessel, ‘foot cream, „which can dissolve thrombi and emboli in blood vessels. Thus, varicose veins and arteritis obliterans can be removed without applying physical surgery and replacement blood vessels, especially of the coronary artery. SBA is working to use directly within the coronary vessels to eliminate vessel spasms that result in saving thousands of patients.
It is one of the greatest achievements in the use of insects in the treatment of man, which will greatly influence the longevity of human beings.
Another rapidly developing direction in applied scientific Center – SBA use of insects to block infections caused by bacteria (staphylococci, streptococci) and oral fungal infections, vaginal disorders. Are registered mouth care preparations, nail care, hair shampoo and lotion.
I think our biggest achievement is the development, patenting and production of pharmaceuticals, IMU-HEPTIN „,, ENTO-HEPTIN”,, IMU-Purines „,, adeno-PROSIN” toxicological testing that have passed, conditioning and management technology.
The first two preparations help stop viral infections (hepatic viruses, herpes), also help stop HIV – AIDS.
Preparations include a series of enzyme inhibitors of protein synthesis and nucleic acids that occur in the insect body keratinization adult stage, when the insect proteins pass into another form of keratin, which is 90%. Experiments in several hospitals of these preparations showed evidence of viral decline, globulin and albumin synthesis regulation to eliminate viruses from the body.
Preparation, imposed-Rhine „(Immuno – MAX) has the ability to considerably raise immunity. The drug is administered in gelatin capsules and in the form of suppositories.
Research insect tissue structure will lead to many pharmaceutical, para-, food supplements, cosmetics, which will solve many of the diseases now considered incurable human, which will decrease in the number of human diseases.

ENTOMOTHERAPY VOL2

Complementary therapies and their levels MAIN ACTION

Acts primarily THERAPY LEVEL MEANS
1. Psychotherapy 1. hypnosis
2. autosuggestion
3. a positive thinking. CNS, autonomic nervous system
2. neuroendocrine system 3. immunity
4. oxidation and antioxidant systems
5. bioenergy
2. A diet therapy. diet
2. composition
3. Preparation 1. digestive system
2. cardiovascular system
3. metabolism 4. immunity
5. oxidation and antioxidant
6. urinary system
3. Balneotherapy 1. mineral waters and thermal mud 1. neuro-vegetative system
2. neuro-endocrine system
3. muscle system, joint
4. skin system 5. digestive system
6. cardiovascular system
7. metabolism
8. immunity
4. Physiotherapy 1. electrostimulation
2. magnitoterapie
3. laser therapy
4. ultrasound
5. using light
6. Electrophoresis
7. UV 1. CNS vegetative peripheral
2. joint system, musculo-axial
3. skin system 5. cardiovascular system
6. metabolism
7. oxidation and antioxidant
8. immunity
5. Physical Therapy 1. gymnastics
2. swimming
3. a physical activity. CNS vegetative peripheral
2. respiratory system
3. cardiovascular system
4. digestive system 5. muscle system, joint
6. metabolism
7. oxidation and antioxidant systems
6. The method is based on acupuncture theory nerve reflex areas; actionandu on their track, it can produce analgesia and even improve the function of organs. 1. CNS vegetative peripheral
2. cardiovascular system
Respiratory 3.sistemul
4. digestive system
5. Urinary system 6. muscle system, joint
7. endocrine system
8. immunity
9. metabolism
10. oxidation and antioxidant systems
7. Phytotherapy 1. herbal medicines
2. use of plant extracts
3. Aromatherapy 1. CNS vegetative peripheral
2. cardiovascular system
Respiratory 3.sistemul
4. digestive system
5. Urinary system 6. muscle system, joint
7. endocrine system
8. immunity
9. metabolism
10. oxidation and antioxidant systems
8. Climatic (speleotherapy) 1. sunlight
2. mountain air
3. a maritime climate. respiratory system
2. cardiovascular system
3. CNS, autonomic, peripheral 4. muscle system, joint
5. metabolism
6. oxidation and antioxidant
9. Faunoterapie extracts obtained from various organs and animal remedies 1. CNS neuro-vegetative system
2. cardiovascular system
3. digestive system
4. Urinary system 5. metabolism
6. immunity
7. oxidation and antioxidant system
10. Entomoterapie use an insect extracts. vascular system
2. immune system
3. digestive system (hepar) 4. urinary system (prostate)
5. skin system
6. joint system, axial
11. Application flow ionoplasma Ionoplasmoterapie skin surfaces of affected areas and a reflector. CNS vegetative peripheral
2. endocrine system
3. vascular system
4. joint system, axial 5. muscular system
6. skin system
7. metabolism

12. Homeopathy use extremely small doses of substances with actions that evoke similar symptoms a disease. CNS neuro-vegetative
2. neuro-endocrine 3. vascular
4. respiratory
5. immune
Natural physical and chemical factors, which in evolutionary reflex became irritating to the body, acting phylogenetic and ontogenetic processes continuously become irritable reflector humoral factors influencing conditioned, to endocrine One of the older systems is the cutaneous receptors which makes tactical perceptions, temperature, pain. In evolutionary processes, as a result of central and peripheral nervous system development, developed and strictly differentiated receptor system and due to their biological reactions responded to the action of various chemicals, under appropriate physical differential perception. Specific factors acting directly at this level physiotherapy, balneology, climatic to
Alternative therapies include a large number of therapeutic methods (over 20) with different characteristics. Whatever the definition of complementary therapies, it can not reflect the essence of these methods, different by origin and plant products, animals and the insects or their analogues.
Most of complementary methods have been studied empirically. Throughout the millennia has been improved and remained only those with higher efficiency without adverse effects. Banning these methods of treatment, unrecognized, will increase the adverse results, because patients will continue to use these methods unsupervised professionals. Osteoporosis
severity, and incidence of osteoporosis are higher in countries where they eat foods high in protein, especially dairy products.
It was reported that the Eskimos, who consume large amounts of fish and bones, the amount of calcium consumed daily reach up to 2500 mg, and protein intake to 200-400 grams. Excessive consumption of animal protein causes osteoporosis, because calcium loss in large quantities. Thus, diets rich in animal protein lowers bone tissue and develop osteoporosis.
Nutrition rich in animal protein, sulfur-containing amino acids, prone to blood acidification. Because blood must have an alkaline pH, the acidity that is neutralized by the accumulation of calcium in the bones, then eliminated through urine. Such is osteoporosis. In case of excess amino acids, liver enzymes break down some substances to urea, which acts as a diuretic, eliminating liquid and minerals. In bone tissue production of nitric oxide in this matter, but decreases production of urea increased the oxide.
The display can be confirmed by the following examples: it was found that in some areas of Africa where the dietary calcium consumed reaches 200 mg / day, hip fractures are the rarest in the world, while the Eskimos, using 2000 mg daily calcium, osteoporotic fractures are most common in the world.
Risk factors for osteoporosis
1. Hereditary factors – transmission from mother to daughter. In these women the risk of fracture is two times higher.
2. Sedentary way of life
3. The use of increased amounts of coffee per day (1.5 cup of coffee)
4. Increased use of animal protein increases the risk of hip fractures
5. Alcohol
6. Insufficient exposure to sunlight
7. Anticonvulsant drugs, antidepressants – doubles the risk of hip fractures.

Normal use of calcium and protein using relatively small amounts up to 30 years decreases the risk of osteoporosis.
After the data authors (Jan Mayer, 1999) – Increased intake of potassium and magnesium in foods that contain vegetarian, lead to increased bone density in elderly men.
Absorption of Ca + + from plant products is much higher than that of milk, of which 70-90% of Ca + + does not absorb. His report found that dietary phosphorus / calcium more than 2 leads to loss of calcium and so on osteoporosis.
In people who consume large amounts of protein risk of kidney stones is 33% (Harvard University). The U.S. recorded the highest consumption of animal protein, and the number of malignant lymphomas is highest.
Large amount of protein in the diet lowers the number of cells so-called „killer” cells that destroy foreign body and the cancer. 30% of diabetic patients who are treated with insulin is kidney failure. Recommended amount of 40 g protein / day allows progression of diabetic nephropathy.
Many sources, including information received from German researchers, reported that sausages and smoked meats containing high salt (100g contains 5-6 g of salt) favors the appearance of hypertension, gastric cancer and osteoporosis. For sausages and other meat products have beautiful color, appetizing add nitrates and nitrites. But the reaction between nitrites and amines form nitrosamines, some – which is supposed to be carcinogenic. Favors production of nitrosamines above 1000C. Sausages and smoked meats contain highly carcinogenic polycyclic aromatic hydrocarbons. These hydrocarbons are formed in meat roasted, grilled, in stews. It turned out that in Iceland, where they eat much meat and smoked fish, the number of people with digestive tract cancer is much higher than in Europe. Studies have shown for decades that temperatures above 1000C in food preparation have meat to the formation of mutagenic compounds pronounced capabilities comparable to those of benzipirenului. Meats rich in polyunsaturated fatty acids omega-G promotes inflammation, thrombosis and vasoconstriction. Arachidonic acid is the main provider of fatty acids as animal proteins (meat, eggs, cheese), which contain arachidonic acid, are the source of polyunsaturated fatty acids omega-G. Last antinflamatorii matter in chronic vascular mechanisms.
Japanese sources reported that after some epidemiological studies have found a potent carcinogenic heterocyclic amines in meats and fish that appear prepared at high temperatures. Were identified over 20 mutagenic or carcinogenic amines. Heterocyclic amines are precursors: Creatine, peptides, amino acids, proteins and sugars.
In Uruguay the amount of per capita meat consumption is highest in the world, but are the most common malignancies. A special interest presents studies by the National Cancer Institute (1998, USA) where 41 836 women were examined. It was found that the women who used the meat prepared by the action of high temperatures and well done, the risk of cancer was 4-6 times higher than women who ate meat less exposed to high temperatures.
It was confirmed that fish oil increases diabetes, blood glucose, as eicosapentaenoic acid reduces the secretion of insulin. For example, the Eskimos, whose diet is rich in fish, are more cerebral bleeding.
Increasing oil content leads to excessive growth of vitamin A and D – which are toxic and lower levels of vitamin E. It was found that foodstuff poisoning caused 15 times more frequently than the products over meat. Over 200 products containing toxic chemicals including: mercury, pesticides and dioxins.
In Japan it was observed that the population that uses products from fish, mercury levels in children is much higher in the umbilical cord. These children have reduced memory and attention. Tumors are frequently found in the population that uses fish products because fish contain more pesticides than fruits, vegetables, cereals.
Data studies in several countries have found that populations who consume mostly carbohydrates (70-80%) do not suffer from degenerative disease: high cholesterol, hypertension, diabetes, obesity.
Studies have shown that the use of latest high amounts of carbohydrates promotes protein synthesis. Animal products are free of carbohydrates, except for milk which contains lactose mammals. Carbohydrates are composed of plant monosaccharides (glucose, fructose, galactose, lactose), disaccharides (sucrose), polysaccharides (starch). To power the normal function of nerve cells and nerve cells need a constant intake of glucose.
Hyperglycemia leads to insulin hiperproducerea and last favors atherosclerosis. Coffee, caffeinated tea, cocoa and chocolate – theobromine, which stimulates the conversion of glycogen to glucose associated with insulin release. Sweet fizzy drinks contain up to 150g of sugar per liter, which corresponds to 10 teaspoons in a glass of liquid.
Simultaneously, legumes, vegetables, unrefined grains contain complex carbohydrates such as starch, which monosaccharides are phased out, and do not lead to excessive growth of hyperglycemia and insulin levels.
Fructose has the formation of fat and can cause resistance to insulin and consumption of time favors the appearance of arteriosclerosis. Sweet drinks containing large amounts of fructose are dangerous, since lead to metabolic disorders (National Institute for the Study of Aging, Baltimore, USA).
Dietary fiber (ballast substances) of vegetable origin (neamidonice polysaccharides) have the necessary function for transport and absorption of chemicals in the digestive system. According to some authors unknown, dietary fiber plays an important role in prevention of intestinal cancer. Aleuron outer layer of cereal fiber and polyunsaturated fatty acids vitamins B and E with antioxidant. Sweet fruits (cherries) contain fibers that have a lower glycemic index, retain the rapid absorption of sugar is important for diabetics.
Based on the above mentioned, it is useful to recall the main features of grain products that contain all the ingredients necessary to maintain optimal physiological condition of the body.
Thus, grain products that contain complex carbohydrates serve as the main energy source of the organism. All grains contain protein, unsaturated fatty acids, soluble and insoluble fiber, vitamins B1, B2, folic acid and minerals: magnesium, iron, calcium.
Whole grain products (PCI) contain large amounts of positive action lactina possessing the intestinal digestion, the immune system by activating ferments, hormones intestinal prevent intestinal cancer. PCI acts against cerebral hemorrhages, cardiovascular disease and diabetes.
Excessive consumption of fat lowers the immune system, favors the development of atherosclerosis, diabetes, obesity, cancer, arthrosis, gallstones. According to WHO (2001), obesity and sedentary lifestyle contribute to cancer causes 33% of the large intestine, kidney, mammary gland, esophagus.
Unlike carbohydrates and proteins, fats do not give the feeling of satiety, that is why they have the ability to make almost unlimited. Heating fats and oils undergo oxidation to form hydroperoxides easily, quickly lead to the formation of oxidation products and aldehydes, epoxides, cyclic hydrocarbon compounds toxic and carcinogenic properties.
According to information Academic Centre in Amsterdam – for 3 weeks feeding of animals in experiments with fish oil – liver tumors were 10 times more frequent, and metastasis of 1000 times more frequent compared with the control group.
Margarine, which is less harmful as butter, vegetable oil is obtained by solidification and over, and solidification is achieved by hydrogenation, where the change occurs unsaturated fatty acids, ie, as is the animal fat. Saturated fatty acids unsaturated fatty acids obtained by transforming pancreatic cells affect insulin secretion and also inhibits bone protein biosynthesis. That’s why osteoporosis occurs.
It was found that 90% of fatty acids, unsaturated fatty acids obtained by transformation from industrial prepared food, processed at high temperatures – fried. After information of authors, high-fat diets negatively affect memory.
Thus, it is an extremely important factor in both the treatment and prophylaxis of various diseases.
Phytotherapy. Phytotherapy there for thousands of years. The accumulated empirical experience different treatment methods have been checked hundreds of times and have been preserved. They come down to us only those confirmed so sick and the doctors who gave favorable results without harming your health.
It is known that by taking the last century various ranks mainly extracted from plants to treat many diseases. Advances in chemistry, technology allowed to obtain many herbal medicines, which have been chemically produced.
Phytotherapy – the use of various herbal extracts or preparations obtained is one of the oldest methods of treatment. For millennia herbal extracts directly or plants were used everywhere as the most effective methods of treatment for many diseases. Starting with the first half of last century, gradually prevailed preparations in clinical practice. It is known that about 40% of drugs are of plant origin, of which the heart is 70%. Phytotherapy is used both to treat acute diseases obvious clinical manifestations, and in cases where development occurs with chronic clinical manifestations, especially with the goal of prevention. We emphasize, as with many chronic diseases, particularly rheumatic and neurological treatment duration and preparations is often associated with different side effects.
Naturals preparations have their natural physiological action because the body was always vegetarian fed. Renal enzymes in various organs may be substituted with enzymes derived from vegetation. Phytotherapy can be recommended for a long time (up to 60 days), while chemo-only preparations for 15-20 days. Significantly, the phytotherapy is not associated with dependence and also very rare occurrence leads to the development of allergic reactions. Not lead to dysbacteriosis, and often under the influence of this treatment, there is normalization of intestinal microflora. Phytotherapy has multilateral action: anti-inflammatory, analgesic, its metabolism
Herbal preparations production technology progressed with the advent obvious chemistry and phyto-phyto-pharmacology. Plants contain many carbohydrates (70-80%), polysaccharides which have anti-inflammatory, gastro-protective, increase secretion of digestive glands. To develop and maintain the body’s normal physiological require the presence of minerals. Most of them are found in medicinal plants: potassium, calcium, sodium, magnesium, phosphorus, sulfur, iron, copper, arsenic, nickel, zinc, silver. In plant cells occurring processes of synthesis of biologically active substances such as morphine, atropine, caffeine, quinine, ephedrine, etc..
Plants are living organisms and synthesize curative substances more physiological for the human body than synthetic preparations obtained in laboratories and chemical plants. Plants and preparations they act on the body more easily affected, not evoke negative reactions, the effect is slow, but sustainable. The main chemical compounds are alkaloids, glycosides, saponins, flavonoids, organic acids, ethers, fatty acids, vitamins, cumarinele, tanantele, enzymes, salts, trace elements.
In medicine occupies a special place alkaloids – substances that contain organic plant juices form of organic acids. Nitrogen-containing alkaloids are used in many dishes: morphine, codeine, platifilina, atropine, caffeine, to Glycosides found in many plants: beet, fruits of different plant species that have selective action on cardiac pacemakers.
Saponins – have biological activity: diuretic action, action antisclerotica, anticancer. Flavonoids – biologically active substances regulate capillary permeability, acting antihypertensive but also in rheumatic diseases, pneumonia, chronic inflammatory diseases. Enzymes – protein substances that act as catalysts when the body part in complex reactions. Fatty acids lead to normalize digestive process, stimulates bowel activity.
To develop and maintain the body’s physiological require the presence of several minerals, most of them are found in medicinal plants: potassium, calcium, sodium, phosphorus, magnesium, sulfur, micronutrients – iron, copper, cobalt, arsenic, nickel, molybdenum, zinc and silver.
Thus, colhicina is used in many rheumatic diseases: psoriasis, scleroderma, sarcoidosis, dermatomiozida as in cirrhosis, Behcet’s syndrome, the disease Periodicals amiliodoza.
The activity of this plant – Alkaloida – was called colchicine, in honor Colhidei, where the plant was transported. Empirical formula was described by Embark (1995) – C22H25O6.
This preparation inhibits cellular reaction mainly polynuclear participants aseptic inflammatory process. Preparation also decreases the permeability of capillaries, inhibit capillary endothelial response to inflammatory mediators. Thus, vascular responses and leukocyte colhicina block in acute inflammation, suppress the secretion and platelet aggregation, stimulates the secretion of steroids, immuno-regulatory influences on cells. In medium doses: decreased production of amyloid colhicina and, therefore, lead to improvement of nephrotic syndrome.
Thus, plants have been and remained one of the main sources of food and medicines, which can be used for long periods without leading to serious side effects.
Chronic diseases require long treatment, which can be achieved by using phytotherapy as chemical remedies most frequently lead to the appearance of many negative reactions. Priority action remedies lies in their physiological naturals, natural, because the body always plant foods. In many states there is chronic lower enzyme activity. Insufucienta enzyme in different organs can be limited by the contribution of enzymes of plant origin.
It is significant that phytotherapy is not associated with occurrence of addiction and rarely cause allergic reactions, does not favor the appearance dysbacteriosis even reverse allows normalization of intestinal flora. Herbal preparations have several actions simultaneously: anti-inflammatory, analgesic, stimulating immune reactions, metabolic, etc.. Plants contain a high percentage of carbohydrates and plant dry weight polysaccharides that act contains anti-inflammatory, gastroprotective, enhance the secretion of endocrine glands.
Chronic diseases are associated with other conditions that lead to production of toxic adverse reactions. That is why in these cases using a different set of plants not associated with these reactions, but give good results.

Advantages of phytotherapy: 1. physiological features, 2. Long-term possibility especially in treatment of chronic diseases, 3. very rarely is associated with adverse reactions, allergic, 4. lack of development Drug addiction, 5. very rarely are contraindications for this treatment, 6. risk of developing intestinal dysbacteriosis missing 7. most herbs grow in all geographical areas 8. possibility of selecting plants necessary because there are large quantities.
However the mechanisms of action of substances in different plants are not studied enough. Simultaneously, the plants often contain various viruses, which rarely can cause pathological processes in humans, not to mention allergic reactions. Therefore it is necessary now, in new conditions can be developed, reviewed and highlighted new substances cleaner that will not lead to negative reactions.
Because chronic diseases are associated with problems of different nature, it is necessary to administer combination therapy, and administration while a few chimiopreparate often give rise to negative reactions, toxic. That’s why, in these cases, using different combinations of plants and avoiding negative reactions achieve the desired effect healing.
Extracts from various plants in infusion, steam, air and fat can be used to evoke local and systemic side effects without. Some plants: gutuiul – contains vitamins C, B, possess anti-inflammatory, diuretic, choleretic, watermelon – diuretic, choleretic, is recommended in patients with gout, nephrolithiasis, pyelonephritis, anemia, diabetes, eggplant is administered in anemia, diabetes, diseases heart, kidney have diuretic action, grapes (juice) have diuretic action, sweat, hypotension, mucolytics and / or expectorant, anti-inflammatory, antinefrolitiazica; leaves of grape-vine percent beneficial in diabetes, extracts of leaves collected in May are Good against high blood pressure, grape seed extract – the diarrhea, the wine is detoxifying and antisclerotic sec. Sour cherries influence antipyretic, mucolytic / expectorant in patients with anemia, bleeding disorders – antithrombotic effect, antibacterial, diuretic. Melon – contains useful in preventing iron deficiency anemia in intestinal dyskinesia. Antisclerotic effect, diuretic, antigout nephrolithiasis, choleretic, sedative. Zamos peel is recommended for acne, moles. Strawberries metabolism, especially the mineral effect antigout nephrolithiasis (recommended – 1 kg / day for 10-15 days per year), lipid metabolism, blood pressure is recommended in patients with hepatitis, regulates thyroid function. Can be used in treating helmintiazei: 3 kg strawberries at a table in combination with steep products have anthelmintic action. Strawberry leaves carbohydrate metabolism, and antihemoragic antiallergic effect. Cabbage is useful in case of headache, insomnia. Application of local leaves is recommended in case of edema, joint swelling, boil, analgesic and antifungal effect. Cabbage is recommended in respiratory diseases has increased in vitamin C content and possesses antiulcer action, favoring the regeneration of intestinal mucosa.

Faunoterapia. From ancient times, in different organs of the animal products were used in the treatment of many diseases. Thus, Aristotle describes some preparations obtained from exotic fish in the treatment of nervous system. Avicenna in his treatise „Canons of medical science” tells about the use of shark meat, whale and marine fish eggs to regulate sexual function.
Medical Pan-Sun, in its publication „Health Source” describes the healing of the liver of bill of exchange (over sea) because it influences blood clotting system. Many substances extracted from animal organs have not been studied enough. In this respect a special interest presents large sponge that contains bioactive substances: antibacterial (including action against Koch bacillus) and of arabinose (which replaces the body’s ribose) develop anticancer preparation cytosine-arabinose. SBA has anti-inflammatory action of sea sponge due to the presence of sodium hexalfluorului (Na2SiF6). Are presented data on the toxicity of fish-ball of which were obtained SBA – acting tetradoxinul 160,000 times, compared with cocaine and anesthesia is used in case of serious operations. Preparations obtained from liver of sharks block cancer cell growth without traumatize other tissues. Based on these statements was developed preparation used in the treatment of diseases pentoxil Blood and that chemotherapy in the treatment of malignant tumors. Ectolin antibiotic is extracted from sturgeon, which has the capacity to prolong the action of other antibiotics. Octopus – remove toxins from that used in homeopathy sepia preparation developed and used in homeopathy sepia preparation and preparation used to treat diseases cefalotaxin nerve, respiratory. Some extracts are effective against rheumatism midi. In nerve disease type prostaglandin substance is used in coral. Another substance in corals (island Hawaii) – politoxina – C1201H2231N3054 – has anticancer action. Bodies of shrimp, coral and sea crayfish chitin was obtained SBA, used against thrombus formation and promote wound healing, to remove cheloizilor burns, warts, moles carcinomas, melanomas.
SBA currently obtained in amphibians are poorly studied. Studied the effectiveness of SBA was obtained from toads, with action on asthma. Toxins derived from skin turtles (South America) were used by Indians for training tips spears against enemies. As was found in solution toxins Toads 1:100 – kills birds and lizards in a few minutes. Turtle toxins have the ability to raise blood pressure and strengthens your heart – that is, possessing drug action strofantin asemenatoare action.

It is known that in some countries (China), turtle meat is used to treat dysentery, has antibacterial and turtle eggs for antirheumatic effect. Also, it is applied to places of snake bite. From frog skin was extracted SBA: serotonin, bradykinin, and opioids toxichinina. Demorfina extracted from the skin of some species of frogs with anesthetic properties 11 times removed of salamander SBA: samadarin, etc. samadamaritin.

Table 4. The bodies of animals used in the treatment of diseases

No. Internal organs of animals in some disease indications
A lamb rennet from the stomach Diarrhea

2 lamb gallbladder disorders microbial eyes, ears, keratoses
3 Hair Growth pig gallbladder

4 The bill gallbladder, eye infections pike Counter

5 of bovine gallbladder and upper respiratory infections Contra Bear
6 gallbladder from birds (crow, quail, stork) To improve vision
7 The bones of cattle, monkeys Against rheumatism

8 turtle bones for anemia

9 bones of tiger, elephant increase sexual potency

10 cattle and chicken liver stimulates the

The liver of many animals is rich in vitamin A. The white bear liver contains vitamin A at a rate of 10,400 units, while shark liver contains only 400 units.
MacLeon Scientist (1916) biologically active substances obtained from the livers of dog, called heparin and then subsequently obtained from other internal organs (spleen, lungs, muscles). Currently, heparin is produced in the lungs of cattle. It has anticoagulant action and is used in the treatment of thrombophlebitis, varicose veins, acute pancreatitis, etc..
Table 5. SBA obtained from animal organs.

BIOLOGICAL ACTIVE BODIES
Salivary gland protein – nerve growth factor (increases skin regeneration)
Brain, spinal cord peptide – functional improvement factor of peripheral nerves sleep, memory
Factor brain contains 105 amino acids alarm: endorphins and enkefaline
Bovine brain and spinal cord preparation that stimulates lipocerebrina cerebrolectina and CNS function. Action antisclerozanta, normalize lipid metabolism.
Bovine brain cholesterol and lecithin in stimulating
Pepsin pig intestinal mucosa
Ocular lens tissue from cattle breath against rheumatism
Bovine testes enzymes: lidaza, ronidaza – to regenerate tissue after burns, trauma
Bovine pancreas insulin, trypsin, chymotrypsin, chimotripsinogenaza.
Ribonucleazele and dezoxiribonucleazele hydrolyze nucleic acids. These enzymes are used to inhibit foreign microflora and viruses. Colagenazele – to eliminate from burns and frostbite necrosis.
Pig pancreas preparations elastolitin, pantrepin against acute pancreatitis. Preparations: contrical, trasilol, tzalol, gordox in the treatment of arthrosis. Pancreatina, digestalul, mezimul, festalul, vegeratina – in gastrointestinal pathology. Calicreinele – andecalin, calicrein, acting hypotensive dilminal
Aminopeptid cattle blood, fibrinosol – food in case of digestive disorders, weight loss. Polibiolin drug – anti-inflammatory and analgesic. Plasmolul – against ridiculitei and stomach ulcers. Solcoseril – to treat ulcers peptide, gangrene, acute burns.
Fibrinogen Blood donors against thrombophlebitis. Thrombin in stopping bleeding. Varicose-liz, thrombo-liz – in varicose thrombophlebitis. Hamor, Liz – against hemorrhoids.
Lymphocyte interferon – proteins against viral infections, viral hepatitis treatment.

Ancient organs of snakes were used to prepare drugs – to treat rheumatism or injury. Meat of hedgehog is recommended in cases of acute poisoning and tuberculosis. The skin is used to stop bleeding hedgehog. Snake meat is recommended in the treatment of systemic scleroderma. Toxins extracted from various species of snakes have action: coagulant and anticoagulant affecting the CNS and peripheral hemopoezei. The only specific treatment – in snake bite antiserum to toxin is the date (in this case it is necessary to know the species that produced snake bite).
Neurotoxinele snake through skin: 1. Peptide – blocks the synaptic membranes of skeletal muscle and sensitive sectors of the brain, 2. Mediator regulates the action of nerve endings, 3. Polypeptides – action of cell membrane depolarization. Was obtained from snake venom active ingredient – acting thromboplastin clotting, used to treat asthma, epilepsy, nerve disorders, haemophilia.
Drugs based on extracts from poisonous snakes toxins activate the blood clotting process, are used in anesthesia, the treatment of CNS diseases (epilepsy).
Spiders and scorpions toxins are used in the treatment of many diseases. I studied about 30 000 species of spiders. In humans, the spider bite is similar Curacuta atropine action: spasm of the sphincters, urinary ducts, intestinal pain association pronounced hypertension.
Spider venom causes the intensive Curacuta acetylcholine, dopamine, norepinephrine and gamma-amino-lipoic acid. Tarantula spider eliminate toxins with hemolytic action. Ornitofagi spiders (predators of birds) secrete venom acting directly on the CNS can cause drowsiness and death. Substance accelerates elimination of acetylcholine in the peripheral nervous system. In Laos the drugs for relief of this spider. There are about 500 known species of spiders that can survive up to 1 year without food. Scorpion toxins acting on the liver, kidneys and cause vomiting, chills, sleepiness. Scorpion venom is hormonal, that increases the glucose, insulin and trypsin causes intensive removal. Leeches – Hiruda medicinalis, ring worms – are widely used as a method of treatment.

. Any medical practitioner, consciously or unconsciously using this method. The famous physician, academician B. Votcel, who studied decades many drugs, write the efficacy of any drug is 60% due to psychotherapeutic effect. Wars and armed conflicts, santajele nuclear weapons, extremism, terrorism, changes in social order, etc.. continue to influence the nervous system and lead to neuro-psychic disorders and, therefore, favors the development of many serious diseases.
Emotional stress as a pathogenic factor psihotraumatic is neutralized by everyone if possible. Is a psychological defense mechanism that ensures perpetual normal resistance to disease and prevention of mental disorganization.
Reception, in these cases is reorganized in such a way that the result of psychological trauma gradually loses its importance.
Autosuggestion – very strong factor that influences the thinking, feeling, against suffering. This power is known about 2000 years. Thus, the philosopher Seneca wrote a friend: „Pain can be easily supported, if not increase their in thought, but on the contrary, I encourage you, saying do not affect or become weaker.”
Psychotherapy (autosuggestion) is most frequently applied by intellectuals, subjects self-trained and the training involves long. The basis of this method are complex physiological mechanisms that act on neural receptors, thereby eliminate the effect of reducing neuromediatorii disease process.
Acute stress and chronic diseases can be considered psychotherapy. Is a natural psychological defense mechanism, continuously providing the body’s resistance to adverse conditions or psychopathological harm. In this case, the body’s defense mechanism is directed toward neutralizing the actions lesional psychological factors. Reforming mechanisms reception is so traumatic psychological effect factor gradually lost its importance and therefore does not lead to the initiation of a pathologic process. An effective dialogue between patient and physician has sedative action.
General Psychotherapy through a complex psychological approaches with positive action on the CNS, increase the body’s disease resistance potential.
Medical psychotherapist is appreciated for these qualities: patience, quiet, critical sense, fairness, confidentiality, tact, ability to open communication, explicit language, objective assessment, empathy, ability to lead and manage the patient, diplomacy and more.
Therapist must be able to discuss with the patient peer.
Thus, psychotherapy is a very important curative factor is necessary for every doctor to use this method of therapeutic activity.

Diet therapy (DT). Latin Diet „diaeta” – lifestyle, thus requires not only the selection of food.
There is food that does not possess curative qualities. The man’s rations included over 600 substances, each of which has curative abilities. To use the most efficient supply substances, first it is necessary to prepare quality. Vicious power constitutes a danger to human health very high. Hippocratic medicine has defined as art that reflects the influence of nature as a healing factor and food were called our medicines.
All complex metabolism in the body depends on the quality of the products ingested. We can modify diet and body condition changes depending on diet composition.
Changes in food quality resulting in the appearance of metabolic disorders that occur as a result of functional changes lead to poor quality food that morphological changes, fixed from generation to generation, in particular genetic turn.
Progress in molecular biology, immunology, biophysics allowed deciphering mechanisms of metabolic processes which usually are strictly related to neuro-endocrine system activity, immune, etc. Oxidation and antioxidant.
Numerous studies in various scientific centers effectuate importance of nutrition in development have established many incurable diseases: cardiovascular, metabolic, degenerative, tumoral processes.
Character of food, it seems, is responsible for the development of cancer to 30-50% of total cases (European Nutrition Conference, Lyon, France, 2001).
It was found that in the past 20 years the incidence of brain tumors in Europe has doubled. Simultaneously, the frequency of systemic osteoporosis has increased dramatically in developed countries, where they consume large amounts of high-fat products: milk, cheese, meat. There erroneous opinions that advanced technologies are sufficient to achieve prevention of these serious conditions without large corrections ciated how to propagate exaggerated sophisticated medication, different diets, miracle follows the „measure” to ensure food good health condition. Chase health enrichment at the expense of human society will destroy the new generation and our descendants will negatively influence health.
For example, alcohol is one of the main causes of mental disorders to new generations. Alcoholic embryology is one of the most serious birth defects, malformations of internal organs, face, brain damage. Even very small amounts of alcohol are able to damage the embryo, fetus. Increase the frequency of alcohol syndrome children: hyperactivity, brain damage, impulsive. Often these children are highlighted in special facial abnormalities: small eye wrinkles at the corner of eye, brain and small deformations of the skull, this hearing disorders, visual coordination, loss of barrier protection.
It was found (University of Minnesota) that the risk for acute myeloid leukemia in children is 3 times higher if the mothers during pregnancy consumed 20 glasses of wine or 20 pints of beer, and if mothers who consumed alcohol in the 2-3 trimester, the risk for the occurrence of acute myeloid leukemia was 10 times higher.
Only in a single year, 1995, in Germany, 55,000 were born with birth children, which is equivalent to 7% of total births, due to alcohol use and the presence of obesity and other factors. The new conditions that were created, appeared resistant to infection by antibiotics and even new pathogens. Advances in modern medicine have resulted in decreased incidence of incurable diseases and even reverse the incidence of cancer, diabetes, atherosclerosis, autoimmune diseases to increased.
National Institute for Combating Cancer in the U.S. reports that 35% of all cancers are caused by improper diet, 30% – smoking, 35% alcohol, viruses, heatstroke, harmful occupational factors, genetic factors, environmental pollution.
As always, physicians are educated to study diseases and regret very little to change thinking to improve lifestyle, food character, habits.
Approximately 400,000 people die annually from diseases related to smoking; 500,000 – due to incorrect diet and sedentary way of life, because obesity 280.000, 100.000 due to excessive alcohol consumption.
In Germany, where they consume large amounts of animal fat, every second death is caused by myocardial infarction, while in Japan, where many plant foods are consumed rarely get sick of colon cancer compared with Western countries.
Reducing the amount of food eaten is one of the necessary measures to extend life and prevent cancer, because cancer cells have higher energy needs more than healthy.
The elderly and immune system decreases the number of T-lymphocytes, leading to increased susceptibility to infections, immune diseases, tumors. Also, your old age there is increasing levels of free radicals (RL) and the use of antioxidant (drugs) man does not give the expected results because they can not replace antioxidantele plant. Plants, other than vitamins, contain various bioactive substances with anti-tumor actions. It is known that fitoestrogenele of lettuce, cabbage, cauliflower, cereals have action against tumors of the breast, colon, prostate, uterus. Leukopenia of red works against prostate cancer and glucosinatele of cabbage, cauliflower, radishes act against infections by activating the immune system. Other studies have found that fitosterinele of sunflower seeds or nuts decrease risk of colon cancer, and flavonoids contained in fruits (cherry, cherries, strawberries, apples) and vegetables (potatoes, onions, peppers, beets) are very active against infections and tumors. Phenols in cereal and nuts are acting antiviral, antifungal, ntioxidanta. Sulfids garlic, leeks, onions have antioxidant and antitumor.  Saponins contained in beans, peas, chickpeas have action against bowel cancer. Terpinele with celery, mint retain cancer development. Polyphenols in fruits, nuts participate in normalizing the vascular system by increasing the activity of nitric oxide production leads to lower risk for cardiovascular disease.
Immunity is closely related to food character. In ensuring a normal immune status, along with vitamins, minerals (zinc, iron, copper, selenium) belongs to an important high protein and vegetable fat.
Acts on the immune system of oxygen free radicals. To support the normal balance between oxidant and antioxidant systems is necessary to use whole grain products, fruits and vegetables. Milt also use dietary supplements that contain antioxidants and vitamins can not replace natural products, vegetables and fruits that contain many bioactive substances.
There were large differences in the incidence of prostate tumors in the population of England, Switzerland, the United States in proportion to the population of Asian countries. They are caused by past use of plant products (especially soybeans containing fitosteroizi, saponins, izoflavoine, acting antitumorala.Produsele grains contain complex carbohydrates that serve as the body’s main energy source. Also they contain protein, unsaturated fatty acids , soluble and insoluble fiber, vitamin B1, B2, folic acid, minerals – magnesium, iron, calcium.
Whole wheat bread and not gain weight, compared with white flour, contains seven times more minerals and 5-10 times more vitamins. Whole grain products (PCI) have actions against cardiovascular disease, diabetes, tumors. Thus, the use of PCI reduces the risk of cerebral hemorrhage and myocardial infarction in 30% and 33% risk of malignant tumors.
In developed countries predominate in animal protein diet containing cholesterol and saturated fat, which promotes development of atherosclerosis and aging.
Animal proteins lead to increased insulin levels and accelerate production of cholesterol, which are the main factors leading to increased risk of cardiovascular disease and plant proteins, on the contrary, lower insulin and cholesterol synthesis. Frequency is proportional to the increase in myocardial insulin because of the consumption of animal protein.
Amino acid content in plant products of protein arginine and glycine is higher than animal proteins. These amino acids lead to inhibition of cholesterol in the body.
In maintaining a normal metabolic balance is important ratio calcium / phosphorus. As is known, increasing the concentration of phosphorus is associated with decreasing serum calcium levels. As calcium levels decrease, and increased levels of phosphorus lead to increased parathyroid hormone, with subsequent development of osteoporosis. Simultaneously, increasing the concentration of phosphorus in the blood leads to storage of phosphorus and calcium in the internal organs: heart, kidneys and other organs, favoring the development of inflammatory and degenerative processes.
It was found that proteins modified by the influence of heat acting toxic, carcinogenic, mutagenic, especially those processed by roasting, smoking and grilled.
World Health Organization calculated that the necessary rules of amino acids in human milk composition corresponds best with goat’s milk. Vegetable products contain all essential amino acids in sufficient quantities. Dairy products are rich in protein. Both severity, and incidence of osteoporosis are higher in countries where they eat foods high in protein, especially dairy products.
It was reported that the Eskimos, who consume large amounts of fish and bones, the amount of calcium consumed daily reach up to 2500 mg, and protein intake to 200-400 grams. Excessive consumption of animal protein causes osteoporosis, because calcium loss in large quantities. Thus, diets rich in animal protein lowers bone tissue and develop osteoporosis.
Nutrition rich in animal protein, sulfur-containing amino acids, prone to blood acidification. Because blood must have an alkaline pH, the acidity that is neutralized by the accumulation of calcium in the bones, then is eliminated through urine. Such is osteoporosis. In case of excess amino acids, liver enzymes break down some substances to urea, which acts as a diuretic, eliminating liquid and minerals. In bone tissue production of nitric oxide in this matter, but decreases production of urea increased the oxide.
The display can be confirmed by the following examples: it was found that in some areas of Africa where the dietary calcium consumed reaches 200 mg / day, hip fractures are the rarest in the world, while the Eskimos, using 2000 mg daily calcium, osteoporotic fractures are most common in the world.
Risk factors for osteoporosis
8. Hereditary factors – transmission from mother to daughter. In these women the risk of fracture is two times higher.
9. Sedentary way of life
10. The use of increased amounts of coffee per day (1.5 cup of coffee)
11. Increased use of animal protein increases the risk of hip fractures
12. Alcohol
13. Insufficient exposure to sunlight
14. Anticonvulsant drugs, antidepressants – doubles the risk of hip fractures.

Normal use of calcium and protein using relatively small amounts up to 30 years decreases the risk of osteoporosis.
After the data authors (Jan Mayer, 1999) – Increased intake of potassium and magnesium in foods that contain vegetarian, lead to increased bone density in elderly men.
Absorption of Ca + + from plant products is much higher than that of milk, of which 70-90% of Ca + + does not absorb. His report found that dietary phosphorus / calcium more than 2 leads to loss of calcium and so on osteoporosis.
In people who consume large amounts of protein risk of kidney stones is 33% (Harvard University). The U.S. recorded the highest consumption of animal protein, and the number of malignant lymphomas is highest.
Large amount of protein in the diet lowers the number of cells so-called „killer” cells that destroy foreign bodies and the cancer. 30% of diabetic patients who are treated with insulin develop later on kidney failure. Recommended amount of 40 g protein / day allows progression of diabetic nephropathy.
Many sources, including information received from German researchers, reported that sausages and smoked meats containing high salt (100g contains 5-6 g of salt) favors the appearance of hypertension, gastric cancer and osteoporosis. For sausages and other meat products have beautiful color, appetizing add nitrates and nitrites. But the reaction between nitrites and amines form nitrosamines, some – which is supposed to be carcinogenic. Favors production of nitrosamines above 1000C. Sausages and smoked meats contain highly carcinogenic polycyclic aromatic hydrocarbons. These hydrocarbons are formed in meat roasted, grilled, in stews. It turned out that in Iceland, where they eat much meat and smoked fish, the number of people with digestive tract cancer is much higher than in Europe. Studies have shown for decades that temperatures above 1000C in food preparation have meat to the formation of mutagenic compounds pronounced capabilities comparable to those of benzipirenului. Meats rich in polyunsaturated fatty acids omega-G promotes inflammation, thrombosis and vasoconstriction. Arachidonic acid is the main provider of fatty acids as animal proteins (meat, eggs, cheese), which contain arachidonic acid, are the source of polyunsaturated fatty acids omega-G. Last antinflamatorii matter in chronic vascular mechanisms.
Japanese sources reported that after some epidemiological studies have found a potent carcinogenic heterocyclic amines in meats and fish that appear prepared at high temperatures. Were identified over 20 mutagenic or carcinogenic amines. Heterocyclic amines are precursors: Creatine, peptides, amino acids, proteins and sugars.
In Uruguay the amount of per capita meat consumption is highest in the world, but are the most common malignancies. A special interest presents studies by the National Cancer Institute (1998, USA) where 41 836 women were examined. It was found that the women who used the meat prepared by the action of high temperatures and well done, the risk of cancer was 4-6 times higher than women who ate meat less exposed to high temperatures.
It was confirmed that fish oil increases diabetes, blood glucose, as eicosapentaenoic acid reduces the secretion of insulin. For example, the Eskimos, whose diet is rich in fish, are more cerebral bleeding.
Increasing oil content leads to excessive growth of vitamin A and D – which are toxic and lower levels of vitamin E. It was found that foodstuff poisoning caused 15 times more frequently than the products over meat. Over 200 products containing toxic chemicals including: mercury, pesticides and dioxins.
In Japan it was observed that the population that uses products from fish, mercury levels in children is much higher in the umbilical cord. These children have reduced memory and attention. Tumors are frequently found in the population that uses fish products because fish contain more pesticides than fruits, vegetables, cereals.
Data studies in several countries have found that populations who consume mostly carbohydrates (70-80%) do not suffer from degenerative disease: high cholesterol, hypertension, diabetes, obesity.
Studies have shown that the use of latest high amounts of carbohydrates promotes protein synthesis. Animal products are free of carbohydrates, except for milk which contains lactose mammals. Carbohydrates are composed of plant monosaccharides (glucose, fructose, galactose, lactose), disaccharides (sucrose), polysaccharides (starch). To power the normal function of nerve cells and nerve cells need a constant intake of glucose.
Hyperglycemia leads to insulin hiperproducerea and last favors atherosclerosis. Coffee, caffeinated tea, cocoa and chocolate – theobromine, which stimulates the conversion of glycogen to glucose associated with insulin release. Sweet fizzy drinks contain up to 150g of sugar per liter, which corresponds to 10 teaspoons in a glass of liquid.
Simultaneously, legumes, vegetables, unrefined grains contain complex carbohydrates such as starch, which monosaccharides are phased out, and do not lead to excessive growth of hyperglycemia and insulin levels.
Fructose has the formation of fat and can cause resistance to insulin and consumption of time favors the appearance of arteriosclerosis. Sweet drinks containing large amounts of fructose are dangerous, since lead to metabolic disorders (National Institute for the Study of Aging, Baltimore, USA).
Dietary fiber (ballast substances) of vegetable origin (neamidonice polysaccharides) have the necessary function for transport and absorption of chemicals in the digestive system. According to some authors unknown, dietary fiber plays an important role in prevention of intestinal cancer. Aleuron outer layer of cereal fiber and polyunsaturated fatty acids vitamins B and E with antioxidant. Sweet fruits (cherries) contain fibers that have a lower glycemic index, retain the rapid absorption of sugar is important for diabetics.
Based on the above mentioned, it is useful to recall the main features of grain products that contain all the ingredients necessary to maintain optimal physiological condition of the body.
Thus, grain products that contain complex carbohydrates serve as the main energy source of the organism. All grains contain protein, unsaturated fatty acids, soluble and insoluble fiber, vitamins B1, B2, folic acid and minerals: magnesium, iron, calcium.
Whole grain products (PCI) contain large amounts of positive action lactina possessing the intestinal digestion, the immune system by activating ferments, hormones intestinal prevent intestinal cancer. PCI acts against cerebral hemorrhages, cardiovascular disease and diabetes.
Excessive consumption of fat lowers the immune system, favors the development of atherosclerosis, diabetes, obesity, cancer, arthrosis, gallstones. According to WHO (2001), obesity and sedentary lifestyle contribute to cancer causes 33% of the large intestine, kidney, mammary gland, esophagus.
Unlike carbohydrates and proteins, fats satutatie fail because of this feeling they have the ability to make almost unlimited. Heating fats and oils easily undergo oxidation to form hydroperoxides, leading quickly to the formation of oxidation products and aldehydes, epoxides, cyclic hydrocarbon compounds toxic and carcinogenic properties.
According to information Academic Centre in Amsterdam – for 3 weeks feeding of animals in experiments with fish oil – liver tumors were 10 times more frequent, and metastasis of 1000 times more frequent compared with the control group.
Margarine, vegetable oil is obtained by solidification and over, and solidification is achieved by hydrogenation, where the change occurs unsaturated fatty acids, ie, as is the animal fat. Saturated fatty acids unsaturated fatty acids obtained by transforming pancreatic cells affect insulin secretion and also inhibits bone protein biosynthesis. That’s why osteoporosis occurs.
It was found that 90% of fatty acids, unsaturated fatty acids obtained by transformation from industrial prepared food, processed at high temperatures – fried. After information of authors, high-fat diets negatively affect memory.
Thus, it is an extremely important factor in both the treatment and prophylaxis of various diseases.
Phytotherapy. Phytotherapy there for thousands of years. The accumulated empirical experience different treatment methods have been checked hundreds of times and have been preserved. They come down to us only those confirmed so sick and the doctors who gave favorable results without harming your health.
It is known that by taking the last century various ranks mainly extracted from plants to treat many diseases. Advances in chemistry have allowed obtaining several herbal medicines, which have been produced by chemical synthesis. Appropriate to mention that, as chemical synthesis does not always correspond to the natural synthesis of organic compounds, therefore synthesized chemical compounds often give many unwanted reactions. Thus interferons by chemical sinyeza for infections and sineucidul viralehepatice causes, states of nervous patients.
Phytotherapy – the use of various herbal extracts or preparations obtained is one of the oldest methods of treatment. For millennia herbal extracts directly or plants were used everywhere as the most effective methods of treatment for many diseases. Starting with the first half of last century, gradually prevailed preparations in clinical practice. It is known that about 40% of drugs are of plant origin, of which the heart is 70%. Phytotherapy is used both to treat acute diseases obvious clinical manifestations, and in cases where development occurs with chronic clinical manifestations, especially with the goal of prevention. We emphasize, as with many chronic diseases, particularly rheumatic and neurological treatment is long lasting. Naturals preparations have their natural physiological action because the body was always vegetarian fed. Renal enzymes in various organs may be substituted with enzymes derived from vegetation. Phytotherapy can be recommended for a long time (up to 60 days), while chemo-only preparations for 15-20 days. Significantly, the phytotherapy is not associated with dependence and also very rare occurrence leads to the development of allergic reactions. Often under the influence of this treatment, there is normalization of intestinal microflora. Phytotherapy has multilateral action: anti-inflammatory, analgesic, its metabolism
Herbal preparations production technology progressed with the advent obvious chemistry and phyto-phyto-pharmacology. Plants contain many carbohydrates (70-80%), polysaccharides which have anti-inflammatory, gastro-protective, increase secretion of digestive glands. To develop and maintain the body’s normal physiological require the presence of minerals. Most of them are found in medicinal plants: potassium, calcium, sodium, magnesium, phosphorus, sulfur, iron, copper, arsenic, nickel, zinc, silver. In plant cells occurring processes of synthesis of biologically active substances such as morphine, atropine, caffeine, quinine, ephedrine, etc..
Plants are living organisms and synthesize curative substances more physiological for the human body than synthetic preparations obtained in laboratories and chemical plants. Plants and preparations they act on the body more easily affected, not evoke negative reactions, the effect is slow, but sustainable. The main chemical compounds are alkaloids, glycosides, saponins, flavonoids, organic acids, ethers, fatty acids, vitamins, cumarinele, tanantele, enzymes, salts, trace elements.
In medicine occupies a special place alkaloids – substances that contain organic plant juices form of organic acids. Nitrogen-containing alkaloids are used in many dishes: morphine, codeine, platifilina, atropine, caffeine, to Glycosides found in many plants: beet, fruits of different plant species that have selective action on cardiac pacemakers.
Saponins – have biological activity: diuretic action, action antisclerotica, anticancer. Flavonoids – biologically active substances regulate capillary permeability, acting antihypertensive but also in rheumatic diseases, pneumonia, chronic inflammatory diseases. Enzymes – protein substances that act as catalysts when the body part in complex reactions. Fatty acids lead to normalize digestive process, stimulates bowel activity.
To develop and maintain the body’s physiological require the presence of several minerals, most of them are found in medicinal plants: potassium, calcium, sodium, phosphorus, magnesium, sulfur, micronutrients – iron, copper, cobalt, arsenic, nickel, molybdenum, zinc and silver.
Thus, colhicina is used in many rheumatic diseases: psoriasis, scleroderma, sarcoidosis, dermatomiozida as in cirrhosis, Behcet’s syndrome, the disease Periodicals amiliodoza.
The activity of this plant – Alkaloida – was called colchicine, in honor Colhidei, where the plant was transported. Empirical formula was described by Embark (1995) – C22H25O6.
This preparation inhibits cellular reaction mainly polynuclear participants aseptic inflammatory process. Preparation also decreases the permeability of capillaries, inhibit capillary endothelial response to inflammatory mediators. Thus, vascular responses and leukocyte colhicina block in acute inflammation, suppress the secretion and platelet aggregation, stimulates the secretion of steroids, immuno-regulatory influences on cells. In medium doses: decreased production of amyloid colhicina and, therefore, lead to improvement of nephrotic syndrome.
Thus, plants have been and remained one of the main sources of drugs, which can be used for long periods without leading to serious side effects.
Chronic diseases require long treatment, which can be achieved by using phytotherapy as chemical remedies most frequently lead to the appearance of many negative reactions. Priority action remedies lies in their physiological naturals, natural, because the body always plant foods. In many states there is chronic lower enzyme activity. Insufucienta enzyme in different organs can be limited by the contribution of enzymes of plant origin.
It is significant that phytotherapy is not associated with occurrence of addiction and rarely cause allergic reactions, does not favor the appearance bacterioses allows normalization of intestinal flora. Herbal preparations have several actions simultaneously: anti-inflammatory, analgesic, stimulating immune reactions, metabolic, etc.. Plants contain a high percentage of carbohydrates and plant dry weight polysaccharides that act contains anti-inflammatory, gastroprotective, enhance the secretion of endocrine glands.
Chronic diseases are associated with other conditions that lead to production of toxic adverse reactions. That is why in these cases using a different set of plants not associated with these reactions, but give beneficial results.
Advantages of phytotherapy: 1. physiological features, 2. Long-term possibility especially in treatment of chronic diseases, 3. very rarely is associated with adverse reactions, allergic, 4. lack of development Drug addiction, 5. very rarely are contraindications for this treatment, 6. risk of developing intestinal missing bacterioses 7. most herbs grow in all geographical areas 8. possibility of selecting plants necessary because there are large quantities.
However the mechanisms of action of substances in different plants are not studied enough. Simultaneously, the plants often contain various viruses, which can produce some cazurti recombinant dangerous for different organisms. Can cause allergic reactions. Therefore it is necessary now, in new conditions can be developed, tests, highlighted new substances cleaner that will not lead to negative reactions.
Because chronic diseases are associated with problems of different nature, it is necessary to administer combination therapy, and administration while a few chimiopreparate often give rise to negative reactions, toxic. That’s why, in these cases, using different combinations of plants and avoiding negative reactions achieve the desired effect healing.
Extracts from various plants in infusion, steam, air and fat can be used to evoke local and systemic side effects without. Some plants: gutuiul – contains vitamins C, B, possess anti-inflammatory, diuretic, choleretic, watermelon – diuretic, choleretic, is recommended in patients with gout, nephrolithiasis, pyelonephritis, anemia, diabetes, eggplant is administered in anemia, diabetes, diseases heart, kidney have diuretic action, grapes (juice) have diuretic action, sweat, hypotension, mucolytics and / or expectorant, anti-inflammatory, antinefrolitiazica; leaves of grape-vine percent beneficial in diabetes, extracts of leaves collected in May are Good against high blood pressure, grape seed extract – the diarrhea, the wine is detoxifying and antisclerotic sec. Sour cherries influence antipyretic, mucolytic / expectorant in patients with anemia, bleeding disorders – antithrombotic effect, antibacterial, diuretic. Melon – contains useful in preventing iron deficiency anemia in intestinal dyskinesia. Antisclerotic effect, diuretic, antigout nephrolithiasis, choleretic, sedative. Zamos peel (melon) is recommended for acne, moles. Strawberries metabolism, especially the mineral effect antigout nephrolithiasis (recommended – 1 kg / day for 10-15 days per year), lipid metabolism, blood pressure is recommended in patients with hepatitis, regulates thyroid function. Can be used in treating helmintiazei: 3 kg strawberries at a table in combination with steep products have anthelmintic action. Strawberry leaves carbohydrate metabolism, and antihemoragic antiallergic effect. Cabbage is useful in case of headache, insomnia. Application of local leaves is recommended in case of edema, joint swelling, boil, analgesic and antifungal effect. Cabbage is recommended in respiratory diseases has increased in vitamin C content and possesses antiulcer action, favoring the regeneration of intestinal mucosa.
Faunoterapia. From ancient times, in different organs of the animal products were used in the treatment of many diseases. Thus, Aristotle describes some preparations obtained from exotic fish in the treatment of nervous system. Avicenna in his treatise „Canons of medical science” tells about the use of shark meat, whale and marine fish eggs to regulate sexual function.
Medical Pan-Sun, in its publication „Health Source” describes the healing of the liver of bill of exchange (over sea) because it influences blood clotting system. Many substances extracted from animal organs have not been studied enough. In this respect a special interest presents large sponge that contains bioactive substances: antibacterial (including action against Koch bacillus) and of arabinose (which replaces the body’s ribose) develop anticancer preparation cytosine-arabinose. SBA has anti-inflammatory action of sea sponge due to the presence of sodium hexalfluorului (Na2SiF6). Are presented data on the toxicity of fish-ball of which were obtained SBA – acting tetradoxinul 160,000 times, compared with cocaine and anesthesia is used in case of serious operations. Preparations obtained from liver of sharks block cancer cell growth without traumatize other tissues. Based on these statements was developed preparation used in the treatment of diseases pentoxil Blood and that chemotherapy in the treatment of malignant tumors. Ectolin antibiotic is extracted from sturgeon, which has the capacity to prolong the action of other antibiotics. Octopus – remove toxins from that used in homeopathy sepia preparation developed and used in homeopathy sepia preparation and preparation used to treat diseases cefalotaxin nerve, respiratory. Some mussel extracts are effective against rheumatism. In nerve disease type prostaglandin substance is used in coral. Another substance in corals (island Hawaii) – politoxina – C1201H2231N3054 – has anticancer action. Bodies of shrimp, coral and sea crayfish chitin was obtained SBA, used against thrombus formation and promote wound healing, to remove cheloizilor burns, warts, moles carcinomas, melanomas.
SBA currently obtained in amphibians are poorly studied. Studied the effectiveness of SBA was obtained from toads, with action on asthma. Toxins derived from skin turtles (South America) were used by Indians for training tips spears against enemies. As was found in solution toxins Toads 1:100 – kills birds and lizards in a few minutes. Turtle toxins have the ability to raise blood pressure and strengthens your heart – that is, possessing drug action strofantin asemenatoare action.

It is known that in some countries (China), turtle meat is used to treat dysentery, has antibacterial and turtle eggs for antirheumatic effect. Also, it is applied to places of snake bite. From frog skin was extracted SBA: serotonin, bradykinin, and opioids toxichinina. Demorfina extracted from the skin of some species of frogs with anesthetic properties 11 times removed of salamander SBA: samadarin, etc. samadamaritin.

Table 4. The bodies of animals used in the treatment of diseases

No. Internal organs of animals in some disease indications
A lamb rennet from the stomach Diarrhea

2 lamb gallbladder disorders microbial eyes, ears, keratoses
3 Hair Growth pig gallbladder

4 The bill gallbladder, eye infections pike Counter

5 of bovine gallbladder and upper respiratory infections Contra Bear
6 gallbladder from birds (crow, quail, stork) To improve vision
7 The bones of cattle, monkeys Against rheumatism

8 turtle bones for anemia

9 bones of tiger, elephant increase sexual potency

10 cattle and chicken liver stimulates the

The liver of many animals is rich in vitamin A. The white bear liver contains vitamin A at a rate of 10,400 units, while shark liver contains only 400 units.
MacLeon Scientist (1916) biologically active substances obtained from the livers of dog, called heparin and then subsequently obtained from other internal organs (spleen, lungs, muscles). Currently, heparin is produced in the lungs of cattle. It has anticoagulant action and is used in the treatment of thrombophlebitis, varicose veins, acute pancreatitis, etc..

Table 5. SBA obtained from animal organs.

BIOLOGICAL ACTIVE BODIES
Salivary gland protein – nerve growth factor (increases skin regeneration)
Brain, spinal cord peptide – functional improvement factor of peripheral nerves sleep, memory
Factor brain contains 105 amino acids alarm: endorphins and enkefaline
Bovine brain and spinal cord preparation that stimulates lipocerebrina cerebrolectina and CNS function. Action antisclerozanta, normalize lipid metabolism.
Bovine brain cholesterol and lecithin in stimulating
Pepsin pig intestinal mucosa
Ocular lens tissue from cattle breath against rheumatism
Bovine testes enzymes: lidaza, ronidaza – to regenerate tissue after burns, trauma
Bovine pancreas insulin, trypsin, chymotrypsin, chimotripsinogenaza.
Ribonucleazele and dezoxiribonucleazele hydrolyze nucleic acids. These enzymes are used to inhibit foreign microflora and viruses. Colagenazele – to eliminate from burns and frostbite necrosis.
Pig pancreas preparations elastolitin, pantrepin against acute pancreatitis. Preparations: contrical, trasilol, tzalol, gordox in the treatment of arthrosis. Pancreatina, digestalul, mezimul, festalul, vegeratina – in gastrointestinal pathology. Calicreinele – andecalin, calicrein, acting hypotensive dilminal
Aminopeptid cattle blood, fibrinosol – food in case of digestive disorders, weight loss. Polibiolin drug – anti-inflammatory and analgesic. Plasmolul – against ridiculitei and stomach ulcers. Solcoseril – to treat ulcers peptide, gangrene, acute burns.
Fibrinogen Blood donors against thrombophlebitis. Thrombin in stopping bleeding. Varicose-liz, thrombo-liz – in varicose thrombophlebitis. Hamor, Liz – against hemorrhoids.
Lymphocyte interferon – proteins against viral infections, viral hepatitis treatment.

Ancient organs of snakes were used to prepare drugs – to treat rheumatism or injury. Meat of hedgehog is recommended in cases of acute poisoning and tuberculosis. The skin is used to stop bleeding hedgehog. Snake meat is recommended in the treatment of systemic scleroderma. Toxins extracted from various species of snakes have action: coagulant and anticoagulant CNS and peripheral impact. The only specific treatment – in snake bite antiserum to toxin is the date (in this case it is necessary to know the species that produced snake bite).
Neurotoxinele snake through skin: 1. Peptide – blocks the synaptic membranes of skeletal muscle and sensitive sectors of the brain, 2. Mediator regulates the action of nerve endings, 3. Polypeptides – action of cell membrane depolarization. Was obtained from snake venom active ingredient – acting thromboplastin clotting, used to treat asthma, epilepsy, nerve disorders, haemophilia.
Drugs based on extracts from poisonous snakes toxins activate the blood clotting process, are used in anesthesia, the treatment of CNS diseases (epilepsy).
Spiders and scorpions toxins are used in the treatment of many diseases. I studied about 30 000 species of spiders. In humans, the spider bite is similar Curacuta atropine action: spasm of the sphincters, urinary ducts, intestinal pain association pronounced hypertension.
Spider venom causes the intensive Curacuta acetylcholine, dopamine, norepinephrine and gamma-amino-lipoic acid. Tarantula spider eliminate toxins with hemolytic action. Ornitofagi spiders (predators of birds) secrete venom acting directly on the CNS can cause drowsiness and death. Substance accelerates elimination of acetylcholine in the peripheral nervous system. In Laos the drugs for relief of this spider. There are about 500 known species of spiders that can survive up to 1 year without food. Scorpion toxins acting on the liver, kidneys and cause vomiting, chills, sleepiness. Scorpion venom is hormonal, that increases the glucose, insulin and trypsin causes intensive removal.
Leeches – Hiruda medicinalis, ring worms – are widely used as a method of treatment. When absorption, remove leech protein – hirudin anticoagulation and inactivation capacity of prothrombin. Hirudotherapy use in cardiovascular disease, thrombophlebitis. Substances obtained from worms is recommended for rheumatic diseases, keratitis, chills, bleeding, epilepsy.
Horn products, hooves, nails, hair and the crust of crayfish have been used 3700 years ago Egyptian pharaohs. These organs contain keratin – used in sexual dysfunction and metabolism.
Pantocrin preparation – 10% suspension of reindeer horn, containing organic substances – fat, inorganic substances – calcium, magnesium, iron, silicon, phosphorus, sodium, Sodium, Nickel, Copper, Titanium, Lead, Barium. Pantocrinul is used to treat many diseases. It increases the immunity and blood clotting, normalizes sleep. It also has a calming effect, ulcer. It is used against epilepsy, psychosis, improves muscle function. About the statement of reindeer horns are known in sec. IV i.e.n. Animal tendons in China to prepare gelatin products used to increase muscle tone and treatment of tuberculosis.
Rumalon product is a preparation of cartilage and bone of domestic animals. Chitozanul used in dermatology, cosmetology as a good anti-inflammatory.
Bile acids influence coledocului activity, endocrine system, central nervous system, reduces kidney function, reduce oxidation processes. Bile acids are widely used to treat rheumatism. Improves liver and pancreas function. Extract bile juice in the composition festalului, aloholului indicated in cholecystitis and enterocolitis. It is used to treat hepatitis and obesity. Chicken egg shells is given in diarrhea and nephrolithiasis.
Scorpions are used to treat lomfoappaty  in case of tuberculosis, dermatitis, skin ulcers. Frog toxins are used to treat rheumatism, stopping internal bleeding.

ENTOMOTHERAPY VOL3

Leeches – Hiruda medicinalis, ring worms – are widely used as a method of treatment. When absorption, remove leech protein – hirudin anticoagulation and inactivation capacity of prothrombin. Hirudotherapy use in cardiovascular disease, thrombophlebitis. Substances obtained from worms is recommended for rheumatic diseases, keratitis, chills, bleeding, epilepsy.
Horn products, hooves, nails, hair and the crust of crayfish have been used 3700 years ago Egyptian pharaohs. These organs contain keratin – used in sexual dysfunction and metabolism.
Pantocrin preparation – 10% suspension of reindeer horn, containing organic substances – fat, inorganic substances – calcium, magnesium, iron, silicon, phosphorus, sodium, Sodium, Nickel, Copper, Titanium, Lead, Barium. Pantocrinul is used to treat many diseases. It increases the immunity and blood clotting, normalizes sleep. It also has a calming effect, ulcer. It is used against epilepsy, psychosis, improves muscle function. About the statement of reindeer horns are known in sec. IV i.e.n. Animal tendons in China to prepare gelatin products used to increase muscle tone and treatment of tuberculosis.
Rumalon product is a preparation of cartilage and bone of domestic animals. Chitozanul used in dermatology, cosmetology as a good anti-inflammatory.
Bile acids influence coledocului activity, endocrine system, central nervous system, reduces kidney function, reduce oxidation processes. Bile acids are widely used to treat rheumatism. Improves liver and pancreas function. Extract bile juice in the composition festalului, aloholului indicated in cholecystitis and enterocolitis. It is used to treat hepatitis and obesity. Chicken egg shells is given in diarrhea and nephrolithiasis.
Scorpions are used to treat limfaadenopatiei in case of tuberculosis, dermatitis, skin ulcers. Frog toxins are used to treat rheumatism, stopping internal bleeding.

Climatic

„The best doctor is the nature – because 75% of patients heal and never wished to express about his colleagues.”

Human health is closely related to climate variations, which is influenced by several factors: temperature limits during the year and their undulations, the number of sunny days during the year, frequency of storms and cyclones and then rain, blizzards, this mountain or plains, areas with underground mineral deposits that intensify Earth magnetism.
For these characteristics of climate and vegetation depend on animal health. Qualitative and quantitative relationships of the above-mentioned factors, determine the specifics of any localities, microclimate characteristics.
The human body in evolution, to accommodate different weather conditions, but most people have adapted to a certain region of Earth, with some calendar features. Examples were seen when patients with serious diseases and radiological changes, moving to another country, in a year were completely healed. Also, patients with dilated cardiomyopathy, which receive large doses of hormone preparations, being in areas with favorable climate at least one year without treatment, finished with complete cure. So, these phenomena are the result of climatic factors influence combinations, etc. cosmic. Climatic complex includes a number of natural (mountains, forests, big rivers, lakes) and has a decisive role in combating disease and prolong life. Mountains have been housed in ancient times human, have evolved together, being threatened by disasters, wild animals etc.. Mountain climate, and barometric pressure reduces the partial pressure of oxygen. In mountain conditions increase the number of erythrocytes and hemoglobin. There are many diseases treated: lung, anemia, tuberculosis, hypertension, muscle fatigue, obesity, neuroses, rickets and multiple endocrine disorders (tiroidismul). Usually the mountains are covered with forests, have several mechanisms that influence the body. Forests were found living pharmacies.
Silovoterapia – affects all body systems: neuro – endocrine, metabolic, cardio – vascular, respiratory and others. Forest is a source of oxygen: a hectare of forest in a sunny day provides about 220 kg of oxygen, which he spread in the atmosphere and absorbs 280 kg of carbon dioxide. The forest is of 5 to 10 times more negative ions than in the urban atmosphere. A hectare of forest of pine or beech, holds about 56-63 tons of dust and a hectare of oak forest spreads around 2 kg of ozone, which has the ability to remove bacillus dysentery and many other microorganisms to inhibit . In a forest m3 air circulates around 500 organisms, while the same amount of air in urban store there are 4 million bacteria. So you can see the importance of forests as antibacterial filter.
Most people have not yet realized that very detrimental factor, noise, is due not only roads and transport, but the rooms equipment: radio, television, telephone and others. Noise term, even if tolerance is responsible in 30% of cases of anxiety and in 80% of cases of migraine. I. Thomson, who performed special investigations, concluded, the phone used intensively and continuously shortens life by 3 years.
Oxygen, nitrogen and carbon dioxide in the air in some fixed proportions, while ozone, vapor in varying proportions. There oxygen in the air at a rate of 20.95%. For man to exercise requires a concentration of 15% oxygen atmosphere. Nitrogen level of 78.09% There is action to stabilize the oxygen. Carbon dioxide concentration in the air there in 0.03%. The concentration of CO2 in the atmosphere than 3% is toxic, and more than 5% lead to asphyxia.
Ozone air also contains 1-2 g per 100 m3, water vapor, gas: argon, helium, neon, xenon, krypton, ammonia, carbon oxide, sodium chloride, smoke and dust. Oxygen is the main component that determines the process of obtaining energy from the body maintain nerves in the processes of oxidative metabolism.
After some calculations of experts, a human adult requires 1 kg of food per day, 1.5 liters of liquid and 12 m3 of air. The maximum concentration of ozone is at a distance of 18-35 km from the earth, forming a protective layer of ozone, which has the function of protecting life on earth, cosmic rays filtering in only 20% reach the ground. On Earth, ozone occurs after electric discharge decomposition of oxygen. In mountainous areas increases the concentration of ozone. It has antibacterial action, which explains mountain fresh air. It was found that air containing high concentrations of ozone, acts positively on the body: it becomes more resistant to cold, toxicity, improve hemocirculatia. In nature ionizes air under the action of radioactivity in the air and ground elements. Also, the ions that are harmful to the body capabilities are neutralized by those with positive action.
The influence of cosmic radiation and the earth there is detachment of an electron from the surface atom and subsequent annexation by another atom, thus becoming the first negative and the second positive. Negative air ionization positive influence on the human body.
Mountain Dry air contains between 800 and 1,500 negative ions in 1 cm3, only 400 plain and the city at only 150 negative ions. Heating and air conditioning reduces the amount of negative ions in cold air. Negative ions favorably affect metabolic processes, respiratory, cardiac, endocrine, CNS, normalizing sleep, making cancers decreased. Simultaneously inhibit the action of microbes and viruses. Cold air stimulates the neuromuscular system function – vascular, increasing resistance against diseases.

UV light is only 1% of what is recorded to normal levels of the atmosphere. UV rays are absorbed by the skin tissue and then converted into vitamin D, calcium metabolism and actively participate in fosorului, activates the thyroid gland function, influencing processes respiratory, digestive, hemocirculatia, the endocrine system. Women are 20% more sensitive than men to influence air, especially during spring. Children and the elderly are less sensitive to UV rays, compared with adults. During the summer body sensitivity is lower than spring and winter. Infrared metabolism, cell activity, hemocirculatia.

Hydrotherapy. Human health is nothing more precious than water. Water was given magic power to become the sap of life on earth (Leonardo da Vinci). All living things have occurred due to the sun and Earth because of water. Water is the most expensive and most perfect substance of nature.
The main sources of fluid in the body are: water, water from food (vegetables, fruits that contain up to 90% water). Simultaneously, within certain limits the body can produce only water needed so – called endogenous water, which is the result of the polymerization reactions of metabolism. Thus, by polymerization of 100 kg of product is obtained 107.1 ml of water. They explain the rise in obesity by using water. Over time, the amount of water in the body decreases. If the age of 30 years constitute 60% of the fluid body, then at the age of 70 years – only 46%. Usually when I drink man is thirsty, but there are a variety of commercially different liquids containing sweet ingredients. Children not drink this liquid because of thirst, but the pleasure of consuming these beverages often contain toxic substances that lead to the occurrence of disturbances in the body. Water is considered as the main drug. Water should not only drink when you are thirsty, but repeated every 1-2 hours to perform necessary physiological actions.

Socrates walked barefoot, saying it favors, sharpening the mind”and Horace was forced to walk barefoot on physician sharp stones and, therefore, was cured of a serious illness. It is recommended to start every 5 minutes walking without shoes, and during these walks to be increased to one hour per day.

Hydrotherapy there for thousands of years and is important in maintaining health. The mechanisms of action are charged to exercise receptors thermal, mechanical and absorption of minerals through the skin.

Waters are used as hydrotherapy when water temperature is between 0 and 42 ° C, as termoterapiei if the temperature is 42-80 º C, in the form of vapor and air overheating in the form of cryotherapy using ice. The bathrooms have vasodilatory action and lead to lower blood pressure to influence vasoconstriction. Simultaneously, the influence and circulation. Thermal baths and steam sauna sweat gland function activates and results in elimination occurs in the capillaries of several metabolites and excretory activity of the kidneys also facilitates eliminating excess fluid from the body.
In our time when artificial and debilitating conditions of daily life of man hit, balneology is a return to nature and it is not simply a return but a return to health, many experimental studies determined effect.
Each source has its own particularities. Besides physical and chemical composition of water in different water fountains there are substances in small quantities but significant effects on the body. However it is possible that additional components to order just the curative capabilities. In the last 20-30 years has been given little attention Balneological treatment, considering that all springs are known for a long time. We think, however, in nature not established reactions that occur under the influence of cosmic energy and the Earth. Disorders that occur in different parts of the Earth affects the composition and physical – chemical water.

Everything in nature is not going straight, but in the form of multiple large and small frequency undulations. Some springs have healing capabilities in the past, but these actions were gradually diminished. Central Institute of Physiotherapy of the former USSR Curortologie and a group of physicians led by Prof. ZE Bahovschi treated a group of patients with sulfur water with concentration of 44 mg / l to 400 mg / l. The results were identical and much weaker in some patients compared with the results of Piatigorsk baths, where the concentration was about 24-40 mg / l. The same results were observed in comparative studies with radon baths and the artificial composition of natural origin. Finally studies have been stopped.
Data presented convince us that actually need to extend studies of many fountains clean, contemporary scientific level.
Studies in the years 1944 – 1960 are mostly devoted to the effects of mineral water due to their action on peripheral receptors. The mineral waters have complex action, because it acts at different levels, first the effect of cutaneous receptors in the neurovegetative system, the subcortical centers and CNS with reflex response and stimulating the endocrine system (adrenal gland) because it normalizes the secretion of hormones and therefore have inflammatory, allergic, angioprotectoare. Simultaneously, water temperatures lead to some vascular bed dilation, increased permeability of the capillary system and has percutaneous penetration of trace elements in the body. Last found, usually in very small quantities, but their effects are favorable, acting on metabolic mechanisms organsimului. Artificial introduction of these elements in large quantities often can have adverse effects. The presence of an excess of trace elements can give rise to a chain reaction producing toxic radicals whose acting is well known injurious.
I amdescoperit 8un minrrala water izvpr key area where the summit Zaganu curgeun spring, which was not used by anyone. In 2007 I got this chance and I arrived at the resort area „NICOLTANA” where I served tap water. I felt a particular aspect of mineral water. When we took evidence and we analyzed in the laboratory, we found that the water contains no chlorine – 0,001 ml, which also fascinated me, now all mineral waters include large amounts of Cl, because all water reserves are clorurizate, DEAC in body Human accumulated maximum amounts of chlorine. Now create a demineralized water storage plant under the name „KEIA” which absorbs large amounts of Cl in the body, beneficial influence human health status.
Some of the positive effects of various private bathrooms: bath sulfur metabolism in the liver, kidney radon baths, containing radioactive gas and basic products, acts on receptors in cutaneous, water and a sodium-chloride-bromine-containing trace elements: iron, bromine , copper, manganese, cobalt, arsenic, potassium silicate, manganese, fluorine was Waters in areas where iodine-containing extract oil and gas in large quantities. These positive influences hemopatii water (increase the number of erythrocytes and leukocytes, the amount of hemoglobin in the blood), improves capillary circulation, normalize blood pressure. Simultaneously, these bathrooms regulate thyroid function and adrenal gland.
Most thermo water for millennia have been primarily used in treatment of joint, muscle, vascular, spinal cord.
Sea water influence on physiological mechanisms of the body occurs through the action of functional control, so it can be appreciated as a medicine. The philosopher Plato said that the great wash all the wickedness of man”and Hippocrates recommended patients seawater baths.
Thus, in antiquity, thalassotherapy was acclaimed as one of the most effective treatment methods.
However, many components found in marine waters have not yet been studied to determine their effect on the body, so treatment of the sea includes several factors: highly purified air, sunshine, hot sand, seascape, aroma and more.
At the congress of thalassotherapy (Saint Malo, France) to said warm sea waters enhances the action of calcium ions, magnesium, potassium, iodine, etc.. with the ability to penetrate inside the body. Also, attention and influence of algae on the skin. Bioactive substances and ionized, minerals, vitamins, proteins positively influence the body’s defense mechanisms.
Seawater therapy treats chronic respiratory stimulates the growth in height in children, acts against allergic diseases, hematological, cardiovascular and joint diseases against axial miofasciale, gynecological and dermatological.
Physiotherapy. Physiotherapeutic methods occupy a special place in the treatment of most diseases important in combination with drug therapy or alone.
Increasing influence of different energies (cosmic power, those in laboratories, radio waves, telephone lines and more) are likely bioenergetic system of human body, predisposing to increased incidence and prevalence of many diseases of CNS and PNS, immune, endocrine, metabolic and oxidation and antioxidarii.
From the above results that physiotherapeutic methods must be used not only to stimulate physiological processes, but more in their functional regulation by selective action on adaptive systems, using micro-doses of very low frequency energy. These methods have not only action at the cellular and molecular level, they influence the metabolism of membrane and other cellular bodies, but also have the ability to alter gene structure.
The use of modern physiotherapeutic methods enable to determine the effectiveness of physiotherapy treatment prognosis of many diseases and rheumatic heart. Physiotherapeutic methods are heterogeneous action with the transition from action to action specific syndrome – pathogenic.
Fundamental studies performed in contemporary physiotherapy phenomena reveal the mechanisms of action of genetic determinism in question methods (physio – genetic and functional capacity of mesenchymal cells modulate the truncated (CMT) which formed the basis of cell therapy fiziomodulatorii.
Functional dependence was evident between the curative effectiveness of physiotherapy factor and genetic characteristics of the patient, which allows us to assess the diagnostic method of gene polymorphism on treatment efficacy of physiotherapy prognosis.
Thus, individual sensory fiziogenetica studying the genetic basis of the patient’s body from physiotherapy and influence functional capacity factor gene: expression, nestabilitatea, mutual reactions between genes to
Now, are successfully used low-intensity laser irradiation, light, magnetic field, electro-magnetic radiation of short wave frequency tuning fork (FSU). Irradiation with laser light influences many biological processes in the body: stimulating the immune system, normalizes metabolic processes, acts anti-inflammatory, analgesic to Low intensity laser irradiation (Ilija), in association with light irradiation (spectrum a range 630-850-890-1300 nm) activates metabolism, immune reactions, contributes to the restoration of cell membrane, activating enzymatic reactions, normalizes blood circulation and lymphatic.
Continuous magnetic field (CMC), the mechanisms which influence the normalization of membrane potential and oxidative processes cause a sedative action, and stimulates the endocrine system antiiflamatoarie. CMC acting on the cellular effect of chromosome orientation in the magnetic field – genetic susceptibility factor to enhance the resonance radiation field.

ENTOMOTHERAPY VOL4

Electromagnetic radiation in low frequency tuning fork stimulates the body’s adaptive processes, normalization neuroumorale functions, lead to changes in physico-chemical composition of blood and lipids in cell membranes. CMC association with low intensity wave action increases the effectiveness of 1.5 – 2 times and duration of therapeutic effect.
Bioresonance therapy methods can be explained by the phenomenon that occurs in functional changes membrane and intracellular organs that are targeted electromagnetic field acting on the processes of oxidation and antioxidant mechanisms related to phosphorylation. These two methods have synergistic action determined by the length of wave action energy, audio component, function and laser diode light source biological effect.
Disorders frequency electromagnetic fields to generate their own cell, which arose from the different pathological processes with several parameters are normalized to the intensity due to reform normal cell generators. Mutual reactions of internal and external fields are essentially mechanisms of action of these methods. Factor is associated with physiotherapy after intercellular biophysical events.
Ilija is based on a field of millimeter wave, and CMC in a field where the micrometer. If the first case the action of resonance occurs at the cellular level and organic, in the second case occurs at the molecular level. Bioenergy field penetration depth and the absorption of these different radiation (2-6 cm for the magnetic field continuously for FSU 300-500 mkm), CMC + irradiation FSU ensure homogenization and subcellular processes in large cellular tissue. Because there is a synergism between these two methods – common effect produced is much higher. Low frequency rays are absorbed by the top layer of skin (epidermis and upper layer of the dermis) that is those regions where the majority are sensory receptors that interact with the CNS.
Intensive absorption of free ion concentration of Ca + + in the cytoplasm. CMC can be applied over clothing, wet dressings with drugs, creams. Low frequency waves are suitable for application on dry fabric, plastic, wood, gypsum, 2 layers of wet gauze.
Low-intensity waves are more efficient, being applied over the organs, vessels, lymph nodes, gladelor endocrine specific acupuncture points.
The parameters of the overall effects (hypotension, coronary dilation, hipolipidemie etc.) were highlighted as factors independent of, the basis”, such as genetic polymorphisms that determine disease development and environmental influence in the quality of which is instability and gene expression .
Functional dependence was evident between the curative effect of physiotherapy and genetic characteristics of factor allowing patients to appreciate the importance of genetic polymorphism diagnosis for effective treatment.
Fiziogenetica physiotherapy field of study is investigating the genetic basis of individual sensory and physiotherapy patient factors influence the functional capacity of legitimate gene: expression, instability, mutual reactions between genes to
Art studies (GN Ponomarecno, 2006) underlying the possibility to prove that physiotherapy methods (laser irradiation, where extremely high frequency) have the ability to stimulate mesenchymal cell migration truncated (CMT) of bone marrow in patients with some serious heart disease (dilated cardiomyopathy).
Polarized light is used to treat many diseases, leading to improvement of microcirculation, exerting anti-inflammatory and immunomodulatory. Is used to treat many diseases polarized polychromatic light produced by the device fototerapeutic,, Bioptron-2”(Switzerland: 480-3400nm, 12J/cm 2, 95% polarization, D = 15 cm). When using this method after 24 hours was found: improving hemocirculatiei and rheological and transport capacity of erythrocytes, decreased platelet aggregation, leukocyte intesificarea activity, decreased plasma concentrations of proinflammatory cytokines (IL6, IL12, TNF-alpha, IFN-1 ) in individuals with the indices raised and increased inflammatory cytokines (IL-10, TGF-beta, IFN-gamma) and stimulate cell proliferation, activation of DNA repair capacity in plasma of affected cells.
The human body uses solar energy, erythrocytes are valued as a source of sunlight. Polarization optical light increases the activity and effectiveness of action. Action polarized polychromatic irradiation device using Bioptron contribute to activation of immune defense and adaptation. It was found that light activates antioxidant enzymes and antioxidant activation leads to prolonged irradiation of erythrocyte membranes.
Mezodiencefalice modulation effect (MMD) on CNS activity is expressed by compensating process and is effective in normalizing hiperexcitare power excitation and inhibition processes to stabilize, which was proven by analysis of psychological testing. MMD will positively affect homeostasis, detoxifying effect, improve processes and adaptive neuro status – psychologically.
Transcranial electric stimulation (EST) is selective action oriented defense system (antinociceptie), mechanisms of nerve formations found in subcortical structures whose function is truncated by the participation of endorphins and serotonin performed as neurotransmitter and neuromodulator. Have established experimental effects such as analgesia and decreased intensive pronounced vasomotor reactions, stimulate tissue repair processes affected, the activation of immune reactions, especially of NK cells (natural killer) led to activation of phagocytosis, inhibition of tumor growth.
Physiotherapeutic methods has been established that positive influence on immune cell activity and humoral processes by activating immunocompetent organ: endocrine glands that regulate lymphoid system imunogeneza and organs.
Acting on the peripheral lymphoid methods consisting of: spleen, peripheral lymph nodes, liver, enhance immunity by place of projection of the endocrine glands: pituitary, thyroid, adrenals.
Rehabilitation includes a complex of processes: mechanisms of biorhythm, mechanisms and phenomena of conditioning, synchronization activity of various organs and systems.
Adaptive synchronization process is altered in acute and chronic and is associated with slowing hemocirculatiei. It was agreed that before and after surgery in patients hemocirculatiei slowdown occurs and then there is normalization of post-operation.
Rehabilitation is a complex activity with many methods of action that lead to normalization of adjustment mechanisms biorhythm (adaptive) and different organs and systems sincronitatea activity. Full activity of the CNS is determined by the acceleration hemocirculatiei brain, which have faster rehabilitation of patients.
Cryogenic physiotherapy is a treatment based on stimulating the action of cold gas (at 150-130 ° C) on the human body. Temperature regime and duration of the procedure are selected by inertia caloric According to our body. Action to significantly lower temperatures are subject to those sections of skin have more receptors for cold temperatures. Change shell skin temperature field is found to no more than 14 mm in depth. Cryotherapy – hemocirculatia stimulates peripheral possesses analgesic effect and stimulates the immune system
Cryogenic Reaction to action is based on information from receptor afferents skin layer. Quantitative link between excitation intensity and the intensity of signals received from the receptors is determined by the law of psycho-physiological Stevenson, describing causation and dependence proportional. It was found that skin surface temperature drops cryotherapy provides up to – 2 ° C, superficial frostbite is possible to decrease skin temperature to -2.5 ° C, therefore, ensure supercooling subtermala cryotherapy skin.

Lemniscal sensory receptor system provides control skin surface cooling. Thus, in the last decade, experimental and clinical results were obtained in November, which allowed the use of low-intensity physical factors extreme healing cellular and molecular level. Physical factors influencing the heterogeneous body, evoking the differentiated pathogenic action. Physiotherapy core studies reveal genetic determinism phenomena curative action mechanisms physiotherapeutic methods. Appear possible to use methods for achieving effective physiotherapy treatment using immunomodulators extremely low doses of physical factors, which are not associated with adverse reactions. The display allows the conclusion that currently, physiotherapeutic methods can be applied more widely, both in chronic processes, and in the acute, both in degenerative diseases, inflammatory and autoimmune as well and are very effective for preventing many diseases.
This condition leads to receptor excitation threshold of the sensory system extralemniscal (SSEL). SSEL receptors are activated only physical actions, the intensity of which presents a danger of irreversible tissue alterations. SSEL appreciate the difficulty locating irritating factor, is why cryotherapy induces analgesia in organs that have not undergone hypothermic effect. Signals received from these receptors are distributed around the brain region responsible for thermoregulatory. A strong signal, but not distributed all over the area, does not evoke an intense reaction response and vice versa. Cryotherapy only stimulate the entire generalized thermoregulatory areas. To activate this system are brutal stimuli required to limit skin damage surfaces. Stimulation is effective if the temperature recorded by cold temperatures receptors terminal is approaching the threshold.
Mechanisms of influence of physiotherapeutic methods are very complex and many lesser-known phenomena, progress in nuclear technology have made it possible to highlight some events that highlight the micro-electrophysiological changes at the molecular level.
Because the disease process initiated by the appearance first bioenergetic system disorders is obviously to develop methods for early diagnosis and effective treatment to make the necessary depth studies in the bioenergetic system.
Currently, methods aimed at physiotherapy less electromagnetic stimulation lead role in regulating energy use disorders microdoze bioenergy fields that are in the body. Circuit which is especially acute pathological processes: spasm-pain-spasm occurs first bioenergetic field disturbances due to their insufficient or microvascular spasm. In this case, low doses of physiotherapeutic factor regulating migration will lead to bioenergetic field, spread it on some neuro-hemostatic pipes. These disorders appear not only in subjects bioenergy that have contact with certain machines, tools, laboratories, factories, and from the influence of television, radio, cellular phones to A very important factor in triggering the disease process is common outside the body rhythms.
Electroimpulsatia is repeated short pulses of low intensity and frequency of pauses. Impulses can be single or in series.
Pulses are differentiated by the shape, duration and frequency. Depending on these characteristics, impulses can irritate (electro muscle) or inhibit (an effect which is based electroanalgezia). The combination of stimulation and inhibition is achieved by diadinamoterapie electroimpulsurilor (amplipulsterapia). Amplipulsterapia modulator is achieved by using low frequency (10-150 Hz), forming a series of pulses with frequency of 10-150 Hz.
Magnetic low-frequency waves work by forming the magnetic field. Action is that the magnetic field effect on charged particles, hence the physical, chemical and biochemical taking place in the body. After magnetic induction law, in blood and lymph is a low power, the change decurgerea metabolic processes, acting on components of crystalline solutions on water, proteins, polypeptides etc.. Under the action of the magnetic field acting electric and magnetic mutual ties of cellular and extracellular structures by editing the permeability of cell membranes and metabolic processes.

Ionoplasmoterapia. Currently, due to disturbances occurring in the environment was found excessive growth of external energy fields that affect the human body’s bio-energy. They have helped many functional disorders and morphological appearance, first in the CNS and neuro-vegetative system, which are major producers and filmmakers of bioenergy. As in any molecule, the cell has a specific electromagnetic charge, the excess energy outside the body greatly influenced the initiation of many pathologies leading to systemic, especially damage to the CNS (nervousness, depression, aggression and, therefore, alcoholism, drug abuse, addiction, suicide, murder of relatives, colleagues (USA). The action of these factors continue to gradually lead to the development of impaired energy morphology, which then turns into genetic processes. increased cosmic radiation, gamma rays, X rays, electron beams and neutrons have very strong influence on the body. pathologic process of developing mechanisms depend very much on the wavelength of radiation. The radiation wavelength 240-300 nm evoke serious changes in the protein. disorders intense electromagnetic influence on oxidation systems and antioxidant content with excessive growth of RL. They play an important role in cellular structures such as proteins, nucleic acids, was evoked by radiation diseases are caused first by the accumulation of large amounts of oxygen free radicals. radicals participate in the mechanisms of cardiovascular pathology free of oxygen, such as nitric oxide.

In order to influence the regulation of bio-energy system, we studied the method in treating many diseases ionoplasmica: rheumatic, neurological, metabolic to, using the device, Rotor”, dst builder Valeriu Rudenko.

Ionic plasma flow is produced by exposure to bipolar ion flow density independent set of positive and negative ions flow to the power efficiency of current 20-300 MCA and exposure time 1-10 s.

The proposed method essentially consists of the following. The passive electrode is attached to the patient, then the affected areas or reflex to act ion flow through the active electrodes, which have direct contact with the body. Active electrodes are bipolar transmit voltage from high voltage generator. The electrodes transmit alternative source switch high voltage positive and negative. In the space between the electrode and skin surface ionization occurs and the patient’s skin are transmitted alternately positive and negative aeroioni. Ion flux density, determined by high-voltage pulse frequency can be set equally for both polarities, but can be different. This is achieved by adjusting the voltage values. Frequency factor is determined by the frequency electric pole change switch contact. Exposure duration for each polarity can be set equal or different. During the procedure depending on the density of ions is determined 5-20 minutes. The total number of procedures is determined by the dynamic recovery process. There were no observed cases of patient deterioration, complications or other adverse effects during treatment with this method and beyond it.
Method of action on the patient’s body with bipolar ion flow, with parameters adjusted independently, allowing differential action and focused on the patient’s affected regions, areas of skin or reflectors, evoking selective inhibition or excitation. May result in the reduction of healing the patient.
Research experience made the recommendation allows noninvasive method for treatment of rheumatic diseases, neurological rehabilitation and post-traumatic and postoperative patients.
Physical activity. Industrialization, automation, work predominantly intellectual and sedentary lifestyle led to the development because many incurable chronic diseases: obesity, osteoporosis, atherosclerosis was
Hypokinesia is associated with muscle hypotrophy, decreased myocardial function, decreased gland secretory function, vital lung capacity shrinks. In this context, obesity has become a matter of medical and social importance, which serves as substrate for the initiation of several cardiovascular disease: myocardial infarction, hypertension as well as osteoporosis, cancer.
The human body is a complex that includes multiple systems with different functions and all works rhythmically, each with a special rate designed to provide optimal physiological functioning and specific. Movement is bioelectrical activity generator that provides the functions of the body, regulates hemocirculatia, digestion, respiration, elimination of toxic metabolites in the body, normalize and enhance the intellectual processes. One of the main physiological factors of maintenance of the body of rules that favor the improvement of body and adapt to new conditions of nature is walking, in other words, the exercise of fundamental human oldest. In the human body in the field went green, vis-à-vis the garden, forest, river, sea, mountain intensify the processes of absorption and utilization, in addition to oxygen, many other substances in the environment.
Physical work, movements are seen as necessary for ensuring health and human existence. Changes that occur in the digestive system to the patient immobilized in bed is a long held that special syndrome that lead to disorders of the pancreas concomitant activity, decreased activity of intestinal motor, dysbacteriosis appearance.
Hypokinesia is associated with decreased muscle function, bioelectrical activity, decreased metabolism and calcium concentration in the system is now bone decreasing gluconeogenesis in the liver processes. Hypokinesia influence lipid synthesis, hydrolysis processes, transport, lipid absorption in the digestive system, supporting hypercholesterolemia and is advantageous for producing a field computer.
Homeopathy. Homeopathy treatment method it represents the standing-like treatment (Similia similibus curantur), that all medicines have the ability to cause disease state in healthy men, however, to remove this condition in patients.
Example – opium in large doses in healthy man, evoke sleepiness, and in small doses cure a patient of this state. Another example – the areas of applied snow frozen.
Following Hanemann (1790) – On any disease can be considered a substance if that substance affects the fair treatment similar in healthy man. Hanemann called this method,”the Greek word homeopathy Homie – similar and pathos – suffering and traditional treatments have been called,”allopathy (Alosa – Alta).
This concept has influenced the old school that was reviewed by the principle that higher doses more intense exercise therapeutic action and established the principle: sigilum summers simplex (simple truth is stamped).
Medications are recommended in the smallest doses, because it acts to annihilate nature and disorders that occurred in the body. Effect of homeopathic treatment usually occurs in late so you have to wait longer.
In case of acute diseases is necessary remedies to be recommended more frequently or in combination with several drugs.
Von Reichenbach’s experiments led to the present power that flows through the nerves – called Fort odica (bioelectric energy), which expresses how he ranks between magnetism, electricity, light and heat, which is like all these powers and also to different from them.
Due to the discovery of bioelectric power, it changed her mind about the mechanisms of disease development. In the opinion of this trend, because any disease is based on the disorders that occur in bioenergetic system activity, which usually occurs before clinical signs of disease. Health is appreciated that the relationship between body and positive and negative bioenergy. In healthy people prevail bioenergetic flow negative activity, which, in animals play an important role compared to that of plants. The more healthy body, the more negative energy grow (Karl Ludwig von Reichenbach).
Hanemann says that homeopathic medicine is spiritual action, as occurs with hypnosis manipulative. Hipnotizorul focuses its healing power, leaving it only to find their way and give directions required homeopath and homeopathic dominate the disease by sharing drug properties sent water or drinks, the bioenergetic peculiarities of homeopathic medicine.

The lower is the amount of the substance, the better it gets into the body, the smaller the particle the greater the qualitative difuzie.Particularitatile her power does not change the reducing substance is the right cantitativa.Organismul – and left with negative Odica force – by force Odica positive. Different drugs outside of their specific action, in some degree or negativa.In positive influence odica force when treatment is prohibited alcohol, coffee, spices, mineral water. It allows simple food, usually with predominance of plant food.
If the dose of drug received, no changes have occurred in the patient’s condition, have to wait a while, then recommend another medication. Only those preparations will remove the disease is selected correctly. When such a drug is identified, with as little or as it is rarely used, the better will be the effect.
In acute diseases or drugs should be administered more frequently is advisable to use 2-3 medicamente.Astfel author describes a new principle of treatment. Now it was found that taste buds can appreciate the strychnine in a dilution of 1:1000000. Effectiveness of homeopathic method is that extremely low doses the patient receives, so it is excluded by toxic action that is seen in all remedies. Receiving treatment for a long time influence on nerve cells.
It is necessary to remember that in most cases, especially when a chronic process, occurring disorders in multiple systems. In all cases the drug helps the body, but does not replace its function. So in many diseases may need a boost guidance, very small due to take place a chain reaction, we assume the mechanisms of free radicals. To protect the allergic reaction, hypersensitivity is sufficient breeze aroma of plant body is sensitized. To include in the overall immune systems, producing neuromediators, interleukins is not necessary to insert large amounts of substance, but again, they cause hypersensitivity effects

What is ENTOMOTERAPIA?

Administration preparations obtained dintesuturile insect species showed different positive effects in treating many human diseases (Ciuhrii, 2005). Insects are among the oldest living things on Earth eukaryotes. Albina is the best known insect to treat human diseases einsecte products obtained are used to treat many diseases. Since ancient times, bee venom to treat many diseases are recommended: for anesthesia, normalize digestion, wound treatment (Egypt, India, China, Greece), in blood pressure, normalize metabolic processes and function processes and regulation of viral life processes and eliminating vital processes against infection. But be aware that tewbuie in cases of viral infections to stimulate the body’s vital life processes, can speed up viruses or other pathogens and mulutiplicarea formatiunelor tumor and then intensify the pathological processes leading to complicatiisi larger body. A classic example is the behavior of dogs, that during severe sfectiunelor stop eating until afectiunele not improve.
Currently not sufficiently studied changes occurring at the molecular level of insects depending on their development phase, which differs considerably compared with those of other creatures. Genetic engineering has made it possible to modify the genetic structure of baculovirus by inserting foreign genes. Therefore bacilovirusilor genome, has a powerful donor creates conditions necessary to secure foreign genes in viral genome structure. This recombinant genome enables to obtain the desired active substance. SBA as interferons, vaccines, interleukins and others were obtained by these methods.
Own gene replacement method of gene foreign Ensure that their protein production (eg A10) to be substituted with the desired protein (M. Ciuhrii, 2003). It is found that arthropod insects have specific composition, which differ greatly in different phases of development of other species.
Thus, larvae that feed very intensively accumulate large amounts of proteins and lipids, and transform into pupae larvae, when part of the lipoprotein components of the larvae turn into polisaharide or protein (chitin or keratin inert) inert, which occupies a large part from pupae. Turns stern protein keratin, which constitutes 80-90% of body butterfly (imago). Subsequently for 4-5 days and lay eggs are fertilized, which have a biochemical structure. In the insect bodies contain proteins that exceed 70% of the dry, every few hours also amino acid composition of proteins changes.
Biologically active substances extracted from insect larvae possess keratolytic action, bactericidal, antiviral, antifungal, antirheumatic, anti-thrombotic, anti-cancer (Fig.). Proteins having keratolytic effect in their content dominated phenylalanine, glutamic acid, asparagine and lysine. Experiments on animals (rabbits, dogs, horses) have shown that using biologically active substances leads to the disappearance of keratin formations (seborrheic warts)
without leaving traces. Keratolytic drugs have a strong effect of resorption keloizilor burns, wounds, or corns (Ciuhr5ii, 2005).
Proteins obtained from haemolymph of insects have a positive effect against staphylococcal and streptococcal infections and population density regulation of E. coli. Currently 5,000 species are known to contain biologically active substances (BAS) with different actions and studied SBA 6000. The large number of insect species diversity SBA determines, with different morphological and biochemical structure.
From ancient times (China, India, Egypt, Greece) were used bee products: venom, propolis, pollen, royal jelly to treat many diseases (injuries, digestive disorders, anesthesia). Purified bee venom was obtained for the first time by N. Pollak (1928). Bee venom contains: toxic peptide, vasoactive amines and enzymes. Is the main component of the venom peptides melittine, which contains 26 amino acids with a molecular weight of 284 Da. Another basic peptide of bee venom is MCD, which includes 22 amino acids and analgesic action has stronger anti-inflammatory effect compared with metilina and 100 times more active as hydrocortisone. Apomina polypeptide that causes neurotoxic venom affects the nervous system of the spinal cord, liver and muscles. Small amounts of other peptides were obtained: tertiapine with presynaptic action, cardiopenul affect heart activity, secapine – sedative and antipyretic, procamina – anesthetic effect. In very small quantities were obtained vasoactive amines such as histamine, dopamine and norepinephrine. Phospholipase hydrolysis processes lizolicitina phospholipids form, the latter effect the destruction of the cell membrane and blocking the release of mediators from nerve cell endings. Of bee venom were obtained enzymes: hyaluronidase, acid phosphatase, fosfomonoesteraza.
Propolis – „pro” – for the „polis” – city – the substance that is used for bonding holes hives, has antibacterial action. Propolis acts effectively on the 100 species of bacteria and has an analgesic effect against wounds, exemelor, varicose ulcers, furunculosis, burns, gastric and duodenal ulcers.
Larva feeds on royal jelly and increases in 6 days or 2700 and make 1500 eggs a day. Her longevity is 3-5 years, while the worker bees is only 1-8 months. Royal jelly contains protein 45.15%, 13.55% fat, 20.39% carbohydrates (glucose and fructose), vitamins, amino acids, trace elements, hormones and other biologically active substances. French scientist Caylas I. (1953) wrote „Bees are the source of youth and life,” that substances produced by them have tonic effect, stimulate metabolic processes, normalize cardiovascular activity and digestive systems. Honey is recommended for diseases of the liver, kidney, stomach, intestine and airways.
Less known are the effects of cockroaches products that contain biologically active substances with curative effect for skin wounds, boost sexual potency and antitumor action.
Extracts of the ants are used in antiquity to treat joint disease or nervous system. Toxins extracted from red ants contain formic acid (CH2O2), which is the active ingredient and excipients and citralul citronealului (9:1), the structure asemenatoare vitamin A, have analgesic action, anti-inflammatory, vasodilator, antikeratozica, anticonjunctivitica. Iridomicina obtained from ants have bactericidal activity. Toxins were extracted from ants creams recommended for rheumatic processes (Serena Samonic sec. II). Currently, preparations are recommended as formic acid in ethyl alcohol (100 ml 14g alcohol 70 °) against rheumatic pain syndrome.
Medicinal products cockroaches (orientalis leaf and leaf Germany) are used to stimulate the activity of sex glands and diuresis, strengthen bone fractures, to remove fluid from patients with liver cirrhosis (SR Botchin, 1876).

Extracts of the larvae of flies are used against many diseases: acute infection, purulent wounds, osteomyelitis, tuberculosis, strep throat. Mechanisms of action of the larvae of flies are expressed through the action of proteolytic enzymes, which inhibit bacterial growth. Urease, found in extracts, the interaction with urea, forming ammonia. Fly larvae extracts were used in the treatment of many diseases: a osteomyelitis, keloizilor burns, gangrene. In ancient times they used extracts from larvae of several species of flies in the treatment of purulent diseases (staphylococcal, streptococcal): wounds, infections, acute osteomyelitis. Avicenna and bugs and fleas Diascorid used as mobile in the treatment of malaria. After some information of the Arabs – Mantis religiosa insect pupae have the ability to stimulate sexual activity in men and women regulate kidney function. Substances extracted from crickets, are administered to treat colitis and hepatitis, and extracts from locusts (China, Japan) are taken with a view to removing moles and hemorrhoids. In many countries malaria is recommended lice, liver cirrhosis. Extracts are useful in treating scabies crickets and urticaria. Biochemical studies have revealed some differences in the composition of lipid extracts obtained from Lepidopterelor, beetles, and Aphidiilor Dipterelor. They are different from those extracted from other creatures, because lipids extracted from insects contain unsaturated fatty acids of the outstanding highlight animal and also the common parts of the plant extarse. Of particular interest are arthropods, which is dezvolarii hransec intense process, accumulating a large amount of fat, and the larvae transform into pupae accumulate some large amounts of protein, keratin last turns constituting 80-90% of body butterfly (imago).
Because amino acid composition of proteins from insects change every few hours, they make it possible to obtain proteins with different properties. Thus, Lepidopterele contain glutamic acid, aspartic acid, proline, alanine and glicocoluluil in phase protein egg protein larva contains alanine, glutamic acid, glicocolul, aspartic acid, leucine, in stern predominant protein glutamic acid and aspartic acid, alanine, glicocolului and serine.
The mechanism of action of antiviral preparations obtained from insect SBA is expressed by their ability to transform some compositions in others. type keratin. In some phase of development of insects appear some inhibitors of protein synthesis and nucleic acids. These inhibitors penetrate the liver cells infected with virus and inhibits protein synthesis and nucleic acids.
they extracted from the haemolymph of insects have antibacterial capabilities (against Staph. Spp., Strep. Spp., E. Colli) successfully used to treat diseases, especially in cases when the missing response to antibiotics.
treatment of oral candidiasis, vaginal and skin were developed antifungal protein that stops multiplication of yeast.
It is necessary to obtain antitumor effects of insect SBA already has found the effectiveness of these substances in the treatment of cutaneous melanomas and carcinomas. Positive results were obtained in the treatment of prostate adenoma and cancer fribomului.

Entomology is a science that studies the insects as such – mormologia, their spread, and therapy is part of medicine, which deals with healing or improving the means for medical diseases – Treatment. In this case the insect tissues are used to produce drugs, because now we realize that in the insect body during morphogenesis, the many changes under the influence of various enzymes and defensin which can adjust certain vital processes of the body. There is a new drug industry based biologically active substances (BAS) from different species of insects. In the near future will produce dietary supplements that will be used to regulate the body’s normal function in certain situations. This will increase the longevity and human and other animals desired by man.
Insects have segmented bodies, each have six legs. Many believe that mosquitoes, locusts, dragonflies, spiders belong to the insect class. This statement is not true, because insects are only those that have segmented bodies.
The first time many people hear that there are natural medicines derived from insects, have a revulsion, a fear and immediately imagines the most common insects that occur in human life, such as cockroach (leaf or leaf orientalis Germany) , flies (dipterous), the Colorado beetle (Colioptera) and others. Repellents are less colorful butterflies, beetles forest. Some find it difficult to understand how these can help human beings? Among insects are bees, which feed the whole world with tasty honey or silk worm, the silk dress with the whole world, which until now is considered the best quality. The question does not exist and other insect species so useful to man? The author of this paper believe that there are still many species of insects, which can play an important role in human life. Lately melanogaster became an object Drossofila classic contemporary genetics studies. This insect has only two chromosomes and is an object of study to obtain genetic information and information about the regularities of transmitting information from one generation to another. All these changes are made only by the two chromosomes, which allows to determine the cellular genome functions. This bug allowed to determine many genetic regularity.
And insects of the family are NOCTUIDAE new, especially Autograph californica, Trihoplusia us, Mamestra brrassicae that can infest the recombinant baculovirus of new proteins to produce certain properties. Thus, it can produce interferonuri, vaccines brand new.
So far in complementary medicine no notion of „Apitherapy” which explores the products obtained from bees (Apis mellifera), especially honey, propolis, bee venom.
„Herbal” – studying the plants used in medicine
„Animal-therapy” – a direction that studying animal products used to regulate life processes of man.
In this context the term ENTOMOTERAPIA – is a new direction in science which studies the use of biologically active substances (BAS) important biologically active substances (BAV) in the regulation of various vital processes of the human body and domestic animals. Nobody has yet thought that tissues of certain species of insects exist SBA, which may serve to regulate certain vital processes of human beings in the regulation of certain compositions, the protein aminoazizilor. Thus, if the human protein components are missing or are not sufficiently certain amino acids it can complement other sources, especially certain species of insect tissues at certain stages of development.
SBA of insects can be used in cases of infection caused by viruses, bacteria or fungi, because some insects may stop replication of SBA certain pathogens or there compositions such as „cytostatic” or „interferons”
Insects that exist on Earth for more than 3 billion years before humans have been another system of defense against bacterial and viral infections. Insects, unlike vertebrates, does not form antibodies, they form the oligopeptides, which regulate the activity of immune bodies. This system is effective and to lift the immunity of human bodies in different cases. If we could adapt some of the bodies immune system of invertebrates were higher then and human longevity with several years – the aspiration of all people.
Insects use in medicine is an entirely new one which will revolutionize the future production of medicines. Few people know that insects are ancient beings on Earth. The diversity of these organisms is extremely high and includes more than 61% of all organisms on Earth (Dimarcq 2003). Over time the insects in turn were attacked by different pathogens, including viruses (Ciuhrii, 1972 – 2007), which responded differently to pathogens. First, insect body does not form antibodies react as vertebrates. Insects have achieved a great immune system from other organisms. Chemical composition of insect tissues (Hetru, Hoffmann, Hancock 2002, Knopp, Mizina 2003) differs completely from other organisms. Unlike other animals, insects go through several stages of development (Fig.): egg, larva, pupa and adult (imago).
Fig. Lepidopterelor morphogenesis: first form the egg, then larva, pupa and imago (adult)

At each stage the insects not only change their morphology but also chemical composition. According to data (Ciuhrii 1977, 1982, 1988, 1995, 2005, Jean-Luc Dimarcq 2003) insect tissue include biologically active substances (BAS) with different properties. Until now man looked more insects to find ways to combat it. Thus was developed the most advanced chemical weapons, biological physical and destroy them. These weapons have caused the emergence of new possibilities of insect resistance by increasing the potential for breeding and changing the chemical composition of tissues to resist these attacks. It is curious that insects have developed new ways of resistance to attacks of various kinds of infections and toxins. Viral infections, insects do not form antibodies (immunity) as vertebrate organisms. Different types of infections resistant to insects is still very little studied.
Fig. Properties of biologically active substances of insects

Intense use of insecticides has led to natural disasters, causing imbalance in natural ecosystem, leading to a large number of diseases of humans and animals.
There was a new discipline where Weiser Insect Pathology (1972) found that insects are attacked by pathogens, among which are the most effective baculovirus (Ciuhrii 1977, 1982, 1988). Research conducted recently (Ciuhrii 2000) have shown that insects, unlike other bodies have other defense than other beings. The tissue composition includes a greater amount of micromolecule (peptides) that plays defense (Cecropine, Drosomycine, Attacine, defensin, Diptericine). The insect can be extracted peptides and polypeptides (1 and alloferon alloferon 2), which raises human immunity against various infections.

Two main directions of complementary medicine:

Homeopathy;
Acupuncture
Phytotherapy;
Entomoterapia;
Apitherapy;
Acupressure;
Reflexology
Therapeutic massage;
Music therapy;
Chromotherapy;
Crystal
Kineto;
Bioenergoterapia;
Sacroterapia
Aero-, helio-and talazoterapia;
Sacroterapia.

Last direction is the oldest and most effective if done with true faith. It is an unimaginable force of human reason yet
All phenomena of nature are directed toward correcting the life processes of human beings, whose structure and functions are not yet fully known, although there
Institute specialized in different areas: cardiology, pulmonology, ophthalmology, ENT, specialist research institutes for the treatment of certain diseases, Institute of oncology, psychiatry, neurology, pftiziologie, Rheumatology, Cardiology and more, have an intense research to identify new methods and systems to improve certain vital human dysfunction. I recorded a lot of inventions of directing human life processes and human longevity however is still lower than that desired. Everyone expects new discoveries in the field of human health, primarily to find new possibilities for food and medicines proper, which would increase longevity.
We must recognize that in many cases desperate private doctors in the deaths of their peers, they can not interfere with the proper methods for saving patients. In many cases, patients resort to other methods, which in some cases can save lives. Cases cured us to examine other methods that are not supported by the Ministries of Health. There are many contradictions between patients and administration that put the deficultate authorities. In many cases occur when situations are desperate cases to recover without medical explanation logical. Exactly this situation makes us to discuss further directions of complementary medicine, which is not yet supported by official medicine. We are also convinced that the meetings have to gain. Maybe some information can come from outside the medical system. Besides allopathic medicine has benefited from many directions of development in different fields: chemistry, physics, mathematics was
The diversity of living organisms
1.5 million species of insects
300 000 plant species
90 000 species of mollusks
70 000 species of vertebrates
35 000 species of arachnids

As far there Phytopathology studying the use of plants in medicine, so the insects used in pharmacy may be called,, entomoterapie ”

The main directions of complementary medicine:

Homeopathy;
Acupuncture
Phytotherapy;
Entomoterapia;
Apitherapy;
Acupressure;
Reflexology
Therapeutic massage;
Music therapy;
Chromotherapy;
Crystal
Kineto;
Bioenergoterapia;
Sacroterapia
Aero-, helio-and talazoterapia;
Sacroterapia.
Last direction is the oldest and most effective if done with true faith. It is still a force of unimaginable human reason. All phenomena of nature are directed toward correcting the life processes of human beings, whose structure and functions are not yet fully known, although there are specialized institutes in various areas: cardiology, pulmonology, ophthalmology, ENT, specialist research institutes for the treatment of certain diseases, Institute of oncology, psychiatry, neurology, pftiziologie, rheumatology, cardiology and many others who have an intense research to identify new methods and systems to improve certain vital human dysfunction. I recorded a lot of inventions of directing human life processes and human longevity however is still lower than that desired. Everyone expects new discoveries in human health, primarily to find new possibilities for food and medicines proper, which would increase longevity.
We must recognize that in many cases desperate private doctors in the deaths of their peers, they can not interfere with the proper methods for saving patients. In many cases, patients resort to other methods, which in some cases can save lives. Cases cured us to examine other methods that are not supported by the Ministries of Health. There are many contradictions between patients and administration that put the deficultate authorities. In many cases occur when situations are desperate cases to recover without medical explanation logical. This situation makes us to discuss further directions of complementary medicine, which is not yet supported by official medicine. We are also convinced that the meetings have to gain. Maybe some information can come from outside the medical system.
Besides allopathic medicine has benefited from many directions of development in different fields: chemistry, physics, mathematics was
As far there Phytopathology, who studies the use of plants in medicine, so the use of insects in pharmacy may be called,, entomoterapie „, which is a new direction more. When we speak of entomoterapie not talking about using insect products (honey, wax, propolis, royal jelly), but extracts from insect tissues at different stages of development. Insects, unlike other bodies, in their cycle of morphogenesis, not only morphology but also changes its chemical structure (chemical composition see inesctelor). These biologically active substances extracted from insects at certain stages of development have certain properties (Fig. 2).
We have focused on the study of lepidopteran insects, Caliopterelor, Dipterelor, Aphidiilor and others who are able to multiply rapidly and in significant amounts. In this way we obtain SBA of insects in significant amounts. So far SC INSECT FARM SA and SC,, TO SHOWCASE MAGIQUE „Ltd. have extracted SBA quantities of more than 40 species of insects, which are used efficiently to produce para preparations, food supplements and cosmetics (see list prepared belonging to the ranges,, FLY – FLY ‘and NOBLESSE „dietary supplements, HEPATITO-LIZ 1 and 2”, „immuno-MAX 1 and 2”), prepared registered at fine health Miniterul Moldova.
Based on SBA were prepared several patented (Patent List), which obtained so far a number of medals and diplomas at international exhibitions and competitions (the list of diplomas and medals).
It appeared the idea of using keratolytic enzymes performing biological operations replace surgical scalpel and scalpel. Biological operations can eliminate unwanted formations on human skin without pain and without leaving traces unpleasant because tissue has the ability to repair genetic exactly as built.
These operations represent a biological world premiere and were distinguished by more than 50 gold medals at International Exhibitions of Inventions and cosmetics.
Such preparations have created large biological perspective for contemporary medicine. It made one of the great aspirations of mankind – biological operations that obtained using SBA of insects can become sick in a healthy tissue.
Was recently recorded a very important biological preparation of prevention of blood vessel, ‘foot cream, „which can dissolve thrombi and emboli in blood vessels. Thus, varicose veins and arteritis obliterans can be removed without applying physical surgery and replacement blood vessels, especially of the coronary artery. SBA is working to use directly within the coronary vessels to eliminate vessel spasms that result in saving thousands of patients.
It is one of the greatest achievements in the use of insects in the treatment of man, which will greatly influence the longevity of human beings.
Another rapidly developing direction in applied scientific Center – SBA use of insects to block infections caused by bacteria (staphylococci, streptococci) and oral fungal infections, vaginal disorders. Are registered mouth care preparations, nail care, hair shampoo and lotion.
I think our biggest achievement is the development, patenting and production of pharmaceuticals, IMU-HEPTIN „,, ENTO-HEPTIN”,, IMU-Purines „,, adeno-PROSIN” toxicological testing that have passed, conditioning and management technology.
The first two preparations help stop viral infections (hepatic viruses, herpes), also help stop HIV – AIDS.
Preparations include a series of enzyme inhibitors of protein synthesis and nucleic acids that occur in the insect body keratinization adult stage, when the insect proteins pass into another form of keratin, which is 90%. Experiments in several hospitals of these preparations showed evidence of viral decline, globulin and albumin synthesis regulation to eliminate viruses from the body.
Preparation, imposed-Rhine „(Immuno – MAX) has the ability to considerably raise immunity. The drug is administered in gelatin capsules and in the form of suppositories.
Research insect tissue structure will lead to many pharmaceutical, para-, food supplements, cosmetics, which will solve many of the diseases now considered incurable human, which will decrease in the number of human diseases.

ENTOMOTHERAPY VOL5

ENTOMOTERAPIA is a new concept that comes from the word meaning the study of insects Entomology to obtain pharmaceuticals.
So far man has not learned to effectively exploit invertebrate animals, and especially insects, which have specific features. Transformations of substances during insect development cycle is fast and spectacular colossal. Duration of the larvae of many insects is only a few days. The insect body accumulates a large amount of fat, then the larvae turn into pupae, which prevailed five types of proteins that turn into other keratinelor similar proteins that form the butterfly (imago). This form of insects take only a few days to fertilization and egg laying. Should I say, as one female can lay up to 3,000 eggs, so the potential is huge breeding of insects, especially unwanted insects by humans – phytophagous inpotriva WHICH insecticides. The more often you apply toxins to their destruction, the greater the potential for breeding of organisms. Of eggs and larvae are formed and the cycle repeats. Some insects have 3-4 generations in a vegetative period of the year. Then it should be noted that insects can be monofage (when they feed only one species or hunger, you feed on several species of plants). Independent food and chemical composition of tissues is different. To extract some biologically active substances is enough to know at what stage of development of insects accumulate these substances and to stop development of the insect in order to extract and use them for certain purposes. Now describes more than one million species of insects and a half. Since they are more than 300 thousand beetles (beetles). It is an enormous potential biologically active substances, which remain to be studied intensively by humans. To make a comparison should know that all vertebrates are nearly 70,000 described species.
To better imagine these natural phenomena to know that every man is statistically about every 250 million insects.
Insect emergence was found during development Devan Earth. They are considered the most ancient eukaryotic organisms. It is known that ladybugs with seven points in case of emergency remove a toxic substance in orange. Substances include alkaloids and coccenellin adalen and ladybugs with 14 points propilein contain alkaloid that is toxic to his enemies. It was found that coccinillina is part of a new type of alkaloids, which does not exist in component plants. Alkaloid is formed only in coccinilidelor body. They are not consumed nor poisonous spiders. When coccinelidele spiders fall into place, they are driven without being pierced as it does with other insects.
Aqueous solutions obtained from haemolymph coccinidelor is toxic to vertebrates and invertebrates. If turns out coccinilide eliminated secretion on human skin when the skin develops a red patch with a similar acute dermatitis, which lasts 12-20 hours. Therefore there is a recipe that is effective to treat toothaches. Take a coccinilida (Coleoptera) and crushed between the fingers, then the finger is applied to the painful teeth. They say that pain go away immediately. Of course, this recipe is no longer used now because there are other relevant drugs that have an anesthetic effect. These substances will be studied and prepared synthesized to develop us. But in homeopathic medicine is also used extracts from 50 coccinilide in 100 ml of alcohol to relieve pain.
One of the best known insect is used in homeopathic treatment of bee and its products: toxins, wax, honey, royal jelly, propolis, pollen. Toxins extracted from bees are recommended for anesthesia, wound repair, digestive diseases, hair loss and other ailments since ancient times in Egypt, India, China, Greece.
The first official description of the curative properties of toxins extracted from bees were medicine men and Plinii I. Galen, who described the toxins extracted from bees that anestiziologice preparations, stimulating the repair of wounds and digestion. Information about using the toxin extracted from bee to stop hair loss. In some cases the substances are effective for treating gout.
But let us see what are the properties of toxins extracted from bees? After pricking the skin with a needle bees particular toxin is eliminated under the skin and causing painful inflammation, which most of us felt. Toxic substance increases the amount of leukocytes in the injected area, dilate blood vessels, lowers blood pressure, permeability of blood vessels and raises obvious red blood cell hemolysis. I especially have a high sensitivity for human beings, horses and dogs. In large doses causes toxic and can cause death contracting muscles of the body.
Application of toxins extracted from a beekeepers bees started, so treating the body with toxins acquired insects called Apitherapy. Use of toxins from the bees has a number of inconveniences. First to be purified. Their purification is a very complicated process. Direct use of bees can be carried out only during summer bee activity. Toxins in pure form were obtained for the first time in 1928 by N. Pollac and FOLF company began selling them as „apicozon”. The drug was recommended in three concentrations and placed under the skin to treat arteritis, neuralgia, myalgia. In Austria have developed a different preparation – „ummenin” which was intended to treat diseases acelorlasi. He was then developed another preparation „apicur” aqueous solution of 1.5%. Toxin elaborated preparation mixed with novocaine „faparin” then appeared preparation „apizatron” – toxin in powder form on which to produce and ointments under the same name.
KF-1 preparations (venapialon) and KF-2, „toxapin” (mellisin) occur in large enough quantities to treat high blood tensiunelor, improve metabolism and to relieve sistemuluinervos. In Estonia has developed complex pharmaceutical preparation „appilit” which has the ability to raise body resistance to the action of radiation.
Based on toxins extracted from bees produce more creams (ointments). It is well known ointment, the bee is outside the toxin include salicylic acid, wax. Another ointment is also produced in the Czech Republic viparin. In Romania occurs ointment „Apidermin” outside of toxins which also includes other components.
To obtain large amounts of bee toxins was invented a method and a special device that consists of a dark room in which bees are placed. The camera includes a tube with a diameter slightly larger than the bee’s body. A crack in the tube is united with ampul. When insects come in a tube they are busy with a dose of weak electrical current. After excitations bees remove the toxin, which flows into the ampul. Thus bees go one by one through the tube and remove toxins without injured. The amount of toxins removed by one bee is 0.4 to 0.8 mg. And other devices are known toxins collection of bees, which are constantly modernized to obtain the greatest possible amount of biologically active substances.
He noted that if bees toxins are heated to 100 ° C for 15 min, then they lose the property to cause reactions on human skin, but the effect of causing parasite and feverish activity is maintained. The action temperature of 100 ° C for 30 min toxin lost property to cause irritation. 150 ° for 30 min completely inactivate the toxin.
Bee toxins include three components: peptides, enzymes and biological amines. Component of polypeptide toxin extracted from bee is melittin. The concentration of the toxin is 50% and includes 26 amino acids with a molecular weight of 28.

Different bee species produce toxins with a different composition of the peptide Melitta. This substance is now well studied in terms of chemical synthesis and performing them. Melitta peptide has the ability to interact with phospholipids of cell membranes and causes a number of effects such as hemioliza erythrocytes, release of histamine from cells, change cellular metabolism and enzyme activity within cells.
Another main component of the toxin extracted from bee – MSD peptide includes 22 amino acids with two sulphide links:
NH2-Ile-Asp-Lyz-Cis-Cis-Lys-Arg-His-Val-Ile-His-Lyz-Pro-Ile-Arg-Liz-Cis-Cis-Gly-Ile-Asp-CONH2-Liz
This substance has the ability to stop the pain of tens of times faster compared with the Melitta as quickly eliminate histamine from cells. It has anti-inflammatory effect and is 100 times more active than hydrocortisone. To determine the mechanism of action of peptide MSD, which is responsible for the anti-inflammatory and histamine release from cells.
Neuropathological effect of the toxin extracted from bee depends on peptide activity apaminn:
NH2-Asp-Cis-Cis-Liz-Ala-Pro-Glu-Ala-Ley-Tre-cis-Ala-Arg-Arg-Cys-GLN-GLN-HLN-Hys-CONH2
Using isotope was found that certain peptide apamin acts on the spinal nerve structures spine, liver and muscles. The action is expressed by fever.
The bee toxin and other peptides were detected in minor amounts. Some of the best known are: tertiapine – has a presynaptic action, cardiopen – acting on heart function; secapine – calming effect and decreases body temperature; procamin – with a nervous system-acting anesthetic. Besides those listed above were detected biogenic amines such as histamine. Contain very small amounts and noradrepalin dafamin.
To detect and phosphatase, which is found at a rate of up to 12%. It has the function of hydrolysis of phospholipids to form lizolecitinei, destructive acting on cell membranes and block the release of mediators from nerve cell endings. Hyalyropidaza enzyme stimulates the spread of toxins in the body. The toxins were detected fosfalaza bees acid, a – glucosidase; fosfomonoestiraza, B – galactozadaza and others.
Thus, the toxin extracted from bee have a broad spectrum of action: effect of stimulating blood circulation, and neurotropic action on the endings of nerve cells, acts positively on normalizing heart function in case of arrhythmia, heart rate, stimulates blood flow in brain regions, normalizing blood pressure increases, MSD has anti-inflammatory peptide, has a protective effect against radiation, which gives it special importance.
Another important product of bees propolis – a sticky substance that bees stick all holes hives. The word comes from Greek „pro” – means for the „polis” – city. But this substance is not only a building material, but it has an antimicrobial effect, protecting the bees from the action of various infections. Interestingly, if the hive gets a mouse or lizard, they are killed by bees. The bodies are treated with propolis is why they are kept for a long time without rotting process begins.
According to information extracted from propolis include plant buds, especially birch and poplar, that bee in her body processes them, turning them into a sticky substance.
Propolis as biologically active substances is very varied and is divided into several groups: a high density with the addition of wax, pollen, used as construction material used for filling cracks hive, propolis is also known and „true” which is processed in the digestive tract after swallowing pollen bees, pollen „minimum” that is used to work fine.
Research pharmacological properties were detected in propolis and stop the pain of wound repair. Antimicrobial effect on more than 100 species of microorganisms. For the first time in propolis preparation „propolizan” was used to treat wounds during World War. It is effective in treating various types of eczema, varicose ulcers, cutaneous forms of tuberculosis, boils, burns, bedsores and other conditions. It is recommended to treat ulcers and internal stomach and duodenum. Propolis can be prepared in aerosol form for treating bronchitis and pharyngitis. Anesthetic effect found their application in dentistry.
Propolis price is quite high worldwide. One kilogram of propolis in the UK costs about 54 pounds. In Japan five times more, in Germany 350-400 DM.
XII Pope John Paul said propolis and royal jelly products holy, so they began to be used with confidence by the population.
Propolis extracts are used in the form of alcohol or olive oil mixed in 2:10 ratio to form ointments. So preparation is well known „propolan” to treat wounds. It is known by 20% propolis ointment with vaseline and sanolina. Preparation „VAIVA” has found application in the treatment of mouth odor. Preparation „promicsa” is used to treat eye infections. But there are still many problems related to standardization of propolis based preparations, because the composition of each time has a different composition depending on the composition of the flora from which bees collect components. This inconvenience is currently investigating to resolve the issue of standardization of products based on propolis.
Another product apical curative properties is royal jelly. This product is made by bees working, you eliminate the pharyngeal glands during depositing offspring. Elimination abundance of royal jelly is done when it is old age or lack of hive. To collect royal jelly from the queen to remove hives, the bees make a new brood in this case remove a cream-like substance, which is royal jelly.
It was found that larvae of jelly, which feeds on royal grow very quickly. In six days of 2700-fold increases. Lay about 1,500 eggs a day which is two times heavier than his body and longevity increases to 3-5 years, when working bees live only 1-8 months.
Royal jelly is a white substance with a yellow hue and taste sour. It contains 45.15% protein, 13.55% fat, 20.39% carbohydrates (glucose and fructose). The composition includes vitamins, amino acids, trace elements, hormones and other biologically active substances stimulating growth. Royal jelly contains five times more protein and carbohydrates compared to human milk.
Getting the royal jelly is a pretty complicated process. Bees are kept in special apiary where bees are bred only to obtain royal jelly. From one family of bees in a year can get about 100 g of royal. Currently many centers are created where bees are bred to obtain royal jelly.
One of the first who observed the curative effect of royal jelly was French agronomist Caylas I. 1953. In his treatise „Bees – fountain of youth and life.” He writes that the administration of royal jelly gives a feeling of rejuvenation, developing energy. Tonic effect, stimulates metabolism, regulates the function of the digestive system and circular.
The healing properties of royal jelly preparations led to the development of energy: apifortill, ulcojeral, raiapan produced in Germany, apiserum (France), spintavit (Italy), lonjipex-plus (Canada), DN-112-Holtinger (Austria) superconcentrates (Romania), vit-APIN (Czech Republic), apilac (Russia), including 10 mg of lyophilized royal.
Royal jelly has a wide application in dermatology and cosmetic creams and ointments for the manufacture of many obvious effect. It has a stimulating effect of the vitality of old people and those who had surgery or were infected with different microorganisms strong. Royal jelly is more effective in fresh or applied by injection directly into the bloodstream through the digestive tract because its use degrades the environment of the stomach under the influence of acid. Usually administered 100-200 ml per day. It is effective and if it puts royal language which is rapidly absorbed into the bloodstream.
Significant in human nutrition has honey, which is known since antiquity. The healing properties of honey are published in many special works, which describes its effect in treating liver, kidney, stomach, intestines, respiratory tract, circulatory system, metabolism, skin etc.. A kilo of honey is 3150 – 3350 calories. Honey is very good for all, especially after a serious illness or fatigue powerful. Honey is used for 2 to 3 times daily 2 hours before the mass: 100-150 g for adults and for children 30-50 g.
Attempts were made to isolate (a split) certain components of honey. For example, after eliminating carbohydrates, other components can be used to remove various microorganisms and tissue repair after trauma and can be used to treat wounds.
Since ancient times honey is heated to 100 ° C before use for treating wounds. Are known more for treating wounds Oriental recipes use honey, boiled for 15 minutes (work by Avicenna).
In Georgia researchers describe method TGNatadze PSCianturievili and obtaining a portion of the bumble bees and honey by boiling and distillation temperature of 130 special -180 ° C. As a result some fractions that are effective for the treatment of wounds. These fractions brakes stops the growth of pathogenic microorganisms and inflammatory process.
Another bee product is beeswax, which is used for healing since ancient times. It has a very complicated chemical composition. Some of the elements that make up the wax and melisinici ceratinici are acids, ethers Cerato – miricilici, and mericilici ceritilici alcohols, carbohydrates such as paraffins, alcohols macromolecular fatty acids and essential oils. Paraffin has a pleasant smell, similar to honey. Wax color varies from yellow to dark brown. At temperatures over 35 ° C becomes plastic, and at 60-65 ° C to liquefy. Waxing is not soluble in water, glycerin and alcohol. It dissolves in benzene, schipidar, ether, fatty acids and alcohols boiling.
There are several types of wax. The quality wax is inside the hives. Wax obtained outside the hive is of lower quality. White wax is obtained after the usual wax remains in sunlight or by chemical oxidants action. It preserves white wax immediately after obtaining them.
Apart from bees wax can be produced by some species of lice that produce silence high quality white wax. Wax is produced by glands of males. Wax is produced and deposited on tree branches. Harvested from the branches and then heated at temperatures of 60-70 ° C and clearing of wood. This wax is pretty consistent and crumbly. Wax content is useful in various creams, which is used to treat wounds. It is used to compress the anesthetic effect on pain, strengthen the nervous system, accelerates the redress of bones after fractures. White wax is different in that they liquefy at high temperatures, including 51% of fatty acids and 49% alcohol atomic.
In medicine is used more frequently yellow wax, which is formed cakes that are applied to the skin for rheumatic pain. Cosmetic creams included in the bleaching skin to give it a tougher consistency. Skin becomes more elastic and more pleasant places with creams that contain wax.
Necessary to remember that wax is used in dentistry for tooth shape.
To show gratitude to the bee man in Poland were dedicated a monument, and in Japan a few important monuments in different cities.
Viespele, which looks very much like bees are less useful to humans. Indians on the American continent as a remedy used to treat viespele poisonous snakes bites. In Asia the population uses viespele, we kill them and dry powder is used to treat skin wounds faster.
In many works meet pharmaceutical recipes from cockroaches. Since they get cooked like „viagra”, which stimulates sexual potency. To stimulate sexual potency and beetles were used. Extracts from these beetles is also used to treat various skin wounds. If these beetles are stacks and their contents applied to the skin, then this region is irritated, fluid blisters appear. In general poisoning can occur at high doses. There are more than 100 species of beetles also, that contain biologically active substances still unstudied. In Asia (especially Kazakhstan) pastors call these cockroaches animals’ alla-Gulec „- which means” nuisance „because if these animals grazing grass and swallow bugs when there is an irritation of the intestines. These beetles have been known since antiquity and described by Aristotle, Plinii. German researcher writes Engolm in 1811 in a magazine that Emperor Friedrich II Prus successfully used extracts from cockroaches to boost sexual potency Melo majalis. These extracts have been studied by many researchers, but only in 1812 renowned French chemist managed to isolate Robicvet of these beetles white crystals, which dissolve in water. The substance was later called cantaridin. It is soluble in alcohol, oil, chloroform. Melts at 218 ° C. In terms of acid anhydride is a chemical weighed. Besides weighing bugs include fats extracts, essential oils with a flavor, Citric acid and urea. Weighed it was found that a substance produced by the sex glands. Young beetles, which do not contain mature weighed.
Bugs (pederus) include biologically active substances identical and are called pederine.
It is known on the actual recipe for massages for rheumatism weighed which includes the following components:
50 parts wax
70 parts rosin
35 parts turpentine
20 parts extract beetles
5 parts milk plant extract cuckoo
20 pieces of fat cow
When applying the skin becomes red composition, but not irritating.

Known and another recipe from the following components:
4 parts beetles (spanoc)
4 parts yellow wax
4 parts rosin
2 parts beef fat
Simple ointment weighed on:
9 parts beetles spanoc
12 parts wax
24 parts olive oil
It also used an infusion of bugs – spanoc, which has the following composition:
– 1 part-spanoc beetles
– 10 parts alcohol
Mixture is recommended to be administered every 3 drops orally 3 times a day. The same mixture can be applied to the hair on the head to activate growth, can be used to relieve rheumatic pain in pneumonia, lupus eritomatos, ceroza and leprosy.
It is known preparation called „Prussian porridge”, which is used to treat rabies, which can occur after bites dog infected with rabies virus. The preparation consists of the following composition:
– 1 part weighed
– 99 parts honey.
Weighed was recommended to activate sexual potential. Drug administration to chance lead to serious complications, often resulting in deaths. G. Meyer and P. Gotlibb indicate that the use of weighed 0.1% tincture causes a feeling of warmth throughout the body, while higher concentrations cause inflammation of the digestive tract and is an abundance of saliva secretion. Weighed as the urine is eliminated from the body often is inflammation of the kidneys (glomerulonephritis) and then cystitis and uterus. There is a strong inflammation of the genitals. Application of high doses kills the body.
Because of complications, management experts weighed without supervision is not recommended.

It is well known historical event. Marquis D’Sad (his name derived from the word „sadism”) made a stupid joke. In order to stimulate sexual activity cause he served his guests inside candy which included a cockroach extract peat (Lytter vesicatoria). There was a poisoning and some among them died. For the Marquis D’Sad joke was sentenced to death, and later the sentence was changed to long prison (see the book „Man and woman” in German Vol I, II – 1911).
Because toxicity is not indicated weighed in official medicine. But some quack homeopaths also indicate weighed in very high dilutions. It is known recipe:
50% extract of beetles Paederus galigatus
70% alcohol
30% of plant extract foot cock
The drug is produced as „stimulin D”, which applies in cases where it is necessary to challenge an irritation in certain points of the body.
Since ancient times used to treat ant extract nervous system and relieve pain from joint areas. Here are some methods to obtain preparations:
In May they gather red ants, which are put in a bottle, more than they add 70% alcohol. Glass is kept at a temperature of 30 ° C and darkness for 2 to 3 weeks
A wide neck bottle is placed in an ant hill. Bottle mouth lubricated with sunflower oil. When glass is filled with ants, is sealed, maintained at a temperature of 30 ° C for 20-30 days in darkness. The juice obtained is filtered through a filter paper and then 10-15 drops administered in the morning on an empty stomach.
The toxin component extracted from red ants enter and formic acid (CH2O2), which is the active ingredient. Among other components may be remembered that essential oils and histamine neurotropic action. Components of citronella and citral (9:1), which after the structure resembles the structure of vitamin A, have an action to improve the anti-inflammatory pain, dilation of blood vessels, which lowers blood pressure. These substances are administered to treat conjuctivitelor, keratitelor and improving blood hypertonic. The effect occurs in concentrations below 1%.
Since ants can extract iridomicina, which has a bactericidal effect in the case of cholera disease, tuberculosis. It is safe for human body.
Sildkneht Pofesorul University of the German city of Heidelberg, using contemporary methods for analyzing chemical structures metatoracale glands of ants (leaf cutting) outside of formic acid and beta fenilcitrici acids found yet – indolilcitric. With mass spectrometry were determined structures.
Beta acids were found – hidrocsinocarbonic (mirmecocin), beta – and beta hidrocsichentancarbonic – hidroxipentacarbonic. These acids have an effect Herbicides (to stop the growth of plants) used ant mounds to keep clean without being covered with plants. Acid is a beta-indolilacetic mycelium growth stimulator of families of ants. These substances are still very little studied and are not applied in clinical practice.
On the American continent red ants migrate from south to north contain a toxin antibiotic effect. Effect on the destruction of fungi and bacteria such as streptococci and staphylococci. The red ants body toxins were detected very strong such as tris-2-methyl-6p undecilpiperidin called „solenapsin A” because it blocks the action of neurotoxic effects of acetilcholinei irritating.
Solenapsinn The histamine causes the cells. The mechanism of action clearly differs from that of the action of the substances and MCD 48/80 – peptide extracted from bee toxins. A similar substance in the body there are small ants in Africa, which is used by aboriginal populations to poison the tips of spears used for hunting wild animals.
In „Proceedings of Hawaiian Entomological Society”, 1982, No. 2 is published information about the detection of biologically active substances from some species of ants on the American continent, which causes hallucinations in humans.
Detection is a very curious phenomenon, which has been described by biologists on the behavior of birds (crow, starling, jay, blackbirds, parrots, turkeys), which sits on anthills of ants when they detect. Ants climbing the body of birds and at one point they spread their wings, eyes are riveted to a certain point and the phenomenon of saliva. After a while the ants birds shake and go. The connection between birds and ants are enigmatic families.
The importance of toxins extracted from ants is mentioned in the writings of Quint Serena still in the second century BC Samonic, which recommended the application massage with extracts from ants to relieve rheumatic pain.
Using giant ants is described by the Aborigines of New Guinea. After surgery complicated human body extracts applied giant ants, which accelerates tissue repair in a very short time.
Can be found in pharmacies medical preparations containing formic alcohol (14 grams of formic acid dissolved in 100 ml of 70% alcohol). Prepare infusions of alcohol and alcohol formic to be used for rheumatic pain stop.
Of particular interest in terms of pharmaceuticals is the cockroaches (orientalis leaf and leaf Germany). In Oriental medicine is used to produce these insects preparation stimulating sexual glands and diuretic preparations. Extracts of cockroaches stimulates bone repair after fractures.
In Russia known recipes extracts obtained from cockroach to elimenarea body fluids or liver cirrhosis patients. Iogan Shaber, a famous German researcher, in 1725, he published a recipe for treating varicose ulcers infected: 100 bugs, which is brewed with hot water. Keep in the dark for two weeks and then squeeze the juice obtained, settles and apply „per os” one tablespoon on an empty stomach in the morning. Wash the wound with the same infusion. In 2-3 weeks ulcers is completely closed.
In 1876 along with assistant professor Botchin Bogomolov experienced bugs to extract fluid extract (ascites) in liver cirrhosis cases. In most cases, ascites disappeared. The researchers reached the following conclusions:
– After use of cockroaches infusion increases the amount of urine;
– Shrink the amount of protein in urine;
– Patients are desumfla hands and belly;
– Decreased body weight;
– Preparation does not affect kidney function.
Of 68 cases of patients suffering from cirrhosis, 32 patients were treated definitively. This means 47%. It is a very good percentage. The mechanism of action is unknown.
In 1882 was recorded an invention, which consists of the following: 10 g of powder made from bugs (the taracani) mixed with 0.5 liters of alcohol and heat to 50 ° C, then infusion filter. Add ammonia to a concentration of 30%, diluted twice with distilled water, mixed with a salt of lead. The suspension is mixed with ashes obtained from burning a piece of coal. Mix 1:1 with sulfur oxide, then filtered to remove impurities, processed in a steam bath and brown crystals are obtained open blaticum called Acid (acid beetles). Biologically active substances in a dose of 0.1 g to 1 kg kills dogs and frogs for a few minutes. In concentrations of 0.08 to 0.06 g death occurs over 15-30 hours.
Lower doses do not cause death and no occurrence of complications. I. Cernasov – a nineteenth-century Russian scientist, studied extracts of cockroaches (leaf orientalis) and has drawn the following conclusions:
– Extracts strongly influences activity of the heart in humans and animals;
– Pulse increases with increasing concentration considerabill extracts;
– Reducing pulse depends on the concentration of blood in the body extracts ingested;
– High concentrations of leaf extracts orientalis acts on heart muscle function and may even stop the heart;
– Influences the activity of kidney extracts
Although evidence of effectiveness found extracts of cockroaches, so far not determined the structure of biologically active substances. There was no able to mass produce growth under controlled conditions of these beetles. They grow spontaneously in kitchens people, but special conditions are impossible to grow.
Appropriate to mention another important event on cockroaches research by a group of American researchers led by B. Sarer. If beetles are two glands with internal secretion remove, then the gut and salivary gland cancer. It was found that the cancer appears under the influence of nerves that conducts these glands. Thus, cockroaches body system has been shown important in the development of cancer.
From antiquity to the role of species of flies found in the treatment of purulent wounds. In 1743 I Brichell being in aboriginal populations in America has seen how some managed to treat baldness quack at people with a body powder made from flies. Flies larvae were used in China for treating purulent wounds but they were used since ancient times to stop acute infection after surgery complicated bones. Treat osteomyelitis, in some cases stop the progression of bone tuberculosis. Demonstrated bactericidal effect of extracts of flies larvae culture of microorganisms. Extracts of the larvae of flies showed a clear effect on streptococci, diphtheria bacillus stafiloccocilor and on. For this purpose have been used on these species of flies: Phorm queen Lucille seritaca, Calliphora eritrocephala (Fam. Muscidae), which is introduced into festering wounds every 3 days. Infections and wounds disappear due to close. It is assumed that an important role in this case it could play bacteriofagii (bacterial viruses) that infect bacteria. The effect was produced about six weeks and in some cases in 3-6 months. But these studies were not completed due to the effect guaranteed. They appeared very complicated problems that were not resolved, then there are a number of other remedies contemporary chemical synthesis with obvious effect.
At first bite larvae extracts are used mostly by surgeons to treat purulent infections. According to the American surgeon Lykingston, in 1932, 60% of patients were successfully treated infections occurred after surgery. In the case of tuberculosis treatment, the effect was minimal for only 5%.
It is believed that the mechanism of action of the larvae of flies is related to the action of proteolytic enzyme that inhibits the growth of microorganisms. The composition of the extracts are found enzymes such as urease, which acts on mocevinei, producing ammonia. It is assumed that maggots of flies extracts causes the formation of bicarbonate and carbonate wound ammonium, which stops the development of pathogenic microflora. This assumption is confirmed by the fact that the wound is producing an alkaline environment, which has an antimicrobial effect. After application in wound extracts appear as allantoinul elements, substances such as calcite and cysteine and glutamine.
Fly larvae extracts were tested in several hospitals for treatment of varicose ulcers, osteomelitelor, kiloizilor burns, gangrene and other diseases. He found an identity between flies and larvae extracts action allantoinei. Considering that physiological allantoina is inert, it is assumed that the mechanism of action would be determined by urea that occurs during metabolism.

Allantoina

The insect body there are many biologically active substances that are not yet studied. Should I mention a very interesting story that happened in the nineteenth century. An English researcher D. Levinghton well known for his research on the continent of Africa, discovered a biologically active substance – strafantina, which is often used in medical practice even today to treat heart disease. He accidentally discovered the substance. In his briefcase field carry spears and a few tips toothbrush. When he washing teeth with toothbrush that he felt was accelerated pulse. The cause was some toxic substances, which are used to process wild animals hunting spears. Thus he discovered the biological substance obtained from plants strafanta Liana. Later he studied other toxins used by Aborigines for processing African spears and found that extracts afidii larvae, known as the Aboriginal „nga” contain a toxin that has the ability to paralyze the animal’s nervous system. Toxin kills animals for several minutes depending on size of animal. meat of animals killed, however this way is edible. It removes only the tissue where it was stung spear.
Later, it was established that toxins are found only in insect larvae, these toxins are missing in adults. Usually used insect pupae, which is dry, then ground to obtain a powder that is mixed with an extract of acatia and other plant extracts preserved toxin activity for up to 12 months. With a spear to kill a giraffe processed 500 kg in a few tens of minutes. 1.5 to 2.8 mg of toxin administered adult kills a rabbit for 3 hours. The mechanism of action is identical with or pirogoldul fenilhidrozinul that damage red blood cells. This cotin spears toxic substance whose peaks are known as „spears calagorsc” and are used for hunting wild animals. Toxin injected animals lose coordination calogarsc spears of movement, are buildings, there is a state phenomenon whooping and heart failure. This toxin does not lose activity at high temperatures during the boiling for 30 minutes. Do not lose activity after processing with absolute alcohol. It is a polypeptide chain with molecular weight of 60000. It is one of the most powerful toxins. lethal dose is 25 grams .
¹ ¹ The concentration of 5×10 M / L causes erythrocyte hemolysis, which corresponds to 65 molecules in a single cell. The importance of this biologically active substances in pharmacology is not yet fully determined.
Recunoscutii ancient scientists Avicenna and bugs and fleas Dioscorid describe the use of furniture for treating malaria. To describe this following recipe: 7 bugs are caught, they are put in a glass of liquid, liquid drink in one gulp; patient lying 30 minutes. This treatment unhygienic, today is unimaginable, but after the ancient medicine men is better than death. Later it was found that the bugs field, with a flavor containing a biologically active substance, but toxic remains unstudied. According to researcher I.D. Chirsenblat toxic substance include some combination of aldehydes and Pora – tridecan. Biologically active substances have a toxic action on other insects, and dragon flies ihneumonidelor. If in a glass bowl put the field 20-30 bugs and insects from the family pot ihneomonidelor place, they die for 10-15 min.
Conformm of information of Oriental medicine man nun kiss of religiosity Mantis stimulates sexual activity in both men and women. Has a beneficial effect on kidney function. In field crickets oriental folk medicine used to treat bowel and liver function in case of hepatitis. In China and Japan locust extracts were used to eliminate moles and hemorrhoids.
From Russia’s information Direcher V lice were used to treat fever swamp, to clean placentas after birth and in cases where children are unable to retain urine at night. For this lice mixed in bread or candy so that patients do not see lice.
Have a beneficial effect on liver cirrhosis. Extracts from racovinele collected under rocks aquatic extraordinarily powerful diuretic effect. Can I remove fluid from the intestines, the liver accumulates during cirrhosis. We have strong diuretic effect and extracts of crickets that can be useful in treating scabies and hives. Have a beneficial effect in the case of hepatitis. Biologically active substances causes the appearance of cicadas culoratiei reddish skin.
There is information about fireflies use to relieve toothaches. A Polish recipe says that if you crush a few fireflies with fingers covered with rubber gloves and then put gloves on his face with tooth pain when the pain disappears within minutes. Biologically active substances can cause various diseases unwanted body’s why African Aborigines fear fireflies, considering them as toxic. V. Direcer describe in a paper that if fireflies dry powder then grind and swallow their wine or soup can treat bronchitis. Or convinced of this and many other quacks, who watched the effect of extracts of firefly. They also have side effects because they can cause vomiting and diarrhea in humans. In some cases these statements were used to treat pulmonary tuberculosis.
Of course it is hard to imagine now fireflies use to treat tuberculosis, when there are many other effective remedies, but they should be taken into consideration by pharmacists and chemists who could use this information.
Oriental medicine has been assigned an important place scolopedrei use, which showed a beneficial effect in treating affections  of spasmodic type, lymph infections arising from tuberculosis bacillus. Can I remove kidney stones.
Scolopendre extracts can be used as contraceptives. They can preantampina pregnancy in women. This phenomenon must be carefully studied. Scolopedre extracts can be used in creams to treat dermatitis and skin ulcers. The recipe includes the following ingredients: honey vinegar, gallium plant (iavanschii Russian).
Scolopedra chemical nature of extracts is not yet effectively studied. But it includes acetilholina, histamine, and other enzymes sulftonina. Scolopendre bites are dangerous especially for warm-blooded animals. After a mouse bites scolopendrei is building in for 7-8 minutes and stay motionless for several hours. In some cases mouse heart stops and causes death. Scolopendrei bites cause severe pain to humans. There is a strong inflammation and in some cases can lead to unconsciousness or death.
INSECT – A STRATEGY FOR OBTAINING SOURCE biologically active substances PHARMACOLOGY FOR CONTEMPORARY.

Although currently known 1.5 million species of insects (the greatest diversity of living beings) yet man does not use any insect species to its true value. Use only a few insect products such as honey, propolis, venom, royal jelly, silk worm thread. In recent years, there were several species of Noctuidae used to use genetically modified baculovirus can be obtained through which biologically active substances (BAS) such as interleukins, vaccines, some types of interferon and others. In this case insects are used as a substrate for the multiplication of viruses, but the most important insect species is the direct extraction of tissue SBA insects. Nobody so far has not exploited insects as a source for extraction of obtaining SBA.
The nutrition committee meeting held OON Rome (Italy) in 2008, stated that insects can be considered as one of the resources can be used in future 99care for Human Nutrition. It is a safe forecast, because the special growth of insects (Entomology technique) includes the production of substances needed to regulate certain vital processes of the body. Entomological products contain valuable compositions, which can activate some necessary functions of the human body function. In some cases nutritional products entomology can fill certain amino acids necessary for the activation or inhibition processes. For example, we found some compositions of certain species of insects, including large amounts of Mg, Ca and P. Based on these compositions have prepared some dishes that can treat osteoporosis that occurs due to lack of Ca assimilated into the human body (Patent no.) SBA to boost human memory (Patent no.). In the other SBA have developed more than 40 cosmetic preparations (patent no.). It should be understood that various species of insect body include a variety of SBA, which can regulate certain body functions.
Most insects change their morphology during their existence (egg, larva, pupa, adult) (Figure 1), and in this process have been a series of transformations of organic substances, enzymes participating in activities and mats. A generation of insects lasts from several days to several months or years. Chemical composition of SBA vary from development phase to another and from one species to another. The insect body accumulates an enormous amount of protein, which sometimes exceeds 70% of dry material (tabel.1). Every few hours the composition of protein amino acid change (Figure 1), that can be obtained large amounts of protein with different properties (Fig.). Electrophoretic analysis of proteins extracted from pupae of L. disappear, representative of the order Lepidoptera includes the following components:
– Total protein 52.04 mg / We;
– Proteins, which are dispersed in the 9 (nine) fractions (bands) with molecular weight of 79, 76, 60, 55, 48, 45, 40, 38.22 kDa
SBA tests taken from Lymantria dispar showed a strong antitumor action (see Table). These tests open up new possibilities for obtaining antitumor preparations, especially human glioblastomas type formations. Only at concentrations of 15 mg / ml, tumor cells were damaged within minutes. (Tab.).
In Lymantria dispar eggs I found a very rare amino acid – 3-methyl-histidine, which is found only in the early stages of development. In the second phase of development of this amino acid eggs disappear.
Proteins extracted from Leptinotarsa decembriata (beetles) have molecular weight of 43.4 mg / We. Unlike representatives representatives Lepidopterelor beetles (Leptinotarsa decembriata) includes more protein composition of protein fractions.
In this case representatives of beetles proteins were divided into 14 fractions with the following molecular weights: 79, 76, 71, 60, 57, 55, 48, 45, 40, 38, 25, 24, 22, 20 kDa (Fig.) . SBA taken in the last phase of development of larvae L decembriata (beetles) as those of anti-tumor properties L.dispar have. Most times the next predominant amino acids: glutamic acid, phenylalanine, lysine, asparagine, arginine, and others.
In extracts of larvae „C” (representing the order coleoptera following amino acids prevalent: glutamic acid, leucine, proline, asparagine, alanine (Tabel.2).
The amount of nitrogen in proteins differ between species of insects and quail eggs content that Aloe vera (Tabel.3).
After the total amount of ash, the first place is P-2 l. larvae disappear after atomization. In second place are L.dispar, P-1. It is very interesting that a component of insect pupae as there are large amounts of calcium, magnesium and phosphorus assimilated by the human body. These items can be obtained in large quantities of protective material composition of eggs L.dispar. Components „P” contain up to 684 mg of phosphorus (Tabel.4). These resurrse not well researched, but information about the presence of phosphorus in the composition is extremely important. Currently proteins extracted from insects”D”include large amounts of phenylalanine and glutamic acid, which are necessary for developing new dishes. One of the new preparations developed and patented by us are prepared to boost human memory (Patent no. Of 2005 N 00,786.1905)
Spectrophotometric analysis of proteins after extraction in 10% HCl solution, recorded a peak curve shows well located in the wavelength of 212 nm with an absorption of 2510. Albumin in distilled water extraction (10 mg atomized powder + 10 ml distilled water) causes a curve with two peaks well highlighted. The first peak is located at the wavelength 190 nm – 210 nm with an absorption of 2.70, and the second peak occurs in the wavelengths of 289.1 nm with an absorption of 1.223 (Fig. 3). Information obtained from spectral analysis of extracts from insects at different developmental stages (egg, larva, pupa and adult) are very interesting. The development stages of insects were investigated albumin and globulins, which behave identically egg stage except that globulins are present in smaller quantities. Register a single peak curve at a wavelength of 204.4 nm with an absorption of 0.921 for the case of globulin and albumin 2.0. The second peak is insignificant (Fig. 4). Albumin and globulin spectral fingerprint of hairy caterpillar larvae powder (L. disappear) differs significantly.
The proteins are present in much higher amounts. In the 210 nm wavelength, globulins to increase absorption of 2.0, and albumin in this area falls to 2.60. Then increase to 3.8 albumin and globulins decrease. In the wavelength 292.3 nm albumin had a higher concentration reaching a 2381 drawings (Fig.5). The pupa stage of middle age, in the wavelength of 200 nm decrease in concentration globulins and albumin increase (Fig.6). In the 210 nm, lower albumin and globulins to increase the absorption of 2.89. In the 234 nm wavelength, the absorption of albumin and globulins increased, after forming a downward curve. In the wavelength 291.1 nm in the composition of compounds „P”, both albumin absorption increases up to 3.5, and the globulin up to 1962 (Figure 7).
The composition of the adult (imago) in the wavelength of 210.9 nm, absorption of albumin and globulin increase obviously. Absorption reaches 2.5 albumin and globulin of 1.5, then decrease. Only in the 288.8 nm, the albumin curve shows a little longer until the absorption of 1257 (Fig.8). After removal of lipids and resume in saline lipoprotein complex, there is a curve with one peak at a wavelength of 203.2 nm with the absorption of 0.6582 (Figure 9).
Tissue lipids of insects play an essential role. Extracted lipids were studied in representatives of Lepidopterelor, beetles, and Aphidiilor Dipterelor. Unlike other living beings, lipids extracted from insects include unsaturated fatty acids, which are not specific to mammals, but are found in plants.
Spectral analysis of lipids extracted with different solvents have shown that there are several types of lipids. Lipid extraction with methanol (10 ml methanol + 10 mg atomized powder „L”) analyzed by spectrophotometer Cintra 5, records the very complicated curve, which starts in the 210 nm wavelength and finishes in the 325 nm absorption of 2415.
CV to extract lipids (5 mg powder + 10 ml ethyl acetate) is a curve with a peak area showed a 255 nm wavelength and ends with the 360 nm absorption of about 3.00. After extraction of lipids from the „C” with xylene (10 ml xylene + 10 mg atomized powder), there is a curve in the 280-311 nm with an absorption of 1.80 (Fig.12). Extracting protein from 2 mg lipoprotein complex „P” with cyclohexane, highlights the emergence of a fingerprint with a very complicated curve forming three peaks: one in the wavelength of 222 nm with the absorption of 2917, second in the 271.5 nm 1948 and the third absorption peak in the 308.3 nm with an absorption of 0933 (Fig.13).
A fingerprint is more complicated and complex after extraction from lipoprotein „P” with 10 ml n-hexane. Curve more peaks form, starting from the 220 nm absorption with 3.40 and ends at the wavelength of absorption 307.5 4.93 (Fig.14). Lipid extraction with methanol in the atomized powder 10mg kiss „D” show a single peak curve (Fig.15) in the 212.6 nm with an absorption of 1388. In most spectral fingerprint in the wavelength 200 nm is a small peak absorption of 0.5-0.8, indicating the presence of albumin (Fig. 10, 11, 12). Thus, the results can be clearly demonstrated that the insect tissues can be extracted a number of SBA, which can be used in different areas: dermatology, cosmetology may be used in different configurations eliminate unwanted human skin nevi, moles, melanoma , carcinomas, corns, mounts, cheloizii, which completely absorb without causing pain and without leaving undesirable traces on human skin (Patent Romania, Nr.00581, 2000). According to this patent have been issued 28 cosmetic (Tabel.2) and para ointments, which are popular worldwide. It is the first time were carried out surgical operations and biological replacing cauterizatorul scalp. These methods of transformation of a tissue, biological preparations directing opens a new era in human health around the world expected much. (Ciuhrii, M., 1999, 2000, 2002, 2003, 2004).
Another important direction is to strengthen immunity and elimination of viral infections, primarily viral hepatitis HIV / AIDS, herpes and others (Ciuhrii, M. 2004). Thus, insect body were found the SBA have immunomodulatory properties and to stop the multiplication of viruses. It is the first time we managed to obtain natural inhibitors of protein synthesis and nucleic acids. Over a generation of insects, which lasts from 4-5 days to several months, turning a complex of lipoproteins in keratin. Biologically active substances on the origin of obtaining inhibitors are antiviral preparations (patent Romania, Nr.00580 and Nr.00579, 2000).
Most living beings complete their development cycle cheratinizarea body. This process is most evident cheratinizare insect, keratin is more than 90% in adults. Egg and larvae stage, the active ingredient is the lipoprotein complex. At the stage of pupa, biologically active substances turns into a lipoprotein complex, which then turns into keratin and organic substances, represented by eggs and sperm. Here there are a number of very powerful enzyme that promotes synthesis of proteins and lipids on the one hand and on the other hand inhibitors. They stopped the synthesis of proteins and nucleic acids and favors the appearance of inert material – keratin. All biologically active substances that produce these changes can be extracted and used for transformation of certain tissues. So complex were obtained from prostate tumor type adenoma, uterine fibroids and hemorrhoids rectal absorption (Patent Romania 2003, No. 00 706).
Other lipoprotein complexes can be used in the absorption of emboli and thrombi cardiovascular (Patent No. 00706 Romania, 2003). Latest SBA extracted from species of insects, which have immunomodulatory action, allowing treatment of many autoimmune diseases such as psoriasis, lupus erythematosus, rheumatoid poliartritelor (Patent No. Romania. 00 556 2004). These diseases considered incurable until now, have the chance to be treated in future SBA extracted from insects at different stages of development. Complex were proteolipidici discover new properties to waive the immunity of organisms and to treat autoimmune diseases (Patent No. 00 556 Romania 2004). For about 10 years of intensive research SBA extracted from various species of insects were allowed to develop completely new technologies that allow routing of very complicated biological processes that result in increasing human longevity by 10-15 years. Thus, the insects will intervene in human life, not as harmful organisms, but the bodies will solve many of the most serious diseases of human being.
Research conducted by the Centre for Scientific Application „Insectfarm” demonstrate that tissues of different species of insects in certain phases of development phases containing active substances with these properties biolgic: cheratolitice, antibacterial, antifungal, antiviral, antiembolice, antitrombice, antitumor and improve memory. Lipoprotein complex can be extracted from insects with specific solvents. Based on these biologically active substances were obtained 24 and 2 cosmetic preparations antiviral para „Entoheptin” and „Imunheptin” to stop the liver infection, „Imupurin” to lift the immunity of the human body and „Adenoprosin” to remove the prostate adenoma.
Each time the conferences where information is asked as part of my idea of using insects in obtaining pharmaceutical preparations. Therefore I’ll start with this topic. The idea came after 30 years of scientific research in the field of virology and biotechnology CONTEMPORARY then. I made deep research that are specific only baculovirus insect. We published the first atlas of the world of baculovirus, appeared in Russian, then translated by the publishers’ press Oxian „in India. Unfortunately in Romanian information about these viruses do not exist, only a few articles published in professional journals. The baculovirus currently bloom became contemporary biotechnology because they have a specific structure. Virionii these viruses are not the final stage of development, these structures are included in supraviriocapside of specific proteins (Fig.), which protects viruses action unfavorable environment factors. Thus these viruses in nature is preserved for hundreds of years because of specific structure. Genome of these viruses is well studied (Fig.) and proved that these viruses have a very strong promoter and may enroll in the genome or foreign genes.
So far we managed to obtain recombinant baculovirus of which allow the production of biologically active substances supraviriocapsidelor instead. For example, instead of M10 protein gene responsible for the synthesis of specific proteins supracapsidelor, you can enter another gene responsible for production of human insulin. Thus, during replication in recombinant baculovirus insect body, or in cell cultures, instead supracapsidelor are synthesized insulin – another protein with other features specific to human insulin.
So far were obtained most of the recombinant baculovirus to obtain vaccines, interleukins, interferons. Currently this work is developing rapidly in some of the laboratories of the University of California (USA) and Tokyo (Japan). These findings are considered full bloom all sciences. Here is the construction of a living organism shape imposed by the man he desired to produce substances and which are then used in the production of pharmaceutical preparations with specific actions.
Otherwise, the study began to be studied baculovirus and insect – host baculovirus. Few are those who think of these processes, but the handling procedures of these structures is the foundation of molecular biology and modern biotechnology in particular. With the deciphering of the human genetic code and some animal species (Fig.) to conststat the kinship between man and monkey are more distant than that of sheep and pigs. So they may have other ideas. To obtain recombinant sheep and pigs of different organ transplant. I think that is a terrible error. To increase human longevity should not we focus so much on transplants. The main direction should be oriented to repair damaged organs function. This can be done using different enzymes that enable the transformation of tissues and their replacement by formation of the same origin. I think this is the most true. But how to solve this problem? New ideas are needed to obtain biologically active substances with new properties. Some of these substances were found in certain stages of development of insect species.
I will try to explain how it happened first obtaining SBA keratolytic effect. In the late nineties I was the resort of Saint-CHRISTOL Comparative Pathology – les-Ales in France, which was led by Constantin Vago member French Academy of Hungarian origin. At this resort had worked several times since 1977. Even now maintain friendly relations with all employees. Productibilitatea research in this resort was amazing for all the colleagues here. I worked at night, when all devices in laboratories were free and could be available to MRA. I am grateful to all colleagues for their support and encouragement.
One night I was working in the laboratory of genetic engineering to obtain a recombinant baculovirus of a baculovirus to change some properties. Manipulating some proteins of insects, at some point I realized that my fingers to completely exfoliated dead skin and there is good blood flow through vessels. Then I realized the effect of these proteins cheratolitic. So I started a brand new cycle of research which we have not told anyone until 1994. This direction was absolutely new for me a „hobby” more years. Returning home to Moldova where he holds the position of chief scientific officer, I thoroughly research but without them in the thematic plan of the institute. Nobody knew the research done by me though all I saw colleagues busy with something permanent. At first we applied the SBA to keratoses of the skin of horses, which are very common. They soften and be absorbed completely. I had a few warts on my body and moles. They were completely absorbed from these substances. Then I caught a lot of courage. I made several biochemical analysis of protein composition, we have built an ointment and I in Romania and then patented in several countries. Research has continued and then we found that proteins extracted from certain species sfingolipidele absorb skeleton of insects such as melanomas and skin tumors carcenoamelor (Fig). We observed that our preparations rapidly exfoliate dead skin cheratolitic effect on the face, removing wrinkles and rejuvenating skin even. A 85 year old woman, came to me to complain that he is ashamed to walk down the street because of wrinkles and multiple seborrheic warts. After 6 months of treatment for home, disappeared on her face many unwanted formations (Fig.). In Moldova after the collapse of the Soviet empire, even the situation remains difficult. Scientific research funding had become unbearable and I, after a major conflict with conucerea Academy of Sciences, I decided to leave Moldova. I received several requests to hire me. One of the opportunities came from the Du Pont company in the U.S., which wanted to develop a new viral preparation in combat NOCTUIDAE species because the owner was in May mutor production technologies viral preparations. HOEOST concern in Germany wanted to build a different preparation, but I’m also attracted more than Romania, where I was invited to contest the presidency and accepted by the Ministry of Labour. However great support from Romania’s leadership we have not received. The situation is worsened more and more research. I decided to embark on their own, I created a private company and started producing the first cheratolitice preparations. At first only two technicians and a scientific collaborator I started. Worked day and night. My collaborator Pompiliu proved a brave man who was not afraid to test the body propirul SBA extracted from insects. First to test these substances was me.
In all preparations we tested their body, then test them on experimental animals. This can testify for the first time and I thank God that I escaped with his life so far. But when I write these lines support a terrible experiment, a skin cancer appeared mucilagenos left coast. (Fig. I felt horrible pain, especially at night. They appeared swollen glands in the neck, armpit and engineering. But you have to experience the action of the tumors such as melanoma sfingolipide multiple confirmed at Institute of Oncology. I was convinced I will make removal tumor without surgery. In Fig. … you may be convinced about the evolution of tumor supported. At first there was a red stain on the body, which cause great pain and rapidly (Fig. ..), causing infernal pain. I felt like gather in the area and cause lymph lymph storage. To sleep, had to run around the bed to decrease the inflammation, then I could sleep a few hours. At that moment I remembered my mother’s grandfather, who died at 53 years because of swelling in exactly the same place as me. I asked my grandmother, who could not tell the diagnosis, but I have an inflammation anintesc as the body that cause pain until he died. Doctors then not have found the correct diagnosis and no effective treatment. grandfather died a few days without having to know the cause. I understand the cause and now I have found the environment for treatment. First I found SBA vasodilators, I made an ointment and I applied the inflamed area. At the same time we lyophilized protein powder of Mamestra brassicae pupae, which turned into a protein powder insect pupae, which have encapsulated it and I used a „per os” of times by day. The area of inflammation was treated with ointment on the same powder Mamestra brassicae. Three times a day. We found that in three days the inflammation disappeared. Then we determined that the pupae are included protein synthesis inhibitors, which have the property The tumor to stop ..
A few days ago I had the opportunity of enormous joy, determined by treating the two types of carcenoame head. The first case, the patient who has Rosiorilor VIRGIL 65, with a carcenom head, left side, width 12-15 cm, which was sent home from the Institute of Oncology, considered as no chance of healing. To my surprise after two weeks of treatment decreased tumor sfingolipide some obvious (Fig). And the village Catelol OLGA Gaza, near Bucharest, which had a cranial tumor, damaging the skull bone, became prominent. After being discharged with no chance of healing, along with her husband and four children – all boys from five to twelve years, were presented to our clinic to discuss the situation. He sent the boys to a problem concerned with childcare’s. It breaks my heart to see them suffering, because people were aware of the tumor carried ruthless. I promised him children as their mother will not die until they grow up and marry. I prescribed a free treatment and I sent home. After two months of treatment with a type of protein encapsulated with anti-tumor effect, the woman came to me with carcenomul absorbed (Fig.). Miracle has occurred to two people the same day. These three cases where patients is one of the undersigned, will begin a revolution in stopping the development of many human tumor, because cancer patients filled to the brim hospitals worldwide.
The same protein can absorb kiloizii – cutaneous formations appeared under the influence of various traumas. Formations have a configuration often unpleasant and annoying.
(Fig. …..) In these formations cheratolitic apply ointments and the greenhouse for 3-4 months are resorbed. Kiloizii are dangerous to children who are growing because they have a hard consistency and does not allow the skin. I had as a child patient suffering from kiloizi appeared after burning, which after 12 months of treatment with ointments our completely healed (Fig.). The region became kiloizilor skin elastic and expanded without surgery. The child is now 14. It is healthy and very lively (Fig.).
We had encouraging results in eliminating moles, moles, varicose veins seborrheic carcenoamelor melonoamelor and skin (Fig.)
Later I found that the same protein that can absorb and absorb skin tumors of the liver tumor, occurring most often in cases of viral hepatitis (Fig). Liver scans are presented before and after treatment.
Good results were obtained in absorption prostate adenoma – in preparation ADENOMO-LIZ. The preparation was built in the form of suppositories, which is given after each stool, then stay in position when the tank is above compared to the head, so after the suppository is lichifiaza flow in the intestines. As inediat suppository is administered after eliminating feces penetrate deep inside, acting directly on proststa adenoma. After 30 days of treatment, obviously shrinks enlarged prostate. Patient urinate more easily and painlessly. If uterine fibroid, the eggs are inserted into the vagina and sits on the back above the basin compared to the head. Changes are seen to perform the same ultrasound device and executed by the same physician.
One of the greatest scientific achievements of the center is applied INSECT FARM detect proteins with antiviral effect. The first patient treated for a viral infection caused by herpes zoster virus was the undersigned. Just when I was extracted during antiviral protein with efest God sent me me a terrible infection caused by herpes virus. Who was infected with the herpes virus – Shingles know what this condition and what can cause terrible pain. I applied directly to infected area active substance and confess with the utmost sincerity that three days after the infection has not left. We had a lot of solved cases (patients healed list is shown).
But I can not be present unusual circumstances. A former Roman citizen of Armenian nationality for 85 years, who had left the U.S. with about 30 years ago, was infected with the virus Zoster zone in America treated him with all that was new, but the virus did not yield . A relative of his was to us. Story for years that the patient could not sleep lying down and screaming everyone unbearable pain. After taking our ointment „zoster-Liz-area”, the infection is gone in a few days. They published articles in several newspapers thanks in Los Angeles, where I was then better known than in Romania. In Fig. You can see a woman infected with the virus Zoster zone before and after 5 days of treatment.
My specialty is basic virology, have always been concerned about this very important direction, because of all infections that attack man, 75% are caused by viruses. Until now man is powerless against viral infections. We have developed vaccines and interferons, which are prepared prophylactic: they can not stop viral infections. Being aware of this and because my life only we have produced biological preparations to destroy, I knew very well that it is not so easy, or to obtain a total mortality. As viruses are programmed, they can not multiply outside of living cells. And viruses are highly specialized, they infect only one and the same tissue or even one and the same cells. If in specific cells of viruses is changing a component of proteins, the virus no longer multiply. This information I had from their own experiences, contributed to the development of new tehlologii to stop viral infections.
So I began to realize methods for obtaining and using liver preparations to stop infections – most common in the early third millennium. For this he had to extract certain proteins in certain species of insects at certain stages of their development.
To be understood correctly you have to explain that insects, unlike other living organisms have a specific metabolism. Insect body at different stages of development completely transforms both morphologically and chemically (Fig.). The life cycle of any insect egg is the beginning of the larva develops. In an insect larva accumulate more fat. Larva stage usually lasts 15-29 days. Larva turn into pupa, a completely closed formation, sterile, in which there are five types of proteins with different molecular weights. These proteins can be separated easily by centrifugation in sucrose gradients different. At the end of the pupa stage all proteins turn into other types of proteins such as keratoses (adults), which is 90% dry matter and eggs or spermatoizi: pure protein in the development cycle is repeated. Nature has prepared us only active biologc substances. But you only need to know where to look. Thus SBA were identified that are able to stop viruses from multiplying stage in capsid assembly nucleic acids. We discovered this phenomenon, shaping the cell culture after infection with two different viruses that contained different nucleic acids (Ciuhrii M, N 12 Compendium 1981, Paris). Assembly process is not performed. Because blocking this process is the presence of foreign proteins. A foreign protein extracted from insects and which, introduced into human blood, blood and blood into the liver, can completely block virus multiplication liver. The mechanism of action requires a more detailed study. Thus we have included another principle to stop viral infections, which unlike known or later INTRON interferon preparation, PEGNINTON and others give very strong reactions and I can not support many patients. Our preparation „HEPATITO-LIZ”, unlike other classical interferons are administered orally and causes no adverse reaction whatsoever to put the patient in difficulty. Instead, after several days of use of the preparation „HEPATITO-LIZ” patients feel an energy during the day and deeper sleep at night. There are two types of capsules is administered. Energizing one morning, one hour before breakfast, swallowed with a glass of tea DE3 cherry stems, which drink the water in one gulp. After taking the capsule in the morning, it is imperative that the patient lie down on the right side for an hour. Manages evening capsule 2-3 hours after dinner, when the stomach is empty, then lies on the right. After administration, the capsules dissolve in about 15-20 minutes, just when you reach the duodenum region where the content is absorbed in the largest blood and is transported to all organs, including liver.
Experimental data of our clinic have shown that these proteins significantly raise the platelet count, scat amount of cholesterol in the body regulates the amount of immunoglobulin G-globulin especially. Decrease to normal transaminases. Viremia (viral load) decreases. Treatment cycle is three months, then repeat the tests for the functional state of liver (transaminases, electrophoresis, complete blood count, ultrasound, viremia). Depending on the patient studies are recommended if treatment is continued or composition changes.
If it is considered that hepatitis were treated with the disappearance of viruses from the body, then we can say that viruses are HBs repid eliminate viruses than HCV.
Another preparation – „immuno-MAX” – has been tested on patients infected with HIV (AIDS). Use of the preparation technique is the same as the „HEPATITO – LIZ”. It is administered by two capsules per day, only evidently different protein composition. Preparation due to the effect parameters are: CD4, CD8, viremia, blood counts, patient’s body weight and height. From our clinical data we have many cases when after using the drug immuno-MAX viremia decreased to undetectable levels, CD4 and CD8 reached normal. All patients increased in weight after treatment, and children grew in height. Preparation „HERPES – LIZ” lizarii for herpes infections, Simplex Simplex 1 and 2, which basically attack the mucous tissues around the mouth and genitalia, including the buttocks. Herpes infections can cause many serious complications and are highly prevalent especially in adolescents. The drug is in the form of ointment, and the active ingredient is a protein with antiviral effect. The ointment is applied to the infected areas and gently massage for several minutes until it is completely absorbed by the tissue. Infection disappears for 7-8 days. The procedure is repeated two or three times until the ringworm is cured.
XXI century will be the century in which research in the field of viral infections will be thorough and will get new information about these structures. It is interesting that so far the structure has been well studied viruses, but it remains to be learned about the relationship between nucleic acids and proteins for viral functions. This issue may be a separate paper, which I hope to write in the future and in Romanian.
SBA extracted from certain species of insects have properties to eliminate bacterial infections, especially those caused by staphylococci and streptococci. For this preparation we have developed „bacteriological-LIZ”. Proteins induce drug resistance cells, and infections are more easily removed. A clear success we demonstrated the elimination of acute acne caused by Staphylococcus aureus and Staphylococcus albus (Fig).
Antibacterial proteins are effective against bacteria that cause sinusitis and bronchitis and so common in the population. Protein preparation are embedded in a special lipogel. Apply at night before bed. Apply in ears with two cotton ball, which is first in lipogel inbiba then inserted into the ear where the leaves all night. Apply in nasal passages, basting the nose with a cotton swab that is placed. With another buffer brush your gums, mouth and massage the language. When the gel is thoroughly mixed with saliva to swallow small sips. It is important that after these procedures to sleep, because sleep is slower salivary glands and then the preparation works for a while longer. First morning gargle is made with a special solution prepared according to the following composition: 200 ml of warm water, add a small teaspoon soda, one of salt and 3-4 drops of tincture of iodine 2 % (solution used by me in the lab for dismantling viruses). Gargle is 3-4 minutes. It is repeated after every meal so that the mouth should not remain any food residue. While the 13 to 14 days to completely clean all sinuses and bronchi. Coughing stopped in a few days. Respiratory structure was clean. After this treatment most patients have returned and thanked me.
Preparation „bacteriological-LIZ” miraculous effects and the pressure sores and paradontozelor considered very difficult to treat. In cases of bedsores preparation applied twice daily in a thin layer covering the entire lesion when changing the dressing. Before applying the preparation to clean the wound thoroughly with rivanol solution plus 59 mg of rimfapicina (antibiotic inhibition of RNA). The wound gauze but not directly put a strip of cellophane disinfected, which prevents sticking wound bandages because destroying crust that forms under the new tissue cells. In the case of periodontitis, before applying the gel with protein antibacterial mouth rinse with the solution described above (200 ml hot water plus a teaspoon of baking soda, one of superfine white salt and 3-4 drops of tincture iodine). After this treatment the infection disappears, and the gums return to normal.

I found the antifungal protein we used for drug development – „MICO-LIZ”, which is effective in fighting oral candidiasis, vaginal, nail and skin fungal infections. To eliminate oral candidiasis is used the same procedure as for sinusitis, only lipogelului composition differs. For vaginal mycosis using special suppositories, including antifungal proteins. They apply every night before bed. After inclusion suppository (eggs) into the vagina is required to sit the patient supine so that the lower rail to be positioned at 25 -30 degrees above the upper rail for uniform dispersion of the protein. Once every three days is necessary to make vaginal douche with calendula tea until the water is perfectly clean eliminated. While approximately 30 days will be removed permanently mycosis without complications.
In case of skin mycosis, delete the infected area at first with sodium bicarbonate solution, salt and iodine tincture then apply the ointment „MICO-LIZ”. Usually the procedure is applied in the evening before bedtime. In more serious cases applies morning.
A new direction of research and application are preparations for cardiovascular prophylaxis. First the marketing standards of veins and thrombus emboli in the arteries. In case applies ointments veins at the base which sits a protein with properties of the thrombus and spazmelor marketing standards. Affected feet with ointment massage „” for cattle ankles „and” cattle legs „since toes, soles, ankles, especially in the area where the foot is brown. Massage is done from the bottom up, to the knees so that the ointment to be completely absorbed by the skin. After 14-28 days of treatment the skin vessels dilated retire and fade to normal skin color. After treatment normalized blood flow. As the temperature returns to normal feet.
In case applies ointments and capsules arteritis protein. The drug used is „ointment for cattle legs”. Adminisreaza administer and capsules are 2-3 hours after eating the evening on an empty stomach and do massage with ointment morning. Foot massage is starting up to genunci laglezne. If the foot is blackened, massages are easy on the fingers affected in all directions. After treatment for 30-40 days in normal circulation returns affected region. Thus, if timely treatment is applied, the legs can be saved from amputation.
Preparations for the treatment of varicose veins trpmboflebitelor and were tested on their body. In 2003 I stayed in hospital for 4 weeks Coltea. I proposed to do surgery „bypass” that could improve the infernal pain. Doctors at the hospital emergency cardiology predicted „death” I was saved only (Patent N) and preparations we recorded the Ministry of Health (N). It shows real images (Fig.) before and after treatment. At one point after an effort made in Belgium at the University of Louvain, Belgium.
In the future we will produce infusion prepared in November, which will allow for prophylaxis of the entire blood system. Will be possible to eliminate inside the blood vessel spasms and eliminate operatiunelor surgery to remove clogged vessels, because after the removal of clogged vessels appear more. In our case we had no surprise that tromozele embolism or to recur.
Preparation „solid cream immuno-MAX” has the ability to absorb and stop bleeding hemorrhoids for 15-30 days while avoiding surgery, which often causes complications in the large intestine or rectum. The preparation is applied after each stool. Wash the anus area with warm water then wipe with a towel. In the case of external hemorrhoids, the ointment is applied directly to hemorrhoids. If internal hemorrhoids and there are two possibilities: special enema or suppository. If enemas, preparing a solution consisting of 20 ml hot water and a gram (a pinch) of ointment. Mix until a uniform suspension, which then is used for enema. The patient is placed supine on the bed. The suspension absorbs a pump which is then inserted rectally. After entering the solution, the patient returns prone by train to 30 degrees lower than higher education and wait for 30 minutes. Such suspension penetrates deep to the intestine, rectum and absorbs hemorrhoidal formations. A second possibility is the special suppositories (solid cream „” Immuno-max „and anti-fracture effect antihemoragic. The patient is placed supine on the bed. Rectal suppository is inserted, the patient returns to prone, with lower rail 30 degrees higher than the upper and wait for 30 minutes. suppository melts at body temperature and smooths in all the anus, hemorrhoids absorbs without causing pain and without leaving undesirable traces.
Other dishes prepared by our center are applied antirheumatic „REUMATO-LIZ”, „SPONDI-LIZ”, „Ciocoi-LIZ”. If rheumatic pain (spondylosis, spondilitelor, astiofitelor), these ointments are massages with the painful areas for 10-15 minutes. Pain disappear after a few massages but only because resolves after 4-5 cycles of 14 procedures massages. The mechanism of action continues to be studied, but the effect is guaranteed.
Some of the most serious diseases in women of 45-55 years are uterine fibroids, ovarian cysts and breast lumps. For such problems we have prepared „FIBROMO-LIZ”. For uterine fibroids were developed eggs (suppositories) species, which is applied in the vagina before bed, then it is necessary to stay with high basin 25-30 degrees from the body for 20-30 minutes. Once every three days are vaginal douche.
All our research in the field of cosmetology started and continue this research, because we found proteins with keratolytic effect that can peel off layers of dead cells and replace them with new ones and thus rejuvenating tissue. We have many examples of skin rejuvenation especially in women (Figure). The problem has become acute skin rejuvenation in the former Soviet Union, especially after the Chernobyl nuclear disaster and many other unreported incidents so far. Who attended the Kiev region, Gomel in Belarus can not be seen as the locals do not look old before our time. Most people aged up to 40 years appear to be 60-70 years. Our creams based on biological proteins extracted from insects are useful not only to rejuvenate the skin, but also to give greater elasticity, so you do not allow penetration of microorganisms causing infection.
Preparation „KERATO-LIZ” horny skin peel has the property, especially in the woof, thickening around nails and more. I am convinced that with the increased productivity of these preparations, we can solve many human diseases.
Another problem is baldness. Especially in men, which after 50 years of age, approximately 70% remain on the surface almost hairless head. Lately, we have developed a shampoo, a lotion and a hair conditioner. (Patents N). Hair lotions containing substances and activating hair growth shampoo and conditioner contain substances that cause regeneration and strengthening hair. You can convince subsemnarului example, that using an ointment with the active substances for absorbing a lipoma on his right hand, I noticed that the hair on hand increased significantly compared with the other hand (Fig.).
Of all known chemical compounds, proteins are the most complex and also most characteristic of living matter. They are present in all living cells, are compounds that are essential as nucleoproteins cell division process and the enzymes and hormones control many chemical reactions in cell metabolism. As the sole constituent of viruses, nucleoproteins are synonymous.

TYPE EXAMPLES
1.Proteine single enzymes, antibodies, hormones, hemoglobin
2. Associated with the protein myosin, actin, tropomyosin, troponin
3. Associated with membrane glycoproteins, lipoproteins, emphore
4. Structural protein collagen, keratinele, elastinele, fibroine
5. Nucleic acids associated with ribosomal proteins, histones, nonhistone.

II. Structural proteins

Grouped as structural proteins or insoluble fibrous proteins and globular proteins have some structural role, but no enzymatic activity.
A contractile protein

One of the characteristics of animals is the mobility that is associated with this contractile protein. In insects, as in other organisms differentiated contractile proteins are present in this one particular tissue and muscle. Major protein components of actin and myosin are muscles, but other components were described protein involved in muscle contraction.
1. Physicochemical properties
Myosin molecular weight is between 102 and 4.58 * 4.58 * 105. And distortion reduction in guanine hydrochloride disocieaza in myosin heavy and light chains in. The Heavy 105 to 2.12 * 1.89 * 105 depending on the method used. Light chains can be 4-7 * 104 or 9-15% of the total mass. Light chains may be 2.3. Proteolytic digestion gives two fragments of myosin light meromiozina (LMM) and heavy meromiozina (HMM). LMM is fibrous and globular HMM is. HMM is also an enzyme (ATPase) that ATP hydrolysis catalizezza, stimulated by Ca2 + and inhibited by Mg2 + very sensitive to pH. Myosin aggregation leads to the formation of a uniform complex and long and 6000-7000 A in diameter and weight of 100-200 A and 6.3 * 106Da ..
Actin exists in two forms, G-actin monomer globular polymer fibers and high molecular weight E-actin.
G-actin in mammals is 4.3 to 4.7 * 104. G-actin contains 374 residues, corresponding to a GM 4.1 to 4.2 * 105 Yes. G-actin contains one molecule of ATP and Ca2 + (or Mg2 +). If exposed to 0.1 M Mg2 + salts are very rapidly polymerizes to F-actin, the ATP is hydrolyzed to ADP process + Pi, is truly an ATP-ozica activity. By ultrasonic treatment with ATP or the reaction is reversible:
(1) G-actin-ADP + ATP → G-actin-ATP + ADP
F-actin structure seems to correspond to a double-helix arrangement of molecules with 13-15 G-actin subunit helix per tour. Dissociation rate is low when ATP is bound Ca2 + and even less when it is bound Mg2 +.
(2) Ca2 +-G-actin-Ca2 + + ATP ↔ G-actin-ATP
(3) G-actin-ATP G-actin + ATP ↔
Actomozina is complex actin and myosin molecular. Is obtained by extraction from muscles first with water to remove enzymes glycol and then with 0.6 M KCl
Another muscle protein is tropomyosin or paramiozina. It is a coiled helix with HM 2.2 * 105 and length approx. 130-140nm.
Tropomyosin B is a double helix coiled with GM 6.3-6.8 * 104nm length.
Tropolina is not a unitary protein can be separated into three components:
– TropolinA Q: GM = 23 000
– Tropolina T: with high affinity for tropomyosin, GM = 37 000
– Tropolina C: with GM = 18 000
The three tropoline seem to be in ratio of 1: 1: 1.

2. Contractile proteins in insects
Insect muscles corresponding to striated muscle of vertebrates. Contractile proteins are in many ways similar to those of vertebrates. Sedimentation coefficient of 2.53 S tropomyosin in the adult and larva of 2.62 S, GM = 64000-84000 for tropomyosin in the larva.
Apparently tropomyosin of the larva is in a more polymer than that of adults. In amino acid composition of larvae and adult tropomyosin is almost identical except for Pro, His and Phe. In amino acid composition resembles that of insects paramiozinei molluscs and annelids, except that the report Glu / Asp is higher. Actomiozina of insect myosin and ATP-phase is active.
(4) ATP + H2O → ADP + Pi
ATP-phase presents an activity because this ADNilat apirazica kinase.
(5) ATP → AMP + PPI
Isolation of myosin, actin and atrial muscle tropolinei of the insect proteins revealed some differences between insects and vertebrates those muscles. The two types of myosin are approximately the same GM but different light subunit composition. Tropomyosin activation seems to be the biggest difference between vertebrate and insect muscles.

B. Fibroms

Fibroms are protein substances excreted by different species of arthropods in special glands and deposited there in solution before extrusion to form filaments. Silk plays an important role in the lives of many insects: not mentioned the importance of silk spiders alive.

1. Structure
Fibroina silk is very diverse in their primary and secondary structure. Were detected by β-fibroina parallel, conformation corresponding types: cross-β, α-helix and even the type of collagen. It speaks of silk from larvae of Hymenoptera (bees, wasps, ants) are α-helix type.
Fibroinele of Saturniidae have a high content of alanine and a lower Gly content and was very much studied Ser. silk from B. die. It consists of double filament fibroina dressed in a globular protein sericinia. B. Fibroina of mills is a protein synthesized and secreted cocoon from the posterior end of worm silk glands. Satuniidae Fibroinele the Bombycidae and have very high content Ala and Gly. B.mori silk filaments have a diameter of 40 A ˚ consisting of two rods about 20 A ˚ in diameter. Fibroinele can be divided into five groups.
One of the problems in the study of molecular structure of silk fibroinei is the difficulty of solubilised fibroina.
Classical procedures solubilization by boiling in alkaline environment degrades fibroina molecule. Newer fibroina was extracted directly from the silk gland and led GM = 3.6 * 105. By treatment with 6-8M guanine hydrochloride or urea were obtained two fractions with a sedimentation coefficient of 4.6 S and another with corresponding sericinei 10S sedimentation coefficient corresponding fibroinei, that GM = 3.65 * 105.
Fibroina forming cocoons in different species of insects have the same function: protection from predators, extreme temperatures, microbiological attack and the general rigors of the climate.

2. Biosynthesis

B. die silk protein contains 45% of Gly residues alternating especially Ala and Ser residues, so the mRNA will have at least 57% of the codons for Gly. Structural gene consists of DNA double helix fibroina of 11.12 106 Yes.
A related issue is the mechanism used fibroina the cocoon of the silk worm and other species to come out of cocoon. For this purpose, specialoizate cells grow to produce a large amount of a proteolytic enzyme coconaza.
Time out, the enzyme that initially takes the form of crystal or semicristal redissolve at pH 8.3 optimn them in a solution secreted by another gland. It is placed in contact with the cocoon and digest sericina linking silk fibers together. Cocoon structure is stable and bug finds its way out. Differentiation of these cells is under hormonal control of juvenile hormone ecdisonei. Shows a remarkable chemical similarity Coconaza with trypsin and other proteases of mammalian serine with GM approximately equal to 24 000. In amino acid composition is very similar to that of bovine trypsin. Coconaza protolitica enzyme is different from moulting fluid, so were messengers specific arenas.

A. The proteins in skin

Structural integrity of a tissue is maintained by the concerted influence of physical forces and covalent bonds between polypeptides and polysaccharides. Like the skin of vertebrates, insects exoskeleton is stable bonds between chains of specific amino acid residues between the protein and fibrous carbohydrates. Cuticle structural proteins and enzymes participate in the setting („tanning”) known as sclerotizare. Involves hydroxylation of tyrosine to dihidroxifenilalanina Sclerotizarea (dopa) to dopamine is decarboxilata dopa-decarboxlaza. Dopamine is the N-N-acetyl acetildopamina. Under the action fenolazei, N-acetildopamina is oxidized to a ortochinona reacts with amino group of cuticle proteins, then oxidized to a respunzatoare a dichinona difenoloxidaza.
Unlike fibroine, cuticulare proteins have amino acids with side chains. Amino acids in proteins cuticulare are: Asp, Glu, Ser, Gly, THR, Ala, Tyr, Val, Phe, Leu, Ileu, Pro, Hyp, Lys, Cys and Met TRP and probably in small quantities.
A special type of insoluble protein is a protein called cuticulara resilina. It is possible that some proteins cuticulare be combined with putty and glycoproteins.
Collagen
Collagen is the most important insoluble fiber in connective tissue. Its physiological function is to act as an inert material that transmits inextensibil exercised muscle tension, such as tendon or bone. Collagen is extremely inert to proteolytic enzymes, especially in Native and is converted into gelatin in boiling water or alkali long. Collagen occurs in many classes of animals, including insects.
Collagen has an unusual amino acid composition: about a third of Gly and another third Pro or Hyp. Tropocolagen collagen molecule (soluble collagen or extracted) consists of three chains that are identical or not identical depending on the tissue and species. Chains are known as α1, α2 and α 3. Different types of collagen are known as I, II and III. Thus were described collagens whose molecules consist of:
– Three apparently identical chains: ex. [(Α1) I] 3, [(α1) II] 3, [(α1)] 3
– 3 different chains: ex. (Α1), (α2), (α) – 2 identical and one different: eg. [(Α1) I] 2α2
Different types of chains differ in some amino acid content, but are probably similar lengths and GM.
Insect bodies are wrapped and in some cases separated by layers of connective tissue that separates the haemolymph parenhibul.
Chromosomal protein A.

Chromosomal proteins especially histoamele were included in the structural proteins. Yet we now know that they play a role in regulating genes.
1. Histone
Basic histone proteins are associated with DNA. Are structural proteins, but also act as repressor activity of rocks. Are highly conserved histone proteins, have very small differences in amino acid sequences. They are classified according to chemical characteristics.
METABOLISM chitin in insects: structure, function and CHITINSINTAZELOR ADJUSTMENT AND CHITINAZELOR
Chitin is one of the most important biopolymers in nature. It is mainly produced by fungi, arthropods and nematodes. Functions as insect cuticle material support for the epidermis and trachea as peritrofice arrays, lined intestinal epithelium. Insect growth and morphogenesis are strictly dependent on the ability to remodel chitin-containing structures.
For this purpose, insects repeatedly produce chitinolitice chitinsintaze and enzymes in various tissues. Coordination of chitin synthesis and its degradation requires strict control of the participating enzymes during development. In this new work summarize recent progress in understanding the synthesis of chitin and its degradation in insects.
Insect cuticle form an exoskeleton that present only a limited ability to allow growth of the body because it is a structure more or less rigid, because this chitin and sclero-proteins. To allow growth and development of insect cuticle have to replace the old with the new one by shedding (ecdysis). Shedding is initiated by the displaced persons, which separates the old cuticle epidermal cells by liquid shedding. Chitinaze liquid which digest protein content and main constituents endocuticulei old and recycled to be absorbed to form cuticle us. Insects repudiate their old shell, which now is called exuvie. Shedding and hormones involved, such hormone hatching.
Chitin is a polymer of N-acetyl-β-D-glucosamine. MRI and gravimetric analysis to see that chitin is up to 40% of dry weight depending on species and exuviei vary considerably with different types of cuticle even the same body. Chitin is associated with proteins that mainly determine the mechanical properties of cuticle. The Locust migration were observed by elecroforeza 2 – D more than 100 different proteins. One of the most well understood resilina protein, a protein-rich and proline glicocol, which gives a great cuticle elasticity of joint regions. Insects contain chitin in the gut lining peritrofice matrices. Two types: Type 1 is the entire digestive route, Type 2 only in the card (between the esophagus and intestine above).
Peritrofice arrays are usually 3-13% chitin. The sextant Manduco peritrofice 40% matrices also contain a mixture of proteins, glycoproteins and proteoglycans.

Chitin STRUCTURE:

It is the most common amino polizazaharid in nature. It is estimated that annually produce nearly as much as cellulose. Especially in the exoskeleton of arthropods, cell walls of fungi, nematodes shell eggs. Chitin oligomers derivatives have been implicated as factors in communication between plants legumionoase morfogenici and Rhizobium and even in vertebrates where they can be important in the early stages of embryogenesis.
Chitin is composed of residues of N – acetyl – glucosamine linked by ties β – (1-4) – glucosidic. Hydrolysis with chitinaza give glucosamine and N – acetyl – glucosamine. However MRI cuticle of the tobacco horn worm showed that glucosamine is not present. Tends to form chitin microfibers (also called rods or crystallites) of about 3 mm in diamteru stabilized by hydrogen bonds between amino and carbonyl. Microfibres peritrofice matrix may even exceed 0.5 μ in length and are frequently associated in bundles containing parallel groups of 10 or more microfiber. X-ray diffraction suggested that chitin is a substance that occurs in three polymorphic crystalline modifications, called chitin α -, β – and μ -. They differ mainly in degree of hydration, the unit size and number of chitin chains. In all chains α form shows a antiparallel orientation, in the form β chains are arranged parallel, in the form μ 2 sets of parallel chains alternate with chains antiparalele single. Transient non-crystalline state were found in mushrooms. All three structures are found in crystalline forms of insect chitinase. Α is the predominant form in cuticle chitin, and β forms are commonly found in cocoons nμ. Peritrofice arrays consist of α and β usually – chitin. Sometimes the presence of β – chitin in cocoons can be explained by the fact that some form of cocoons peritrofice matrices, eg the Australian spider beetle Ptinus tectus of a beetle specialist.
Antiparallel arrangement of chitin molecules in the form of α allows the fibers of chitin close packing consisting of about 20 chains of chitin stabilized by a large number of hydrogen bonds intra and inter molecular. This arrangement contributes significantly to the physical properties – eg chemical cuticle. strength and stability. In contrast, in the forms β and μ packing strength and number of hydrogen bonds between chains are reduced, as a large number of water connections H2. The high degree of hydration and strength leading to reduced packing chitinase structures more flexible and soft, or cocoons peritrofice matrix. Differences in the arrangement of the fibers between the cuticle and chitin matrices peritrofice help understand their function. Cuticle is secreted in the form of thin layers of epidermal cells microvilii beekeeping. Of chitin microfibres are included in the matrix protein and stabilizes the reinforced concrete. Peritrofice microfibres are placed in the matrix normally in a network of structures included in an amorphous matrix and only in few cases were found highly ordered configurations.
TRAINING chitin
Trehalose (trehalose )____ β – D – glucose (hexotinaza) ___
Glucose – 6 – phosphate (glucose – 6 – phosphate isomerase)
Fructose – 6 – phosphate (glutamine: fructose – 6 – phosphate aminotransferase)
Glucosamine – 6 – phosphate (Glucosamine – 6 – phosphate N – acetyltransferase)
N – acetilglucozamin – 6 – phosphate (fosfoacetilglucozamin move)
N – acetilglucozamin – 1 – phosphate (VDP – N – acetilglucozamin pirofosforilaza
UDP – N – acetilglucozamina (chitinsintaza) chitin

Fig.1. Chitin biosynthesis in insects. The path starts with trehalose, the main sugar in many insect haemolymph.

Chitinsintaza is UDP – N – acetyl – D – Glucosamine: chitin, or
4 – β – N – acetilglucozamiltransferaza (EC2.4.1.16), an enzyme found in any organism that synthesize chitin from UDP – N – acetilglucozamina (UDP – GlcNac). It involves the formation of a lipid intermediate to form dolichildifosfo – N – acetilglucozamina. Chitinsintazele are dependent on the presence of ions Mg2 + or Mn2 +.
There are two models for the activity in vesicles Golgi chitinsintazei:

A – extravezicular
UDP – GlcNAc – chitin
– UDP
B – intravezicular
UDP – GlcNAc – chitin (in cytoplasm) → sp. Extracellular
– UDP (in cytoplasm)
Failed to chitinsintazei purification to homogeneous substance. Optimum pH 7.2; p.I 6.1 to 6.7

Chitin – SINTESYES OF INSECTS:

It requires approximately G.M. 180 kDa with 15-18 transmembrane helixuri, indicating that the enzyme is integrated membrane protein. The PCR was seen that it is detectable in all stages of development and that are located in epidermal cells under procuticula.
Fungi have multiple genes encoding isoforms of chitin synthase. Nematrozii and insects have a limited number of copies of the gene.
AA sequence chitinsintazelor of fungi, nematodes and insects reveals that the enzymes of insect nematodes are closer than in fungi.
Chitinsintazele of insects are large transmembrane protein GM 160 kDa – 180 kDa. The molecule consists of three areas: A, B, C.
A field is in the region N – terminal. A field has a variable number of transmembrane helixuri. Depending on their number, the N – terminal seems to be located in different areas of the membrane or to the extracellular environment or in the cytoplasm.
Field B is in the center of the molecule and comprises approximately 400 AA and contains the enzyme catalytic center. Is highly conserved and contains two unique reasons, EDR (Glu – Asp – Arg) and QRRRW (GLN – Arg – Arg – Arg – TRP) which are present in all types of chitin synthase and therefore can be regarded as sequences, signatures’ ‘. Some conserved residues are believed to be essential for catalytic mechanism that may be involved in substrate protonarea. Substitution of others in the AA sequences drastically reduced the activity of chitin sintazelor. 3 blocks have been described yet highly conserved in the insect chitin sintazele: CATMWHXT (Cys – Ala – THR – Met – TRP – His -? – THR; poz.583 – 590), QXFEY (GLN -? – Phe – Glu – Tyr , pos 794-798) and WGTRE (TRP – Gly – THR – Arg – Glu, pos 1076-1080 0 in a CHS protein in Drosophila.
Domain C contains the C – terminal and contains 2 AA could also be involved in catalysis: W (TRP, pos 803) and T (THR, poz.805) immediately after the transmembrane helix 5. He has seven transmembrane helixuri.
Based on sequence differences sintazelor chitin were grouped into two classes: CHS – CHS A and – B. Many insects seem to have a copy of the gene for each enzyme. Both genes are located on one chromosome to Drosophilla and Anopheles, it is possible that they come from a single ancestor through gene duplication.
CHITINSINTAZELOR ADJUSTMENT:

Formation and degradation of chitin is essential for insect development. Insect metamorphosis is regulated by releasing ecdisonei, a steroid hormone secreted by the gland haemolymph protoracica.
Chitinsintazelor activity is increased by limited proteolysis. It is tempting to speculate on the existence of an inactive pool proenzime cell that are activated by specific signals. Besides proteases, factors affecting the activity of chitin synthase regulators that can exist in insects, in yeast have been described several proteins involved in regulating chitin synthesis.

Chitin DEGRADATION:
and enzymes work hand in hand in reshaping the structures of chitin. Degradation enzymes include chitinazele {poly [1,4 – (N – acetyl – β – D – glucozaminid)] glicanohidrolaza, EC 3.2.1.14} and β – N – acetilglucozaminidazele (β – N – acetyl – β – D – hexozaminid N – acetyl – hexozaminohidrolaze, EC 3.2.1.52). All catalyze hydrolysis of bonds β -) 1-4) – glycosidic bonds of chitin polymers and oligomers. Some of them including an enzyme catalyzes reactions of insects transglicozilare. Because enzymes that degrade chitin can be used to convert raw material components used to chitin in biotechnology, they are important for chemical and pharmaceutical industries. In addition, chitinazele and their inhibitors can be adopted for harmful insecticides or fungicides.
The organisms that produce enzymes chitin is essential for maintaining normal chitinolitice functions lifecycle, eg. morphogenesis in arthropods or cell division in yeast and other fungi sporularea. They are also found in organisms that do not contain chitin but using chitin as a food source, for example. Streptomyces spp were identified genes in the genome chitinaza poliedrrozei virus nuclear (family Baculoviridae) Autograph californica insect, virus specific to arthropods.
Enzymes that degrade insect chitin plays a crucial role in the development postembrionara, especially larvae and impupare shedding. Chitinolitice enzymes are also found in some Hymenoptera venoms of spiders in the digestive fluids where they can facilitate prey toxins through the cuticle. Recently it was discovered a body chitinaza specific milk fat and gland tissue may be important for the development of tsetse flies intrauterine larvae of Glossina morsitans livebearers.
Because chitin is difficult to split because of its physicochemical properties.
Endo – helps break down at a chitinazele Chitose – oligomers. Then converted from monomers by exo – β – N – acetilglucozaminidaze.
Enzyme exo – off units of N – acetyl – glucosamine at the end nereducator and prefer smaller than chitinazele substances. As a result the overall speed is limited by the action of chitin hydrolysis produces chitinazei Chitose – oligomers, which increases the effective concentration of substrate for β – N – acetilglucozaminidaza.
The mechanism of catalysis appears to be similar to that which is supposed to cellulase complex (endo – and exocelulaza).
USE STRATEGY chitin in human life

So far chitin is considered a waste material, which further confused human being as a waste. I support the intense use of chitin in various aspects of human activity, chitin can be called a building material of various objects.
First chitin can serve a building material of many items, including construction of houses and household objects pentrtu (cutlery, linen and others). At no time will find new technologies to use in construction of chitin jacks (tables, chairs, objects artizenale). Chitin in the future may replace the iron, aluminum, wood and other
Lately we intend to elaborate nanotechnology to build blood vessels in some tissues of invertebrate animals.
Keratin after them in the future poare strucrura replace iron, aluminum, copper and other construction materials. According organized structure of chitin, it can be adapted to other useful structures of man.
In Tompa omtogenezei bodies, especially the amount of chitin increases human. Cheratinizeaza skin becomes more rigid and can form different injuries that can penetrate various dangerous infections. Cheratinizarea skin is aging: wrinkles appear, seborrheic vertuci, moles, warts and other unwanted formations.

Chapter 6

Peptide ANTIBIOTIC
I. INTRODUCTION

A. peptides in innate defense

Despite confrontations with a variety of microbes, mammals remain protected from infectious diseases. The life of mammals, is relatively long in comparison with other animal species, showing their exceptional efficiency defense capacity. Mammalian antimicrobial defense is two ways: interest (cloned) and innate. Acquired immune system uses white blood cell class to mediate highly specific responses against antigens. These responses lead to immunologic memory that gives effective adaptation against a subsequent infection with the same microorganism. However, the first exposure to a microbe response require days, even weeks to reach its maximum activity leaving the host vulnerable to other defense needs. Innate immunity, a system comprising a complex series of ele-mediated defense as effector cells and local assets, give immediate protection. Innate system is always prepared or immediately inducible. It includes recognition receptors for microbial organisms, effector molecules and elimination of pathogens and the inability of molecules that signals and coordinate various defense responses including acquired immune system communication. Some elements have been described by Metchnikoff (18 Flemming and others ().
B. General properties of antimicrobial peptides

Antimicrobial peptides of mammals have similarities with those of plants and invertebrates. Are encoded by genes and are initially synthesized as a propeptide containing a sequence N-terminal endoplasmic reticulum targeting (also called signal or pre-sequence) adjacent precursor sequence (called sequence propeptidului) and mature peptide at the C-terminal. Active mature peptide is released from the precursor by proteolytic cleavage and has activity against a large number of microbes, including bacteria, fungi and some parasites. Structurally, the peptides are generally amfipatice, although most are cationic recently been described and anionic peptides. It acts by destroying the membrane structure and function.
II. Microbial Peptides CLASSIFICATION

Antimicrobial peptides in mammals are usually grouped by structure, by anatomical site of expression after gene family that encodes. Number of mammalian antimicrobial peptides identified switch 100. Differ from species to species. Given the common origin of mammals, the complexity of the structure and distribution of antimicrobial peptides suggest different evolutions.

A. Classification based on peptide structure

Most antimicrobial peptides are cationic and amphiphilic mammal. Many have disulfide bridges. Defensinele best characterized antimicrobial peptides from mammals have three intramolecular-SS-bridges, so six cysteine. Depending on the position deck α-, β-, Φ-.
Proterinele (of pig neutrophils) have two axles. Dodecapeptidul of cattle has a deck.

Chemical Class Examples Source
Helix linear Cecropina P1
Cramp
LL-37 Pork
Mouse
Man
Linear, rich in certain amino-5 Bac
Histotina-1
PR-39
Profenina
Bovina Indolicina
Man
Pork
Pork
Bovine
The bridge-S-S-Dodecopeptidul
Protegrina-1
HNP-1 (α-defensin)
TAP (β-defensin)
RTD-1 (π-defensin) cattle
Pork
Man
Bovine
Macaque

The vast majority of peptides belonging to two families of mammals: defensin and cathelicidin.

B. Defensinele

Defensinele of mammals, over 80 described so far, have three intramolecular-SS-bridges. Α-and β-positions differ in the 6 defensinele Cysteine, length prosegmentului different structure and position of genes on the chromosome. Have similar three-dimensional structures and similar antimicrobial activity. Β-chains have three.
α-defensinele were found in the intestinal mucosa and reproductive as well as in leukocytes.
Β-defensinele in several species of mammals and birds in the kidney, skin, oral mucosa and respiratory epithelium.
Recently it was discovered in the macaque neutrophils cyclic Φ-defensin.
C. Cathelicidinele

Are very different to the structure. Propetida segment (about 100 amino acids) is similar in protein sequence Catheline, a cysteine-protease inhibitor isolated from pigs. Molecule antimicrobial activity is 12-100 amino acids, located at the C-terminus of the precursor.
SPECTRUM OF ACTIVITY
A. Antimicrobial activity

Many antimicrobial peptides in mammals are active against a wide range of microbes: gram-negative and gram-positive, fungi, viruses and protozoa. Some have more limited spectrum of activity. Antimicrobial peptides can act synergistically with other antimicrobial factors, such as the bactericidal permeability inducing protein. It is believed that kills germs by destroying membrane integrity. Are divided into cationic and amfipatice, properties that facilitate interaction with biological membranes.
Hypothesis: interaction with membrane electrochemical gradient dissipation is destroyed.
Another possibility: peptide crosses the membrane, is associated with certain molecules and leads to cell functions deranjearea. Defensinele induce the formation of pores in the double layer of phospholipids.

B. Other activities

Antimicrobial peptides may act in wound healing, in inflammation and adaptive immune response. At high concentrations can be cytotoxic.
Some defensin and cathelicidin can chemoatractante activities for lymphocytes and increase antibody response with IgG and dendritic cells. In future studies will be the integration of innate defense responses and adaptivity.

III. Genes and Transcription ADJUSTMENT

AMPs are gene encoded prototype, unlike other antibiotics that are produced by nature multienzimatice waterfalls. Both the plant and the animal are encoded by genes with 2 or more exons is a unique family of genes.

A. Defensinele

Defensinelor have selective expression genes, some genes that encode defensinele are constitutive, others are induced by infectious agents and inflammatory stimulation.
Defensinele are encoded by human chromosome 8. There are α-, β-, Φ-defensin. Φ-defensinele have 18 amino acids .. Half of the peptide is encoded by a gene, the other half is encoded by another gene entirely different, and are united.

B. Cathelicidinele

Catheline field is encoded by all four exons of cathelicidin gene, and antimicrobial peptide-mature (at the C-terminal) is encoded in a segment of exons 4. In humans a single gene has been characterized by cthelicidina LL-37, which is found on chromosome 3.

IV. Biosynthesis AND PROCESSING

Peptides are synthesized as precursor molecules including N-terminal sequence that targets the endoplasmic reticulum (signal sequence). Along with the signal segment is prosegment that may be important for intracellular processing, neutralization of pregnancy and / or folding cationic C-terminal peptide. Some are split extracellular other intracellulare. Processing posttranslationala: formation of disulfide bonds, amidarea C-terminal and N-terminal piroglutamat formation.

B. small intestine

Paneth cells are secretory epithelial cells which are located at the base of crypts and are involved in defending Lieberkühn small intestine mucosa. α-granules are located in apical defensinele of these cells. The same granules are found near other molecules defensin antimicrobial, including lysozyme and sPLA2. Α-gene expression defensinelor Paneth cells is induced during pathological processes including hemorrhagic enterocolitis necozanta and shock.
C. airways

Transcriptional induction of β-defensinelor defense is a response to certain mucosal epithelial cells. Epithelium cells and possibly those of other mucosa areas can autonomously detect bacteria and to increase antimicrobial activity.
Lower respiratory tract of mammals is generally free of bacteria. If there are bacteria produce β-defensin epithelial cells.

Skin and other epithelia flat D.

Epithelia flat, keratinized or necheratinizate are barriers in many areas. Necheratinizate flat epithelia of the tongue, esophagus, vagina, producing β-defensin and cathelicidin. β-cells are produced and defensinele leather, for example in psoriasis crusts, noninfectious inflammatory skin disease that compromises the normal function of the skin barrier. Just in inflamed skin.
VI. In Defense of innate antimicrobial peptides mucosal surfaces
In mammals and other higher animals with pathogens initial meeting usually takes place on the surface, especially the skin and mucosal surfaces of the gastrointestinal tract, respiratory and genitourinary. He recently proposed a model mucosal surface defense. Expression of inducible and constitutive defenses include antimicrobial peptides, inorganic molecules and proteins that inhibit antimicrobial activity directly the survival of microbes. These factors are produced local antimicrobial epithelial cells, but in some cases can be derived from circulating cells and plasma.
It suggests that inflammation and acquired immune response are support systems that eliminate the persistent or invasive confrontations.
VII. Future prospects

Among the innate immune mechanisms in mammals is the production of a variety of antimicrobial peptides remains to establish structure-function relationships, biological activity and regulation of these peptides.
Innate defense is affected by altered expression of antimicrobial peptides linked to genetic defects, immaturity, chronic inflammation, environmental toxins, systemic disease. A deficiency in antimicrobial peptide levels lead to an increased risk of neonatal sepsis, otitis, tooth disease, this pathogen in nasofaringe, urinary tract infections.
A better understanding of innate defense mechanisms leads to therapeutic strategies that increase efficiency defense. Topical antimicrobial agents or may be systemic.

ENTOMOTHERAPY VOL6

Functional role of lipids in insects

Lipids have gained considerable functional significance during evolution class Insecta. They are a functional structural component of cell membranes and cuticle, is a rich source of metabolic energy for energy demand periods, facilitates water conservation by forming a waterproof barrier and by getting water cuticulare metabolic oxidation and they include important hormones and pheromones.
The term is applied to a heterogeneous group of lipid compounds that have two properties, namely:
1. Relative insolubility in water;
2. Large non-polar solvents such as solubility in chloroform and acetone.

II. Necessity of lipids

A polyunsaturated fatty acids
Polyunsaturated fatty acids, especially the C18 series are undefined in the diet of many species of animals.
1. Nutrition Studies

Data from studies of dietary deficiency must be interpreted with caution. Polyunsaturated fatty acids are essential for components of food. In other species has shown that deficiency of polyunsaturated fatty acids in food can result in one or both symptoms as follows:
a) incomplete growth and development going up in emerging poor, unable to stretch their wings and even the lack of wings, scales on the body;
b) reduced reproductive capacity.
As constituents of the cell membrane, where they participate as fosfogliceride, their absence will lead to a malfunction of the membrane.
In vertebrates, the acid precursor of prostaglandins and arabidonic is possible to have the same role and insects.
2. Biochemical studies. Radioactive marker proved that insects do not synthesize fatty acids.

A. sterols

Sterols contribute to a variety of functions for insects:
– Essential components of sub-cellular membranes;
– Shedding and hormone precursors vitelogemic, ecdisona;
– Constituent of cuticle wax on the surface;
– Constituents of lipoproteins transporting molecule.
Nutritional Studies

The phytophagous insects, phytosterols are often a suitable substrate and possibly better food cholesterol. Insects can convert phytosterols to cholesterol. These phytosterols are plant sterols, campesterol, stigmasterol and ergosterol. Many insects rely on gut symbiotes sterols.
Sterols present in food need to demonstrate the absence of insect cholesterol synthesis pathways as proposed for vertebrates and microorganisms.
Synthesis starts from acetate and mevalonic acid an important intermediate. Farmeziprofosfatul is an important intermediate in the production of juvenile hormone.

III. Digestion and absorption

Macromolecules that form the feeding insects do not penetrate the intestinal wall. It must be reduced to a form absorbent by the digestive process.

A. Digestion

It is not necessary for digestion or modification sterons these molecules to be absorbed. Fat is digested in the gut is triacilglicerolul acilglicerol requiring long-chain ester hydrolysis. Lipolysis is performed in the presence of lipases, a class of esteroze. Triacilglicerolului hydrolysis was investigated in few species, more cockroaches. The enzyme is activated in the presence of Ca 2 +, analogous to the mammalian pancreatic lipase. That mechanism involves hydrolysis of fatty acids in the first stage in position 1 and 3 of glycerol. Purification and characterization Failed enzyme. In some species, glicerintrioleina is hydrolyzed faster than tripalmitina. Eg locusts, trioleinei hydrolysis are obtained large amounts of metabolic substrate needed for prolonged periods of flight. Optimal enzymatic activity is obtained after emulsify the substrate. Do not know the nature of emulsifying agents to insects, however not as vertebrate bile salts. It seems that effect is given by acilgraspeptide emulsifier.
Absorption. Lipolytic byproducts. It is assumed that the absorption of the hydrolysis product triacilglicerolului is similar to mammals. Absorption takes the form of chylomicrons.
2. Sterols. In insects, sterolesterii are absorbed faster than free cholesterol.
IV. Transportation

In insects, haemolymph lipids transported from place to place absorption or synthesis or storage use.
A. haemolymph lipids

Classes of lipids that can be isolated from the haemolymph of insects are insoluble in water and therefore are not present in the haemolymph as free molecules, but form complex macromolecular lipoproteins.

B. Release and uptake of haemolymph lipids

1. Primary source of haemolymph is diacilglicerol triacilglicerol of body fat reserves. Release of body fat requires hydrolysis triacilglicerolului triacilglicerolului stored and reported that there lipolytic activity in fat body of a species. This includes selling a simple monoacil. It is assumed that partial hydrolysis and fatty acid triacilgliceroluluila diacilglicerol or process can be dominant.
Diglycerides of fatty body release requires the presence of protein acceptors in haemo
lymph. It is possible that in some species in certain condtii physiological reserve lipids to be released in the form of triglycerides and / or free fatty acid.

2. Lipids are an essential component of all structural and metabolic cell and thus are taken from the haemolymph in all tissues. There lipoprotein lipase that releases free fatty acids from lipoprotein complexes and they enter cells. The enzyme is activated by mucopolysaccharides, heparin, and this substance is a required part of the complex coinsiderata enzyme. If capture is preceded by hydrolysis of neutral lipids in the immediate vicinity of the extracellular tissue are expected hydrolysis rates increased during periods of increased energy demand.
Capture vitelogeninei containing lipids in the ovary appears to be preceded by selective capture of specific haemolymph lipoproteins. This explains the large amounts of triglycerides in eggs.

V. The use of lipid

Sucecesul evolutionary class Insecta was facilitated by the ability to store large amounts of animal fat and use this substrate as a source of energy for muscle activity and as a source of metabolic water which supplements your body’s water reserves. Fat is stored and transported mainly in the form of tri and diglycerides and ester hydrolysis is a necessary prelude to escape the fatty acid.

A. Lipase extradigestive

Little is known about the specificity of lipases extradigestive glycerides. In some species flight muscles occurs preferential hydrolysis of monoglycerides. In other species there are specific enzyme for digloiceride. Do not know anything about the specific positional specificity of fatty acids and digestive lipases stereospecificitatea. Do not know anything about the nature of adjustment mechanisms lipolytic activity.

B. Oxidation of fatty acids

It has been shown that body fat of many insect species β oxidation of fatty acids occurs. Carnitine (1,3-hydroxy-4-trimetilamoniumbutirat) is a required cofactor in some species serve to facilitate transport to and from mitochondria acyl grouping by the action of an enzyme, canitinacil transferase.
Acyl-CoA + S-carnitine + CoA ↔ acilcarnitina
It is believed that carnitinacil transferase is localized within mitochondria. Not all insects carnitine is required cofactor for oxidation of fatty acids. It seems that the insects which use lipids as primary energy source carnittina has a small role or place in the oxidation of fatty acids. Membrane permeability for long chain fatty acids increases with temperature and it is possible that carnitine need to be more pronounced at lower temperatures and during the initial phase of flight, before the body temperature to rise.

C. The fate of glycerol

Glycerol is also produced by the action of lipolytic enzymes by neutral enzyme activity. It seems that glycerol is transported in body fat, which is the source of glycerol 3-phosphate for re-esterification.

D. Formation of ketone bodies

Under certain conditions can occur ketones, acetoacetate and D-3-hydroxybutyrate.

VI. Lipid biosynthesis
A. Fatty acids

Insects synthesize long chain saturated fatty acids and monounsaturated CoA.Astfel any compound acetyl-CoA acetyl give can be considered a potential precursor of fatty acid:
Acetyl-CoA + 14 NADPH + 7Malonil-CoA → 14H + + 7H2O + palmitic 1Acid 14NADP + + 6H2O
In vertebrates and microorganisms, but also in other insect enzymes that synthesize fatty acids are linked to proteins as a cytoplasmic enzyme complex firm, fatty acid synthase.
The first phase of condensation can take place with propionyl-CoA instead of acetyl-CoA. In this case occurring fatty acids with odd number of carbon atoms. The vertebrate enzymes and microorganisms that synthesize fatty acids are bound to proteins and form a cytoplasmic enzyme complex, synthetic fatty acid. So is the case and insects. Pyridine-nucleotide synthesized only in insects is NADPH.
Route of synthesis of fatty acids is somewhat inverse β-oxidation.
Monounsaturated fatty acids are formed naturally in the microsomal system you are desaturate saturated fatty acids to monoenoic equivalent. Monounsaturated fatty acids cis or trans can be conformed.
B. acyl glicerolii

Free fatty acid content in tissues of insects is relatively low, the amount is presented as great as di-or esterified or fosfogliceride triacilgliceroli. Major place of synthesis of di-and triacilglicerolului body fat is.

C. Fosfogliceridele

In some insect orders, phospholipids majority is phosphatidylcholine (lecithin), and others is fosfatidiletanolamina. Major place of synthesis of microsomal fraction appears to be fosfoacilglicerolului. It seems that mitochondrial fosfogliceridele are transferred to mitochondria.
Invstigate and phospholipids were minor fosfatidiletanolamina ceramide, inositol fosfotidil, fosfatidilserina and fosfatidilglicerolul. They go through similar metabolic pathways in mammals:
Ceramide Ceramide + fosfatidiletanolamina + HOH → Fosfatidiletanolamina
Ceramide + HOH → Fatty acids + Sfingozina

D. Lipids cuticulare

The largest portion are hydrocarbons: alkanes (n-alkanes, 3-metilalcani, monometilalcani internal branched, branched dimetilalcani internal) alcadiene.

VII. Regulating lipid metabolism of endocrine

Insects in fat content fluctuates in life. The changes reflect variations in metabolic balance between fat synthesis (including inputs by food) and lipid utilizrea direct or indirect result of the action of hormones and / or neurohormone. Development processes, migration, diapauza, reproduction and flight, all under the control of endocrine, lipid metabolism.
Adipokinetic factor A.

Aqueous extracts of corporate influence lipid levels in heart fat body and haemolymph in some species. Interspecific differences in response to extracts of corpora heart do not seem to result from evolutionary changes in nature adipokinetici factors.
Precise physiological role remains unspecified factors, although it seems to involve more than simple homeostatic control of lipid levels in haemolymph, rather factors provide appropriate substrates for flight muscle metabolism. It’s long as locust flight muscles during the early stages catabolizeaza carbohydrates flight, and lipid become dominant when the flight continue. Such metabolic switch from using carbohydrates to lipids can be adjusted using the secretions of „corporate heart.” Apparent duplicity of action „adipokinetic hormone” may reflect the cumulative effects of two or more factors. It is known that the corpus cardiacum contain and release several neurohormonal and until these factors were released, physiological roles can not be attributed to individual molecules.
Lipids are a better substrate than carbohydrates for long migratory flights, due to higher caloric content and a higher production of metabolic water by oxidation.

B. hormone from the corpus Allatum

Synthesize and secrete hormones Corpus Allatum that play important roles in regulating development and reproduction. Active molecule was isolated and characterized in several species of insects, and studies have shown that individual species often exist in several forms homosequitetpenoide molecular structures. Different molecular forms were not attributed physiological significance. Hormone induces synthesis of body Allatum vitellogeninei a few species.
Contribution to lipid metabolism Allatum case concerns the interrelationship in insects and corpus Allatum secreting cells.
C. Ecdysona

The role of the insect moulting hormone in the metamorphosis of insects Ecdysona known for many years. The hormone is released from the α-Ecdysona protoracice glands in response to a trophic hormone in the brain. It is believed that it acts as a precursor is converted to β-Ecdysonamai forward. The most obvious effect of β-Ecdysonei is to initiate processes of epidermal tissue lysis which withdraws from the old cuticle before moulting.
It is believed that β-Ecdysona stimulates the biosynthesis of hydrocarbons during pupari. Causes hormone release from the ovary Ecdysonei α-induced synthesis vitellogeninei rest in body fat.
Some metabolic pathways that occur in vertebrates and insects have been described, yet it is also important to recognize those aspects of lipid metabolism in which the two different classes of animals, namely:
– Insect haemolymph contains high concentrations of diacilglicerol and low levels of free fatty acids, unlike vertebrates;
– Lack of steroidogenesis in insects led to the development of the corpus Allatum hormone;
– The role of lipids in insect protection to dehydration.

II. Carbohydrates in the nutrition of insects

For many species, glucose, fructose and sucrose are sugars nutritional
appropriate. The need for carbohydrates varies with age, sex and metamorphic stage. Other carbohydrates such pentozele (arabinose, xylose, ribose, etc.) are not necessary and may even inhibit the growth of larvae.
It is obvious that an insect’s ability to utilize specific carbohydrates depends on a complex inter-relationship which includes taste, digestion, absorption and metabolism.
The larvae of some species may replace carbohydrates with protein or fatty foods.
For many species, the optimal concentration of carbohydrates in the diet is in close range. Instead, larvae that require high concentrations of carbohydrate food, eg larvae that feed on starch.
Some of them use the branched polysaccharide amylopectin better than linear saccharide amylose.
Adults consume carbohydrates as an energy source for flight, reproduction, and longevity: nectar, seeds, etc..

III. Growth factor-carbohydrate

Besides the need for sugars and starches, insects require a source of carbohydrate conjugates and derivatives in the form of vitamins and related compounds: vitamin B2 (riboflavin), vitamin B12 (ciancobolamina).
Vitamins are necessary for hydrogen transfer reactions, transmetilari in gluconeogenesis. Vitamin C (ascorbic acid L) seems to have nonspecific antioxidant role.
Enozitolul (hexahidroxiciclohexanul) can exist in several isoforms, but only four are found naturally (myo-, sciyllo-, neo-, chiroenozitolul) in insects and other organisms, myo-isomer is very important because it is the only isomer which is incorporated in fosfatidilenozitol, essential structural component of cell membranes and in the cell. Insect tissues it is present in much lower concentration than the two main phospholipids in insects, and fosfatidiletanolamina fosfotidilcolina.
IV. Carbohydrate digestion

B. Carbohydrates common

Insect digestive Carbohidrazele hydrolyzes poly-, oligo-and disaccharides in constituent monosaccharides for absorption: α and β amylases which hydrolyze glucosidic bonds of polysaccharides, and glycosidic bonds hydrolyze in glucozidazele that oligo-and disaccharides.
1. Digestive amylases hydrolyze starch (amylose and amylopectin) and glucogenul. α-amylase or endoamilaza (1,4-α-D-glucan glucanohidrolaza) give a mixture of dextrins of variable length chain and is found in the salivary glands and / or intestinal glands of insects. It is a single chain polypeptide with MW = 68kDa, and a pi = 4.0, optimal pH 5.8, optimum temperature 37 ˚ C, and chloride ions activated florurii ions inhibited.
2. Glicozidazele digestive. Insects contain 5 glicozidaze: α-glucosidase, β-glucosidase, α-galactosidase, β-galactosidase and β-fructofuranozidaza.

C. Carbohidraze special digestive

1. α-bee-bees glucozidazele of business is nectar feed containing mainly glucose, fructose and sucrose.
2. Celulazele of termite-cellulase can be synthesized by microorganisms digestive or intestinal cells in the gut. Cellulase, a β-glucosidase with cellulose hydrolyzes via celodextrine to celotrioza, celobioza and glucose.
Microorganisms in the gut are some protozoa in lower termites. The higher termites, cellulase is produced by its cells. The cockroaches that eat wood, celulazele are produced by salivary glands and the microorganisms present in the intestinal lumen.
V. Absorption of carbohydrates

The most common monosaccharides are absorbed from the intestinal lumen glucose and fructose which are absorbed into the haemolymph by epithelial cells. Then they are transported in body fat for trehalose synthesis.
In some species of insects, absorption of sugars is not for an active system that requires energy, in some species (larvae of diptych) active transport takes place by simple diffusion for the intestinal epithelium is facilitated by the presence of high concentrations of trehalose in the haemolymph.
VI. Excretion and detoxification

A. Adjusting the excretion of carbohydrates – is by Malpighi’s tubules and the rectum. Tubes produced an ultrafiltrate of the haemolymph Malpighii and rectum there is a useful small molecules reabsorption (glucose, trehalose and amino acids) is possible for a controlled selective permeability of tubules of the enzyme is involved in conservation Malpighii of haemolymph sugars.
B. glycosides in detoxification
Detoxification reactions that transform organic compounds less toxic metabolites foreigners often involves the formation of glycosides. A glycoside form when toxic metabolite of (aglycone) is combined with a remainder of monosaccharides (usually glucose) with a link to atom C1 acetyl. The reaction usually takes place in body fat.
Glycosides are more polar and less toxic than unconjugated aglycone, and thus are excreted quickly.
(1) UTP + D-glucose 1-phosphate → + UDPglucoza pyrophosphate (glucose-1-
uridiltransferaza phosphate)
(2) UDPglucoza + Phenol → UDP + aryl β-D-glucoside
(UDPglucoziltransferaza)

UDPglucoza detoxification reaction that occurs serves as a source of glucose for the synthesis of glycogen and trehalose normal.

VII. Carbohydrates in structural components and pigments

A. chitin
The main structural component of insects is chitin body consisting mainly of unbranched chains of β-(1,4)-2-acetamido-2-deoxy-D-glucose (N-acetyl-D-glucosamine).

(3) ATP + D-glucose → ADP + D-glucose 6-phosphate (Hexochinaza)
(4) D-glucose 6-phosphate → D-6-phosphate fructozo (Glucozofosfat isomerase)
(5) D-6-phosphate fructozo + L-glutamine → 2-amino-2-deoxy-D-glucose 6 –
phosphate + L-glutamate
(Glucozoaminofosfat isomerase)
(6) Acetyl-CoA + 2-deoxy-D-amino2 glucose 6-phosphate → CoA +
+ 2-acetamido-2-deoxy-D-glucose 6-phosphate (Glucozoamonofosfat
acetyltransferase)
(7) UTP + 2-acetamido-2-deoxy-D-glucose 1-phosphate → UDP-2-pyrophosphate +
acetomido-2-deoxy-D-glucose
(UDPacetilglucozoamino pirofosforilaza)
(8) UDP-2-2-deoxy cetoamido-D-glucose + [1,4 – (2-deoxy-2-acetomido-β-D-glucozil)] n → UDP + [1,4 – (2 – acetomido2-deoxy-β-D-glucozil)] n +1

Failed to separation and isolation of insect chitinsintazei. The enzyme may be related to subcellular membranes and probably turns off during tissue processing.
B. glycosides and sclerotinizarea

Cuticle of insects hardens and turns when it forms a protein-quinone complex (screlotina) of proteins and phenols present polihidrici external cuticle layers. It is not known if the glycosides are involved in regulating the formation screlotinei integumentare. But they come from screlotinizarea premature precursors of the tanning agents masking functional groups, a dihydric phenol.
C. pigments and cardiac glycosides glycosidic

The color depends largely on insects in this non-carbohydrate pigments: screlotina, melanin, omocromi, pterine, carotenoids and bile pigments present in the integument or internal tissues, especially haemolymph or body fat. Some are protective coloration glycosidic pigments. Β-glucosides can or 6-acetyl-β-D-glucosides with naphthalene or anthracene phenols and related quinones.
Some bright colored insects stores glycosides of host plants that are toxic to predators, especially birds. Other insects mimic inedible. Those that feed on plants containing „milk” (Milky-Weeds), contain cardiac glycosides, cardenolide. Cardenolidele are powerful heart drugs, cause vomiting if eaten by predators. Females usually have more emetic than males.
D. Glicozaminoglicanii connective tissues and cements
There are relatively few in insect connective tissues that give support integumentul main organs. Contain acid and neutral glycosaminoglycans (mocopolizaharide), often linked covalently to proteins (proteglicani) and associated with collagen. Collagen found in connective tissue hyaluronic acid, chondroitin, sulfate dermaton, keratansulfati.
Central nervous system is surrounded by fibrous connective tissue.
Proteoglicanii glicozaminoglicanii insect and domestic work as a cement cells and external linking, as an adhesive to encapsulate parasites and foreign corpus, in saliva or an adhesive that sticks to kiss on their substrate.
VIII. Carbohydrates in the metabolism of insects
A. Synthesis, nature and structure of carbohydrate reserves

Reserve carbohydrates in the haemolymph are glycogen, trehalose, glucoproteine.
1. Glycogen synthesis.

Glycogen, branched polysaccharide composed of α-D-scrap glucopiranoza is the main reserve polysaccharide insects. MW = 106-108. Linear portions containing 1,4-glucosidic bonds. 1,6-glucosidic bonds ramifications are.
Branching points are between 12 to 18 glucose residues, so has a high glycogen branching. Synthesis is similar to that of vertebrates.
(9) ATP + D-glucose → ADP + D-glucose 6-phosphate (hexochinoza)
(10) D-glucose 6-phosphate → D-glucose 1-phosphate (fosfoglucomutaza)
(11) UTP + D-glucose 1-phosphate → + UDPglucoza pyrophosphate (glucose-1-phosphate
uridiltransferaza)
(12) UDPglucoza + (1,4-α-D-glucozil) n → UDP + (1,4-α-D-glucozil) n +1
The most important deposits of glycogen are fat body, flight muscles, intestines, central nervous system. Exception: tsetse fly used as an energy source for flight oxidation of amino acid proline, flight muscles contain only 1% glycogen and intestinal tissues contain 14 times more glycogen than muscles of flight
2. Synthesis of trehalose (α, α-trehalose) (α-D-α-D-Glucopyranosyl-glucopiranozid)

Is predominant sugar in many insect species, but not all, may be more than or equal to 2 M. There are other organizations that reserve component or as free sugars in different glicolipide. Other organizations outside of insects: bacteria, algae, yeast, fungi, nematodes, annelids, crustaceans and some ferns and seed plants.
Glucose or fructose is synthesized:
(13) ATP + D-glucose → ADP + glucose 6-phosphate (hexokinase)
(14) D-fructose + ATP → ADP + D-fructozo 6-phosphate (hexokinase)
(15) → ATP + D-fructose 6-phosphate D-glucose (glucose-phosphate isomerase)
(16) D-glucose UDPglucozo 6-phosphate → UDP + α, α-trehalozo 6-phosphate (α, α-
6-phosphate synthase trehalozo)
(17) Trehalozo 6-phosphate + H2O → trehalose + orthophosphate (trehalozo-phosphatase)

Synthesis occurs in fat body cell cytoplasm and in smaller amounts in muscle and intestinal tissue of some species. The largest amount found in haemolymph 23:175 mM or (8:60 mg / ml), depending on species, stage of development and gender. It is an important reserve saccharides that is rapidly hydrolyzed to glucose entering oxidative processes to give energy. Trehalose concentration in haemolymph homeostasis is regulated by metabolic and hormonal control of synthesis and hydrolysis. Circadian rhythm in concentrations There trehalose.

3.Glicoproteinele

Besides proteoglicanii present in connective tissues, insects contain varying amounts of glycoproteins in other tissues, especially in the haemolymph.
Glycoproteins can function as backup molecules, enzymes, or to protect their constituent monosaccharides by enzymatic attack. It is not known whether similar to Antarctic fish, protect them from insects in diapauza negative temperatures.

Gluconeogenesis is important because it offsets the need for glucose when carbohydrates are limited by food and clean haemolymph metabolites (lactate and glycerin) that are not oxidized as rapidly as glucose. Enzymes were found in the corpus luteum and in muscle.
Unlike microorganisms and plants, insects do not gluconeogenesis from lipid substrates.

Lipid synthesis from glucose.

Body fat contains insect enzyme systems needed to convert glucose into fatty acids and glycerol, later incorporated into neutral lipids and phospholipids, especially triglycerides, and fosfatidiletanolamina fosfatidilcholina. The size of the conversion of carbohydrates into fat reserves depends on the chemical nature of nutrients, growth stage, nutritional status and activity level. B. larvae die such that large amounts of triglyceride stores, incorporating 8.4% of glucose labeled in acids palmitic, oleic palmato-, stearic and oleic. Insects convert glucose into triglycerides reserves for fatty acid oxidation generates more calories and metabolic water than equivalent amounts of glucose oxidation or glycogen.

Mobilization of carbohydrate reserves

Trehalose and glycogen stores are mobilized through enzymatic reactions that generate glucose control to support all life processes.

Glycogenolysis

Glycogenolysis refers to reactions that degrade fosforolitice and hydrolytic glycogen to glucose units. The most important reaction is split fosforolitica generating glucose-1-phosphate molecule to the reducing end of glycogen:
(18) (1,4-α-D-glucozil) n + orthophosphate → (1,4-α-D-glucozil) n-1 + α-D-glucose 1-phosphate (glycogen phosphorylase)
Glycogen phosphorylase is an enzyme allosteric to exist in an active form (a) and an inactive form (b).
(19) a + 4H2O → Fosoforilaza 2Fosforilaza b + 4Ortofosfat (phosphorylase
fosfateaza)
(20) b + 4 ATP → 2Fosforilaza phosphorylase a + 4ADP
(Fosforilazchinaza)
Α-amylase also can hydrolyze glycogen. Amylase isoenzymes are present in haemolymph, fat body, muscle and reproductive system.

Hydrolysis of trehalose

It is made of α, α-trehalose (α, α-trehalose glucohidroliza):
(21) α, α-trehalose + H2O → 2D-glucose (α, α-trehalose)
The enzyme is very active in body fat, muscle, intestine and salivary glands. It seems that the enzyme is localized in the mitochondrial membrane.

Glycolysis and the way pentozo-phosphate – glycolysis process in insects, when sugars are metabolized to pyruvic acid by their phosphorus derivatives is similar to other organisms. Pyruvic acid is then converted into acetyl-CoA is oxidized to CO2 and water through the tricarboxylic acid cycle and terminal oxidation. Conversion of 1 mol of glucose to pyruvic acid 2 moles ATP results.
Although glycolysis is the major route of conversion of glucose to pyruvic acid, or phosphate way pentozo-monophosphate hexozo operates in insects. There are important for getting energy, but provides NADPH for the synthesis of fatty acids, and nucleic acid synthesis pentozofosfatii for triozofosfati for glycogen synthesis.

Regulating carbohydrate metabolism-regulating enzyme via metabolites, ions and hormones control the rate of interconversion of glycogen, trehalose and glucose in insects. These adjustments are important in maintaining homeostasis of haemolymph sugars. Activators and inhibitors have been identified. A central role in glucose and glucose 1-phosphate 6-phosphate. Besides they probably act hiperglicerniant hormone (glucogan-like) hipoglicerniant hormone (insulin-like).
Hiperglicerniant hormone is a polypeptide, probably synthesized by cells of the body neurosecretorii heart.
Hipoglicerniant hormone (insulin-like) is synthesized in the corporate heart. Trehalose concentration in haemolymph causes loss.

IX. Carbohydrates in metamorphosis

Metamorphic changes endopterigote both insects and are usually accompanied exopterigote substantial depletion of their reserves of carbohydrates for metabolic energy through them to ensure the necessary transformations. For example the maximum age larvae contain only 1% carbohydrates and they must rely mainly on fat. Carbohydrate reserves are supplemented by 2-amino aminozaharuri-2-deoxy-D-glucose derived from chitin in shedding.
Carbohydrates can also be secreted with the silk cocoon.
Although many species there is variation in the relative use of reserves of glycogen and trehalose during metamorphosis, it is clear that insects rely on carbohydrates stored metamorphosis during the larval period as an energy source and substrate for the synthesis of chitin and other cell components.
Carbohydrates in flight muscles X.

Initiation and maintenance of insect flight requires a very effective oxidative metabolism of carbohydrates and fat is fed. Enzyme activity in the muscles of flight exokinaza carnitinpalmitoiltransferaza acting glucose and fatty acid oxidation.
Insects may use different energy sources depending on the stage of flight. For example locusts during flight using fatty acids and carbohydrates to initiate flight. Dipterele sucking blood oxidative metabolism using amino acid proline to maintain flight.
As in other organisms, energy is obtained from oxidation that occur in muscle.
Once an insect flight reached its stationary, reversible mechanisms of mitochondria oxidize pyruvate and 3 glycerophosphate formed immediately. Regenerate NAD + cycle through a system closely linked to glycolysis and electron transfer chain.
XI. Carbohydrates in reproduction and embryo development
Carbohydrates are necessary for normal male and female reproductive system and embryo development. In males, sugars form an important component of the testes and seminal plasma. In females, the accumulation of carbohydrates in the preparatory stage oocet is essential for embryo development.
A male and female reproductive systems

In males, fructose and glucose formed 83% of testicular and carbohydrates were present in plasma but not in sperm.
Fructose is rapidly metabolized by sperm and does not seem to be involved in storing their sperm ducts. Glucose, trehalose together with amino acids probably serve as an energy source seminal vesicle sperm penru maintaining and sperm ducts. In the female system, carbohydrates are necessary for the formation glicozoaminoglicanilor vitelogeneza and present in chorionic membrane and yolk. Vitelogeneza involves accumulation of carbohydrates, lipids and proteins in oocet to compensate for structural and metabolic needs of the developing embryo. Serving as the main carbohydrate glycogen is synthesized in the ovary of glucose and trehalose and fat body coming from the haemolymph.

B. Development of the embryo
During embryonic development, carbohydrates and lipids form the main substrate for energy production. Glycogen is the source of glucose for synthesis of chitin that forms the larval cuticle age I.

XII. Carbohydrates and winter hardiness in diapauza
Diapauza insect is to stop development that is able to survive in adverse environmental conditions and to synchronize the active stages of the life cycle or the availability of food sources available. Depending on the species, diapauza can intervene at the stage of egg, larva, pupa or adult. It is a genetically controlled life phase that includes the accumulation of fat and carbohydrates to short days and low temperatures in temperate areas. Once installed diapauza breath drops dramatically to 2% from the previous phase.

A. Maintaining diapauzei

Many insects in diapauza rely on reserves of triglycerides, glycogen and trehalose and to a lesser extent on protein and amino acids. These reserves are accumulated mainly in fat body and haemolymph in diapauzei previous feeding period. In the early stages of diapauzei are consumed preferentially glycogen and trehalose reserves. Glucose is used to meet energy needs and serves as a limited precursor for the synthesis of alcohols polihidrici. Polialcoolii contribute to resistance to low temperatures. Long-term survival of insects in diapauza depends on adequate lipid reserves. Lipid oxidation generates 9 calories per gram, while carbohydrates and proteins generates only 4 calories per gram.

B. Polialcoolii in resistance to cold

In temperate and cold areas, can withstand insects diapauza long periods in cold. It seems that it contributes to increased production of polyhydric alcohols. Both insects susceptible to frost, and the tolerances are capable of supercooled without formation of ice crystals. Insects survive at temperatures of about -30 ˚ C. Air
(22) Dihidroxiacetonfosfat + NADH → Glycerol-3-phosphate + NAD +
(Glycerol 3-phosphate dehydrogenase)
(23) Glycerol 3-phosphate + H2O → glycerol + orthophosphate (phosphatase)

Another is polyhydric alcohols sorbitol.

(24) D-glucose-6-phosphate + NADPH → NADP sorbitol 6-phosphate + +
(Polioldehidrogenaza)
(25) Sorbitol 6-phosphate + orthophosphate + H2O → sorbitol (phosphatase)

Glycerol, sorbitol and other small molecules supercooled drop point to many insects susceptible to frost. A high cold resistance is determined by a high titre of trehalose and / or 3itol.
XIII. Carbohydrates and behavior of insects
A. carbohydrates and feeding insects

Many secondary plant substances exist in nature in the form of glycosides which has been shown to regulate feeding and control insect host selection. Example: mustard oil glycosides, glycosides present in the tissues of plants oxosteroide „milk”. Glucose, fructose, sucrose, maltose, melibioza, raffinose, acids: linoleic, oleic, palmitic act as attractive.

Exocrine glands glycosides B.

Exocrine glands of insects contain precursors of substances with defense and pheromones in the form of glycosides. Glycosides mask reactive group secretion, prevents auto-toxicity and maintain solubility. For example the final secretions contain benzochinone arthropods and are found in the form of phenolic glycosides are hydrolysed and oxidized at the time of discharge.
Pheromones are stored as glycosides of benzyl alcohol and / or feniletanolului. Under the action of β-glicozidaze gland pheromone is released from pool.
Most research in carbohydrate metabolism were made on five major orders: beetles, diptych, Hymenoptera, Lepidoptera, Ortoptere.

Functional role of lipids in insects
Need lipids, digestion and absorption, transport, use of lipids, lipid biosynthesis, endocrine regulation of lipid metabolism.
Lipids have gained considerable functional significance during evolution class Insecta. They are a functional structural component of cell membranes and cuticle, is a rich source of metabolic energy for energy demand periods, facilitates water conservation by forming a waterproof barrier and by getting water cuticulare metabolic oxidation and they include important hormones and pheromones.
The term is applied to a heterogeneous group of lipid compounds that have two properties, namely:
1.Relativa insolubility in water;
Non-polar solvents 2.Mare solubility in chloroform and acetone for example.

Necessity of lipids
A polyunsaturated fatty acids

Polyunsaturated fatty acids, especially the C18 series are undefined in the diet of many species.
1. Nutrition Studies

Data from studies of insect diet must be interpreted with caution. Polyunsaturated fatty acids are essential components of food as well. In other species has shown that deficiency of polyunsaturated fatty acids in food can result in one or both symptoms as follows:
a) incomplete growth and development going up in emerging poor, unable to stretch their wings and even the lack of wings, scales on the body;
b) reduced reproductive capacity.
As constituents of the cell membrane, where they participate as fosfogliceride, their absence will lead to a malfunction of the membrane.
In vertebrates, the acid precursor of prostaglandins and arabidonic is possible to have the same role and insects.
2. Biochemical studies. Radioactive marker proved that insects do not synthesize fatty acids.

B. sterols

Sterols contribute to a variety of functions for insects:
– Essential components of subcellular membranes;
– Shedding and hormone precursors vitelogemic, ecdisona;
– Constituent of cuticle wax on the surface;
– Constituents of lipoproteins transporting molecule.

The phytophagous insects, phytosterols are often a suitable substrate and possibly better food cholesterol. Insects can convert phytosterols to cholesterol. These phytosterols are plant sterols, campesterol, stigmasterol and ergosterol. Many insects rely on gut symbiotes sterols.
Sterols present in food need to demonstrate the absence of insect cholesterol synthesis pathways as proposed for vertebrates and microorganisms.
Synthesis starts from acetate and mevalonic acid an important intermediate. Farmeziprofosfatul is an important intermediate in the production of juvenile hormone.
Macromolecules that form the feeding insects do not penetrate the intestinal wall. It must be reduced to a form easily absorbed by the digestive process.
Digestion
It is not necessary for digestion or modification steronilor these molecules to be absorbed. Fat is digested in the gut is triacilglicerolul acilglicerol requiring long-chain ester hydrolysis. Lipolysis is performed in the presence of lipases, a class of esterases. Triacilglicerolului hydrolysis was investigated in few species, more cockroaches. The enzyme is activated in the presence of Ca 2 +, analogous to the mammalian pancreatic lipase. That mechanism involves hydrolysis of fatty acids in the first stage in position 1 and 3 of glycerol. Purification and characterization Failed enzyme. In some species, glicerintrioleina is hydrolyzed faster than tripalmitina. Eg locusts, trioleinei hydrolysis are obtained large amounts of metabolic substrate needed for prolonged periods of flight. Optimal enzymatic activity is obtained after emulsify the substrate. Do not know the nature of emulsifying agents to insects, however not as vertebrate bile salts. It seems that effect is given by acilgraspeptide emulsifier.
A. Absorption lipolytic byproducts. It is assumed that the absorption of the hydrolysis product triacilglicerolului is similar to mammals. Absorption takes the form of chylomicrons, B. sterols. In insects, sterolesterii are absorbed faster than free cholesterol.
Transport-The insect haemolymph lipids transported from place to place absorption or synthesis or storage use.
Haemolymph lipids in lipid classes that can be isolated from the haemolymph of insects are insoluble in water and therefore are not present in the haemolymph as free molecules, but form complex macromolecular lipoproteins.
Release and uptake of haemolymph lipids
1. Primary source of haemolymph is diacilglicerol triacilglicerol of body fat reserves. His release requires hydrolysis triacilglicerolului stored and reported that there lipolytic activity in fat body of a species. This includes selling a simple monoacil. It is assumed that partial hydrolysis and fatty acid triacilglicerolului diacilglicerol is the dominant process.
Diglycerides of fatty body release requires the presence of protein acceptors in haemolymph. It is possible that in some species in certain physiological conditions, lipid reserve to be released in the form of triglycerides and / or free fatty acid.

2. Capture. Lipids are an essential component of all structural and metabolic cell and thus are taken from the haemolymph in all tissues. There lipoprotein lipase that releases free fatty acids from lipoprotein complexes and they enter cells. The enzyme is activated by mucopolysaccharides, heparin, and this substance is a required part of the complex coinsiderata enzyme. If the capture of neutral lipid hydrolysis is preceded by the extracellular tissue in the immediate vicinity are expected hydrolysis rates increased during periods of increased energy demand.
Capture vitelogeninei containing lipids in the ovary appears to be preceded by selective capture of specific haemolymph lipoproteins. This explains the large amounts of triglycerides in eggs.

Use of lipid-class Insecta evolutionary success was facilitated by the ability to store large amounts of animal fat and use this substrate as an energy source for muscle activity and metabolic water as a source of supplementing the body’s water reserves. Fat is stored and transported mainly in the form of tri and diglycerides and ester hydrolysis is a necessary prelude to escape the fatty acid.
Lipase extradigestive-Little is known about the specificity of lipases extradigestive glycerides. In some species flight muscles occurs preferential hydrolysis of monoglycerides. In other species there are specific enzyme for diglycerides. Do not know anything about the positional specificity of fatty acids and digestive lipases stereospecificitatea or nature lipolytic activity control mechanisms.
-Oxidation of fatty acids in body fat has been shown for many insect species occurs β-oxidation of fatty acids. Carnitine (1,3-hydroxy-4-trimetilamoniumbutirat) is a required cofactor in some species the group serves to facilitate transport of mitochondria through the action of an acyl enzyme, canitinacil transferase.
Acyl-CoA + S-carnitine + CoA ↔ acilcarnitina
It is believed that this enzyme is localized within mitochondria. Not all insects carnitine is required cofactor for oxidation of fatty acids. It seems that the insects which use lipids as primary energy source carnitine has a small role or place in the oxidation of fatty acids. Membrane permeability for long chain fatty acids increases with temperature and it is possible that carnitine need to be more pronounced at lower temperatures and during the initial phase of flight, before the body temperature to rise.
The fate of glycerol-glycerol is also produced by the action of lipolytic enzymes, the neutral enzyme activity. It seems that glycerol is transported to body fat which is the source of glycerol 3-phosphate for re-esterification.
Formation of ketone bodies, in certain circumstances may occur ketone bodies, acetoacetate and D-3-hydroxybutyrate.

Lipid biosynthesis
Insects synthesize fatty acids, long chain fatty acids, saturated and monounsaturated CoA.Astfel any compound acetyl-CoA acetyl give can be considered a potential precursor of fatty acid:
Acetyl-CoA + 14 NADPH + 7Malonil-CoA → 14H + + 7H2O + palmitic 1Acid 14NADP + + 6H2O
In vertebrates and microorganisms, and other insects, enzymes that synthesize fatty acids are linked proteins form a cytoplasmic enzyme complex, fatty acid synthase.
The first phase of condensation can take place with propionyl-CoA instead of acetyl-CoA. In this case occurring fatty acids with odd number of carbon atoms. The vertebrate enzymes and microorganisms that synthesize fatty acids are bound to proteins and form a cytoplasmic enzyme complex, fatty acid synthase. So is the case and insects. Pyridine-nucleotide synthase only in the insect is NADPH.
Route of synthesis of fatty acids is somewhat inverse β-oxidation.
Monounsaturated fatty acids are formed naturally in the microsomal system you are desaturate saturated fatty acids to monoenoic equivalent. Monounsaturated fatty acids are cis or trans conformation be.

Glicerolii acyl-content in free fatty acids in insect tissues is relatively low, the large amount is present as the di-esterified or triacilgliceroli or fosfogliceride. Major place of synthesis of di-and triacilglicerolului body fat is.
Fosfogliceridele-In some insect orders, phospholipids majority is phosphatidylcholine (lecithin), and others is fosfatidiletanolamina. Major place of synthesis of microsomal fraction appears to be fosfoacilglicerolului. It seems that mitochondrial fosfogliceridele are transferred to mitochondria.
Invstigate and phospholipids were minor fosfatidiletanolamina ceramide, inositol fosfotidil, fosfatidilserina and fosfatidilglicerolul. They go through similar metabolic pathways in mammals:
Ceramide Ceramide + fosfatidiletanolamina + HOH → Fosfatidiletanolamina
Ceramide + HOH → Fatty acids + Sfingozina
Lipids-In cuticulare are most abundant hydrocarbons: alkanes (n-alkanes, 3-metilalcani, branched monometilalcani internal dimetilalcani internal branched), alkenes, alcadiene.

Regulating lipid metabolism of endocrine

Insects in fat content fluctuates in life. The changes reflect variations in metabolic balance between fat synthesis (including inputs by food) and use of lipids and direct or indirect result of the action of hormones and / or neurohormone. Development processes, migration, diapauza, reproduction and flight, all under the control of endocrine, lipid metabolism.
A. Factor (ii) adipokinetic (i) aqueous extracts of corpora-cardiac influence in body fat levels and haemolymph lipids in several species. Interspecific differences in response to extracts of corpora heart do not seem to result from evolutionary changes in nature adipokinetici factors.
Precise physiological role remains unspecified factors, although it seems to involve more than simple homeostatic control of lipid levels in haemolymph, rather factors provide appropriate substrates for muscle metabolism by using metabolic zbor.Comutarea carbohydrates lipids can be adjusted using The secretions of „corporate heart.” Apparent duplicity of action „adipokinetic hormone” may show cumulative effects of two or more releases factori.Corpus cardiacum contains several neurohormonal and until these factors were released, physiological roles can not be attributed to individual molecules.
Lipids are a better substrate than carbohydrates for long migratory flights, due to higher caloric content and a higher production of metabolic water by oxidation.

B. hormone from the corpus Alltum
Synthesize and secrete hormones Corpus Allatum that play important roles in regulating development and reproduction. Active molecule was isolated and characterized in several species of insects, and studies have shown that individual species often exist in several forms homosequitetpenoide molecular structures. Different molecular forms were not attributed physiological significance. Hormone induces synthesis of body Allatum vitellogeninei a few species.
Allatum corpus contribution to lipid metabolism of insect cells secreting concerning inter-relations.

C. Ecdysona
The role of the insect moulting hormone, Ecdysona in metamorphosis is known for many years. The hormone is released from the α-Ecdysona protoracice glands in response to a trophic hormone in the brain. It is believed that it acts as a precursor is converted to β-Ecdysona more active. The most obvious effect of β-Ecdysonei lysis is to initiate processes that epidermal tissue is removed from the old cuticle before moulting.
It is believed that β-Ecdysona stimulates the biosynthesis of hydrocarbons in pupare. Causes hormone release from the ovary Ecdysonei α-induced synthesis vitellogeninei rest in body fat.
Some metabolic pathways that occur in vertebrates and insects have been described, yet it is also important to recognize those aspects of lipid metabolism in which the two different classes of animals, namely:
– Insect haemolymph contains high concentrations of diacilglicerol and low levels of free fatty acids, unlike vertebrates;
– Lack of steroidogenesis in insects led to the development of the corpus Allatum hormone;
– The role of lipids in insect protection to dehydration.
Functional role of proteins
Of all known chemical compounds, proteins are the most complex and also most characteristic of living matter. They are present in all living cells, are compounds that are essential as nucleoproteins cell division process and the enzymes and hormones control many chemical reactions in cell metabolism. As the sole constituent of viruses, nucleoproteins are synonymous.

TYPE EXAMPLES
1.Proteine single enzymes, antibodies, hormones, hemoglobin
2. Associated with the protein myosin, actin, tropomyosin, troponin
3. Associated with membrane glycoproteins, lipoproteins, emphore
4. Structural protein collagen, keratinele, elastinele, fibroine
5. Nucleic acids associated with ribosomal proteins, histones, nonhistone.

Structural proteins are grouped as structural proteins or insoluble fibrous proteins and globular proteins have some structural role, but no enzymatic activity.
. One of the characteristics of contractile proteins, is the mobility of animals is associated with this contractile protein. In insects, as in other organisms differentiated contractile proteins are present in this one particular tissue and muscle. Major protein components of actin and myosin are muscles, but other components were described protein involved in muscle contraction.
. Physicochemical properties, molecular weight is between 4.58 myosin and 4.58 * 102 * 105. And distortion reduction in guanine hydrochloride disocieaza myosin heavy and light chains in. The Heavy 1.89 * 105 to 2.12 * 105 depending on the method used. Light chains can be 4, 7 * 104 or 9-15% of the total mass. Light chains may be 2.3. Proteolytic digestion gives two fragments of myosin light meromiozina (LMM) and heavy meromiozina (HMM). LMM is fibrous and globular HMM is. HMM is also an enzyme (ATPase) that ATP hydrolysis catalizeza, stimulated by Ca2 + and inhibited by Mg2 + very sensitive to pH. Myosin aggregation leads to the formation of a uniform complex and long and 6000-7000 A in diameter and weight of 100-200 A and 6.3 * 106Da ..
Actin exists in two forms, G-actin monomer globular polymer fibers and high molecular weight E-G-actin actina.La mammals is 4.3 to 4.7 * 104. G-actin contains 374 residues, corresponding to a GM 4.1 to 4.2 * 105 Yes. G-actin contains one molecule of ATP and Ca2 + (or Mg2 +). If exposed to 0.1 M Mg2 + salts are very rapidly polymerizes to F-actin, the ATP is hydrolyzed to ADP process + Pi, is truly an ATP-azica activity. By ultrasonic treatment with ATP or the reaction is reversible:
(1) G-actin-ADP + ATP → G-actin-ATP + ADP
F-actin structure seems to correspond to a double-helix arrangement of molecules with 13-15 G-actin subunit helix per tour. Dissociation rate is low when ATP is bound Ca2 + and even less when it is bound Mg2 +.
(2) Ca2 +-G-actin-Ca2 + + ATP ↔ G-actin-ATP
(3) G-actin-ATP G-actin + ATP ↔
Actomiozina is complex actin and myosin molecular. Is obtained by extraction from muscles first with water to remove enzymes glycol and then with 0.6 M KCl
Another muscle protein is tropomyosin or paramiozina. It is a coiled helix with HM 2.2 * 105 and length approx. 130-140nm.
Tropomyosin B is a double helix coiled with GM 6.3-6.8 * 104nm length.
Tropolina is not a unitary protein can be separated into three components:
– Tropolina Q: GM = 23 000
– Tropolina T: with high affinity for tropomyosin, GM = 37 000
– Tropolina C: with GM = 18 000
The three troponin seem to be in ratio 1: 1: 1.
Contractile proteins in insect-insect muscles striated muscles of vertebrates correspond. Contractile proteins are in many ways similar to those of vertebrates. Sedimentation coefficient of 2.53 S tropomyosin in the adult and larva of 2.62 S, GM = 64000-84000 for tropomyosin in the tropomyosin larva.Aparent larva is in a more polymer than that of adults. In amino acid composition of larvae and adult tropomyosin is almost identical except for Pro, His and Phe. In amino acid composition resembles that of insects paramiozinei molluscs and annelids, except that the report Glu / Asp is higher. Actomiozina of insect myosin and ATP-azica is active.
(4) ATP + H2O → ADP + Pi
ATPase activity presents apirazica because of this AND-kinase.
(5) ATP → AMP + PPI
Isolation of myosin, actin and atrial muscle tropolinei of the insect proteins revealed some differences between insects and vertebrates those muscles. The two types of myosin are approximately the same GM but different light subunit composition. Tropomyosin activation seems to be the biggest difference between vertebrate and insect muscles.
Fibroinele-Fibroinele are protein substances excreted by different species of arthropods in special glands and deposited there in solution before extrusion to form filaments. Silk plays an important role in the lives of many insects: not mentioned the importance of silk spiders alive.
Fibroina silk structures is varied in its primary and secondary structure. Were detected by β-fibroina parallel, conformation corresponding types: cross-β, α-helix and even the type of collagen. It speaks of silk from larvae of Hymenoptera (bees, wasps, ants) are α-helix type.
Fibroinele of Saturniidae have a high content of alanine and a lower Gly content and was very much studied Ser. silk from B. die. It consists of double filament fibroina dressed in a globular protein sericina. B. Fibroina of mills is a protein synthesized and secreted cocoon from the posterior end of worm silk glands. Satuniidae Fibroinele the Bombycidae and have very high content Ala and Gly. B.mori silk filaments have a diameter of 40 A ˚ consisting of two rods about 20 A ˚ in diameter. Fibroinele can be divided into five groups.
One of the problems in studying the molecular structure of silk fibroinei is the difficulty of solubilised fibroina. Classical procedures solubilization by boiling in alkaline environment degrades fibroina molecule. Newer fibroina was extracted directly from the silk gland and led GM = 3.6 * 105. By treatment with 6-8M guanine hydrochloride or urea, were obtained two fractions: one with a sedimentation coefficient 4.6 S and another with corresponding sericinei 10S sedimentation coefficient corresponding fibroinei, that GM = 3.65 * 105.
Fibroina forming cocoons in different species of insects have the same function: protection from predators, extreme temperatures, microbiological attack and the general rigors of the climate.
Silk protein biosynthesis of B-die contains 45% of Gly residues alternating especially Ala and Ser residues, so mRNA will have at least 57% of the codons for Gly. Structural gene consists of DNA double helix fibroina of 11.12 * 106 Yes
A related issue is the mechanism used fibroina the cocoon of the silk worm and other species to come out of cocoon. For this purpose, specialized cells develop to produce a large amount of a proteolytic enzyme-coconaza.
Time out, the enzyme that initially takes the form of crystal or semicristal redissolve them in optimum pH of 8.3 in a solution secreted by another gland. It is placed in contact with the cocoon and digest sericina linking silk fibers together. Cocoon structure is stable and bug finds its way out. Differentiation of these cells is under hormonal control of juvenile hormone ecdisonei. Shows a remarkable chemical similarity Coconaza with trypsin and other proteases of mammalian serine with GM approximately equal to 24 000. In amino acid composition is very similar to that of bovine trypsin. Coconaza proteolytic enzyme is different from moulting fluid, so have specific messenger RNA.

Tegument proteins, structural integrity of a tissue is maintained by the influence of physical forces and covalent concentrated between polypeptides and polysaccharides. Like the skin of vertebrates, insects exoskeleton is stable due to links between chains of specific residues of amino acids in proteins and fibrous carbohydrates. Cuticle structural proteins and enzymes participate in the setting („tanning”) known as sclerotizare. Involves hydroxylation of tyrosine to dihidroxifenilalanina Sclerotizarea (dopa) to dopamine is decarboxilata dopa decarboxylase. Dopamine is the N-N-acetyl acetildopamina. Under the action fenolazei, N-acetildopamina is oxidized to a ortochinona reacts with amino group of cuticle proteins, then oxidized to dichinona as a responsible difenoloxidaza.
Unlike fibroine, cuticulare proteins have amino acids with side chains. Amino acids in proteins cuticulare are: Asp, Glu, Ser, Gly, THR, Ala, Tyr, Val, Phe, Leu, Ileu, Pro, Hys, Lys, Cys and Met TRP and probably in small quantities.
A special type of insoluble protein is a protein called cuticulara resilina. It is possible that some proteins cuticulare be combined with putty and glycoproteins.

Collagen Collagen is the most important insoluble fiber in connective tissue. Its physiological function is to act as an inert material that transmits inextensibil exercised muscle tension, such as tendon or bone. Collagen is extremely inert to proteolytic enzymes, especially in Native and is converted into gelatin to boiling water or alkanes long. Collagen occurs in many classes of animals, including insects.
Collagen has an unusual amino acid composition: approximately one third and another third Pro Gly or Hys. Tropocolagen collagen molecule (soluble collagen or extracted) consists of three chains that are identical or not identical depending on the tissue and species. Chains are known as α1, α2 and α 3. Different types of collagen are known as I, II and III. Thus were described collagens whose molecules consist of:
– Three apparently identical chains: ex. [(Α1) I] 3, [(α1) II] 3, [(α1)] 3
– 3 different chains: ex. (Α1), (α2), (α) – 2 identical and one different: eg. [(Α1) I] 2α2
Different types of chains differ in amino acid content in some, but very likely length and GM insect asemanatoare.Organele are wrapped and in some cases separated by layers of connective tissue that separates the parenchyma of haemolymph.
Chromosomal protein histone proteins chromosomal especially, were included in the structural proteins. Yet we now know that they play a role in regulating genes.
Histone-histone proteins are associated with DNA bases. Are structural proteins, but also act as repressor activity of rocks. Are highly conserved histone proteins, have very small differences in amino acid sequences. They are classified according to chemical characteristics.

METABOLISM chitin in insects: structure, function and CHITINSINTAZELOR ADJUSTMENT AND CHITINAZELOR

Chitin is one of the most important biopolymers in nature. It is mainly produced by fungi, arthropods and nematodes. Functions as insect cuticle material support for the epidermis and trachea as peritrofice arrays, lined intestinal epithelium. Insect growth and morphogenesis are strictly dependent on the ability to remodel chitin-containing structures.
For this purpose, insects repeatedly produce chitinolitice chitinsintaze and enzymes in various tissues. Coordination of chitin synthesis and its degradation requires strict control of the participating enzymes during development. In this paper summarize recent progress in understanding the November chitin synthesis and its degradation in insects.
Insect cuticle form an exoskeleton that present only a limited ability to allow growth of the body because it is a structure more or less rigid, because this chitin and sclero-proteins. To allow growth and development of insects, they have to replace the old cuticle by shedding new one (eczuvii). Shedding is initiated by the displaced persons, which separates the old cuticle epidermal cells by liquid shedding. The fluid contains proteases that digest and chitinaze old endocuticulei main constituents, and they will be reabsorbed and recycled to the formation of cuticle us. Insects repudiate their old shell, which now is called exuvie. Shedding and hormones involved, such hormone hatching.
Chitin is a polymer of N-acetyl-β-D-glucosamine. MRI and gravimetric analysis to see that this polysaccharide, chitin, is up to 40% of dry weight depending on species and exuviei vary considerably with different types of cuticle even the same body. Chitin is associated with proteins that mainly determine the mechanical properties of cuticle. The Locust migration were observed by elecroforeza 2 – D more than 100 different proteins. One of the most well understood resilina protein, a protein-rich and proline glicocol, which gives a great cuticle elasticity of joint regions. Insects contain chitin and in the matrix lining the tube digestive.ex peritrofice two types: Type 1 is the entire digestive route, Type 2 only in the card (between the esophagus and intestine above).
Peritrofice arrays are usually 3-13% chitin. The sextant Manduco peritrofice 40% matrices also contain a mixture of proteins, glycoproteins and proteoglycans.
Chitin STRUCTURE: It is the most widespread amino polysaccharide in nature. It is estimated that annually produce nearly as much as cellulose. Especially in the exoskeleton of arthropods, cell walls of fungi, nematodes shell eggs. Chitin oligomers derivatives have been implicated as factors in communication between plants legumionoase morfogenici and Rhizobium and even in vertebrates where they can be important in the early stages of embryogenesis.
Chitin is composed of residues of N – acetyl – glucosamine linked by ties β – (1-4) – glycosidic bonds. Hydrolysis with glucosamine and N resulted chitinaza – acetyl – glucosamine. However MRI cuticle of the tobacco horn worm showed that glucosamine is not present. Tends to form chitin microfibers (also called rods or crizalide) of about 3 mm in diameter stabilized by hydrogen bonds between amino and carbonyl. Microfibres peritrofice matrix may even exceed 0.5 μ in length and are frequently associated in bundles containing parallel groups of 10 or more microfiber. X-ray diffraction suggested that it is a substance that occurs in three polymorphic crystalline modifications, called chitin α -, β – and μ -. They differ mainly in degree of hydration, the unit size and number of chitin chains. In all chains α form shows a antiparallel orientation, in the form β chains are arranged parallel, in the form μ 2 sets of parallel chains alternate with chains antiparalele single. Transient non-crystalline state were found in mushrooms. All three structures are found in crystalline forms of insect chitinase. Α is the predominant form in cuticle chitin, β and μ forms are commonly found in cocoons. Peritrofice arrays consist of α and β usually – chitin. Sometimes the presence of β – chitin in cocoons can be explained by the fact that some form of cocoons peritrofice matrices, eg the Australian spider beetle Ptinus tectus of a beetle specialist.
Antiparallel arrangement of chitin molecules in the form of α allows the fibers of chitin close packing consisting of about 20 chains of chitin stabilized by a large number of hydrogen bonds, intra and inter molecular. This arrangement contributes significantly to the physical properties – eg chemical cuticle. strength and stability. In contrast, in the forms β and μ packing strength and number of hydrogen bonds between chains are reduced, as a large number of water connections H2. The high degree of hydration and strength leading to reduced packing chitinase structures more flexible and soft, or cocoons peritrofice matrix. Differences in the arrangement of the fibers between the cuticle and chitin matrices peritrofice help understand their function. Cuticle is secreted in the form of thin layers of epidermal cells microvilii beekeeping. Of chitin microfibres are included in the matrix protein and stabilizes the reinforced concrete. Peritrofice microfibres are placed in the matrix normally in a network of structures included in an amorphous matrix and only in few cases were found highly ordered configurations.
TRAINING chitin
Trehalose (trehalose )____ β – D – glucose (hexotinaza) ___
Glucose – 6 – phosphate (glucose – 6 – phosphate isomerase)
Fructose – 6 – phosphate (glutamine: fructose – 6 – phosphate aminotransferase)
Glucosamine – 6 – phosphate (Glucosamine – 6 – phosphate N – acetyltransferase)
N – acetilglucozamin – 6 – phosphate (fosfoacetilglucozamin move)
N – acetilglucozamin – 1 – phosphate (VDP – N – acetilglucozamin pirofosforilaza
UDP – N – acetilglucozamina (chitinsintaza) chitin
Fig.1. Chitin biosynthesis in insects. The path starts with trehalose, the main sugar in many insect haemolymph.
Chitinsintaza is UDP – N – acetyl – D – Glucosamine: chitin, or
4 – β – N – acetilglucozamiltransferaza (EC2.4.1.16), an enzyme found in any organism that synthesize chitin from UDP – N – acetilglucozamina (UDP – GlcNac). It involves the formation of a lipid intermediate to form dolichildifosfo – N – acetilglucozamina. Chitinsintazele are dependent on the presence of ions Mg2 + or Mn2 +.
There are two models for the activity in vesicles Golgi chitinsintazei:
A – extravezicular
UDP – GlcNAc – chitin
B – intravezicular
UDP – GlcNAc – chitin (in cytoplasm) → sp. Extracellular
Failed to chitinsintazei purification to homogeneous substance. Optimum pH 7.2; p.I 6.1 to 6.7.
Chitin – SINTAZELE OF INSECTS: It requires a GM about. 180 kDa with 15-18 transmembrane helixuri, indicating that the enzyme is integrated membrane protein. The PCR was seen that it is detectable in all stages of development and that are located in epidermal cells under procuticula.
Fungi have multiple genes encoding isoforms of chitin synthase. Nematodes and insects have a limited number of copies of the gene.
AA sequence chitinsintazelor of fungi, nematodes and insects reveals that the enzymes of insect nematodes are closer than those of fungi.
Chitinsintazele of insects are large transmembrane protein GM 160 kDa – 180 kDa. The molecule consists of three areas: A, B, C.
A field is in the region N – terminal. A field has a variable number of transmembrane helixuri. Depending on their number, the N – terminal seems to be located in different areas of the membrane or to the extracellular environment or in the cytoplasm.
Field B is in the center of the molecule and comprises approximately 400 AA and contains the enzyme catalytic center. Is highly conserved and contains two unique reasons, EDR (Glu – Asp – Arg) and QRRRW (GLN – Arg – Arg – Arg – TRP) which are present in all types of chitin synthase and therefore can be regarded as sequences, signatures’ ‘. Some conserved residues are believed to be essential for catalytic mechanism that may be involved in substrate protonarea. Substitution of others in the AA sequences drastically reduced the activity of chitin sintazelor. 3 blocks have been described yet highly conserved in the insect chitin sintazele: CATMWHXT (Cys – Ala – THR – Met – TRP – His – THR; poz.583 – 590), QXFEY (GLN -? – Phe – Glu – Tyr; Pos . 794-798) and WGTRE (TRP – Gly – THR – Arg – Glu, pos 1076-1080 0 in a CHS protein in Drosophila.
Domain C contains the C – terminal and contains 2 AA could also be involved in catalysis: W (TRP, pos 803) and T (THR, poz.805) immediately after the transmembrane helix 5. He has seven transmembrane helixuri.
Based on sequence differences sintazele chitin were grouped into two classes: CHS – CHS A and – B. Many insects seem to have a copy of the gene for each enzyme. Both genes are located on one chromosome to Drosophilla and Anopheles, it is possible that they come from a single ancestor through gene duplication.
CHITINSINTAZELOR ADJUSTMENT: Formation and degradation of chitin is essential for insect development. Insect metamorphosis is regulated by releasing ecdisonei, a steroid hormone secreted by the gland haemolymph protoracica.
Chitinsintazelor activity is increased by limited proteolysis. It is tempting to speculate on the existence of an inactive proenzime cell pole that can be activated by specific signals. Besides proteases, regulators factors (which influence chitin synthase) exist in insects
DEGRADATION chitin: chitinolitice Chitinsintazele and enzymes work hand in hand in reshaping the structures chitin. Degradation enzymes include chitinazele {poly [1,4 – (N – acetyl – β – D – glucozaminid)] glicanohidrolaza, EC 3.2.1.14} and β – N – acetilglucozaminidazele (β – N – acetyl – β – D – hexozaminid N – acetyl – hexozaminohidrolaze, EC 3.2.1.52). All catalyze hydrolysis of bonds β – 1 – 4 – glycosidic polymers and oligomers of chitin, some of them including an enzyme catalyzes reactions of insects transglicozilare. Because enzymes that degrade chitin can be used to convert raw material components used in biotechnology, they are important for chemical and pharmaceutical industries. In addition, chitinazele and their inhibitors can be adopted for harmful insecticides or fungicides.
The organisms that produce chitin, enzymes are essential for maintaining normal chitinolitice functions lifecycle, eg. morphogenesis in arthropods or cell division in yeast and other fungi sporularea. They are also found in organisms that do not contain chitin but using chitin as a food source, for example. Streptomyces spp were identified genes in the genome nucleopoliedrozei chitinaza virus (family Baculoviridae) Autograph californica insect, virus specific to arthropods. Chitinaza baculovirus can play a crucial role in virus infectivity. For plant and vertebrate chitinazele, including those produced by human macrophages, it is believed that they act in defense against pathogens or pests that contain chitin.
Enzymes that degrade insect chitin plays a crucial role in the development postembrionara, especially larvae and impupare shedding. Chitinolitice enzymes are also found in some Hymenoptera venoms of spiders in the digestive fluids where they can facilitate prey toxins through the cuticle. Recently it was discovered a body chitinaza specific milk fat and gland tissue may be important for the development of tsetse flies intrauterine larvae of Glossina morsitans livebearers.
Because chitin is difficult to split because of its physicochemical properties, required more than one type of enzyme.
Endo – helps break down at a chitinazele Chitose – oligomers. Then converted to monomers by exo – β – N – acetilglucozaminidaze.
Enzyme exo – off units of N – acetyl – glucosamine at the end nereducator and prefer smaller than chitinazele substances. As a result the overall speed is limited by the action of chitin hirolizei chitinazei producing Chitose – oligomers, which increases the effective concentration of substrate for β – N – acetilglucozaminidaza.
The mechanism of catalysis appears to be similar to that which is supposed to cellulase complex (endo – and exocelulaza).
Interesting thing: the appearance of both enzymes appears to be chitinolitice in reverse order. In Manduca, Bombyx mills and Locustae xo – chitinaza shedding occurs earlier than endochitinaza. Since the cuticle is chitin and protein matrix strongly related, must be present and proteases.
CHITINAZELE of insects: the insects belong to the family Chitinazele 18 superfamilies glicohidrolazelor and have a high degree of similarity of the AA. Chitinazele of insects have theoretical molecular weight of 40 kDa – 85 kDa, pH optimum variable sites (4-8), variable pI (pH 5-7). Basic structure consists of three domains: the catalytic region, a region pest – like rich in AA Pro, Glu, Ser, thr and Cys-rich region. The last two areas seem to be necessary for the chitinazica.
Catalytic domain of chitinazelor the fam. 18 includes N-terminal half of the enzyme. It is believed that the N-terminal domain influences the substrate binding or hydrolysis. There are two highly conserved regions within the catalytic domain, a 2 – to include catalytic center. It has a barrel-shaped structure, forming a well. This dip is considered active center, which bind carbohydrate units of chitin, possibly portions (GLC NAC) 6.
Chitinazele of insects are anchored to the substrate through the C-terminal, characterized by six Cys reason.
This conserved acidic residues appears to be a common feature of the active site glicohidrolazelor. Since the tertiary structure of the family is similar to other chitinaze glicohidrolaze was postulated that proposes a mechanism for hydrolysis of AA preserved. FDxxDxDxE signature sequence (Phe – Asp – x – x – Asp – X – Asp – x – Glu) is found in the active site, including a change of Glu essential for catalysis. Highly conserved sequence YDFDGLDLDWEYP (Tyr – Asp – Phe – Asp – Gly – Leu – Asp – Leu – Asp – TRP – Glu – Tyr – Pro) is chitinaze family signature, by mutagenesis, by replacing the Glu in the active center, when there was loss of enzymatic activity, therefore Glu is essential for activity. Based on crystallographic data has been postulated that the active site cleft for binding hexamers N – acetilglucozamina. Catalytic mechanism of soluble byproducts are chitotetroza, chitobioza chitotrioza and (predominantly).
Chitin DEGRADATION CONTROL: Because of the vital role of chitin in insect development, its degradation should be well settled as synthesis. Chitinazelor activity in skin is restricted and impupare shedding periods, while the intestine chitinazele are induced by feeding.
Cuticle degradation by enzymes chitinolitice certainly require fluid contribution in shedding proteases that degradeza protein components. These proteases may also function in the proteolytic activation of precursors of chitinazelor reagents.
Proteolytic activation of chitinazelor was extensively investigated in Manduca and Bombyx. A probable zimogenica chitinazei form with a molecular weight of 215 kDa was observed in Bombyx during the spinning mills. 2-3 days later, when enzyme activity is detectable, there are three active fragments of 88 kDa, 65 kDa and 54 kDa, which may be the result of successive proteolytic processing. They have a common sequence N – terminally so differ in length at the C – terminal.
It was suggested that the enzyme of 88 kDa containing a chitin binding domain strongly. This domain may be lost by proteolysis from the C – terminal, resulting in variations that are more active chitinaze shorter substrates.
Similar results were observed in the skin of Manduca where a protein of 119 kDa can be considered as a precursor protein and several smaller zimogen the activated proteolytic fragments. These enzymes chitinelor degradation properties are very important. We have extracted from some species of insects chitinaze. They are able to adjust some regeneration processes of keratin formation as seborrheic warts, carcinoma, keloizii, which occur very often and the skin of humans, especially in intaintate flows (after 60). Biologically active substances extracted from insects (Lepidoptere. Colioptere, diptych) at certain stages of development were used for making special ointments „skin care”, which are able to eliminate skin chitinase or keratin formations. These formations aging human skin. The skin becomes rigid and loses its elasticity. Therefore the use of BSA in insects can occur in aging skin regeneration and treatment of various formations whose skeletons are made of keratin or chitin.
Using cheratolitice properties of these biologically active substances, we have built a range of preparations and cosmetics para very effective in treating some skin diseases. We were early, I guessed that some substances with specific insects, and humans can act.
METABOLISM INHIBITORS chitin: Because chitin metabolism is crucial for the development of fungi and arthropods, inhibition or disruption of key enzymes are important targets for the development of fungicides and insecticides. It is believed that the chitin polymers are absent from vertebrates. But later it turned out that included keratin and chitin in some formations but skin of vertebrates.
Chitin synthesis inhibitors were classified into three major groups: peptidyl nucleoside acyl urea and substances that interfere with hormonal control. Peptidyl nucleosides isolated from various species of Streptomyces and act as substrate analogs include polioxinele and nikomicinele. They inhibit both competitive chitinsintazele fungi as well as insects, probably by binding to the catalytic site. Polioxinele have found some applications in combating phytopathogenic. Nikomicinelor commercial application is uncertain, although it seems to be more potent inhibitors than polixinele. In general use nukes peptide is complicated because of low permeability, hydrolytic lability, variable susceptibility of species of fungi and the many negative responses in animals.
Acyl urea plays an important role in integrated control of insects. Although it is well established that acyl urea (enzuronul and teflubenzuron) affects the synthesis of chitin, their mode of action is unclear.
The third group of inhibitors affect hormonal regulation of insect growth and development. One of the many effects is disruption of chitin synthesis probably by inhibiting chitin synthase expression or adjustment factors. Regulating hormones may be disturbed in the biosynthesis of hormones. It was shown that some synthetic derivatives of imidazoles and prevents cholesterol biosynthesis ecdysteroidului. Heterocyclic compounds and alkaloid brevioxima arborina presents a significant blockage of juvenile hormone synthesis.
Chitinazei inhibitors can be grouped into two major classes: either mimic carbohydrate substrates or intermediates. The most studied inhibitor is allosamidina chitinazei a pseudotrizaharid. Allosamidina consists of two sugars of N – linked to a allosamizolina acetilallosamina mimicking catalytic intermediary and can not be hydrolyzed because it lacks oxygen piranozic.
Allosamidina is a potent inhibitor of chitinazei. Its production is expensive because it is difficult to synthesize. A new class of inhibitors includes alternative and argadina ciclopentapeptidele arginine. Their synthesis is cheaper.
Until now the development process of insects were studied in order to develop methods of their destruction by chemical, physical and unwanted insect population density biologice.Reglarea using chemical insecticides or physical methods of nature, adversely affect not only targeted insects but also human health. Therefore currently safe methods are needed that eliminate unwanted insects do not affect health but useful organisms. Developing these methods involve more detailed study of physiological processes of insects. With these studies, we investigated in how insects can be used for human benefit. For example, some species of insects that accumulate large amounts of energy by eating plants, is lost without any help, other tissues of insects destroyed pollute the environment and human health.
At one point, the author of this work came the idea of using insects to obtain SBA that may occur in the treatment of diseases of the worst human rights. Thus, information can induce the extraction of insect biochemistry SBA may intervene in regulating human life processes and especially the treatment of tumor diseases and viral infections, causing death of young people from ages yet. Such insects can help to increase human longevity.
We are still far from understanding how the action of enzymes involved, especially chitinsintazelor and chitinazelor. We do not know the mechanisms that control and coordinate control biosynthesis and activity during development. A major problem in the study of insects chitinsintazelor is that we still do not have a homogeneous preparation of native sources, probably due to lack of new information. Lately recombinant baculovirus, containing genes responsible for synthesis of insect chitinazelor constitute potent biocide that can disrupt the functioning of infected insects peritrofice matrix, resulting in an increased susceptiblitate than other toxic compounds. These viruses have a complicated structure and allows for obtaining recombinant genome that can be used to synthesize the major compositions for the manufacture of new pharmaceuticals. So obviously increases the importance of insects. Breeders are organized for some species of insects. Special growth direction is called Entomology insect technique.
It proposes the development of food supplements in insect tissues (Ciuhrii, 2009) or synthesis „interferons” and „cytostatic” in some insect tissues at different stages of development (Ciuhrii, 2009).
In conclusion, understanding the basic principles of insect chitin metabolism and regulation will open new avenues of pest management.

RECIPES QUALITY

Trademark „Dr.CIUHRII”

Shampoo hair care
No. Reference 206

Ingredients INCI:
Water
Cethyl Alcohol, Chloride Behentrimonium
Cetearyl Alcohol
Glycerin
Pentylene Glycol
Quercia Cortex Extract
Bombyx Extract
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Perfume
BHA
2-Bromo-2-Nitropropane-1, 3 Diol

It is recommended for dry and damaged hair after prolonged exposure to sunlight, use permanent solutions, painters, etc. repeatedly. By using secure deelectrizarea hair, restore it with suppleness, shine and vitality
Directions for use: apply after washing with a good shampoo, shampoo preferably produced by the company „The windows magique” lipoprotein complex extract extracted from certain species of insects. Washing is easy, massaging the hair and scalp. The head is wrapped in a towel and leave on for 10-15 minutes, then wash thoroughly with warm water.

Dr. trademark „M. Ciuhrii ”
Massage cellulite cream gel
No. Reference 014

INCI Ingredients
Water
Mineral oil
Lanolin
Trolatum
Caprylic / Capric Triglyceride
Extract of sage (Salvia officinalis)
Dimethicon
Bombyx Extract
Polyglyceryl-4 Isostearate, Cetyl PEG / PPG – 10 / 1 Dimethicone, Hexyl laurate
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Carbomer
Sodium hydroxide
Acrylic alkyl Acrylates/C10-30 Crosspolymer
Tocoperyl acetate
Retinyl palmitate
Perfume
2-Bromo-2-Nitropropane-1, 3 Diol.
Biologically active substances in this preparation is a complex lipoprotein extracted from insects. Absorption results in cellulite. Apply to fat areas for 15-20 minutes massage with circular movements. To achieve the desired effect needed to be massaged with ointment affected area 2 times daily for 14-24 days by a specialist in massage.

Teen cream
No. Reference 021

Ingredients INCI:
Water
Glyceryl monostearate (and) Behenyl Alcohol (and) Palmitic Acid (and) Stearic Acid (and) Lecithin (and) Lauryl Alcohol (and) Myristyl Alcohol (and) Cetyl Alcohol
Lanolin
Caprylic / Capric Triglyceride
Glycerin
Pentylene Glycol
Extract of Humulus lupulus
Cetearyl Alcohol
Oil Calendulae
Butyrospermum parkii
Stearic acid
Tea Tree Oil (Malaleuca alternifolia)
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Bombyx Extract
Allantoina
BHA
2-Bromo-2-Nitropropane-1, 3 Diol
C.I. 42 090
Cream can solve problems and eliminate infections caused by streptococci stafilococci and that adolescents often appear on the skin. And absorption can solve keloizilor arising from infection and trauma after shaving.
To use: apply the cream at night before bed, in one or two coats, depending on disease severity and left to act overnight. Morning is removed using warm water and soap with glycerin, then apply a cream shadow you want or after shave.

Mark „FLY-FLY”
Body Massage Cream
No. Reference 012

INCI Ingredients
Water
Mineral oil
Pentylene Glycol
Cetearyl Isononanoat
Bombyx Extract
Glycerin
Extract of Sp. Plantago
Calendulae Officinalis Oil
Polyglyceryl-4 Isostearate, Cetyl PEG / PPG – 10 / 1 Dimethicone, Hexyl laurate
Urea
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Carbomer
Sodium hydroxide
Acrylic alkyl Acrylates/C10-30 Crosspolymer
Allantoin
Tocopheryl Acetate
Retinyl palmitate
2-Bromo-2-Nitropropane-1, 3 Diol
It is recommended for sensitive skin care and treatment of pain due to spurs on the spine. It is indicated in spondylosis, spondylitis and inflammation.
Usage: Apply a thin layer gently massaging the affected areas until complete absorption of the ointment. In acute cases ointment application is twice a day. Morning and evening. To avoid allergic reactions before applying, the areas affected by alcohol mint pellet of 70%.

Mark ‘FLY – FLY ”
Cleavage care cream
No. Reference 017

Ingredients INCI:
Water
Mineral oil
Lanolin
Pentylene Glycol
Petrolatum
Glycerin
PEG-40 castor oil, hydrogenated
Bombyx Extract
Calendulae Officinalis Oil
Polyglyceryl-4 Isostearat, Cetyl PEG / PPG – 10 / 1 Dimethicone, Hexyl laurate Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Carbomer
Sodium hydroxide
Acrylic alkyl Acrylates/C10-30 Crosspolymer
Perfume
BHA
2-Bromo-2-Nitropropane-1, 3 Diol.
Lipogel cleavage applying for care, especially in cases of developing breast lump and breast cysts. It also works on warts around the neck. Quickly penetrates deep Lipogelul by restoring skin tissue elasticity.
Usage: Apply 2-3 layers of cream gently massaging the affected areas (neck, breasts) until completely absorbed skin ointment. The circular is breast massage in the affected areas easily. In the neck, if there papilloma, intense massage is applied with fingers massaging each skin formation. The treatment is applied two times a day, morning and evening. Massage until complete absorption into the skin ointment.

Mark „FLY-FLY”
Gel dentifrices and gums
No. Reference 101

INCI Ingredients
Water
Sorbitol
Alcohol
Glycerin
Bombyx Extract
Polysorbate 80
Carbomer
Mentha piperita oil
Methylparaben
Allantoina
Propylparaben
2-Bromo-2-Nitropropane-1, 3 Diol
C.I. 42 090
Protein gel includes anti-inflammatory, antibacterial and antifungal agents that eliminate diseases caused by candidiasis, stafilococci, streptococci. Consistency strengthens the gums, bleeding stops.
Usage: The gel is applied in the evening before bedtime. The index finger and massage the gums above the bottom, then mouth. The gel is mixed with saliva and then swallow it in small sips, so as to form a film across the esophagus. During the night salivary glands slow work and preparation works for a longer time.

Mark „TO SHOWCASE MAGIQUE”
Gel mask for teens
No. Reference 061

INCI Ingredients
Water
Alcohol
Pentylene Glycol
Glycerin
PEG-40 castor oil, hydrogenated
Tea Tree Oil (Malaleuca alternifolia)
Bombyx Extract
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Polysorbate 80
Carbomer
Sodium hydroxide
Allantoina
2-Bromo-2-Nitropropane-1, 3 Diol
C.I. 42 090
Mask – gel is recommended teenagers who irritated skin with a tendency toward acne. Can be used throughout the body affected, especially for front, back or chest.
Usage: apply mask throughout the infected area two or three layers with your fingers gently massaging until complete absorption. To accelerate the healing process, the mask is applied thicker layer at night before bed.
Mark „Dr.CIUHRII”
Cavitatatii oral care gel
No. Reference 102
INCI Ingredients
Water
Sorbitol
Alcohol
Glycerin
Hippophae rhamnoides Extract
Bombyx Extract
Carbomer
Mentha piperita oil
Sodium hydroxide
Methylparaben
Acrylic alkyl Acrylates/C10-30 Crosspolymer
Allantoina
Propylparaben
2-Bromo-2-Nitropropane-1, 3 Diol
C.I. 42 090
It is recommended to disinfect the mouth, if there are unpleasant odors. Adjust the pH of the mouth, stops bleeding gums. Remove esophageal varices.
Usage: it manages the preparation of a special or well-washed finger. The gel is applied to the gums and mouth tissue massage gently then mix well with saliva and swallow it in small sips to form a layer across the esophagus.

Mark „FLY-FLY”
Intimate gel H
No. Reference 152

INCI Ingredients
Water
Mineral oil
Propylene Glycol
Glycerin
Dimethicone
Polyglyceryl-4 Isostearat, Cetyl PEG / PPG – 10 / 1 Dimethicon, Hexyl laurate
Isopropyl Myristica
Bombyx Extract
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Calendulae Officinalis Oil
Carbomer
Sodium hydroxide
Allantoina
Acrylic alkyl Acrylates/C10-30 Crosspolymer
2-Bromo-2-Nitropropane-1, 3 Diol.
It is a remedy for hemorrhoids and anal fistulas.
To use: Apply immediately after stool around the anus and rectum. After this procedure is mandatory that the patient is placed in the supine train lower than higher education, for 20-30 minutes. If internal hemorrhoids preparation is applied with a pump designed for aspiration of nasal secretions chewing in children. Previously preparing a solution consisting of a gram of gel and 30 ml of warm water that is drawn into the pumped after that, is inserted into the rectum after stool ..

Mark „FLY-FLY”
Gel for mouth care
No. Reference 103

INCI Ingredients
Water
Sorbitol
Alcohol
Glycerin
Extract of sage (Salvia officinalis)
Bombyx Extract
Carbomer
Mentha piperita oil
Sodium hydroxide
Allantoina
Acrylic alkyl Acrylates/C10-30 Crosspolymer
Methylparaben
Aluminium lactate
Propylparaben
2-Bromo-2-Nitropropane-1, 3 Diol
C.I. 42 090
Gel is recommended for disinfection of the mouth, eliminating unwanted microflora at the mouth and causing an unpleasant odor.
Usage: The gel is applied with a special device on the gums and mouth at night before bed. The liquid is mixed with saliva and swallowed in small sips. This formareaza a film on the entire esophagus. Mornings is gargling with solution A and B alternative: A solution one day and another day with solution B.

Mark „FLY-FLY”
Intimate gel V
No. Reference 151

INCI Ingredients
Water
Mineral oil
Propylene Glycol
Glycerin
Dimethicon
Polyglyceryl-4 Isostearat, Cetyl PEG / PPG – 10 / 1 Dimethicon, Hexyl laurate
Isopropyl Myristica
Bombyx Extract
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Carbomer
Sodium hydroxide
Acrylic alkyl Acrylates/C10-30 Crosspolymer
2-Bromo-2-Nitropropane-1, 3 Diol
Gel for removal of unwanted microbial flora of the genital areas.
Usage: Apply in the evening after the general hygiene in the intimate areas. It can be used both women and men. Application in women can be both external and internal in the event of vaginitis.

Mark „FLY-FLY”
Ankle care cream

No. Reference 042
Ingredients INCI:
Water
Caprylic / Capric Triglyceride
Cetearyl Alcohol
Ceteareth – 30
Isopropyl Myristica
Butyrospermum parkii
Pentylene Glycol
Glycerin
PEG-40 castor oil, hydrogenated
Extract of Plantago
Aesculus hippocastanum Extract
Dimethicon
Mineral oil
Grapeseed oil (Vitis vinifera)
Bombyx Extract
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Perfume
BHA
2-Bromo-2-Nitropropane-1, 3 Diol.
The drug is designed to treat varicose veins and thrombophlebitis of the lower limbs and anticuperotic effect.
Usage: apply ointment 2 times a day, morning and evening or night twice at an interval of 2-3 hours. Areas affected by massage with ointment that are completely absorbed by the skin. Massage is done from top to bottom (from knee to foot).

Mark „FLY-FLY”
Skin care cream
No. Reference 011

Ingredients INCI:
Water
Ceteareth-30
Pentylene Glycol
Cetearyl Alcohol
Lanolin
Isopropyl Myristica
Cetyl Alcohol
Bombyx Extract
Glycerin
Castor oil PEG-40 Hydrogen
Butyrospermum parkii
Castor oil (Ricinus communis)
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Carbomer
Perfume
BHA
2-Bromo-2-Nitropropane-1, 3 Diol.
It is designed to eliminate unwanted configurations on human skin such as moles, moles, seborrheic warts, wrinkles, warts, melanomas, frames, corns and other skin formations.
Usage: before administration of keratolytic ointments, wash affected area thoroughly, apply ointment and massage until complete absorption. It is administered 2 times a day: morning and evening. Active substances in this preparation are able to destroy skin skeleton formations, which is then removed from the body is recognized as „foreign body”. Thus, cutaneous formations to remove without causing unwanted pain and marks on the skin.

Mark „M. Ciuhrii»
Lotion for teenagers
No. Reference

INCI Ingredients
Water
Alcohol
Pentylene Glycol
Glycerin
PEG-40 castor oil, hydrogenated
Tea Tree Oil (Malaleuca alternifolia)
Extract of Humulus lupulus
Allantoina
2-Bromo-2-Nitropropane-1, 3 Diol.
Is for teenagers with skin infections caused by streptococci stafilococci and whose action is stimulated under the influence of juvenile hormone.
Usage: Apply with cotton wool or gauze especially throughout the affected area before applying ointments and specific mask.

Mark „M. Ciuhrii»
Hair lotion
No. Reference 191

INCI Ingredients
Water
Alcohol

It is designed to stop hair loss, increase capacity and enable them shine and vigor of the hair. And eliminate dandruff lotion on the scalp surface.
Usage: After washing hair with shampoo produced by „TO SHOWCASE MAGIQUE”, apply lotion and massage the scalp to the hair root for 15-20 minutes, until the perfect uniformity of the preparation.

Mark „FLY-FLY”
Body Massage Cream
No. Reference 015

INCI Ingredients
Water
Lanolin
Petrolatum
Aesculus hippocastanum Extract
Stearic acid
Mineral oil
Cetyl Alcohol
Pentylen Glycol
Rosmarinus Officinalis Oil
Glycerin
Bombyx Extract
Glyceryl stearate
Grapeseed oil (Vitis vinifera)
Sodium hydroxide
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
BHACamphor
2-Bromo-2-Nitropropane-1, 3 DiolMethyl Nicotine
It is designed to massage the whole body, especially joints and upper leg pain. The drug can replace conventional grease used for massages. Ointment has an anti-inflammatory and antirheumatic.
How to use + Re: The cream is applied all over. If spondylosis applied along the spine. Two fingers are moving up and down until the ointment is totally absorbed by the skin. In case of rheumatic pain, massage is done along the joints.
Mark „TO SHOWCASE MAGIQUE”
Gel mask for teens
No. Reference 061

INCI Ingredients
Water
Alcohol
Pentylene Glycol
Glycerin
PEG-40 castor oil, hydrogenated
Tea Tree Oil (Malaleuca alternifolia)
Bombyx Extract
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Polysorbate 80
Carbomer
Sodium hydroxide
Allantoina
2-Bromo-2-Nitropropane-1, 3 Diol
C.I. 42 090
Mask – gel is recommended teenagers who irritated skin with a tendency toward acne. Can be used throughout the body affected, especially for front, back or chest.
Usage: apply mask throughout the infected area two or three layers with your fingers gently massaging until complete absorption. To accelerate the healing process, the mask is applied thicker layer at night before bed.
Mark „Dr.CIUHRII”
Cavitatatii oral care gel
No. Reference 102
INCI Ingredients
Water
Sorbitol
Alcohol
Glycerin
Hippophae rhamnoides Extract
Bombyx Extract
Carbomer
Mentha piperita oil
Sodium hydroxide
Methylparaben
Acrylic alkyl Acrylates/C10-30 Crosspolymer
Allantoina
Propylparaben
2-Bromo-2-Nitropropane-1, 3 Diol
C.I. 42 090
It is recommended to disinfect the mouth, if there are unpleasant odors. Adjust the pH of the mouth, stops bleeding gums. Remove esophageal varices.
Usage: it manages the preparation of a special or well-washed finger. The gel is applied to the gums and mouth tissue massage gently then mix well with saliva and swallow it in small sips to form a layer across the esophagus.

Mark „FLY-FLY”
Intimate gel H
No. Reference 152

INCI Ingredients
Water
Mineral oil
Propylene Glycol
Glycerin
Dimethicone
Polyglyceryl-4 Isostearat, Cetyl PEG / PPG – 10 / 1 Dimethicon, Hexyl laurate
Isopropyl Myristica
Bombyx Extract
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Calendulae Officinalis Oil
Carbomer
Sodium hydroxide
Allantoina
Acrylic alkyl Acrylates/C10-30 Crosspolymer
2-Bromo-2-Nitropropane-1, 3 Diol.
It is a remedy for hemorrhoids and anal fistulas.
To use: Apply immediately after stool around the anus and rectum. After this procedure is mandatory that the patient is placed in the supine train lower than higher education, for 20-30 minutes. If internal hemorrhoids preparation is applied with a pump designed for aspiration of nasal secretions chewing in children. Previously preparing a solution consisting of a gram of gel and 30 ml of warm water that is drawn into the pumped after that, is inserted into the rectum after stool ..
Mark „FLY-FLY”
Gel for mouth care
No. Reference 103

INCI Ingredients
Water
Sorbitol
Alcohol
Glycerin
Extract of sage (Salvia officinalis)
Bombyx Extract
Carbomer
Mentha piperita oil
Sodium hydroxide
Allantoina
Acrylic alkyl Acrylates/C10-30 Crosspolymer
Methylparaben
Aluminium lactate
Propylparaben
2-Bromo-2-Nitropropane-1, 3 Diol
C.I. 42 090
Gel is recommended for disinfection of the mouth, eliminating unwanted microflora at the mouth and causing an unpleasant odor.
Usage: The gel is applied with a special device on the gums and mouth at night before bed. The liquid is mixed with saliva and swallowed in small sips. This formareaza a film on the entire esophagus. Mornings is gargling with solution A and B alternative: A solution one day and another day with solution B.

Mark „FLY-FLY”
Intimate gel V
No. Reference 151

INCI Ingredients
Water
Mineral oil
Propylene Glycol
Glycerin
Dimethicon
Polyglyceryl-4 Isostearat, Cetyl PEG / PPG – 10 / 1 Dimethicon, Hexyl laurate
Isopropyl Myristica
Bombyx Extract
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Carbomer
Sodium hydroxide
Acrylic alkyl Acrylates/C10-30 Crosspolymer
2-Bromo-2-Nitropropane-1, 3 Diol
Gel for removal of unwanted microbial flora of the genital areas.
Usage: Apply in the evening after the general hygiene in the intimate areas. It can be used both women and men. Application in women can be both external and internal in the event of vaginitis.

Mark „FLY-FLY”
Ankle care cream

No. Reference 042
Ingredients INCI:
Water
Caprylic / Capric Triglyceride
Cetearyl Alcohol
Ceteareth – 30
Isopropyl Myristica
Butyrospermum parkii
Pentylene Glycol
Glycerin
PEG-40 castor oil, hydrogenated
Extract of Plantago
Aesculus hippocastanum Extract
Dimethicon
Mineral oil
Grapeseed oil (Vitis vinifera)
Bombyx Extract
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Perfume
BHA
2-Bromo-2-Nitropropane-1, 3 Diol.
The drug is designed to treat varicose veins and thrombophlebitis of the lower limbs and anticuperotic effect.
Usage: apply ointment 2 times a day, morning and evening or night twice at an interval of 2-3 hours. Areas affected by massage with ointment that are completely absorbed by the skin. Massage is done from top to bottom (from knee to foot).

Mark „FLY-FLY”
Skin care cream
No. Reference 011

Ingredients INCI:
Water
Ceteareth-30
Pentylene Glycol
Cetearyl Alcohol
Lanolin
Isopropyl Myristica
Cetyl Alcohol
Bombyx Extract
Glycerin
Castor oil PEG-40 Hydrogen
Butyrospermum parkii
Castor oil (Ricinus communis)
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Carbomer
Perfume
BHA
2-Bromo-2-Nitropropane-1, 3 Diol.
It is designed to eliminate unwanted configurations on human skin such as moles, moles, seborrheic warts, wrinkles, warts, melanomas, frames, corns and other skin formations.
Usage: before administration of keratolytic ointments, wash affected area thoroughly, apply ointment and massage until complete absorption. It is administered 2 times a day: morning and evening. Active substances in this preparation are able to destroy skin skeleton formations, which is then removed from the body is recognized as „foreign body”. Thus, cutaneous formations to remove without causing unwanted pain and marks on the skin.

Mark „M. Ciuhrii»
Lotion for teenagers
No. Reference

INCI Ingredients
Water
Alcohol
Pentylene Glycol
Glycerin
PEG-40 castor oil, hydrogenated
Tea Tree Oil (Malaleuca alternifolia)
Extract of Humulus lupulus
Allantoina
2-Bromo-2-Nitropropane-1, 3 Diol.
Is for teenagers with skin infections caused by streptococci stafilococci and whose action is stimulated under the influence of juvenile hormone.
Usage: Apply with cotton wool or gauze especially throughout the affected area before applying ointments and specific mask.

Mark „M. Ciuhrii»
Hair lotion
No. Reference 191

INCI Ingredients
Water
Alcohol

It is designed to stop hair loss, increase capacity and enable them shine and vigor of the hair. And eliminate dandruff lotion on the scalp surface.
Usage: After washing hair with shampoo produced by „TO SHOWCASE MAGIQUE”, apply lotion and massage the scalp to the hair root for 15-20 minutes, until the perfect uniformity of the preparation.

Mark „FLY-FLY”
Body Massage Cream
No. Reference 015

INCI Ingredients
Water
Lanolin
Petrolatum
Aesculus hippocastanum Extract
Stearic acid
Mineral oil
Cetyl Alcohol
Pentylen Glycol
Rosmarinus Officinalis Oil
Glycerin
Bombyx Extract
Glyceryl stearate
Grapeseed oil (Vitis vinifera)
Sodium hydroxide
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
BHACamphor
2-Bromo-2-Nitropropane-1, 3 DiolMethyl Nicotine
It is designed to massage the whole body, especially joints and upper leg pain. The drug can replace conventional grease used for massages. Ointment has an anti-inflammatory and antirheumatic.
How to use + Re: The cream is applied all over. If spondylosis applied along the spine. Two fingers are moving up and down until the ointment is totally absorbed by the skin. In case of rheumatic pain, massage is done along the joints.

Mark „FLY-FLY”
Foot care cream
No. Reference 041

Ingredients INCI:
Water
Caprylic / Capric Triglyceride
Cetearyl Alcohol
Ceteareth-30
Isopropyl Myristica
Butyrospermum parkii
Pentylene Glycol
Glycerin
PEG-40 castor oil, hydrogenated
Calendulae Officinalis Extract
Aesculus hippocastanum Extract
Dimethicon
Mineral oil
Grapeseed oil (Vitis vinifera)
Bombyx Extract
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Carbomer
Perfume
BHA
2-Bromo-2-Nitropropan-1, 3 Diol.
Cream is effective in treating varicose veins because the vessel dilator effect and improves peripheral circulation in the legs affected. It is recommended for swollen feet, tired, in peripheral circulation disorders.
Usage: massage top is down to the feet, until total absorption by the skin ointment. After massage massaged skin surface becomes red, because the ointment and the vasodilator effect trombele dissolve and disappear completely after 30-40 days. Cream eliminates all types of edema in the human body
Mark „FLY-FLY”
Flaky skin cream
No. Reference

Ingredients INCI:
Water
Mineral oil
Propylene Glycol
Bombyx Extract
Glycerin
Dimethicon
Polyglyceryl-4 Isostearat, Cetyl PEG / PPG – 10 / 1 Dimethicon, Hexyl laurate Isopropyl Myristica
Urea
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Kitozan kitina obtained from insect
Carbomer
Sodium hydroxide
Acrylic alkyl Acrylates/C10-30 Crosspolymer
Tocopheryl Acetate
Retinyl palmitate
2-Bromo-2-Nitropropane-1, 3 Diol.
Cream has a very fine structure, with property and regeneration of the skin to exfoliate layers of dead cells. Apply on dry skin and flaking areas, with a strong softening and moisturizing.
Usage: The cream is applied to all affected areas and massage until complete absorption of circular ointment to the skin.
Cream regenerate epithelial tissue elasticity and suppleness restore them.

Mark ‘FLY-FLY ”
The solution

No. Reference 121

INCI Ingredients
Water
Sodium hydroxide

It is an alkaline solution, used for disinfection lipogelului nails before applying nail, when treating fungal infections. Apply according to instructions on set.

Mark „FLY-FLY”
Solution B
No. Reference 122

INCI Ingredients
Lactic acid
Water

It is an acidic solution, used for disinfection lipogelului nails before applying nail fungal infections during treatment. A solution is given alternately every three days to complete elimination of infection.
Usage: At 200 ml boiled and cooled water add two tablespoons of solution A or B, mix well. Feet or hands are infected with fungi are introduced into this solution for 10 to 15 minutes.

„Brand” FLY-FLY ”
Special cleaning solution

No. Reference 161

INCI Ingredients
Water
Sodium hydroxide
Soda
Sodium chloride
Potassium iodid
2-Bromo-2-Nitropropan-1, 3 Diol
C.I. 14 700

Solution: 200 ml boiled and cooled water add 200 ml solution and wipe the face or affected tissue to open the pores and for the ointment to penetrate the tissue better.
Usage: The solution is applied 10-15 minutes before using creams. The solution is applied to the affected area with a cotton ball or gauze.

Mark „FLY-FLY”
Lipogel for nail care
No. Reference 141

INCI Ingredients
Aqua
Ceteareth-15 (and) Glyceryl stearate
Caprylic / Capric Triglyceride
Isopropyl Myristica
Castor oil (Ricinus communis)
Cetyl Alcohol
Bombyx Extract
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Carbomer
BHA
Aroma2-Bromo-2-Nitropropan-1, 3 Diol.

Ointment can be designed to treat fungal infections of the nails and adjacent regions, to remove unwanted microbial flora on the hands and feet.
Usage: apply ointment every night before bed on nails and infected foot. Massage until complete absorption into the skin. Before applying lipogels, disinfect the affected nails alternatively, 3 days then 3 days with Solution A Solution B

Mark „FLY-FLY”
Cream for stretch marks
No. Reference 016

Ingredients INCI:
Water
Caprylic / Capric Triglyceride
Cetearyl Alcohol
Ceteareth-15 (and) Glyceryl stearate
Isopropyl Myristica
Butyrospermum parkii
Pentylen Glycol
Glycerin
PEG-40 castor oil, hydrogenated
Calendulae Officinalis Extract
Dimethicon
Mineral oil
Grapeseed oil (Vitis vinifera)
Bombyx Extract
Propylene Glycol (and) Diazolidinyl Urea (and) Methylparaben (and) Propylparaben
Perfume
BHA
2-Bromo-2-Nitropropan-1, 3 Diol

Cream is specially constructed to eliminate stretch marks in women, especially after childbirth or after changes in metabolism (supraponderenta and sudden weight loss). Has the ability to change skin tissue consistency so that the structure of its own level without leaving undesirable traces on the skin.
Usage: apply cream to sleep at night throughout the affected area, massaging gently over the stretch marks to complete absorption of the ointment.
Suppository

Water
Cocoa Seed Butter (Theobroma cacao)
Polyglyceryl-4 Isostearat, Cetyl PEG / PPG – 10 / 1 Dimethicon, Hexyl laurate
Bombyx Extract
2-Bromo-2-Nitropropan-1, 3 Diol

Suppositories are administered immediately after the seat is used to treat internal hemorrhoids and anal fistulas. They have a positive effect on prostate adenoma, if it exceeds the volume of 48 cm3.
Usage: After each seat, rinse with warm water, rectal suppository is inserted, then kept supine position for 30-35 minutes, the basin above the head.
Withdraw completely after treatment hemorrhoids, anal fissures are closed and no more bleeding and an enlarged prostate shrinks in volume.

Mark „Dr. M. Ciuhrii
Preparation „HEPATITO-LIZ”

The drug is useful for improving liver infection caused by viruses A, B, C, D, E, G.
The effect of preparation is based on several types of proteins extracted from several species of insects. No. It is patented ….. and registered at the Ministry of Health of Romania no.,,, has a miraculous effect on stopping the virus multiplication step nucleic acids in nucleocapsid assembly. The principle of action-LIZ HEPATITO preparation differs essentially from interferons and vaccines. It is based on non-specificity of viruses, creating an unfavorable environment for copying them. Thus the presence of a nonspecific protein block normal replication of viruses.
The drug is produced in the form of gray or yellow powder, which is placed in special capsules, which do not allow her breakdown in the first segment of the stomach. Capsule dissolution occurs in the duodenum, which is rapidly absorbed into the bloodstream and is transported throughout the body, including liver cells.
Usage: is administered by two capsules daily on an empty stomach. One capsule morning, an hour before breakfast with a glass of this tea, after which the patient lie on the right side for an hour and another capsule in the evening, two hours after last meal with mint tea or wolf’s claw, which acts during sleep.
The drug is given several months. Every three months the analysis are: transaminases, viremia, electrophoresis, complete blood count, ultrasound, showing the evolution of the curative process. According to this analysis or further treatment is recommended.
Experience of many years showed us that preparation has a regeneration of liver function, lowers blood cholesterol, triglycerides micsoreza raise the whole body resistance.

MARK „Dr Ciuhrii»
Preparation „immuno-MAX”

Designed to lift immunity and stimulating the energy of the entire operating system.
Component: proteins extracted from insects placed in gelatin capsules;
Usage: The preparation is adiministreaza on an empty stomach to absorb more blood, morning and evening before meals, two hours after eating.
It is a powerful stimulator of energy especially for dystrophic children.
The drug has a beneficial effect in patients infected with HIV / AIDS.
Of the 200 patients infected with HIV, 75% of those using immuno-MAX preparation added weight and levels of CD4 and CD8 were obviously improved, the platelet count increased obviously. Their body’s physiological condition has improved and patients have become resistant to candidiasis and tuberculosis.
After treatment for 12 months with immuno-MAX, patients infected with HIV mortality was zero, compared with patients receiving antiretroviral, where mortality occurred in 50%. The data obtained are encouraging and we hope to develop a technology for obtaining the drug in larger quantities to help our patients more desperate.

INSECT BIOCHEMISTRY
The larvae of insect species can replace carbohydrates with protein or fatty foods. For many species, the optimal concentration of carbohydrates in the diet is in close range. Instead, larvae that require high concentrations of carbohydrate food, eg larvae that feed on starch. Some of them use branched polysaccharide amylopectin better than linear saccharide amylase.
Adults consume carbohydrates as an energy source for flight, reproduction, and longevity. Besides the need for sugars and starches, insects require a source of carbohydrate conjugates and derivatives in the form of vitamins and related compounds: vitamin B2 (riboflavin), vitamin B12 (cyanocobalamin). Vitamins are required for hydrogen transfer reactions, transmetilari in gluconeogenesis. Vitamin C (ascorbic acid) seems to have nonspecific antioxidant role.
Enozitolul (hexahidroxiciclohexanul) can exist in several isoforms, but only four are found naturally (myo-, scillo-, neo-, chiroenozitolul) in insects and other organisms. Isomer „mio” is very important because it is the only isomer which is incorporated in fosfatidilenozitol, essential structural component of cell membranes and in the cell. Insect tissues it is present in much lower concentration than the two main phospholipids in insects, phosphatidylcholine and fosfatidiletanolamina.
As far as we know, proteins are the most complex and also most characteristic of living organisms. They are present in all living cells and their components as nucleoproteins, which are essential in cell division processes, enzymes and hormones that control many chemical reactions in cell metabolism.
As the sole constituent of viruses, nucleoproteins are synonymous with the most elementary forms of life. Cells are found free in cytoplasm or associated with other molecules.
Spectacular progress in protein synthesis research has produced a revolution in our understanding of the functioning of biosynthetic processes. This gave the opportunity to discover another mechanism of cellular systems.
Genetic information contained in DNA is transferred by the phenomenon of messenger RNA transcription. Ribosome at translation takes place, where information messenger RNA is used to synthesize specific amino acid sequence that chain. This translation is an expression of the genetic code and thus result in proteins that characterize an organization.
Traditional classification is based on protein solubility, ionic properties and function. As dynamic constituents of cells, proteins can be classified on the basis of associated structures.
Globular protein unrelated proteins correspond, in classical classification, they are the albumin and globulin. Many of these proteins are enzymes, antibodies, protein hormones and contractile proteins.
Nucleoproteins correspond either nucleic acids associated protein (histone and nonhistone) or ribosomal nucleic acids. Proteins associated with cell membranes are the lipoproteins, protein carriers, glycoproteins, mucoproteine.
Finally, there are proteins that have enzymatic activity and serve as structural skeletons. In this category are: collagen, elastin, keratin and fibroina. Fibrillar proteins are also known as,, passive”and are made of rigid molecules that contain a high degree of inter-and cross-links intrapeptidice.
In contrast to the fibrillar proteins, protein „active” are capable of recognition and catalysis of reactions at the molecular level. In this category are enzymes. Proteins, active enzymes”were not named emfori.
It is unfortunate that only a few proteins in insects have been obtained pure. As a result, information about the chemical structure of proteins in insects is insufficient.
PROTEIN STRUCTURE

Proteins are grouped by structure or insoluble fibrous and globular with a structural role, but no enzymatic activity.
Fibrous protein studies are often complicated by the wide variety of cross connections, either between themselves or with other components.
Such links are difficult subunit precursor recognition and isolation, examining the primary structure so as to be very difficult.
Protein structure is no exception to the general rule, namely that govern three-dimensional structure primary structure.
. The proteolytic digestion of myosin result: easy meromiozina (LMM) and heavy meromiozina (HMM). Meromiozina is easy while the fibrous protein is a globular protein meromiozina hard.
Meromiozina hard is also an enzyme that catalyzes the hydrolysis of ATP, adenosine triphosphate ase (ATP). ATP activity – azei is stimulated by Ca2 + and inhibited by Mg2 + and is very sensitive to pH. After proteolysis, only retain the activity of ATP meromiozina – azei.
Overcrowding links form a complex of myosin uniform length 6000 – 7000 A diameter of 100 – 200 A and particle weight of 6.3 ּ 106 daltons. Actin exists in two forms, namely: monomer globular G – actin and polymer fiber with a high molecular weight, F – actin.
After a few years, molecular weight of breast muscle G actin was considered 5.5 to 6 ּ 104, but recent determinations show 4.3 to 4.7 ּ 104.
G-actin contains 374 residues indicating a molecular weight of 4.1 to 4.2 ּ 105 daltons. This value is similar to values reported in a variety of animals from invertebrates that trout in amoeba. G-actin contains one mole each ATP and Ca ² + (or Mg ² +) per mole of actin. Idepartarea ATP, or Ca ² + chelating agents like EDTA leads to inactivation and dimerization, but there is no further aggregation.
If G-actin is exposed to 0.1 M salt containing Mg ² +, polymerizes rapidly to F – actin. In the process, ATP is hydrolyzed to ADP (adenosine phosphate) and Pi. While ADP in F-actin does not change easily with the ATP, actin can not be considered ATPase. By ultrasonicare or mechanical rupture in the presence of ATP, the reaction can be reversed.
G-actin – ADP + ATP → G-actin – ATP + ADP.
In these artificial conditions, F-actin may be an ATPase. It is unclear whether ATP hydrolysis of G-actin polymerization is the F-actin. F-actin structure corresponds to a double helix arrangement of molecules with G-actin subunits 30-50 of spiral helix flow. Functions Mg ² +, Ca ² + changed nucleotides alternating with G-actin can be explained by the presence of a high affinity for Mg ² +, Ca ² + in G-actin site occupation is needed to stabilize actin complex – nucleotides. Speed is low when ATP dissociation ² As + is bound.
As a ² + – G actin – ATP ß à As ² + + Gactina – ATP
G actin – ATP + ATP → G-actin
Actomiozina is a molecular complex consisting of actin and myosin. Is obtained by extraction from muscle, first with water to remove enzymes and then with 0.6 M glicolitice KCl. After the second extraction solvent is a solution viscosity ridicata.Cand actimiozina pure solution is sprayed through a narrow hole, over a dilute solution of salt, actomiozina precipitate in the form of long filaments. These filaments, when exposed to ATP in the presence of K + and Mg ² + contract in the most dramatic way while ATP is hydrolyzed to behave like insects ADP.Actomiozina actomiozina vertebrates, although different ions at pH = 7 and t = 0 and C are soluble in concentrations of KCl to 0.3 M and precipitate between 28-32% ammonium sulphate in the presence of 0.5 M KCl, as does rabbit actomiozina. In the presence of ATP contraction of actomiozina ball in the form of tubes is called superprecipitare. Actomiozina of insects from 0.03 to 0.11 M KCl at pH = 7 and t = 25 ° C show typical superprecipitarea.
Also in actomiozina rabbit, Mg ² + is required for superprecipitare.
Another muscle protein is tropomyosin A (paramiozina). Corresponds to a height of 2.2 ּ helix 105 and a length of 130-140 mm. Tropomyosin B is a double-stranded helix with two chains, with height of 6.3 to 6.8 ּ 104 and a length of 40 mm.
Molecule is separated into two identical units in certain conditions. α-Actinina actomiozinei activity increases ATP – ase, under certain conditions increase the rate superprecipitarii, increase blood actomiozinei chains. The protein forms a complex with F – actin whose training is inhibited by tropomyosin. Molecular weight is 1.8 ּ 105 with sedimentation coefficient of 6.35. Apparently a molecule is related actinina α 10 G-actin molecules and compete with α actinina tropomyosin, binding sites. Αctinina α line is associated with Z.
Numerous studies have shown that ATP actomiozina superprecipitarea azei I determine it and requires a low concentration of Ca ² +.

Repeated extraction (NAM) natural atomiozinei ionic low-makers remove the requirement of Ca ² + and results in a system known as desensibilizat.Actomiozina (DAM), since activity is not ATP-sensitive azei low concentrations of Ca.
Myoglobin is present in vertebrate muscles is absent in muscles of insects and is replaced with a tracheo complement.
The basic elements in all cases are thick and thin filaments.
Thick filaments of myosin miofibrilei essentially correspond.
Since thick filament has a bipolar structure, myosin molecules are packed in a parallel and antiparallel in the central region the rest of the filament.
Thin filaments are composed of actin, tropomyosin and troponin.
Antibodies before HMM A focus in the center lane and antibodies before LMM portions focuses band A. When muscles contract, the two sets of thin and thick filaments slide each other under the influence of cross bridges and cycling of projection corresponding HMM.
When the muscle is relaxed HMM attachment to actin is inhibited, after the Ca ² + reticulum are made of thin filaments sarcoplasmatic and removes inhibitions.
Myosin cross-bridges can form actin filaments in thin.
This attachment is followed by a change in conformation of myosin in muscle tension generating cross bridges in pursuit of actin. This cycle repeated collapse events associated with ATP produces an energy source.
Amino acid composition Phorm queen-G actin is very similar to rabbit muscle actin, also contains a little more glutamic acid, lysine and nitrogen amide increases, net change actin insects are similar to other invertebrates. Bee myosin rabbit myosin is very similar lengths ranging between 1700 and 200 A. Azei myosin ATP activity of bee looks like the same features as rabbit myosin and lepidopteran insects and similar amino acid composition. Skeletal muscle myosin contains dorsal Lethocerus at a rate of 55% of the total protein miofibrilare.
Electrophoretic spectrum of proteins in muscle of Lethocerus cordifanus, Lethocerus Heliocopris maximus and beetle flies miofibrilele japetus is similar except for an increased content paramiozina. Extraction of myosin and actin extensive Z leaves only band with molecular weight of 95,000, corresponding to α actininei component.
Myosin cordifanus L., L. maximus and H. japetus electrophoretic spectrum is similar to P. Queen myosin 200,000 molecular weight and molecular weight subunit 2.
Tropomyosin was isolated from the larva and adult P. Queen.
Sedimentation coefficient of protein in the adult is 2.53 while S sedimentation coefficient of protein of the larvae is 2.62 S.
Molecular weight varies between 65.000 and 84.000 to tropomyosin of larva.
Apparently the larva tropomyosin polymer is more than tropomyosin in adult amino acid composition of tropomyosin also in the larva and adult is almost identical, except for proline, histidine, phenylalanine.
50 essential peptides are similar, but the basic peptides are present in the digestion of tropomyosin typical larva and adult are not found.
Made with electron microscopy studies on actin filaments in H. japetus show protein bands located at 40nm.
Troponin in vertebrate muscle tropomyosin binds actin filaments and that containing the same periodicity.
Flight muscle of Sarcophaga filaments bull presents cross bridges that are in groups that myosin filaments of 14.5 nm repeat along the filament.
Each cross represents a bridge myosin molecule.
In terms of groups called the corona, was estimated to be sufficient for myosin molecules per crown in June and Lethocerus Sarcophaga.
Unfractionated extracts of flight muscle regulatory proteins
(Tropomyosin, troponin) have an inhibitory effect on ATP desintetizarii actomiozinei azei or synthesis of the rabbit.
Fractionation with 40-80% ammonium sulfate fraction give ranadament containing tropomyosin and protein molecular weight is 18,000, 27,000 and 30.000kDa, corresponding to troponin.
These occur as a ² + fractionation. Inhibition of protein molecular weight sensitive and only 18,000 kDa indruma00actiivarea As ² +. .
Bullard and Rudy (1973) extracted and purified from muscle Flight paramiozina cordifanus L., L. maximus, H. japetus and Pachnoca ephippiata.
Subunits of molecular weight is estimated by polyacrylamide gel electrophoresis in the presence of Na dodecyl sulfate and sedimentation is 107.000kDa is 3.17 S.
Dicroism molecule is characterized by a 2-bar chains. Amino acid composition resembles paramiozinele paramiozinei molluscs and paramiozina anelidelor and the proportion of glutamic acid and aspartic higher.
Approximately 6.3% of miofibrile consist of paramiazina L. cordifanus and 9.5% in Pachnoda.
The proportion of myosin and paramiozina in L. cordifanus is 8.2%.
Observations on the contractile properties of Silemon insects were collected in 1961. In the presence of 0.15 m KCl and 1 M MgCl2 actomiozina the bee is observed.
Viscosity loss to adding ATP and the subsequent finding that ATP is hydrolyzed added was first found in actomiozina of locusts.
Intrinsic viscosity actiomiozinei insect is 2.7 and 1.9 without addition of ATP with ATP and pH = 7 and 20 ˚ C (1 / 2 and 0.62) at medium speed gradient of 100 sec ¹. Ultracentrifugation clearly indicate that it dissociated insect actomiozina actin and myosin in to add to actomiozina (30 s).
After adding ATP in the presence of Mg ² +, myosin becomes very sharp peak and peak or actomiozina or actin, settles very quickly.
ATP-myosin activity or actomiozinei azei been studied in insects.
The reaction shown in Eq corresponds to typical adenosinetrifosfataza.:
ATP + H2O → ADP + Pi
Since most of the insects are completely pure actomiozine, ATPase activity apirazei show rather than the ATP-azei in the presence adenilatkinazei:
ATP → AMP + Pi
AMP is converted to IMP format while adenylate deaminase is not present in the insect Actomiozina actomiozina azei ATP in many insect enzyme acts as vertebrates (Cheshny, 1975).
The high concentration of KCl is inhibitory.
ATP-optimal temperature azei house flies is 45 º C, similar to other species.
As one of the characteristics ² +-ATPase is activated and is dependent on pH.
The work presents a curve with a little difazica at pH = 9 and at another pH = 6, also at home after Cheshny flies (1975) who made an extensive study of kinetics and properties related to Musca domestica, maximum activity is observed only alkaline pH.
Apparently, the pH dependence may be due to the characteristics of light and heavy subunits of myosin molecules.
The phenomenon of substrate inhibitor of ATP has been well studied azei actomiozinei to insects such as water beetle cordifanus L. (Chaplain 1967). ATP inhibition azei ATP concentrations can be obtained at very low, at 1.6 mM in the chest muscle and the low value of 5 mm.
The values of K of 0.2 mM ATP are.
Apart inhibit ADP-aza insect muscles (Cheshny 1975).
Mg ² + ions are required to activate the ATPase, as shown by L. maximus.
Maximum activities were obtained at 1 mM Mg ² + in the presence of 2 x 10-5 M ² + As. With a constant concentration of Mg ² + there is an activity of 10-6 M ² As +, but inhibition is observed at 1 mM As ² +.
The activity is inhibited by chelating agents such as ethylene glycol-bio (aminoetileter β), N, N tetra acid.
From these observations might be differences between insects and vertebrates, namely actomiozinei ATPase.
Ca ² + levels lower than 10-7M, just working muscles and the muscle fibers of insects actomiozine
Evidence was presented by this dual system of Ca ² + regulation in muscle thin filaments of Lethoarus associated with myosin.
It is possible that the concentration of Ca ² + to be ATPase actomiozinei need to be present at a reduced size sarcoplasmatic reticulum (Smith 1965).
Such differences were shown between muscle fibers flying and legs muscles nonfibrelor water beetle L. maximus.
Similar observations show gradual control by ATP concentrations azei As found in other types of muscle fibers, those of bees and beetles, while the muscles of the beetle nonfibrilari have increased sesibilitate CA ² +.
Degradation typical of L. maximus muscle fibers leads to a decrease in ATP sensitivity at Ca ² + azei actomiozinei.
Adding partially restores the sensitivity of rabbit tropomyosin system then suggests that tropomyosin – troponin regulating system is operative in insect muscles. Apparently there is less muscle tropomyosin in flight than his feet.
Inhibition by ATP-ADP azei actomiozinei appears to be cooperative and a corresponding phenomenon was interpreted alosteric (Chaplain, 1966).
L. maximus and L. cordifanus were used to demonstrate this phenomenon. Also inhibition of ADP’s can be inhibited by the presence of ATP analogue (β – ribofuranozilpurina 5 tri phosphate) as substrate for a real way.
These observations suggest the presence of distant stereospecifice of ATP receptor sites azei actomiozinei.
Actomiozinei ATPase can exist in two stages: one with low affinity for the substrate and the other with high affinity, the latter being inactivated catalytic. Change the balance between actin and inhibit ATPase affinity for active state and the low concentration of Ca2 + inactive state becomes less accessible. Type of inhibition produced by ATP also suggests the presence of a third stage of the ATP-azei, which show an affinity for nature ADP.Deasemenea alosterica of ATP was defeated azei actomiozinei insects, studies show fiber glycerin synergistic action of Ca, the activity ATP-azei.
Both ATP-activity curves of high blood azei and are biphasic but reach a plateau of 10-7 M Ca2 +. ATPase value remains high at 10-4 M Ca2 +, but the fibers are fully relaxed.
Differences in conformation and ATP-voltage activity suggests azei suggest that the same steps are involved in reactii.Tensiunea curves in sequences of fibrillar muscles of insects is generated mainly by ADP binding site. Is considerable evidence that changes reticulum Ca2 + sarcoplasmatic concentrations (from 0.01 to 1.0 μ M) during contraction cycle control, not only ATP-azei miofibrilare activities but also the key enzyme, including exterior mitochondrial membrane enzyme phosphorylase (Ebashi and Endo, 1968).
Similar changes in Ca2 + concentration change intramitocondriale enzyme activity, such as pyruvate dehydrogenase. Mitochondria can play a complementary role in reticulum sarcoplasmatic in control changes the intracellular concentration of Ca2 +. These changes in Ca2 + intramitocondrial in L. cordifanus and Schistocerca gregarious is regulated by NAD dependent izocitrat dehydrogenase to control the formation of energy in the contractile (Zammit and Nerosholme, 1976). Isolation of myosin, actin and troponin in fibrillar muscles and insects (L. cordifanus, L. maximus, H. japetus) showed some differences between proteins of insects and the vertebrate muscle.
Also myosin from both types of muscle has the same molecular weight, light subunits with different compositions, reconstruction and heteroloage homoloage actomiozinei using myosin, indicating a low activity of ATP-azei actomiozinei containing insect myosin. The ATP-azei tropomyosin activity, as discussed in the conditions in which this may be due to properties of insect myosin, which prevents interaction with actin in the absence of tropomyosin. Activation by tropomyosin seems to make a big difference between vertebrate and insect muscles. Minor differences between the existing Finally contractile proteins of insects and vertebrates, skeletal tissue and their mechanism of action is essentially similar.
Oversimplified model described here gives way to many unanswered questions, but provides some indication of how a highly sophisticated complex involving enzymes (ATP-azei) two sets of regulatory proteins (tropomyosin and troponin) and an interaction between pairs fibrillar proteins (actin and myosin) transferring energy created by ATP hydrolysis in a mechanism that works in insect muscles (Heilmeyer, 1976).
FIBROINELE
Sorry, until now only used silk thread obtained from the Bombyx Mori (viemele silk). In nature there are still many species of insects that produce fibroine, but not used at their fair valoare.In this way, the future will reveal many more new materials (nono-materials), which will play an important role in human life . We now get started major research new materials present in the composition fibroine insect tissues. In the future new materials will be obtained to replace human organs. So for example, can be replaced with new ones damaged blood vessels from some parts of the tissues of some species of insects. It is a very important direction started by us for the first time. Of insects will get very important and many colors, to be used in painting.
From the information presented above has shown that in insect muscles there SBA component that can improve muscle activity in humans. We have developed a series of foot care creams, which have saved many people the hellish pain of the legs, especially at night.
Myosin extracted from insect tissues activates ATP in human limbs, so that after applying the ointment for foot care, blood circulation is stimulated and produces an intense energy in leg muscles. The SBA component extracted from insects included large amounts of Ca, Mg and P, which enhance muscle function.
It is a very good start and I am convinced that in the future based on data will develop many new pharmaceutical preparations that will improve health and increase longevity of human beings.
STRUCTURE
Fibroina silk has been well researched over time. It is most interesting with primary and secondary structure. At the same time were studied fibroinele β and collagen. Helix hymenopteranα silk from bees, wasps, ants is still very little studied. To all this is prezentafibroina α helix type. The bee larvae, silk glands is stored in the tubular lumen in tactoide microscopic.
In the optical and electronic microscope, these appear to be ribbed tactoide, twisted as if they were composed of filaments and filament length terminals. The bumble some tactoide are present, attached to the inside walls of the glands, but usually is well-defined arrangement. Insects have fibrons, which belong to family Saturnudae have a high content of alanine, somehow, and small amounts of glycine serine.
Bombyx silk mill has a different amino acid composition. Silk worm that was the most studied. In natural conditions fibroine fibers contain filaments double the globular protein and serine are included.
B. Fibroina die is a protein synthesized and secreted from the donut back of the glands, as in bombicide. Fibroinele Anaphe and Hipsoides genus are distinguished by the fact that alanine and glycine is a big part of their surface. 94% of the Anaphe Moloney fibroina consists of 2 amino acids and essential material is a polymer of these two amino acids, so are the simplest proteins studied by Lucas et al, 1960. Chrysopa sp strain Fibroina egg contains 40% serine.
Fraction patterns vary fibroinei insect meridian reflection series. The bees, bumble bees, wasps and other colonial species, axial measurements indicate a period of at least 280. Bombyx silk filaments appear to be uniform die 40A, with some differences, so that each filament consists of two bars of about 20 diameter.
X-rays shot from several studies show fibroine spots and springs models indicating that some of the polypeptide chains are mutually arranged so that these measurements cristale.Din form springs and distances of atoms in crystals plans were calculated on this basis fibroinele can divide into 5 groups, each group member with the same distance. These two groups can be subdivided based on visual differences in intensity of these two equatorial spots.
Dimensions in the two directions are the same for all fibroinele.
These directions are along the fiber axial repeat distance of 6.95 where Ă representing two residues in a peptide chain and between two chains which is directly related to hydrogen.
The third dimension is a direction projecting that distinguish the differences between amino acid chains and the size varies between 5 groups from 9.3 to 15.7 A. All belong to the group Saturnidae fibroinele from X-rays (Lucas, 1960). They are divided into groups 3a, 3b and apparently reflect differences in the components of alanine.
As was established before the B. fibroina die is unusual amino acid composition.
A similar type of product seems to be fibroinei parasinana Bena.
Second group is found along the chest to rise and Hypsoides Thaumetopolal where alanine is 50%.
Group 2b is located at SP Clan, a member of Psychidae.
Spider silk from madagascariaensis and Nephilim Nephilim senegalnsis are different amino acid composition and X-ray group
This is due to various functional forms that arise from different glands fibroinelor. N. Fibroina madagascariaensis of spider is repaired while the adult fibroina N. senegalensis egg cocoon fiber is repaired.
The Bombyx silk mills fibroina indicate that the molecule is not homogeneous but consists of half the lens and the second amorphous phase which does not contribute to X-ray model
Antiparallel chain structure was proposed β fibroinei regions of Bombyx.
This structure is based on the assumption suggested by chemical evidence such as every second residue is glycine in silk polypeptide chain. Lucas and his collaborators have isolated (Lucas et al., 1958, 1960) chymotrypsin resistance (CTP), fraction of solubilised fibroina believed that it derived from crystalline regions. Proposed for this fraction shows sequential formula Eq.

Gly-Ala-Gly-Ala-Gly [Ser-Gly-(Ala-Gly m)]
Ser-Gly-Ala-Ala-Gly-Tyr
Where m varies with an average value of m = 2.

Polymers have similar sequences. They were prepared and studied by X-ray diffraction
Schnabel and Zahn (1958) summarizes the hexapeptide
Ser-Gly-Ala-Gly-Ala-Gly
and suggest to the X-ray diffraction space, in forms that are extended chain conformation and hexapeptide β crystal structure is probably similar to silk fibroina.
Fraser and colleagues (Fraser, 1966) have synthesized polymers (Ala-Gly) n and Ala-Gly-Ala-Gly-Ser-Gly) m and X-ray diffraction pattern studied of these polymers.
X-ray diffraction and CTP fraction of polypeptides (Ala-Gly-Ala-Gly-Ser-Gly) is similar, they support the proposed sequence for the CTP fraction. This added oxygen atom in every 6 residues (Ala-Gly-Ala-Gly-Ser-Gly) n leads to a decrease between the sheets, space compared with (Ala-Gly) n. The values obtained are similar to those reported in various insect species fibroine.
One of the problems studied by the molecular structure of silk is difficult fibroinei fibroinelor solubilisation. Most solubilization procedures were involved in boiling or alkali treatment. These procedures can drastically degrade the molecule and molecular weight fibroina are 3.3 • 104 and 106 reported earlier suggestion of this possibility.
Recently fibroina was extracted directly from silk gland and the molecular weight of 3.6 • 105 was obtained. When fibroina was washed with water to remove the covering fibroina sericina was dissociated in the presence of 6 – 8M urea guanidine hydrochloride (Sasahni and Nada, 1973). When the analysis is balanced by sedimentation, the two bands were obtained with a 10S sedimentation coefficient corresponds to fibroinei.
3.65 • 105 molecular weight was obtained from fibroina and did not change in concentration jump 6M or 8M urea guanine hydrochloride, which suggests that fibroina subunits linked by connections not necovalente.
Polyacrylamide gel electrophoresis, sedimentation equilibrium Sephadex G200 column chromatography and viscosity measurements indicate that the molecule is made up of components fibroina small molecular weight 2.6 x 104 and a molecular weight of components of 2.8 x 10 5 connecting through disulfide bonds.
Sericin is the largest polypeptide of fibroina and amino acid composition differs from the fibroina small polypeptide. The number of cysteine residues in the molecule is 8-9 fibroinei. If all are cysteine residues, and four existing disulfide bonds. This has three parts big and small, need at least 3 disulphide bond, the cysteine residues are sufficient. A future analysis of cocoon fibroinelor amino acid composition is the variation of amino acid composition of various insects. Fibroinele that provides the structural basis of different types of insect cocoon lead to the same function for each. It is remarkable that large variation in amino acid composition was found fully compatible with this function. .

Biosynthesis
Large-scale synthesis of specific proteins is equivalent to a large-scale gene expression of the particular. Gene expression can be controlled at different levels. But it is interesting to find posttranscriptionali steps (selection of messenger RNA, carriers, stabilizers) in phases and posttranslatie translational (protein cleavage, assembly, turn – over), involved a large-scale expression of a particular gene may allow identification and isolation of mRNA as demonstrated by hemoglobin, myosin and other proteins in eukaryotes.
Experience has been made to obtain mRNA which directs the synthesis of insect primary fibroinelor. A part of the gland that synthesize silk thread was divided into columns of cellulose. This has resulted in the ability to incorporate directed RNA-protein amino acids, modeling this process in the bacterium Escherichia coli.
It was noted that RNA fraction obtained from the middle silk gland is directed to the incorporation of glycine, alanine and serine, but the percentage of those amino acids incorporated resembles sericinei percentage rather than fibroina.
Silk protein contains 45% B. die glycine residues predominantly alternating alanine and serine with debris as shown Sasahi and Noda (1973).
A calculation of prediction accuracy of these codes of amino acids, messenger RNA fibroina should be at least 57% G + C, a value that is higher than the ribosomal DNA or RNA B. die.
This increase in G + C content should include an increase in G content of 40% of these basic residues.
By adding repeated sequences of amino acids of fibroinei involves simple repetition of amino acid sequences of mRNA.
When larvae aged 5 to 24 hours are marked with ortho – P32 and 45S and 65S RNA’s settles between isolated, is found in the waste content of 59% and 40% G + C residues RNA is synthesized very easily G. and is very stable. 1.4% of total RNA corresponds to the posterior gland fibroinei messenger RNA.
Spectra of RNA oligonucleotides obtained by digestion can be compared with the spectrum can be predicted by the sequence of amino acid sequence fibroina messenger knowing and using proper code. Digestion product is close to this prediction as a result, with no doubt that the isolated RNA has a larger amount of pure fibroina than mRNA, in which glycine is encoded by GGU and GGA, alanine and serine of the UCA GCU. Fractional density coupled with molecular hybridization was used to obtain information on the length of DNA (Lizard and Broron, 1974).
Fibroinei messenger RNA is extracted and corresponding DNA was synthesized for use reverse transcription. The length of DNA from 6 x 10 6 daltons double-stranded DNA – this compares to the size of fibroinei messenger RNA, from 5.5 – 6 x June 10 daltons.
This means the only, gene fibroina is structural and should be to 11 to 12 • June 10 daltons.
A question concerning the cocoon fibroinei is the mechanism used to worms and other species of Lepidoptera. For this purpose specialized cells develop to produce a proteolytic enzyme measured lift cocoon (Kafatos, 1972).
The enzyme removed outside surface of the adult developmental delay before it can be found as a dry semi-crystalline layer. The moths, 0.1 mg or more can be collected with forceps to each insect.
The material consists of euzina pure virtual. During measurement, euzima is redissolved in pH optimum of 8.3 in bicarbonate is secreted by another gland izotonic.Acesta and is brought into contact with the cocoon, helping digestion and linking sericinei silk fibers together. Insect cocoon structure is lost and find your way out.
Glial cells to produce Antherea polyphemus cocoons as inactive precursors.
The difference of these cells lies in the hormonal control of juvenile hormone ecdysonei. Ecdysona draw the differences, but when juvenile hormone is present, the remaining cells differentiate and inhibit the transom characteristic stage.
Cocoon synthesis has been studied extensively by Kafatos (1972). It was shown by messenger RNA for protein noncocon, which has a much shorter life – 1.5 – 2 hours, usually cocoon existence of messenger being at least 7 days. Synthesis begins cocoon frequently, perhaps using existing message. Cocoon show remarkable chemical similarity to trypsin and other SERINE mamaliana proteases. Molecular weight is about 24,000, so the pupae of B. die proteins have molecular weight about 20,000
Amino acid composition is very similar to that of trypsin cattle. Euzina has a cross reactivity with trypsin and chymotrypsin. Coconaza is different proteolytic euzina fluid form, which is secreted by epidermal cells in the body in order insect cuticle digestion during lizarii old. Differences between protease and melting coconaza fluid, indicating specific positions of both messenger RNA.
Skin Proteins

Tissue structural integrity is maintained by the influence of concentrated power of covalent bonds between polypeptides and polysaccharides.
As happens in the skin of vertebrates, insects exoskeleton stability derived from links between specific amino acids, residues in ion or water connections, properties of polysaccharides and carbohydrates from the direction permitted by the elements associated with basic proteins.
The structure of proteins and enzymes known to participate in the cuticle sclerotizare.
Involves hydroxylation of tyrosine to dihidroxifenilalanina Sclerotizarea is decarboxilata of dopamine dopa – decarboxylase.
Dopamine is converted to the N-acetylated to form N acetildopamina.
By this action the system is oxidized fenolazei I acetildopamina to zero. Diphenols oxidase as activator was also purified oxidase did not show the dichinona acetildopamina correspondence.
Fenoloxidaza is a precursor or pro inactive (fenoloxidaza) and takes place in Calliphora larvae haemolymph and cuticle activator.
It is obvious that an oxidase diphenols often refers to tyrosinase, fenolaza, phenol oxidase, polyphenol oxidase and oxidase catecholului cuticulare corresponding protein.
Drosophilla melanogaster larvae cuticle also contains a number of dehydrogenase, phosphatase, esterases and aminopeptidaze, also the possibility to derive from late enzinele contaminated cuticle tissue during extraction. Phenol oxidase B. cuticulara to die in the pupae stage can be classified as lactase protein and brass seems that sensitivity to cianidietildihidrocarbomate, oxidase, fenilendiaminaza, is insensitive to carbon monoxide. Enzyme properties are similar to those of the enzyme obtained from pupae of Drosophilla norilis and Papillo Xuthus. B. die enzyme has 3 isoforms with molecular weights of 62000-70000. Phenol oxidase activator synthesis and the control ecdizonei dopo decarboxylase. Bursicon, a protein hormone with weight of 40,000 also appears to control the flying adults sclerotizare new and fresh striped lizarii the cockroach.
It was also suggested that bursiconul can be controlled by tyrosine in Sarcophaga Pro hydroxylation (phenol oxidase) in die form B. 3 subunits of molecular weight 35.000, 47.000 and 58.000.
The cuticle protein is heterogeneous and no structures in proteins involved in sclerotizarea protein leather have not been fully elucidated.
The cuticle protein heterogeneity was shown by extraction of protein fractions with different solubility and amino acid composition of proteins extracted by electrophoresis mobility and immunological procedures.

By adding protein extracts from different insect species also differ.
The American Periplaneta number of cuticle protein bands has an electrophoretic result, ranging from 7-14 depending on the stage of development.
Globular protein fraction from the larvae of Sarcophaga crassipalis cuticle acts as a single component by analyzing the sedimentary, with a molecular weight of 7000-8000, otherwise the protein is heterogeneous.
Globular fraction of Acheta domesticus from cuticles was solved in 5 parts and all molecular weights corresponding to multiples of 7000. Protein solubility Schistocerea gregarious larvae occupy 6% by weight of dry cuticle, while the residual protein arrange to 44-49% dry weight.
In other insect species varies from 13-23% soluble protein dry weight, but are insoluble proteins as in S. gregarious.
In the larva cuticle Agrianome spinicollos (Coleoptera) is a big difference between different proteins. Fraction solubilised in water contains 13 products, protein solubility in KCl causes the appearance of 11 protein fractions. After solubilisation of proteins in urea, there are 20 proteins. In proteins solubilised in NaOH 11 proteins appear, as expected proteins fractionated in urea and NaOH of protein aggregates in buffer solution with pH = 7. Characterization is needed to operate this protein as well as to elucidate their biosynthesis. Fibroinele In contrast, proteins were abundant amino cuticulare aggregate links to other structures on the surface. Soluble proteins apparently do not have untreated protein without any tanning process but can be obtained in vitro.
Cuticulare reports that protein amino acids are aspartic acid, glutamic acid, serine, glycine, alanine, tyrosine, valine, leucine, isoleucine, proline, hydroxyproline, lysine and tryptophan. Cysteine or meticenina are both also present but in low concentrations in all insect cuticles.
Cuticulare protein amino acids, indicate some similarities in the composition of insect cuticle Agrianieme (Coleoptera) and Bombyx (Lepidoptera). Cuticle have similar protein amino acid composition, but differ from larvae cuticles Lucille (dipterous). Drosophilla species have similar but different amino acid components of Calliphora pupae and Lucille.
Cuticle proteins at different stages of development in Galleria mellonella show a  greater  percentage of glycine and alanine. Alanine is present in all cuticle pupae. A special type of cuticle protein is more insoluble protein called chitin resilin and it able to isolate. Amino acid composition is different from other resilins structural proteins. No structure was observed in the electron microscope. Resilin is located in regions where they occur arched movements. S. joint gregarious larvae contain 86% rezilina. It is possible that some of the joints to be combined with proteins and glycoproteins chitin. Link between chitin and protein nature has not been elucidated.

COLLAGEN

Collagen is the most important connective tissue insoluble fiber. Mark inert collagen proteolytic enzymes especially native status and turn into jelly by heating the water and alkali. Collagen is common in many insects. The composition is unusual amino acids 1-3 residues glycine and proline and hydroxyproline are other 1-3. The collagen or tropocolagen (soluble or extracted) molecule consists of three links, which are identical or different tissues and species given in the coming.
Links have the same polarity and associated overlapping to form collagen fibers, so preparations corresponding electronic photomicrography with specific features and antibenzilor bands. Links polypeptide of collagen molecule are known as α 1.22 and α 3.
Different types of collagen are known as I, II and III. This collagen molecules consisting of those described (a) in three appearances identical links [(α 1) I] 3, [(α 1) II] 3, [(α 1) III] 3, (b) 3 different links (α 1), (α 2), (α 3) or (c) 2 identical or different links [(α 1) I] 2α2.
X-ray diffraction and electron microscopy suggest that the nerve sheath component called noncelulara the neural lamella, consisting of matrix and a part that is inserted into the collagen fibers. Collagen that forms a material part of stroma also nervous systems of insects. Cockroach L. maderae and collagen in Blaberus craniifer was demonstrated by a variety of techniques. Electron microscope with which they conducted research on various organs of insect connective tissue showed that fibrillar collagen are linked characteristic. Fibrillar connective tissue apparently insects show considerable variation in the tissue ultrastructure. This refers to setting the diameter of fibers and axial periodicity. Low values were determined at 170a to certain insects to G. mellonella as axial periodicity. The cockroaches frequency of 500-600A is typical.
Analysis of amino acid fractions of heart tissue and corpora corpora allata complex shows that waste water contains a significant amount of hidroxilizina and a smaller amount of hydroxyproline. These two amino acids are marked by the presence of collagen. Proteolysis can be achieved by using collagenase with additional substances in the presence of collagen.
Amino acid composition of collagen coating was obtained from carcasses cockroaches. Carcass composition of collagen cockroaches is similar to that reported by other sources.
Proteins Chromosomes

Histone chromosomal proteins, especially protein structure were included in knowing that plays an important role in regulating genes.

Histone-core proteins are associated with DNA. Are generally specialized chromatin structural proteins but act like repressor of the activity. Histone proteins are kept at a high level, but we have a small variation of amino acid sequences from different sources. They are acetylated, methylated or phosphorylated, but the sequences of these changes were not understood at present. Histone are classified in relation to chemical characteristics (and Elgin, 1971). Primary structure of histone from various sources was determined and detailed histone composition and sequence obtained, the insects, except Drosophilla.
TABLE 1
PREPARATIONS FOR INTIMATE CARE

NAME OF THE PRODUCT ACTION
FLY-FLY “ INTIMATE GEL V “
NOTIFICATION  NUMBER: 13596/16.10.2003 It contributes to the elimination of the flora which is not specific for the feminine intimate part of the body
FLY-FLY “INTIMATE GEL H “
NOTIFICATION  NUMBER
13604/16.10.2003 It contributes to the elimination of the flora which is not specific for the masculine intimate part of the body

PREPARATIONS FOR ORAL CARE

NAME OF THE PRODUCT
ACTION
FLY-FLY “ ORAL MUCOUS MEMBRANE GEL“
NOTIFICATION NUMBER
13603/16.10.2003 it has antiinflammatory properties
it contributes to the adjustement of the flora of the oral mucous membrane.
FLY-FLY “ORAL CAVITY GEL “
NOTIFICATION NUMBER 13606/16.10.2003 It contributes to :
the disinfection of the oral cavity
the refreshing of the breath
FLY-FLY “TOOTH AND GUM GEL“
NOTIFICATION  NUMBER
It contributes to:
the disinfection of the oral cavity
the refreshing of the breath
the anti-inflammatory action
FLY-FLY “MOUTHWASH “
NOTIFICATION  NUMBER
13590/16.10.2003 refreshing of the breath
it has a cooling/ refreshing effect
it contributes to the oral hygiene

Preparations  for bodily care

NAME OF THE PRODUCT ACTION
FLY-FLY “ BODILY MASSAGE CREAM“
NOTIFICATION  NUMBER
12372/26.11.2002 It contributes to  :
the increanse of skin elasticity
the intensification of blood circulation
FLY-FLY “FOOT CREAM “
NOTIFICATION  NUMBER
13600/16.10.2003 It contribues to :
the increase of skin elasticity
the increase of the mobility of the limbs joints
the toning of the  epithelial tissue
it gives the sensation of comfort and relaxation
it removs the sensation of heavy legs
FLY-FLY “ANKLE CREAM“
NOTIFICATION  NUMBER
13609/16.10.2003 It contributes to :
the increase on skin elasticity
the intensification of blood circulation
the decrease of the deformation of the blood vessels
FLY-FLY “NAIL LIPOGEL “
NOTIFICATION  NUMBER
13601/16.10.2003     It contributes to:
the treatment of the depreciated nails and the contiguous areas
PREPARATE WITH KERATOLYTIC ACTION

NAME OF THE PRODUCT
ACTION
FLY-FLY “ SKIN CREAM“
NOTIFICATION  NUMBER
13598/16.10.2003 It contributes to  :
the diminution decrease of the schin of the human body
the refreshing and moisturizing of the skin
FLY-FLY “CREAM FOR EXFOLIATED SKIN “
NOTIFICATION  NUMBER
13602/16.10.2003 It contributes to the refreshing and moisturizing of the skin with a tendency for exfoliation
FLY-FLY “DECOLLETAGE CREAM
NOTIFICATION  NUMBER“
13607/16.10.2003 It contributes to the toning and refreshing of the epithelial tissue
FLY-FLY “GEL CREAM ANTICELLULITIC MASSAGE “
NOTIFICATION  NUMBER
13597/16.10.2003 It contributes to  :
the care the maintenance and the treatment of the parts of the body affected by cellulitis
the decrease of the adipose tissue
FLY-FLY “VIBEX CREAM “
NOTIFICATION  NUMBER
13608/16.10.2003 : It contributes to
the toning, omfort and neutralization of the free radicals
the reconstruction of the collagen
PREPARATIONS FOR HAIR CARE

NAME OF THE PRODUCT ACTION
LA VITRINE MAGIQUE “ HAIR LOTION“
NOTIFICATION  NUMBER
13594/16.10.2003 it prevents and fights the hair fall and the dandruff
it brings back the glistening and the elasticity of the hair
it contributes to the vitality of the hair
LA VITRINE MAGIQUE  “HAIR CONDITIONER“
NOTIFICATION  NUMBER
13593/16.10.2003 it brings back the vitality of the hair
it gives elasticity and volume
it does not electrify the hair
LA VITRINE MAGIQUE “SHAMPOO“
NOTIFICATION  NUMBER
13591/16.10.2003 it contributes to the prevention of the hair fall and to its regeneration
it has antifungic properties

NAME OF THE PRODUCT
ACTION
LA VITRINE MAGIQUE

“ CREAM FOR TEENAGERS“
“GEL MASK FOR TEENGERS“
“LOTION FOR TEENGERS“
NOTIFICATION  NUMBER
1266/28.01.2003

They maintain the state of cleanlinesse and health of the tissue
The elimination of mechanical impurities
They contribute to the decrease of the microbial germs on the epidermis
They contribute to the adjustement the  secretion of the sebaceous glands

ENTOMOTHERAPY VOL7

COSMETIC PREPARATIONS FOR TEENAGER

Own results of the protein content in different insect species at different stages of development (Tab.)
Protein varies depending on the stage of development and depending on the species of insects. For example the hairy caterpillar oak is 91.27 g/100g dry eggs, from which protein 66.29 g/100g. In dry larvae constitute 90.27 per 100, of which 73.17 g/100g protein, fat and sugar 0.556 11.78 g/100g g/100g. The development phase is 93.19 g/100g dry kiss of which 66.36 g/100g protein, fat and sugar 8870 23.50 g/100g g/100g. G/100g dry adult 95.40, 55.54 g/100g protein, fat and sugar 1.90 28.32 g/100g g/100g.
At Euproctis hrisorhoea (caterpillar with red tail) dry 91.05 78.83 g/100g g/100g of the protein, fat and sugar 2010 12.54 g/100g g/100g. P.e.p. is 88.89 55.86 g/100g g/100g of that protein, fat and sugar 3.64 55.86 g/100g g/100g.
Bombyx pupae to die is 82.43 g/100 g dry matter of which 74.79 g/100g protein, fat and sugar 2890 16.36 g/100g g/100g. The adult is dry 94.86 51.69 g/100g g/100g Dinca has protein, and sugar lipde 18.46 g/100g g/100g 3880.
Neustr Malacasoma adult dry substance of which is 93.88 g/100g g/100g protein 49.54, fat and sugar 2650 26.94 g/100g g/100g.
The Colorado beetle larva is dry 92.58 48.48 g/100g g/100g of that protein, fat and sugar 4.6 g/100g g/100g 20.39. The Colorado beetle adult is 90.36 dry 65.28 g/100g g/100g of that protein, fat and sugar 4.23 6.57 g/100g g/100g.
Musca domestica larvae to dry which is 91.79 g/100g g/100g protein 47.03, fat and sugar 0 g/100g g/100g 22.24. The adult Musca domestica is dry 94.10 53.21 g/100g g/100g of that protein, fat and sugar 4.28 22.27 g/100g g/100g.
La Galleria mellonella larvae is 95.09 dry 44.67 g/100g g/100g of which protein, fat and sugar 5.4 g/100g g/100g 38.62. La Galleria mellonella is 91.48 g/100g dry adult of which 55.93 g/100g protein, fat and sugar 0 g/100g g/100g 9.02.
When Li is dry 97.07 45.20 g/100g g/100g of that protein, fat and sugar 4.4 g/100g g/100g 20.63.
The dry matter is mellolontha Mellolontha 97.12 50.09 g/100g g/100g of which protein, fat and sugar 4.3 g/100g g/100g 20.92.
The protective substance (spray) is dry 88.28 66.84 g/100g g/100g of that protein, fat and sugar 2.2 g/100g g/100g 0.
The grape seed is dry 94.89 12.45 g/100g g/100g of that protein, fat and sugar 5.4 8.4 g/100g g/100g.
The quail egg is dry 96.92 43.14 g/100g g/100g of that protein, fat and sugar 2.06 29.5 g/100g g/100g.

TABLE 2. QUANTITATIVE ANALYSIS biologically active substances extracted from various species of insects in various stages of development.

Nr crt. Specia Substanta uscata
g/100 g Proteine
g/100 g Lipide
g/100g Zaharuri
g/100g
1.  L.d.O 91,27 66,29 16,91 2,380
2. L.d.(I) 90,27 73,17 11,78 0,556
3. L.d.(p) 93,19 66,36 23,50 8,870
4. L.d.I(at) 95,40 55,54 28,32 1,900
5. P.e.p(at) 88,89 55,86 23,62 3,640
6. P.e.p 91,05 78,83 12,54 2,010
7. B.m(p2) 82,43 74,79 16,34 2,890
8. Bm.I.(at) 94,86 51,69 18,46 3,880
9. M.n.I(at) 93,88 49,54 26,94 2,650
10. C(I) 92,58 48,48 20,39 4,600
11. C2(a) 90,36 65,28 6,57 4,230
12. Dm.I 91,79 47,03 22,24 –
13. Dm.I(m) 94,10 53,21 22,27 4,280
14. Gm.I(a) 95,09 44,67 38,62 5,400
15. Gm.F 91,48 55,93 9,02 –
16. Li 97,07 45,20 20,63 4,040
17. mm 97,12 50,09 20,92 4,030
18. P.u.f 88,28 66,84 – 2,200
19. Grape seeds 94,89 12,45 8,40 5,400
20. Pr(a)-quail egg 96,92 43,14 29,50 2,060

Comparative analysis of preparations subjected to surgery delipidizare with acetone in the extraction system type Soxhlett

Nr.crt. Proba analizata S.usc.g/100g Proteine
g/100g Proteine
g/100g s.usc. Lipide extrase
g/100g
1. Litta vesicatoria. 92.86 57.91 62.36 –
2. Litta  vezicatoria. (delipidizat) 95.89 64.18 66.93 13.08
3. G.mellon.( liofilizat)  97.82 37.26 38.69 –
4. G.mellonella delipidizat, liofilizat 98.54 65.34 66.30 48.1
5. Ou L/dispar 92.85 70.48 75.90 –
6. Ou L.dispar (delipidizat) 95.29 64.77 67.97 6.5

Spectrophotometric analysis Excerpts from different insect species
Earlier research biochemical structure of insect tissues, which include a lot of differential spectrophotometry method we have included ABB, which is considered the most accurate method of analysis because the absorption spectrum more accurately determine the fraction of absorption there is a certain solution . Each component has a specific absorbency, which is expressed by a curve forming different peaks certain wavelengths. It is the most accurate method of analysis of organic compounds and can be compared only with the method of titration of certain components.
Analysis and biochemical analysis of SBA is that suspension to pass through a special prism with a certain amount of suspension liquid .In produce different spectral fingerprint of the various suspensions imiges. The fotospectrometrica wave  forms an absorption of different spectrum image. This component depends on the species from which to extract certain chemicals and solvents. The main  protein that is used is distilled water, saline water wave acidified.Lungimea suspension depends on which light can pass to a certain level Spectrometry . This level is considered as an absorption spectrum that characterizes data.Absorbtia suspension depends on the number of atoms in the beam of light that can penetrate up to a certain level, reducing the light intensity.
To clarify more precisely the composition of research results for the SBA, which predominate protein derived from insects, we characterized the protein solvents.Cell best solvent is distilled water, which forms a fingerprint spectral curve with a peak wavelength of individual 198.5 nm and concentration (ABS).

Absorption spectrum of solution extracted from chitosan in acetic acid wich forming a curve with maximum peaks located in the wave of 213nm and lunigimilor min at 275.9 nm and 340.5 nm. (Various concentrations).

Studies mades  on the  Lepidoptera example, more concrete of the species of the Lepidoptridae family indicate the prezence of a large curves wich forming more large peaks in the wavelength of 230.0nm area with more than 3,000 ABS and another less pronounced curve in the wavelength of 280.0nm,.

Spectral fingerprint of SBA extracted from pupae of Malacosoma neustria in distilled water (20mg + 10 ml distilled water). The curve formed many maximum peaks in the wavelength of 230.0 nm area and a minimum peak in the 280.0 nm
Spectral fingerprint obtained from SBA extracted from Euproctis hrissorhea L in distilled water to form a obvious curve in the wavelength of 209.3nm with ABS 2.4058, characteristic area for polysaccharides, and another less pronounced curve in the 262.6nm, characteristic area of the protein.

Spectral fingerprint of SBA extracted from pupae of E.hrissorhea L in distilled water (20mg + 10 ml water dist). The curve  forms a peak maximum peak in the wavelength of 230.0nm area with ABS 4000. (double then previous concentration).

The last two SBA spectra extracted from the same family insects, indicate the existence of identical components in distilled water.

The absorption spectrum of bovines serum albumin (2mg+6ml NaCl 9%) form a curve with a peak in the wavelength 222.0nm area with ABS 2.7823. The suspension was obtained after its decantation fraction 5

To more accurately detect SBA (biologically active substances) with anti-tumor effect fotospectrometriei method we used, which allowed us to isolate the exact proteins, lipids and carbon hihdratii insects that appear in certain phases of this we have made studies dezvoltare.In fotospectrometrice to establish inhibitory effect of certain organic compositions (interferons) which can stop certain vital processes without intervention by chemical synthesis citoststice and interferons. The research done by us is a world first book. No one has yet thought about the fact that insects are present cytotoxic and natural interferon, which can also function in the body of human beings.
Insects, unlike other organisms in the process of morphogenesis have four phases of development: egg, larva, pupa and adult (imago). Every phase change not only the morphology but also the chemical structure of the composition: proteins predominate egg stage, larva stage of lipoproteidele occur and appear stern polisaharidele phase (chitin, keratin, fibroinele). These events allowed us to develop a totally new technology to eliminate lumps carcenoamelor type, melonoamelor, lipomas, glioblastomas, and uterine adenomas. We found and natural interferon that can stop the multiplication of viruses dangerous to human beings. This process was first demonstrated in baculovirus (insect-specific) at a certain stage of development. Researching these viruses in many insect species, we observed that in the last stages of development of insect larvae, baculovirus no longer reply and their morphogenesis cycle is stopped.
Then I extracted SBA in the development phase before the formation of insect pupae, when the synthesis of proteins and nucleic acid replication process is stopped. Inhibitors or interferons formed at this stage stops the multiplication of all tumor formations and viral infections. SBA testing antiviral preparations were made in insect cell culture and in several animal species. Testing was done on dogs to eliminate lipomas (Fig) and the undersigned body.
At the moment I was convinced that health and human longevitea creativity depends very much on people’s research not only doctors but also by specialists in biology, pharmacology and other specialties.
Spectrophotometric methods allow detection of SBA with certain properties and absorption has different aspects. This method is one of the most effective structures to detect the most important contemporary pharmacology.
Spectrophotometry method can detect certain chemical components that may be necessary to achieve para preparations, cosmetics, or dietary supplements useful for human nutrition. I have to mention that insects do not produce cholesterol and regulate their use in human food and deposit cholesterol in the body of vertebrates , including humans. Insects include large amounts of chitin or keratin, the amount of which increases along with aging, causing blistering of the tissue type chitinelor cheratinelor or skin, which causes the appearance often many human cancers .. So we were able to detect natural interferons and chemotherapy based on which we have developed antiviral and antitumor preparations. In the study of formation or degradation or cheratinelor chitinelor were developed pharmaceutical, para-and cosmetic properties to correct certain skin quality. For the first time we demonstrated the possibility of eliminating unwanted formations on human skin, ie biological operations were performed, which is painless and does not leave unwanted traces oamenilor.Acesta body was the first method we use in detecting certain SBA which was later used in modern biotechnology in the use of certain preparations for treating serious human diseases.
The first para prepared by us were prepared for removal of keratitis and keratoses on the skin tissue of the first biological preparations oamenilor.Unul KERATO-LIZ was designed to eliminate keratoses, bone spurs, keratitis and was extracted from tissues bataturilor.SBA of lepidopteran species in the elimination phase of keratin, keratin that is, when the insect is eliminated from the body ..
We need to remember that any order of insects has four phases of development: egg, larva, pupa and adult (imago). In these cases a larger amount of keratin formation occurs when pupae, then the adultilor.Cheratina can be detected and when moulting insect larvae ie when hatching eggs, eliminating another tegument.Dizolvare exzuviilor and keratin formation occurs in several stages of development insectelor.Primul decheratinizare moment occurs when the larvae hatching is performed in Ponte (egg). In this Since there is a hole in the shell eggs hatch larvae of insects that. Now we have collected large amounts of insect eggs before hatching, when a SBA peptides and enzymes, which includes some other time when there cheratolitice.Un greenhouse SBA cheratolitic in pupae coating which eliminates the time coating adultii.In pupae focuses in much greater quantities of eggs compared with the formation of pupae appear orificelor holes which pupae hatch adults coating which eliminates adults. At this point in the opening training focuses cheratolitice substances which occur under the influence of large quantities of greenhouse cheratolitic SBA to eliminate adult.
It should be noted that SBA can be collected before hatching adultului.SBA synthesized in pupae cheratolitic effect can be used to remove wrinkles in cosmetic and skin keratitis in tissue.
One of the most accurate methods for detecting certain SBA is that in our case spectrophotometry was used for 20 ani.Noi believe that this method is the most accurate and easy to utilizat.Materialele obtained were interpreted very difficult because the compounds complex fingerprint formed variables.
Proteins usually appear on the prints in the wavelength of 280 nm in the 200-250 nm carbohydrates, lipids appear different depending on the solvent in many areas, the most specific being 300-315 nm in solvents such as chloroform, n- heptane, ethanol-cloroform.Toate prints are made ra UV spectrum.
During the study of proteins, lipids and carbohydrates have received an enormous number of fingerprints that are presented in this lucrare.Poate that other specialists will be able to find other interpretations than those presented by spectrophotometric autor.amprentele tissue of insects to certain phases of and development of certain organs of vertebrates.
Thus we can see the absorption spectrum of the SBA of certain tissues of some species of insects and various organ tissues of vertebrates and insects under the action of certain solvents.
According to literature data, the analysis made by spectrophotometry method demonstrated that proteins extracted from tissues of various insect species is distinguished by the fact that the curve peaks differ from other fingerprint spectrophotometric fingerprints of proteins extracted from other species of vertebrates and plants. Usually proteins are located in areas of 280nm wavelength and 215nm. Proteins extracted from insect tissues are located in areas of 200-250nm and another little usually less than 250-280nm. Power absorption depends on protein concentration.
If Our staff have been fingerprinted for bovine albumin, which causes a single bit to mark the wavelength of 224nm with an absorption of 2.8 (Fig.17). Protein extracted from tissues of Bombyx die, kiss 8 days to form a single curve in the PIAC wavelength of 193.5 with a concentration of 1.0726 Abs.
After extraction of proteins in water for 8 days PL pupae (Lepidoptera), mortars and then stand for 24 hours at 4 ˚ C, the suspension forms a white sediment and a pink and gray matter. Analyses conducted in the sediment and fotospectrometrice or the supernatant, which form the fingerprints fotospectrometrice identical curves (Fig.). From pupae of Lepidoptera formed an impression with two peaks. The suspension of the supernatant (protein and other water-soluble components) form a little more pronounced in the wavelength of 215nm with the absorption of 2980 and the second bit is formed in the wavelength of 277nm with an absorption of 0.9413 Abs.
B. Proteins from sediment suspension form die a little less intensity in the wavelength of 211.5 nm with the absorption of 0.9413 compared to those of the sediment (Fig. 3). Curve obtained from the MM suspension imago (beetles) diluted 4 times cause a curve in the wavelength 209.5 nm in the absorption of 5.2 Abs (Fig. 4). Curve with a single bit is obtained from MD (diptych)
Amino acid composition in different species of insects vary greatly., But in many cases dominated glutamic acid, lysine, and phenylalanine aspargina

CARACTERISTICA ACIZILOR AMINICI EXTRASI DIN PROTEINA “O”

DENUMIRE mg / 1g
Acid glutamic 75,4945
Lizina 45,1406
Asparagina 42,9061
Prolina 36,5011
Alanina 27,0075
Leucina 23,8904
Cisteina 22,1680
3 – metilhistidina 21,9060
Arginina 21,1857
Treonina 20,7983
Serina 20,4660
Tirozina 19,2085
Glicina 18,0638
Fenilalanina 17,1836
Valina 15,5811
Izoleucina 13,6430
Amoniac 13,0170
Histidina 11,7169
Σ acizi aminici 461,9876
Σ acizi proteinogeni 436,3811
Σ acizi succesibili 261,8154
Σ acizi nesuccesibili 174,5057

CARACTERISTICA ACIZILOR AMINICI EXTRASI DIN PROTEINA “Pe”

DENUMIRE mg / 1000mg
Acid glutamic 39,647
Asparagina 31,698
Fenilalanina  39,6320
Arginina  21,287
Lizina 17,650
Leucina 15,185
Alanina 16,878
Pirolizin 13,936
Glicina 13,156
Treonina 15,872
Prolina 12,995
Valina 13,329
Izoleucina  11,515

CARACTERISTICA ACIZILOR AMINICI EXTRASI DIN PROTEINA “Gm”

DENUMIRE mg / 1000mg
Acid glutamic 40,517
Fenilalanina 31,702
Asparagina 29,931
Arginina  19,920
Lizina 19,689
Leucina 1,7732
Alanina 17,110
Prolina 15,372
Treonina 1,4760
Serina  1,2719
Glicina  13,951
Valina 12,480
Izoleucina  12,649
Pirolizin  11,124
The feature caracteristic) of amino acids that were extracted from protein „PL”
DENUMIRE mg / 1000mg
Fenilalanina 84,520
Acid glutamic 68,441
Asparagina 52,339
Lizina 39,386
Leucina 32,788
Pirolizin 30,443
Treonina 27,378
Alanina 28,693
Prolina 29,489
Glicina 22,646
Valina 25,392
Izoleucina 22,427
Arginina 26,030
Serina 18,645
Histidina  14,232
DISCOVERY the peptides from insects

The insects have been particularly prosperous in the evolution and current estimates. This shows that they represent three-fourths of all existing species. With the exception of most authors who have studied the biochemistry of insects, which occupy nearly all ecological niches on Earth. They are compared with other pathogens: bacteria, viruses, fungi, protozoa and parasitic worms. During evolution, insects have developed defense mechanisms other than specific pathogens.
Studies by Metchnikow (1) and Cuenot (2) the late 19th century, outlines the role of haemolymph in this resistance. A more complex picture was developed in 1920, when some researchers have shown that insects can be immunized against lethal doses of bacteria by an injection of any culture attenuated by heat or low doses of virulent culture (3). Induced protection was apparent as early as 3 hours after injection. Are there relatively broad spectrum of protection and this was accompanied by the appearance of activity in haemolymph bacteriolitice thermostable power (4.5). Surprisingly, these promising studies, almost fallen into oblivion and the host defense of invertebrates have been completely abandoned before 1970, when HG Boman and associates in Stockholm began several series of investigations of defensive reactions and later the moth Drosofilei Sitotroga ( 7). These authors found that injection of bacteria in the moth pupa has the effect of immune protein synthesis. They have some of these proteins purified and characterized two new classes of antibacterial peptides that we have called cecropine (7) and atacine (8). The time was then ripe for large isolation induced immune molecules in various species of insects and in the years that followed, an unexpected variety of antimicrobial peptides were isolated induncibile in several laboratories in different species of insects (their number exceeds 150) . AMPs were produced in body fat, body functional equivalent of mammalian liver. These peptides are supposed to synthesize in a few hours after septic aggression. They are secreted in haemolymph justifying bacteriolitica activity evidenced by previous authors.
Recent studies have shown that in addition to this defensive reaction, it is now immune response in epithelial cells of the cuticle, traheelor, intestine and other types of epithelia. Current opinion is that the insect host defense has many aspects and involves, besides the rapid synthesis of antimicrobial cationic small peptides, the phagocytosis and encapsulation formations which occur in haemolymph cells. Additional defensive reactions are insect haemolymph clotting and melanizare process.
I reflected on some of the reactions produced by cells of the lepidopteran appearance bacterial infections, which causes the appearance of antimicrobial peptides in haemolymph and body fat cells.

ENTOMOTHERAPY VOL8

Author’s comments

Lately there was  more information about the existing low molecular weight peptides in insects. Most information belonging to chemists, to comment on this molecular structure formations strictly as antibacterial properties. But no one thought to another biological aspect. Most insects have four stages of development: egg, larva, pupa and adult. After our data at the stage of egg proteins are present predominantly lipids that form a complex and very complicated lipoprotein. The larva stage is a larger amount of fat and protein. But the most complicated reactions occur in pupa stage, when the lipoprotein complex turns on the very active part in SB, which forms eggs or spermatoizii, on the other hand, form a quantity of inert material such as keratin or chitin, with a composition very complicated. There appear various fantastic colors of some butterflies or beetles. Often synthesize materials to fix eggs glued tree stems, or protective material that covers the eggs with a thick layer of keratin enough to protect them from adverse environmental actions inconjurator.Aici there are still many material compositions unidentified. So far been identified only silk silk worm, but there are still many unidentified materials. We work with new materials to build the composition of insect blood vessels and materials that can replace human skin.

All these materials are synthesized in the pupa stage. Here there is a factory where new materials are obtained and compositions appear new.In this stage of development there is a wide range of peptides and polypeptides. Occurring enzymes and oligopeptides, inhibitoari of protein synthesis and of nucleic acids. Thus, these structures, perhaps small peptides can induce multiplication stopping viruses, bacteria and yeast so common in nature, which causes incurable diseases to humans. These inhibitory substances served to us in the development of many biological prepared waive the immunity of human body. Thus the composition of many insect species there are many substances with curative properties that will increase human longevity.

The peptides that form α-HELIXURI AMFIPATICE-CECROPINELE
??
In insects, the only inducible antimicrobial peptides containing α-helixuri amfipatice are cecropinele. They have from 31-39 amino acids lacking cysteine residues. These highly basic N-terminal region and a long hydrophobic formation in C-terminal half. Cecropinelor a three-dimensional structure, as is deduced from nuclear magnetic resonance studies (NMK) in water trifluoretanol (16), consists of 2 α-helixuri joined by a glycine-proline region containing doublet. N-terminal α helix is almost perfect amfipatic. Since the initial report in 1981 on cecropinei of Hyalophora (7) up to 28 isoforms of cecropina were isolated from the blood of insects assaulted by bacteria belonging to various species of Lepidoptera and dipterous (tab1). Despite several investigations detailed cecropinele were not so far reported in order of insects. Cecropinele are very active [minimum inhibitory concentration (MIC3) low molecular weight] against some gram-positive and gram-negative. Recently, a new cecropina was isolated from a cell line of Aedes albopicus; sequence of this molecule is significantly different from all other cecropine reported (Table 1)
Intramolecular disulfide peptides BRIDGES

Insects produce several types of antimicrobial peptides with disulfide bridges, namely, defensinele of insects. Below we describe Tanatina, a peptide with one disulfide bridge, which contains two decks Androctonina, defensinele insects, 3 bridges and finally Drosomicina, which shows four bridges.

TANATINA

Antimicrobial peptide isolated is a bug Podisus Maculiventris Hemiptera. Tanatina has no sequence homology with other insect defense molecules, but has large similarities brevininele, a family of antimicrobial peptides isolated from frog skin secretions on (33). Sequence homology between tanatina general and brevinina is 50% (tab2), and both contain a C-terminal loop 6 (tanatina) or 5 (brevinina) amino acid residues formed intramolecular disulfide bridge from. This loop carries a strong positive charge in both molecules and contains a central rest of threonine, which separates the two subgroups of electropozitivitate. A similar arrangement (2 cystine C-terminal charged residues flank a group separated by a rest or Ser THR) has been described in other antimicrobial peptides from frog skin (eg, esculentine, gaegumine and ranalexine) and improved molecule from the wound. Insect molecule molecule differs from Rana by adding a loop rest of ASN (34).
Tanatina has a broad spectrum of activity against gram-positive and gram-negative bacteria and fungus. Activity is observed at concentrations from 0.5 to 10 nm, corresponding to those found in the blood of insects imunizate.La these concentrations, is both bactericidal tanatina and fungicides. Tanatina and is not hemolytic for brevininelor.
Preliminary results indicate that the cytoplasmic membrane is targeted and that this molecule tanatinei unlike defensinele and cecropinele of insects, is a peptide that forms pores. Furthermore, results suggest that a tanatina involved more than one mechanism of activity in destroying bacteria and fungi (32).
H-NMR spectroscopy and two-dimensional molecular modeling indicates that the β sheet structure tanatina adopt a folded antiparallel to the rest 8 to the C-terminus (Fig. 1) (rest 21) including bridge-SS (35). Despite the presence of two proline residues, seems to be a large degree of variability in N-terminal segment.
ANDROCTONINA? /?

Recently the 25th remnant antimicrobial peptide was isolated from scorpion Androctonus australis blood (36). This peptide has four cystine disulfide bridges attached in two related intramolecular Cys with Cys 4 and Cys 10 linked second CYS16 (tab 3). Androctonina is highly cationic with a calculated pi of 10.2 and contains eight positive charge, including a group of three residues Gly residue ARG about two in the central part of the molecule.
Interestingly, this reason is also observed in two scorpion Leiurus defensin isolated from blood and Androctomus (tab.4). Androctonina has no sequence similar to other defensin molecules. However, show a high degree of similarity to tahiplensinele, cationic antimicrobial peptide family of Japanese crab, Tachypleus tridentatus (37). In addition androctonina has some structural similarities protegrinele, which are antimicrobial peptides isolated from porcine leukocytes (38 ). The crowd disulfide (Cys1-Cys4 and Cys 2-Cys3) is identical to the three families, suggesting a similar three-dimensional structure.
Is active against both bacteria Androctonina both gram-positive and gram-negative and also exhibit a broad spectrum of activity against fungi. Even at high concentrations (150γM), hemolytic activity against androctonina no red blood cells of cattle or pigs.

DEFENSINELE of insects

The name of the insect defensin was originally proposed by Lambert and associates (1989) 4-kDa peptide for 2, isolated from blood larvae of flies infected with bacteria which showed similarity Phornia terranovae frequency with defensinele in mammals.
In an independent study, the authors and collaborators have shown that an embryonic cell line, NIH bits 4, derived from another species of dipterous Sacrofaga pilgrimage produces an insect defensin from isoform, which they called a sapecina.
Many of the insects are active defensinele against gram-positive bacteria but little activity against gram-negative bacteria. They are not hemolytic. These molecules have a wide distribution among classes of insects. Their presence has been reported by others in dipterous, Caleoptera, Trichoptera, Hymenoptera, Neuroptera, Hemiptera and Sighisoara (look tab.4 and references in it). Antimicrobial peptides similar sequences were also found in scorpions and mollusk Mytilus edullis.

In recent work published on the insect peptides with bactericidal or fungicidal effect may report the following: during morphogenesis, the insects go through four phases of development: egg, larva, pupa and adult.La each development phase not only morphological changes, but also biochemically. The predominant egg protein component (Fig.), lipids are the second, and carbohydrates are very few. The larval component (single phase that feeds) there are many proteins and lipids. The most interesting phase is the transformation happen extraordinare.Proteinele pupa.Aici soluble protein becomes insoluble – keratin and chitin, which forms the adult, eggs or spermatoizi, protective substance eggs to protect them from adverse environmental actions . Approximately 90-93% of material is the material inactive pupae.
Typically, females are larger in volume and weight compared to males, because they include large amounts of protective material to protect the eggs and are usually active oualor.Adultii to 5 days. Only this time accumulated energy reaches. After mating, the adults die and outgoing.
Cheratinizare process of different insects and occurs very rapidly. From this point of view, some species of insects are models of transformation of SBA research in biologically inactive. During these transformations occurring enzymes and peptides that allow these first appear transformari.In SBA (enzymes and peptides), which inhibits the synthesis of proteins and nucleic acids, thus inhibiting the life processes. This process can be detected and isolated a series of activators and inhibitors of vital processes. Here there are many types of defensin (inhibitors). Peptides inhibit the multiplication of pathogenic organisms, which were recently discovered (defensin), which speaks much, is not nothing but SBA to stop protein synthesis and nucleic acids.
reported above for I can bend the presence of peptides with different structures.
I believe in insect pupae is an intense process of tissue chitinizare cheratinizare or invertebrates. This we can prove the amount of insoluble protein increases rapidly and soluble protein (s) that decrease obviously. Lipids and carbohydrates in the last phase of larvae and pupae away, that turns into lipo-protein complex. These transformations take part in specific peptide that inhibits the synthesis of proteins and nucleic acids specifici.In this situation can not form any pathogens, especially viruses.
I worked a lifetime with baculovirus, and pupa stage viruses disappear as morphological structures. Can be integrated in the genome, where you can not find? Biologically active substances extracted from the insect antiviral effect.
SBA detect antiviral effect is a world first. These preparations will produce a revolution in contemporary medicine. Proteins extracted from certain species of insects cause a foreign environment for specific viruses vertebrates
Based on SBA extracted from certain species of insects has been developed HERPES-LIZ preparation in the patent in 2000 I 00579/118114, which is in the form of an ointment that is applied to the infected tissue 2-3 times a day. Matrix ointment has the ability to penetrate to the depths of infected tissue, inducing and active substance that inhibits virus replication at the stage of nucleic acids in nucleocapsid assembly. Nucleic acids are destroyed nucleocapsidelor out quickly and are eliminated from the cells as a foreign body.
Vesicles with liquid dries immediately and repair lesions without leaving undesirable traces on the skin. (Fig.). The figure is shown a case at baseline and over 5 days of treatment.
Another antiviral preparation is developed based on the 2000 patent 00580/118115 N, which is called HEPATITO-LIZ and is intended to eliminate liver infections caused by viruses A, B, C, D, E, G, very common in populations with high density. Viruses are well trained and infects only certain areas of the liver, causing liver virozele borne difficult patients.
In the tissues of insects still holds many SBA miraculose, still undiscovered by humans. But the most important of these substances are the antiviral effect, which is a type of viral protein synthesis inhibitors, as the stage of training programs that begin to form in the kiss, is the hardest one keratin ( dead substance).

The METABOLISM of chitin in insects

Are interesting research information and Lars Zimoch Merzendofer Hans, who plays chitin metabolism in insects, but do not speak anything of keratin, the cuticle of insects there are in it.
According to information the authors mentioned above, chitin is one of the most important biopolymers in nature. It is mainly produced by invertebrate animals, fungi, especially in Arthropoda and Nematode. The insect acts as support material for skin and cuticles as matrices peritrofice trachea, intestinal epithelium lined. Insect morphogenesis is strictly dependent on the ability to remodel chitin-containing structures.
For this purpose, insects repeatedly produce chitin synthase and chitinolitice enzymes in various tissues. Coordination of chitin synthesis and degradation them, require strict control of the participating enzymes during development. We mention the recent progress in understanding chitin synthesis and degradation them to insects.
Insect cuticle form a rigid exoskeleton which can not expand because of this, at certain stages of development is done shedding – by chitin and keratin cuticle changes. In the biochemical changes which occur shedding enzymes under the influence and chitinazelor cheratinazelor exzuvie (shell), larvae detach from the body. Instead exzuviilor larvae detached from other forms of chitin and keratin formation, which protects the body larvae. Often the surface is covered with insect larvae hairs very hard. To allow growth and development of insect larvae is necessary to replace the roof with a new one by shedding (ecdysis).
Shedding is initiated by the displaced persons, a process that separates the old cuticle epidermal cells by liquid shedding. The fluid contains proteases that digest and chitinaze endocuticulei main constituents old to be reabsorbed and recycled for cuticle formation in November. Insects repudiate their old shell, a process now called shedding. In the process of shedding occurring hormones, such as hormone hatching.
Chitin is a polymer of N-acetyl-β-D-glucosamine. MRI and gravimetric analysis to see that it is up to 40% of dry weight depending on the species exuviei and vary considerably with different types of cuticle even the same body. Chitin is associated with protein mainly determine the mechanical properties of cuticle. The Locust migration were observed by elecroforeza 2 – D more than 100 different proteins. One of the most well understood resilina protein, a protein-rich and proline glicocol, cuticle elasticity gives high joint regions. Insects contain chitin and peritrofice matrices that line the digestive tract and is of 2 types: Type 1 is the entire digestive route, Type 2 only to cardia area (between the esophagus and intestine above).
Peritrofice arrays are usually 3-13% chitin. The sextant Manduco peritrofice 40% of arrays also contain a mixture of proteins, glycoproteins and proteoglycans.
STRUCTURE chitin

It is the most common amino polizazaharid in nature. It is estimated that annually produces almost as much as cellulose. Especially in the exoskeleton of arthropods, cell walls of fungi, nematodes shell eggs. Chitin oligomers derivatives have been implicated as factors in the relationship between plants morfogenici bean and Rhizobium and even in vertebrates where they can be important in the early stages of embryogenesis.
Chitin is composed of residues of N – acetyl – glucosamine linked by β links – (1-4) – glucosidic. Hydrolysis with glucosamine and N chitinaza results – acetyl – glucosamine. However MRI cuticle of the tobacco horn worm with showed that glucosamine is not present. Tends to form chitin microfibers (called rods or crystallites) of approximately 3 mm in diameter, stabilized by hydrogen bonds between amino and carbonyl. Microfibres peritrofice matrix may even exceed 0.5 μ in length and are frequently associated in bundles containing parallel groups of 10 or more micro. X-ray diffraction suggested that this substance, chitin, is a substance that appears in three polymorphic crystalline modifications, called chitin α -, β – and μ -. They differ mainly in degree of hydration, in unit size and number of chitin chains. In all chains form α has a antiparallel orientation, in the form β chains are arranged parallel, in the form μ 2 sets of parallel chains with alternating single antiparalele chains. Transient non-crystalline states have been found in fungi. All three structures are found in crystalline forms of insect chitinase. Α is the predominant form in cuticle chitin, forms β and μ are commonly found in cocoons. Peritrofice matrices and usually consists of α β – chitin. Sometimes the presence of β – chitin in cocoons can be explained by the fact that some form of matrices peritrofice cocoons, for example those of Australian beetle Ptinus tectus

Antiparallel arrangement of molecules of chitin in the form α close packing of the fibers allows consisting of chitin chitin about 20 chains stabilized by a large number of hydrogen bonds intra and inter molecular. This arrangement contributes significantly to the physical properties – eg chemical cuticle. Strength and stability. In contrast, in the forms β and μ, packing strength and number of hydrogen bonds between chains are reduced, as a large number of water connections H2. The high degree of hydration and strength resulting in reduced packing chitinase structures more flexible and soft matrix peritrofice or cocoons. The differences in the arrangement of the fibers between the cuticle and chitin matrices peritrofice help understanding their function. Cuticle is secreted in the form of thin layers of skin cells microvili beekeeping.  A microfibre of chitin is included in the matrix protein and stabilizes as reinforced concrete. Peritrofice microfibres are placed in the matrix normally in a network of structures included in an amorphous matrix and only few cases have been found highly ordered configurations.

FORMATION OF chitin

Trehalose (trehalose )____ β – D – glucose (hexotinaza) ___
Glucose – 6 – phosphate (glucose – 6 – phosphate isomerase)
Fructose – 6 – phosphate (glutamine: fructose – 6 – phosphate aminotransferase)
Glucosamine – 6 – phosphate (Glucosamine – 6 – phosphate N – acetyltransferase)
N – acetilglucozamin – 6 – phosphate (fosfoacetilglucozamin move)
N – acetilglucozamin – 1 – phosphate (VDP – N – acetilglucozamin pirofosforilaza
UDP – N – acetilglucozamina (chitinsintaza) chitin

Fig.1. Chitin biosynthesis in insects. The path starts with trehalose, the main sugar in the haemolymph of many insects.

Chitin synthase is UDP – N – acetyl – D – Glucosamine: chitin, or
4 – β – N – acetilglucozamiltransferaza (EC2.4.1.16), an enzyme found in any organism that synthesizes chitin from UDP – N – acetilglucozamina (UDP – GlcNac). It involves the formation of an intermediate with a lipid to form dolichildifosfo – N – acetilglucozamina. Chitinsintazele are dependent on the presence of Mg2 + or Mn2 + ions.
Two chitin synthase activity in models of Golgi vesicles
A – extravezicular
UDP – GlcNAc – chitin
– UDP
B – intravezicular
UDP – GlcNAc – chitin (in cytoplasm) → sp. extracellular
– UDP (in cytoplasm)
Failed to purify chitin – substance synthase until homogeneous.
Optimal pH 7.2; p.I 6.1 to 6.7
Chitin – SINTAZELE of insects

It is assumed that the molecular weight of insect chitin is aprox.180 kDa with 15-18 transmembrane helixuri, indicating that the enzyme is a protein integral membrane. PCR was seen that it is detectable in all stages of development and that are located in epidermal cells under procuticula.
Fungi have multiple genes that encode isoforms of chitin synthase. Nematodes and insects have a limited number of copies of the gene.
AA sequence of the chitin sintazelor fungi, nematodes and insects reveals that insect enzymes are closer to nematodes than fungi.
Sintazele of insect chitin are transmembrane proteins 160 kDa large GM – 180 kDa. The molecule consists of three areas: A, B, C.
Field in region A is N – terminala.Acesta has a variable number of transmembrane helixuri. Depending on their number, the N – terminal seems to be located on different parts of the membrane or extracellular environment to either the cytoplasm.
Field B is in the center of the molecule and comprises approximately 400A and contains the enzyme catalytic center. Is highly conserved and contains two unique areas, EDR (Glu – Asp – Arg) and QRRRW (GLN – Arg – Arg – Arg – TRP) that are present in all types of chitin synthase and thus can be viewed as sequences, signature ‘ ‘. Some conserved residues are believed to be essential for catalytic mechanism that may be involved in substrate protonarea. Substitution of these sequences AA others drastically reduce the activity of chitin sintazelor. 3 more blocks have been described in highly conserved in insect chitin sintazele: CATMWHXT (Cys – Ala – THR – Met – TRP – His -? – THR, poz.583 – 590), QXFEY (GLN -? – Phe – Glu – Tyr , pos 794-798) and WGTRE (TRP – Gly – THR – Arg – Glu, pos 1076-1080 0 in a CHS protein in Drosophila.
R contains the C – terminal and contains 2AA could also be involved in catalysis: W (trp, pos 803) and T (THR, poz.805), immediately after the transmembrane helix 5. He has seven transmembrane helixuri.
Based on sequence differences of chitin sintazelor were grouped into two classes: CHS – CHS A and – B. Many insects seem to have a copy of the gene for each enzyme. Both genes are located on one chromosome in Drosophila and Anopheles, it is possible that they come from a single ancestor by gene duplication.

ADJUSTMENT chitin SINTASIS (SINTAZELOR)

Chitinizare process and cheratinizare insect is primarily important for us to understand how to make some natural polymers in other compounds. This information allows us to find and understand the mechanisms of conversion to determine the presence of certain enzymes in the tissues of some species of insects and the possibility to use them effectively to develop new dishes tissue regeneration body, primarily the human skin, which deteriorates very quickly and some that are considered incurable diseases.
It should be noted that insects are the most specialized organisms on Earth, because according to them there is information about. 3 billion. years and during this time were better adapted to conditions on metabolism terestre.Informatiile insect defense against adverse environmental conditions have made more sophisticated defense substrates compared to those of mammals.

Existing SBA Some insects can occur tissues to conduct operational trials of human skin. So, for example, the substance that helps eliminate unwanted formation of human skin tissue can be found in the composition of insect species when they occur at some time or chitinolitice cheratolitice substances, making the natural polymers to other substrates, which are eliminated as „ „ foreign bodies. Thus lipoprotein tissues of some insect larvae at some point turn into other nonspecific substances. Enzymes and peptides of insect tissues that occur when some transformations can transform tumor (carcenoame, lipomas and others), turning them into other tissues, which is eliminated from the body as foreign objects.
Formation and degradation of chitin is essential for insect development. Insect metamorphosis is regulated by releasing ecdisonei, a steroid hormone secreted by the gland haemolymph protoracica.
Sintazelor chitin activity is enhanced by limited proteolysis. It is tempting to speculate on the existence of a pole proenzime inactive cell that activates specific signals. Besides proteases, factors affecting the activity of chitin synthase regulators that can exist in insects. The yeast were described several proteins involved in regulating the synthesis of chitin and keratin.

The DEGRADATION of chitin

Sintazele chitin and works closely chitinolitice enzymes in the remodeling structures chitin. Degradation enzymes include chitinazele {poly [1,4 – (N – acetyl – β – D – glucozaminid)] glicanohidrolaza, EC 3.2.1.14} and β – N – acetilglucozaminidazele (β – N – acetyl – β – D – hexozaminid N – acetyl – hexozaminohidrolaze, EC 3.2.1.52). All catalyzes hydrolysis of β bonds -) 1-4) – glycosidic bonds of chitin oligomers and polymers. Some of them including an enzyme catalyze reactions of insect’s transglicozilare. Since the enzymes that degrade chitin can be used to convert raw material to chitin components used in biotechnology, they are important for chemical and pharmaceutical industries. In addition, chitinazele and their inhibitors may be adopted as the SBA, which can regulate some vital body processes.

The organisms that produce chitin and keratin, enzymes are essential for maintaining normal chitinolitice functions lifecycle, eg. morphogenesis and cell division in arthropods or the yeast and other fungi sporularea. They are also found in organisms that do not contain chitin but using chitin as a food source, for example. Streptomyces spp gene were identified in the genome chitinaza nucleopolihedrovirusului (family Baculoviridae) Autograph californica insect, arthropod-specific virus. Chitinaza baculovirus can play a crucial role in the ability of the virus infection. For plant and vertebrate chitinazele, including those produced by human macrophages, are thought to act in defense against pathogens or pests that contain chitin.
In insects, enzymes that degrade chitin plays a crucial role in postembrionara development, especially shedding larvae and impupare. Chitinolitice enzymes are also found in some Hymenoptera venoms of spiders in the digestive fluid which may facilitate prey toxins through the cuticle. Recently it was discovered a specific chitinaza body fat in the milk gland tissue and may be important for the development of tsetse flies intrauterine larvae of Glossina morsitans livebearers.
Because chitin is difficult to split because of its physico-chemical properties, is needed more than one type of enzyme.
Endo – helps break down chitinazele Chitose – oligomers, then they are converted to monomers by exo – β – N – acetilglucozaminidaze.

Enzyme exo – off units of N – acetyl – glucosamine at the end nereducator and prefer substances smaller than chitinazele. As a result the overall speed is limited by the action of chitin hirolizei chitinazei producing Chitose – oligomers, which increases the effective concentration of substrate for β – N – acetilglucozaminidaza.
The mechanism of catalysis appears to be similar to that which is assumed to complex cellulase (endo – and exocelulaza).
Interesting thing: the emergence of both enzymes appears to be chitinolitice in reverse order. In Manduca, mills and Locustae Bobyx xo – chitinaza shedding occurs earlier than endochitinaza. Since the cuticle is a matrix of chitin and protein strongly linked, must be present and proteases.
CHITINAZELE of insects
Chitinazele family of insects belonging to 18 superfamilies glicohidrolazelor and have a high degree of similarity of AA. Chitinazele of insects have theoretical molecular weight 40 kDa – 85 kDa, pH optimum variable sites (4-8) variables pI (pH 5-7). The basic structure consists of three areas: (1) catalytic region, (2) a PEST region – like rich in AA Pro, Glu, Ser, thr and Cys-rich region. The last two areas seem to be necessary for the chitinazica.
Chitinazelor catalytic domain of the fam. 18 includes N-terminal half of the enzyme. It is believed that the N-terminal domain influences the binding or hydrolysis of the substrate. There are two highly conserved regions within the catalytic domain, the 2 – to include the catalytic center. It has a barrel-shaped structure, forming a well. This dip is considered active center, linking carbohydrate units of chitin, possibly portions (GLC NAC) 6.
Chitinazele of insects are anchored to the substrate through the C-terminal, characterized by six Cys reason.
This conserved acidic residues appears to be a common feature of active site glicohidrolazelor. Since the tertiary structure of family 18 is similar to other chitinaze glicohidrolaze was postulated a mechanism of acid hydrolysis of AA proposing preserved. FDxxDxDxE signature sequence (Phe – Asp – x – x – Asp – x – Asp – x – Glu) is found in the active site, including a change of Glu essential for catalysis. Highly conserved sequence YDFDGLDLDWEYP (Tyr – Asp – Phe – Asp – Gly – Leu – Asp – Leu – Asp – TRP – Glu – Tyr – Pro) is 18 chitinaze family signature.

By mutagenesis, by replacing Glu in the active center, when there was loss of enzyme activity, thus Glu is essential for activity. Based on crystallographic data has been postulated that the active site binding cleft for hexamers of N – acetilglucozamina. Catalytic mechanism of soluble byproducts are chitotetroza, chitotrioza and chitobioza (predominantly).

Chitin and keratin DEGRADATION CONTROL

Because chitin and keratin vital role in the development of insects, their degradation should be well adjusted as synthesis. Chitinazelor activity and cheratinazelor of skin shedding is restricted to periods and impupare while chitinazele the intestine are induced by feeding.
Degradation by enzymes cheratinazelor cuticles and certainly require specific fluid contribution in shedding proteases, which degrade protein components. These proteases may also function in proteolytic activation of precursors of chitinazelor reagents.
The proteolytic activation has been intensively investigated chitinazelor in Manduca and Bombyx. A probable zimogenica chitinazei form with a molecular weight of 215 kDa was observed in Bombyx during spinning. 2-3 days later, when enzyme activity is detectable, there are three active fragments of 88 kDa, 65 kDa and 54 kDa, which may be the result of successive proteolytic processing. They have a common sequence N – terminal, so different in length at the C – terminal.
It was suggested that the enzyme contains a 88 kDa domain of chitin binding strong. This domain may be lost by proteolysis from the C – terminal, resulting in variants that are more active chitinaze shorter substrates.
Similar results were observed in the skin of Manduca where a protein of 119 kDa can be seen as a precursor protein zimogen and some smaller than activated proteolytic fragments.

METABOLISM INHIBITORS chitin

Because chitin and keratin metabolism is crucial for insect development, inhibition or disruption of key enzymes are important targets for development Entomoterapiei as a series of SBA may conduct a series of problems in vertebrate animals, including humans.
Chitin synthesis inhibitors were classified into 3 major groups: peptidyl nucleosides, acyl urea and substances that interfere with hormonal control.
Peptidyl nucleosides isolated from Streptomyces species diverse acts as substrate analogues and include polioxinele and nikomicinele. They competitively inhibit chitin sintazele of both fungi and insects, probably by binding to the catalytic site. Polioxinele have found some applications in controlling pathogens. Nikomicinelor commercial application is uncertain, although it seems to be more potent inhibitors than polixinele. In general use nukes is complicated because peptidyl low permeability, hydrolytic lability, varying susceptibility of species of fungi and the multitude of responses in animals.
Acyl urea plays an important role in integrated pest control. Although it is well established that acyl urea, for example chitin synthesis affect diflubenzuronul and teflubenzuron, their mode of action is unclear.
The third group of inhibitors affect hormonal regulation of insect growth and development. One of the many effects is probably chitin synthesis by preventing disruption of chitin synthase expression or adjustment factors. Regulating hormones can be disturbed in the biosynthesis of hormones. It was shown that some synthetic derivatives of imidazole and of cholesterol biosynthesis prevents ecdysteroidului. Heterocyclic compounds and alkaloid brevioxima arborina presents a significant blockage of juvenile hormone synthesis.
Chitinazei inhibitors can be grouped into two major classes: either mimic carbohydrate substrates or intermediates. The most studied inhibitor is allosamidina chitinazei a pseudotrizaharid. Allosamidina consists of two sugars of N – linked to a allosamizolina acetilallosamina mimicking catalytic intermediary and can not be hydrolyzed because it lacks oxygen piranozic.
Allosamidina is a potent inhibitor of chitinazei. Its production is expensive because it is difficult to synthesize. A new class of inhibitors includes alternative and argadina ciclopentapeptidele argifina. Their synthesis is cheaper.

CONCLUSION AND OVERVIEW

Use of insecticides is essential for crop pest control, public hygiene, for comfort and for veterinarians. However, the effectiveness of commercial insecticides is becoming increasingly compromised by the emergence of resistance, which leads to detoxify the compound or modified target sites.
To overcome the problems of insufficient long-term pest must be identified new compounds that act to new target sites. As I pointed out chitin synthesis and degradation is crucial for growth and development of insects and are therefore ideal targets for interruption and disruption by new insecticides. We are still far from understanding how the action of enzymes involved, especially chitin and chitinazelor sintazelor. We do not know the mechanisms that control and coordinate regulation biosynthesis and activity during development. A major problem in the study of insect chitin sintazelor is that we still do not have a homogeneous preparation of native sources, probably because of their intrinsic instability. Recombinant baculovirus that chitinaze of insect genes are potent biocide that can disrupt the functioning of infected insects peritrofice matrix, resulting in an increased susceptiblitate from other toxic compounds.
In conclusion, understanding basic principles of insect chitin metabolism and regulation will open new avenues of pest management.

Examples:

Antiviral drug HEPATITO-LIZ. Based on complex lipoprotein extracted from several species of insects and patented (patent N 2000-00579 / 118 114). This patent, in April 2003 was awarded the gold medal and bronze medal at the Salon of Inventions in Geneva.
The drug was initially registered as a food supplement with N. ….. Ministry of Health of Romania. Pharmaceutical dossier was made at the Department of Pharmacy State University of Moldova. Clinical tests were performed at Hospital for Infectious Diseases of the Ministry of Health of the Republic of Moldova, which have shown an improvement in key parameters: transaminases, electrophoresis, complete blood count, triglycerides, cholesterol, viremia.
Below are the concrete analysis of patients who were under treatment with the preparation HEPATITO-LIZ:

CONCLUSION AND OVERVIEW

Use of insecticides is essential for crop pest control, public hygiene, for comfort and for veterinarians. However, the effectiveness of commercial insecticides is becoming increasingly compromised by the emergence of resistance, which leads to detoxify the compound or modified target sites.
To overcome the problems of insufficient long-term pest must be identified new compounds that act to new target sites. As I pointed out chitin synthesis and degradation is crucial for growth and development of insects and are therefore ideal targets for interruption and disruption by new insecticides. We are still far from understanding how the action of enzymes involved, especially chitin and chitinazelor sintazelor. We do not know the mechanisms that control and coordinate regulation biosynthesis and activity during development. A major problem in the study of insect chitin sintazelor is that we still do not have a homogeneous preparation of native sources, probably because of their intrinsic instability. Recombinant baculovirus that chitinaze of insect genes are potent biocide that can disrupt the functioning of infected insects peritrofice matrix, resulting in an increased susceptiblitate from other toxic compounds.
In conclusion, understanding basic principles of insect chitin metabolism and regulation will open new avenues of pest management.
Examples:

Antiviral drug HEPATITO-LIZ. Based on complex lipoprotein extracted from several species of insects and patented (patent N 2000-00579 / 118 114). This patent, in April 2003 was awarded the gold medal and bronze medal at the Salon of Inventions in Geneva.
The drug was initially registered as a food supplement with N. ….. Ministry of Health of Romania. Pharmaceutical dossier was made at the Department of Pharmacy State University of Moldova. Clinical tests were performed at Hospital for Infectious Diseases of the Ministry of Health of the Republic of Moldova, which have shown an improvement in key parameters: transaminases, electrophoresis, complete blood count, triglycerides, cholesterol, viremia.
Below are the concrete analysis of patients who were under treatment with the preparation HEPATITO-LIZ.
The CHITINASES from  insects

The chitinases from insects belong to family 18 of superfamilies glicohidrolases and have a high degree of similarity of AA. The chitinases from insects have theoretical molecular weight 40 kDa – 85 kDa, pH optimum variable sites (4-8) variables pI (pH 5-7). The basic structure consists of three areas: (1) catalytic region, (2) a PEST region – like rich in AA Pro, Glu, Ser, thr and Cys-rich region. The last two areas seem to be necessary for the chitinazica.
The chitinases catalytic domain of family 18 includes N-terminal half of the enzyme. It is believed that the N-terminal domain influences the binding or hydrolysis of the substrate. There are two highly conserved regions within the catalytic domain, the 2 – to include the catalytic center. It has a barrel-shaped structure, forming a well. This dip is considered active center, linking carbohydrate units of chitin, possibly portions (GLC NAC) 6.

The chitinases from insects are anchored to the substrate through the C-terminal, characterized by six Cys reason.
The presence of conserved acidic residues appears to be a common feature of active site of glicohidrolases. Since the tertiary structure of family 18 is similar to other chitinaze glicohidrolaze was postulated a mechanism of acid hydrolysis of AA proposing preserved. FDxxDxDxE signature sequence (Phe – Asp – x – x – Asp – x – Asp – x – Glu) is found in the active site, including a change of Glu essential for catalysis. Highly conserved sequence YDFDGLDLDWEYP (Tyr – Asp – Phe – Asp – Gly – Leu – Asp – Leu – Asp – TRP – Glu – Tyr – Pro) is 18 chitinaze family signature. By mutagenesis, by replacing Glu in the active center, when there was loss of enzyme activity, thus Glu is essential for activity. Based on crystallographic data has been postulated that the active site binding cleft for hexamers of N – acetilglucozamina. Catalytic mechanism of soluble by products are chitotetroza, chitotrioza and chitobioza (predominantly).
Chitin and keratin DEGRADATION SETTING

Because chitin and keratin vital role in the development of insects, their degradation should be well adjusted as synthesis. The chitinases activity and cheratinazelor of skin shedding is restricted to periods and impupare while chitinazele the intestine are induced by feeding.
Degradation by enzymes cheratinazelor cuticles and certainly require specific fluid contribution in shedding proteases, which degrade protein components. These proteases may also function in proteolytic activation of precursors of The chitinases reagents.
The proteolytic activation has been intensively investigated The chitinases in Manduca and Bombyx. A probable zimogenica chitinazei form with a molecular weight of 215 kDa was observed in Bombyx during spinning. 2-3 days later, when enzyme activity is detectable, there are three active fragments of 88 kDa, 65 kDa and 54 kDa, which may be the result of successive proteolytic processing. They have a common sequence N – terminal, so different in length to the C – terminal.
It was suggested that the enzyme contains a 88 kDa domain of chitin binding strong. This domain may be lost by proteolysis from the C – terminal, resulting in variants that are more active chitinaze shorter substrates.
Similar results were observed in the skin of Manduca where a protein of 119 kDa can be seen as a precursor protein zimogen and some smaller than activated proteolytic fragments.
The INHIBITION OF chitin’S METABOLISM

Because chitin and keratin metabolism is crucial for insect development, inhibition or disruption of key enzymes are important targets for development Entomoterapiei as a series of SBA may conduct a series of problems in vertebrate animals, including humans.
Chitin synthesis inhibitors were classified into 3 major groups: peptidyl nucleosides, acyl urea and substances that interfere with hormonal control.
Peptidyl nucleosides isolated from Streptomyces species diverse acts as substrate analogues and include polioxinele and nikomicinele. They competitively inhibit chitin sintazele of both fungi and insects, probably by binding to the catalytic site. Polioxinele have found some applications in controlling pathogens. Nikomicinelor commercial application is uncertain, although it seems to be more potent inhibitors than polixinele. In general use nukes are complicated because peptidyl low permeability, hydrolytic lability, varying susceptibility of species of fungi and the multitude of responses in animals.
Acyl urea plays an important role in integrated pest control. Although it is well established that acyl urea, for example chitin synthesis affect diflubenzuronul and teflubenzuron, their mode of action is unclear.
The third group of inhibitors affects hormonal regulation of insect growth and development. One of the many effects is probably chitin synthesis by preventing disruption of chitin synthase expression or adjustment factors. Regulating hormones can be disturbed in the biosynthesis of hormones. It was shown that some synthetic derivatives of imidazole and of cholesterol biosynthesis prevent ecdysteroidului. Heterocyclic compounds and alkaloid brevioxima arborina presents a significant blockage of juvenile hormone synthesis.
Chitinazei inhibitors can be grouped into two major classes: either mimic carbohydrate substrates or intermediates. The most studied inhibitor is allosamidina chitinazei a pseudotrizaharid. Allosamidina consists of two sugars of N – linked to a allosamizolina acetilallosamina mimicking catalytic intermediary and can not be hydrolyzed because it lacks oxygen piranozic.
Allosamidina is a potent inhibitor of chitinazei. Its production is expensive because it is difficult to synthesize. A new class of inhibitors includes alternative and argadina ciclopentapeptidele argifina. Their synthesis is cheaper.

CONCLUSION AND OVERVIEW

Use of insecticides is essential for crop pest control, public hygiene, for comfort and for veterinarians. However, the effectiveness of commercial insecticides is becoming increasingly compromised by the emergence of resistance, which leads to detoxify the compound or modified target sites.
To overcome the problems of insufficient long-term pest must be identified new compounds that act to new target sites. As I pointed out chitin synthesis and degradation is crucial for growth and development of insects and are therefore ideal targets for interruption and disruption by new insecticides. We are still far from understanding how the action of enzymes involved, especially chitin and The chitinases sintazelor. We do not know the mechanisms that control and coordinate regulation biosynthesis and activity during development. A major problem in the study of insect chitin sintazelor is that we still do not have a homogeneous preparation of native sources, probably because of their intrinsic instability. Recombinant baculovirus that chitinaze of insect genes are potent biocide that can disrupt the functioning of infected insects peritrofice matrix, resulting in an increased susceptiblitate from other toxic compounds.
In conclusion, understanding basic principles of insect chitin metabolism and regulation will open new avenues of pest management.

Examples:

Antiviral drug HEPATITO-LIZ. Based on complex lipoprotein extracted from several species of insects and patented (patent N 2000-00579 / 118 114). This patent, in April 2003 was awarded the gold medal and bronze medal at the Salon of Inventions in Geneva.
The drug was initially registered as a food supplement with N. ….. Ministry of Health of Romania. Pharmaceutical dossier was made at the Department of Pharmacy State University of Moldova. Clinical tests were performed at Hospital for Infectious Diseases of the Ministry of Health of the Republic of Moldova, which have shown an improvement in key parameters: transaminases, electrophoresis, complete blood count, triglycerides, cholesterol, viremia.
Below are the concrete analysis of patients who were under treatment with the preparation HEPATITO-LIZ:

TITLE: biological preparations for the treatment of hepatitis – PROCEDURE FOR OBTAINING AND METHOD OF USE

An absolutely new idea: a lipo-protein complex extracted from the insect stops the multiplication of viruses hepatitis A, B, C, D.
The invention relates to obtaining sfingo-lipid complex in a certain stage of development, certain species of insects. Fraction is sterilized, dry by lyophilization and placed in gelatin capsules or suppositories is included in the composition of special. The capsules are administered in the morning on an empty stomach, and suppositories immediately after each defecation.
Spectral footprint includes complex lipids in the range of 180-280mm and 280-380mm in fats.
Reducing the viral load is observed immediately, starting with the third. Complete elimination of viral infection, after 12 months of treatment is about 40-45% for hepatitis C and 50-55% for hepatitis B.
Advantages compared with Roferon interferon:
-No side effects
Increases the number of platelets
-Reduced viral load
Normalize the triglycerides
-Fatigue disappears.
Another preparation is registered with the Ministry of Health MAX.Acest immune prepared to waive the immunity of human body action of tumor types (especially the prostate adenoma) and HIV / AIDS. The test results are presented below.
It is a world premiere, which will revolutionize the future general dermatology and cosmetology. It all started with an observation that seems simple at first glance. During the investigation of protein extracted from genetically engineered insects in the laboratory of Comparative Pathology resort of Saint-CHRISTOL les Ales in France I noticed an unusual phenomenon. My fingertips became very fine. Keratin layer completely disappeared and I could see the blood vessels. Then I realized the keratolytic action, these proteins we have started a special study day and night nespunand anyone what I was doing. We investigated the developmental stages of insects included a higher amount of these proteins. We determine the species of insects possess keratolytic and methods for protein isolation of these proteins without causing any unwanted changes. Proteins that have a strong keratolytic included fenilanalina, glutamic acid, asparagine and lysine. At first experiments were made on the body of rabbits, horses and dogs, which have many keratoses. I noticed that in all cases keratolytic formations disappeared without leaving a trace. I experienced these proteins on their body and to my astonishment I had some moles including a melonom who disappeared several weeks (Fig.) on the skin of rabbits at first, then on my skin, I experienced a few proteins that have succeeded in record time (5zile) tissue repair and this occurred without causing pain and unwanted signal (Fig.). Keratolytic preparations showed a miraculous effect in absorption keloizilor that occur after burns or other actions and are considered incurable. These formations are especially dangerous to children because they do not allow expansion of growing organs in this case required surgery that could allow tissue expansion. But unfortunately many of surgery complications and more serious causes producing keloizi and more pronounced. We found that elimination is possible through the action of proteins keloizilor keratolytic, when the body of a child only three years, which was brewed with hot water have produced a series of upper and lower limbs keloizi on a consistent take inoperable. And We took the treatment and for 6 months until I became absorbed keloizii elastic. Bright red color disappeared and became the color of normal skin (Figure). Later keratolytic proteins were tested on different types of melanoma and skin carcinoma. KERATO-LIZ preparation that I registered at the Ministry of Health was used to remove corns and body mounts on the limbs.
Later on keratolytic proteins were prepared and other preparations now recognized on the international market.
ANNEX: List of keratoses treated patients. Figures keratoses treated patients
Examples:
UTILIZAREA SUBSTANTELOR BIOLOGIC ACTIVE EXTRASE DIN INSECTE  IN COSMETOLOGIE  SI  DERMATOLOGE

THE USE OF BIOLOGICAL ACTIVE SUBSTANCES EXTRACTED FROM INSECTS IN COSMETOLOGY AND DERMATOLOGY
Biologically active substances (BAS) extracted from tissues of insects, far too little studied, but future research will intensify these beings. Insects have the greatest diversity of living organisms in their cells and include many SBA still unidentified, that in the near future can produce a revolution in modern biotechnology.
Up to detect SBA in insect body, these bodies have been used by humans through baculovirus, which have a specific structure. These viruses have become a classic in biotechnology for getting more SBA interferonurilor type, vaccines, insulins and more. Only a few years ago (Ciuhrii, 1999) were identified SBA keratolytic properties, which allowed the development of several cosmetic keratolytic effect. Ointments they are able to exfoliate dead tissue that is replaced with a different skin becomes elastic tissue nou.Astfel looking refreshed. Interestingly, the SBA extracted from insects are able to eliminate some unwanted formation of the human body such as skin warts, moles, warts seborrheic melanomurilor, karcenomurilor, wrinkles very common lately. Preparations act on keratin, which is the skeleton skin formations, destroying them and the other elements are removed as foreign bodies. Thus, unwanted formations disappear without leaving a trace and without causing dureri.De example, the action of a keratolytic ointment on a carcenom for 30 days is that the party finally disappear (Fig. 1). In old age people with different formations usually occur in skin and especially seborrheic warts, skin that turns a kitinoasa structure, very hard, without elasticity. After application of keratolytic preparations for 12 months skin becomes elastic and some formations disappear completely, without leaving undesirable traces (Fig. 2). In other cases, brown spots on the skin due to excessive tan in the sun, no longer despar long time. Preparations on ABB keratolytic effect can completely remove, giving skin a normal, beautiful (Fig. 3).

Another miraculous action on keloizilor have keratolytic creams that occur after trauma, especially burns. Such formations are especially dangerous to children who are growing because these structures do not allow extension Peli. In these cases required surgery to transplant skin from other parts of the body. But in such situations often occur keloizi and more, which slows the body’s normal growth. Keloizii have a stiffer, but keratolytic preparations under the action turns into a normal elastic tissue that can expand and reduce traces to a maximum (fig. 4). The photos show the transformation of keloizilor in a normal tissue period of 12 months in a child three years, which was burned ferbinte water. The child was not operated any time. Tissue regained its normal structure and developed normally.
Later they were found and other properties of SBA extracted from insects with bactericide, antifungal and antiviral (fig.5)
Biologically active substances (BAS) extracted from tissues of insects, far too little studied, but future research will intensify these beings. Insects have the greatest diversity of living organisms in their cells and include many SBA still unidentified that in the near future can produce a revolution in modern biotechnology.
Up to detect SBA in insect body; these bodies have been used by humans through baculovirus, which have a specific structure. These viruses have become a classic in biotechnology for getting more SBA interferonurilor type, vaccines, insulins and more. Only a few years ago (Ciuhrii, 1999) were identified SBA keratolytic properties, which allowed the development of several cosmetic keratolytic effect. An ointment they are able to exfoliate dead tissue that is replaced with a different skin becomes elastic tissue nou.Astfel looking refreshed. Interestingly, the SBA extracted from insects are able to eliminate some unwanted formation of the human body such as skin warts, moles, warts seborrheic melanomurilor, karcenomurilor, wrinkles very common lately. Preparations act on keratin, which is the skeleton skin formations, destroying them and the other elements are removed as foreign bodies. Thus, unwanted formations disappear without leaving a trace and without causing pain.
For example, the action of a keratolytic ointment on a carcenom for 30 days is that the party finally disappear (Fig. 1). In old age people with different formations usually occur in skin and especially seborrheic warts, skin that turns a kitinoasa structure, very hard, without elasticity. After application of keratolytic preparations for 12 months skin becomes elastic and some formations disappear completely, without leaving undesirable traces (Fig. 2). In other cases, brown spots on the skin due to excessive tan in the sun, no longer despar long time. Preparations on ABB keratolytic effect can completely remove, giving skin a normal, beautiful (Fig. 3).
Another miraculous action on keloizilor have keratolytic creams that occur after trauma, especially burns. Such formations are especially dangerous to children who are growing because these structures do not allow extension Peli. In these cases required surgery to transplant skin from other parts of the body. But in such situations often occur keloizi and more, which slows the body’s normal growth. Keloizii have a stiffer, but keratolytic preparations under the action turns into a normal elastic tissue that can expand and reduce traces to a maximum (fig. 4). The photos show the transformation of keloizilor in a normal tissue period of 12 months in a child three years, which was burned ferbinte water. The child was not operated any time. Tissue regained its normal structure and developed normally.
Mai tarziu au fost depistate si alte proprietati ale SBA extrase din insecte cu efect bactericid, antifungic si antiviral  (fig.5)
Later they were found and other properties of SBA extracted from insects with bactericide, antifungal and antiviral (fig.5)
THE ACTION OF SBA EXTRACTED FROM INSECTS

KERATOLYTIC

ANTIVIRAL                            SBA FROM INSECTS                            FUNGICE

BACTERICIDAL

which occur on other preparations. To solve problems related to the challenge of staphylococcus or streptococcus bacterial infection may apply bacteriological preparations, Liz series, which eliminate bacterial infections. The most common is acne in the stage of puberty, which no longer responds to antibiotics because microorganisms resistant to these preparations were obtained.
Proteins extracted from insects, can replace in the near future, many antibiotics to which bacteria do not react. The same problem happens with cutaneous mycoses, particularly candidiasis lately very common skin and mucosal tissue.
A special perspective presents SBA antiviral effect, which occurs on some preparations miraculous effect in eliminating herpes viruses that cause significant changes of mucosal tissue, unbearable pain and complications. Viral infections can be eliminated within a few days, without leaving undesirable traces, applying antiviral preparations on ABB extracted from insects. The SBA are in research and soon will be developed, antiviral preparations.
During the development cycle of insects, miraculous changes happen fast and SBA. Larval stage, which lasts up to 25 days to accumulate more fat, which then turns into some type of protein, with a specific structure. Development cycle ends with the formation of adult insects (butterflies), the structure which consists of keratin tissue where sperm or eggs are included. Butterfly stage last few days, then the cycle starts from the beginning (fig. 6):
stage of development of insects:
THE DEVELOPMENT STAGE OF INSECTS:

EGG                 LARVAE                    PUPAE                         ADULT

PROTEINS         LIPIDS           PROTEINS + LIPIDS             KERATOSES

Fig.6.
In each stage of development of insects can be found SBA with specific properties. The analysis of nucleic acids in proteins are extracted from the insects demonstrate a specific variety. Prevail following acids: succinic amide amino-b, glutamate, proline, alanine, Licinia, lysine. Total amino acids – 425.9390, proteinogenic acids – 411.3521, acids sequences – 213.5668 197.7854 non-sequences acids.
In the extracts of Lepidopterans constitutes 52.4 mg / We – 9 bands total protein constitutes electroforetice. The total  43.0 mg / We and 14 electrophoretic bands. CONCLUSIONS:
1. SBA extracted from insects with keratolytic effect differ from other proteins by amino acids composition, amino acid dominated the b amide succinic, glutamic acid, proline, alanine, and lysine Licinia.
2. SBA extracted from insects are able to eliminate skin formations such as warts, moles, melanomurilor, carcinomurilor without causing pain and unwanted marks.
3. Antimicrobial proteins in the near future will be able to replace some of the antibiotics that are ineffective to stop infections caused by bacteria and viruses.

SBA extracted from insects with antimicrobial properties
According to some basic information, some insect haemolymph protein composition, are able to stop the multiplication of staphylococci and streptococci bacteria type. These data and confirmed in practice. Proteins extracted from the haemolymph of insects can eliminate juvenile acne so common among the population. Later we could demonstrate the preparation and action on sinusitis, otitis, not responding to antibiotics, gaining a resistance to them.
Based on SBA was created a number of ointments for skin infections caused by staphylococci elimination and streptococci ..
Some SBA now uses to adjust stocking density of E.coli.in intestine.
Usage: If staph and strep infection skin with ointments are used on different molds, which were described above. To adjust the population density of E. coli proteins encapsulated or suppositories are administered according to instructions above.
ANNEX: List of patients treated bacterioze:
Examples:

SBA extracted from insects antifungal effect.

In some insect species have been detected antifungal protein that stops multiplication of yeast, especially Candida albicans, which causes oral candidiasis some, vaginal and skin. Proteins are extracted after certain technologies developed by us. In case of using ointments, SBA is included in special molds that can cause tissue inside the SBA. For oral candidiasis is preparing a special gel that is applied in the mouth, a lipogel that apply in the ears and nose before sleep. So during sleep, when salivary glands work more slowly and preparation can act lasting longer. Gargle after every meal is made with a special solution consisting of 200ml water, a teaspoon of baking soda, one of salt and 3-4 drops of tincture of iodine. In vaginal candidiasis infected with suppositories applied as directed previously described.
EXAMPLES:
“The insects utilization in contemporary pharmacology”

Mircea CIUHRII

Scientific Applicative Center “Insect Farm”, Bucharest
Romania, zip 020715, e-mail: ciuhrii@insectfarm.com
Introduction

The insects have the largest diversity of the living world and there are known more than 1.5 million species.
Until now, people used only the products that they make, such as been honey, propolis, venom, royal jelly, wax, silk of the silkworm.
Lately, a few insect species are used to obtain biologically active substances (BAS) that make possible to obtain of vaccines, interferons and insulin.
We managed to extract these BAS from insects, at certain stages of development, which allowed us to register 24 cosmetic and parapharmaceutical products, in conformity with European demands.
Keywords: BIologIcaly active substances (BAS), Lepidoptera, Colioptera, Diptera.
Pharapharmacy, glutamic acid, argenin, leucin.
Material and methods

The species that has been used are from the Diptera, Coleoptera and Lepidoptera families, grown in special laboratories, with special food.
BAS has been extracted by applying special technologies, in order to obtain complex compounds. A few of those technologies are: special mills, special filters and centrifuges type K-24.
The extract has been put to conservation, after a special dehydration. The analyses were made with the spectrophotometer “Cintra-5” and with the analyzer for aminoacids, type “Tesla”.

Results and discussions

The obtained extracts contain a lipoproteic complex, where the proteins are predominant (Table 2) and lipids are in different proportions, with many properties (Figure 1).
The proteic complex contains aminoacids and the predominant are: glutamic acid, arginine, leucine (Diagram 1).
The keratolytic enzymes allowed the elaboration of new technologies to make cosmetic products, with special properties (Fig. 2). These products can eliminate cutaneous formations, without pain and without unpleasant marks.
I have elaborated antibacterial products, such as “Juvenile lotion”, “Juvenile cream” and “Juvenile mask” with a benefic effect in affections like acne (Fig. 3).
It has also been isolated a complex with antiviral properties, which allowed the registration of new antiviral products, such us “Hepatito-liz 1 and 2” with immunomodulatory action for hepatic cells and an inhibitory process of viral protein and nucleic synthesis acids (Patent RO 2000 N 00580; RO 2000 N 00579). This product can eliminate viral infections (Fig. 4).
Another product is “Herpes-liz”, who can stop the multiplication of the herpetic viruses and herpes-zoster viruses and I can say that it has a spectacular effect (Fig. 5).
BAS with antitumoral properties allowed the registration of the products “Adenoma-liz” and “Fibroma-liz”, which can eliminate the prostate adenoma and the uterine fibroma (Patent RO N 00707). They are made as suppositories, which are quickly absorbed into tissues and treat any inflammation (Fig. 6). It has been demonstrated the efficacy of them and I can say that it represents 75%.
The products “Varico-liz” and “Trombo-liz” have the property to dissolve the thrombus that blocks the veins (Patent RO N 00706) and the circuit of blood become normal again (Fig. 7).
The anti-inflammatory and immunomodulatory products have a benefic action in autoimmune affections, such us psoriasis, rheumatism, erythematic lupus (Patent RO N 00556), making the pain goes away. They are made as creams, for massages.

Conclusions
The extracts from insects in certain stage of development will rise the longevity by 15-20 years.
The lipoproteic complex has the power to make biological operations to eliminate cutaneous formations such us moles, warts, carcinomas, melanomas and whithout causing any pain or marks.
The suppositories have the property to absorb prostate adenoma and uterine fibroma, whithout causing complications.
For the first time, it have been obtained antiviral products, based on inhibitory extracts obtained from insects, which can stop protein synthesis and viral nucleic acids synthesis, in anticipation of total elimination.
The BAS property of eliminating thromboses, that blok the venous circulation, will allow the replacement of surgical operations.

TABLE 1
PREPARATIONS FOR INTIMATE CARE

NAME OF THE PRODUCT ACTION
FLY-FLY “ INTIMATE GEL V “
NOTIFICATION  NUMBER: 13596/16.10.2003 It contributes to the elimination of the flora which is not specific for the feminine intimate part of the body
FLY-FLY “INTIMATE GEL H “
NOTIFICATION  NUMBER
13604/16.10.2003 It contributes to the elimination of the flora which is not specific for the masculine intimate part of the body

PREPARATIONS FOR ORAL CARE

NAME OF THE PRODUCT
ACTION
FLY-FLY “ ORAL MUCOUS MEMBRANE GEL“
NOTIFICATION NUMBER
13603/16.10.2003 it has antiinflammatory properties
it contributes to the adjustement of the flora of the oral mucous membrane.
FLY-FLY “ORAL CAVITY GEL “
NOTIFICATION NUMBER13606/16.10.2003 It contributes to :
the disinfection of the oral cavity
the refreshing of the breath
FLY-FLY “TOOTH AND GUM GEL“
NOTIFICATION  NUMBER
It contributes to:
the disinfection of the oral cavity
the refreshing of the breath
the anti-inflammatory action
FLY-FLY “MOUTHWASH “
NOTIFICATION  NUMBER
13590/16.10.2003 refreshing of the breath
it has a cooling/ refreshing effect
it contributes to the oral hygiene

Preparations  for body care

NAME OF THE PRODUCT ACTION
FLY-FLY “ BODY MASSAGE CREAM“
NOTIFICATION  NUMBER
12372/26.11.2002 It contributes to  :
the increanse of skin elasticity
the intensification of blood circulation
FLY-FLY “FOOT CREAM “
NOTIFICATION  NUMBER
13600/16.10.2003 It contributes to :
the increase of skin elasticity
the increase of the mobility of the limbs joints
the toning of the  epithelial tissue
it gives the sensation of comfort and relaxation
it removs the sensation of heavy legs
FLY-FLY “ANKLE CREAM“
NOTIFICATION  NUMBER
13609/16.10.2003 It contributes to :
the increase on skin elasticity
the intensification of blood circulation
the decrease of the deformation of the blood vessels
FLY-FLY “NAIL LIPOGEL “
NOTIFICATION  NUMBER
13601/16.10.2003     It contributes to:
the treatment of the depreciated nails and the contiguous areas
.

PREPARATE WITH KERATOLYTIC ACTION

NAME OF THE PRODUCT
ACTION
FLY-FLY “ SKIN CREAM“
NOTIFICATION  NUMBER
13598/16.10.2003 It contributes to  :
the diminution decrease of the schin of the human body
the refreshing and moisturizing of the skin
FLY-FLY “CREAM FOR EXFOLIATED SKIN “
NOTIFICATION  NUMBER
13602/16.10.2003 It contributes to the refreshing and moisturizing of the skin with a tendency for exfoliation
FLY-FLY “DECOLLETAGE CREAM
NOTIFICATION  NUMBER“
13607/16.10.2003 It contributes to the toning and refreshing of the epithelial tissue
FLY-FLY “GEL CREAM ANTICELLULITIC MASSAGE “
NOTIFICATION  NUMBER
13597/16.10.2003 It contributes to  :
the care the maintenance and the treatment of the parts of the body affected by cellulitis
the decrease of the adipose tissue
FLY-FLY “VIBEX CREAM “
NOTIFICATION  NUMBER
13608/16.10.2003 : It contributes to
the toning, omfort and neutralization of the free radicals
the reconstruction of the collagen
PREPARATIONS FOR HAIR CARE

NAME OF THE PRODUCT ACTION
LA VITRINE MAGIQUE “ HAIR LOTION“
NOTIFICATION  NUMBER
13594/16.10.2003 it prevents and fights the hair fall and the dandruff
it brings back the glistening and the elasticity of the hair
it contributes to the vitality of the hair
LA VITRINE MAGIQUE “SHAMPOO“
NOTIFICATION  NUMBER
13591/16.10.2003 it contributes to the prevention of the hair fall and to its regeneration
it has antifungic properties

COSMETIC PREPARATIONS FOR TEENAGER
NAME OF THE PRODUCT
ACTION
LA VITRINE MAGIQUE

“ CREAM FOR TEENAGERS“
“GEL MASK FOR TEENGERS“
“LOTION FOR TEENGERS“
NOTIFICATION  NUMBER
1266/28.01.2003

They maintain the state of cleanlinesse and health of the tissue
The elimination of mechanical impurities
They contribute to the decrease of the microbial germs on the epidermis
They contribute to the adjustement the  secretion of the sebaceous glands

FLY-FLY
’’ SPECIAL SOLUTION”
NOTIFICATION  NUMBER
:13595/16.10.2003

It cleansesthe epidermis, thus preparing it for the application of the cosmetic products

TABLE 2
QUANTITATIVE ANALYSES OF THE SBA
extracted from different species of insects
in different stages of development

No crt. Specimen Dry substance g/100 g Proteins
g/100 g Lipids
g/100g Sugar
g/100g
1.  L.d.O 91,27 66,29 16,91 2,380
2. L.d.(I) 90,27 73,17 11,78 0,556
3. L.d.(p) 93,19 66,36 23,50 8,870
4. L.d.I(at) 95,40 55,54 28,32 1,900
5. P.e.p(at) 88,89 55,86 23,62 3,640
6. P.e.p 91,05 78,83 12,54 2,010
7. B.m(p2) 82,43 74,79 16,34 2,890
8. Bm.I.(at) 94,86 51,69 18,46 3,880
9. M.n.I(at) 93,88 49,54 26,94 2,650
10. C(I) 92,58 48,48 20,39 4,600
11. C2(a) 90,36 65,28 6,57 4,230
12. Dm.I 91,79 47,03 22,24 –
13. Dm.I(m) 94,10 53,21 22,27 4,280
14. Gm.I(a) 95,09 44,67 38,62 5,400
15. Gm.F 91,48 55,93 9,02 –
16. Li 97,07 45,20 20,63 4,040
17. mm 97,12 50,09 20,92 4,030
18. P.u.f 88,28 66,84 – 2,200
19. Grape seeds 94,89 12,45 8,40 5,400
20. Pr(a)-quail egg 96,92 43,14 29,50 2,060

Annex: list of patients treated for candidoses

SBA extracted from insects with antitumoral effect.

Obtaining SBA with antitumoral effect is a world premiere. The mechanism of action is the destruction of tumor formations skeletal tumors and other components removed from the body as foreign bodies. These SBA is difficult to obtain because they can detect very slowly and only at certain stages of development of some insect species.
The most common tumor and skin removed are melanomas and carcenomas skin type (Fig.). We have solved many cases of prostate adenoma. It may be absorbed using special suppositories (Annex with ultrasound before treatment and after treatment). We have solved many cases of uterine fibroids when suppositories are inserted into the vagina at bedtime. Then he sits on a base that makes it stand above the basin head for 25-30 minutes. Lavages with calendula tea using an irrigator every three days (Annex the list of patients and ultrasound).

SBA extracted from insects with antiparadontoses effect
The preparation for gum care for the treatment of periodontal disease was studied in a few dental centers. All patients were organized into a few groups according to age: 20-30 years, 30-40 years, 40-50 years, 50-60 years and over 60 years. Preparation effect is greater in patients with younger ages. The preparation has a regenerative action. Diseased gums, the soft consistency, with pus, which is separate from the teeth (fig) within 3 months of treatment gums are pink, with a hard consistency, which does not bleed brushing teeth (Fig.). Each group includes about 20 – 25 patients. The characterization patients was done according to several criteria: name, surname, age, address, occupation, reasons for presentation to the doctor, hetero-collateral history, personal history, history of periodontal disease, allergies, occupational hazards, smoker or not, alcohol, exam general clinical examination, clinical and regional, state lining, language status, mastication, phonation, vicious habits: parodontomia before treatment

11VMOD                21 MOD
12V MOD               22VMOD
13V MOD              23V MOD
14 V MOD             24 V MOD
15 V MOD              25 V MOD

41 V MOD             31 V MOD
42 V MOD              32 V MOD
43 V MOD              33 V MOD
44 V MOD            34 V MOD
45 V MOD            35 V MOD
46 V MOD             36 V MOD
47 V MOC             37 V MOD
48 V MOD             38 V MOD
ADDITIONAL PROFESSIONAL EXAMS

TREATMENT: „ Intimate gel” at night before bedtime, massage gel gums and palate. The gel is chewed with saliva, and then swallows with small sips so as to form a film across the esophagus. Morning, gargle with a solution of 200ml water, a teaspoon of baking soda, one teaspoon of superfine white salt and 3-4 drops of tincture of iodine. Is gargle after every meal so that food scraps do not remain in the mouth.
PERFORMING PARODONTOMETRA AFTER TREATMENT

The treatment effect is noticed after three months. If you need further treatment until symptoms of paradontoza.

RECOMMENDATIONS

REGULAR CONSULTATION

Biologically active substances it includes a special matrix composed of the following ingredients: water, mineral oil, propylene glycol, glycerin, dimetican, poligliceril-4 stearate, isopropyl myristate-, propyl paraben, carbomer, sodium hydroxide, acrilat/c10- 30, acrilates / c10-30 Alvyl crosspolimer acrylate, 2-bromo-Dial nitropropan-43, glutamic acid, asparagine, lysine, arginine. The preparation is produced as a gel that is applied to the gums, the evening before bedtime.

Biological preparations to treat Cardiovascular
Procedure for obtaining and using

The invention relates to treating varicose veins, thrombophlebitis, arteritis and other cardiovascular disease, which causes the highest fatalities.
Currently human varicose veins on the legs treated with venoruten, cheerful, hepatrombina, Trent, pentoxifylline, planners, but in most cases recourse to surgery, not permanently solve the problem because the veins adjacent to the duties of the operator sclerozeaza and they and the disease in most cases recur.
If thrombophlebitis is given about the same treatment as in varicose veins, adding some type anticoagulants Coumadin, heparin and low dose aspirin, which can maintain the formation of new thrombi.
Arteritis-clogging arteries, is a process common in human population and cause serious health problems. In the case of arteritis often are given some type of anticoagulant preparations sedamin Trent, halides, sermion, but these have no effect prepatate quickly and are often ineffective, recourse to surgery, which are painful and very dangerous.
The purpose of the invention is to develop a biological preparation for absorption trombelor and embolism within blood vessels. The active substance is based on extracts of lipo-protein products derived from certain species of insects, which during morphogenesis produce biologically active substances with the property to dissolve deposits in blood vessels – emboliile.Pornind from the fact that when a atingererii with hairy larvae human skin red spots, which causes dilation of a protein are determined sanguine.Acestea urticarial yet unstudied by anyone. We have managed to isolate these substances from larval tissues to use both passwords and in some types of creams and built-in special capsules, used to attack some fibrosis of blood vessels.
Obtaining biological active substance (SBA) of larval tissues is a specific process. Hairy caterpillar using larvae of the oak (Lymantria dispar L), the dudului (Hyphontria cunea Drury), ring (Melacosoma Neustr L), the caterpillar with red stem (Euproctis crissorhaea L), which are found in nature or bred in the laboratory artificial environments.
Stage I larvae of the last age (5-6varste are), are collected in plastic pots with tweezers to avoid penetration into the skin of fingers perisorilor operators, then the larvae are washed 3-4 times with clean water, are held in a serosal solution, where 10 liters of water add 90-95 g of pure sodium chloride and keep for 15-20 minutes. All larvae are passed through a solution of 70% alcohol, where it disinfects their surface.
Stage II. Larvae are chopped with a mortar washed with 4 electric knives. To do this, in a plastic cylinder with a height of 55-60 cm and 20-22 cm in diameter from 2 to 2.5 kg each place larvae, then entering the cylinder device mortar and moving it to the bottom and the surface for 12-15 minutes at a speed of 4500-5000 rpm / min, the larvae are chopped up to form a mass of light gray, with particle size of 10-15 Hm.
Stage III. The suspension may also occur through a meat grinder machines, which has a sieve with 1.5-2mm. The suspension formed is filtered through a cloth Evelina and centrifuge speed of 3000 revolutions / minute for 12-15 minutes, until the formation of three layers: one at the bottom of the tubes (which is a chitin), one in the middle , uniform (which is a lipoprotein complex) and one on the surface (which is fat).
Stage IV. With a special separator to collect the middle of biologically active substances.
Stage V. The suspension is at a temperature of 130-140 0C liofilizeaza a special freeze or spray atomizes a brand,, Niro „(Denmark) at 140-1500C temperature of 85-90 0C input and output. Analyzed with fotospectometrul produce substances obtained specific fingerprints, which mostly consists of proteins and lipids 28.10% 55.54%. Spectral fingerprint of SBA extracted from Lymantria dispar larvae causes the appearance of a sharp curve in the 200-300 Hm (Fig. 1) after extraction in alkaline medium. Another mark appears after extraction in acetone (Fig. 2) that in the wavelength of 300-310, forms a little intensity exceeding 5Abs. In the wavelength 150-300Hm, complex oscillations occur. At higher resolutions, oscillations stand out better (Fig. 3). After delipidizarea extract is one curve (Fig. 4), which locates in the wavelength of 200-250Hm with a higher intensity of 2Abs without complicated oscillations. It can be seen that this curve is composed of proteins and sugars (chitin). The other components that appeared on prints with intricate curves disappear after performing delipidizarii.
After studies to develop a quality standard of preparation. Spectral fingerprint of this preparation shows the presence of two curves: one large, with little in the wavelength region of 280-380Hm 3Abs with an intensity of which is the (matrix) ointment, and a lower curve, with little and the lower intensity of 1Abs, which is the active substance (Figure 5).
Spectral fingerprints serve as an indicator for the quality of preparation for foot care. Higher peak indicates matrix ointment, and the lowest active substance (Figure 5).
Protein extracted from larvae disappear Limantria includes the following amino acids, represented qualitatively in descending order:

The powder is light gray in a matrix includes forming a special ointment that penetrates the skin immediately. In the case of arteritis (arterial thrombosis) SBA is incorporated in special capsules and administered,, per os „or you can make direct infusion into blood vessels. For external use, the protein is in the matrix includes a massage ointment on the area that are varicose or arteritis. If varicose veins, massage is done on the States, from foot to knee, and if arteritis, massage is done from the knee to foot. Ointment penetrates the skin quickly, for 3-5 minutes.

Ointments are produced as follows: oily phase material is 0C and melt at 70 separate raw materials which compose the aqueous phase at a temperature of 70 0C. When both phases reach a temperature of 70 0C, the emulsion is made by adding the aqueous phase to phase fat, shaking with a special mortar for 25-30 minutes at a speed of 2500-3000 rpm / miunut until a mass uniform. Ointment obtained is packed in boxes or special tubes are sold.

Nr.crt Denumire materie prima Denumire INCI Cantitate g/100g
1. Apa distilata Aqua  50,97
2. Neobee M5 Caprylic/Capric Triglyceride 8,00
3. Stenol 1618 Cetearyl Alcohol 6,00
4. Eumulgin B3 Ceteareth – 30 5,00
5. IPM Isopropyl Myristate 4,00
6. Shea Butter Butyrospermum Parkii 2,50
7. Hydrolite-5 Pentylene Glycol 2,50
8. Glicerina Glycerin 2,50
9. Sabowax ELH40 PEG – 40 Hidrogenated Castor Oil 2,50
10. Extract de galbenele Calendulae Offinalis Extract 2,50
11. Extract de castanet Aesculus Hippocastanum Extract 2,50
12. Extract de salvie Salvia Officinalis (Sage) Extract 2,50
13. Ulei siliconic AK 350 Dimethicone 2,00
14. Vara 200 Mineral Oil 2,00
15. Amestec AA 11 Glutamic Acid
Aspargine
Arginine
Alanine 2,00
16. Ulei de rozmarin Rosmarinus Officinalis Oil 1,00
17. Garmaben II E Propylene Glycol (and) Diazolidinyl
Urea (and) Methylparaben (and)
Propylparaben  1,00
18. Polygel CA Carbomer 0,20
19. Parfum Parfum 0,20
20. BHA BHA 0,10
21. Metilnicotinate  Methyl Nicotinate 0,03
Encapsulated drug is produced as follows: powder obtained after lyophilization or atomization is inserted directly into gelatin capsules, which are administered in the morning on an empty stomach.
Example: in the months May-August larvae appear last age of the caterpillar hairy. The most common are those of oak (Lymantria dispar), the dudului (Hyphantria cunea L.), caterpillars with red stem (Euproctis crissarhaea L.), inelarele (Malacosama Neustr L.) and other species of insect larvae that password.
Hairy caterpillar larvae of the last age group to have property in the trees mentioned above strains to impupa. This is a moment that allows their collection and lasts 3-4 days. If they escape this time a year is lost and therefore is forecast and determine the location of outbreaks, to perform a full collection of nature. This collection is the most economical because the larvae eat leaves of trees spontaneous.
The larvae can grow in the laboratory under controlled conditions. For this winter in February – March, hairy caterpillars are harvested eggs, especially Lymantria dispar, whose technology is studied better growth, put in special vessels artificial environments, where the main components are: embryos germinated wheat, agar – agar, vitamins, yeast, amino acids, salts, antibiotics and oils.
The media also put out the eggs from which larvae, then in time of 15-18 days reach the last age, when they formed and SBA. On artificial media is harvested larvae, which are washed in clean water 3-4, then hold a serous solution (10 liters of distilled water add 90g of pure salt – NaCl).
Larvae collected in nature more intense wash in several waters until the water remains clean and then the serosal solution. After 15-20 minutes are held in this solution is passed through 70% alcohol, thus executed a total disinfection.
Another phase is washed and disinfected larvae maceration. For this procedure using a mortar and meat grinders electric, which is mounted sieves with small, 1.5-2mm. Larvae are chopped several times, until the particles get a mass of 10-15mm.
The next step is filtering the product soak a cloth with 200 holes on Evelina 1cm2. The filtrate is performed under pressure, squeezing, squeezing until Evelina is full of juice,